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Search Results: 1 - 10 of 402777 matches for " Preeti M. Chavan-Gautam "
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Matrix Metalloproteinase-1 and -9 in Human Placenta during Spontaneous Vaginal Delivery and Caesarean Sectioning in Preterm Pregnancy
Deepali P. Sundrani, Preeti M. Chavan-Gautam, Hemlata R. Pisal, Savita S. Mehendale, Sadhana R. Joshi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029855
Abstract: Preterm birth is a major public health problem in terms of loss of life, long-term and short term disabilities worldwide. The process of parturition (both term and preterm) involves intensive remodelling of the extracellular matrix (ECM) in the placenta and fetal membranes by matrix metalloproteinases (MMPs). Our previous studies show reduced docosahexaenoic acid (DHA) in women delivering preterm. Further omega 3 fatty acids are reported to regulate MMP levels. This study was undertaken to examine the placental levels of MMPs and their association with placental DHA levels in women delivering preterm. The levels of MMP-1 and MMP-9 in 74 women delivering preterm (52 by spontaneous vaginal delivery and 22 by caesarean sectioning) and 75 women delivering at term (59 by spontaneous vaginal delivery and 16 by caesarean sectioning) were determined by enzyme-linked immunosorbent assay (ELISA) and their association with placental DHA was studied. Placental MMP-1 levels were higher (p<0.05) in women delivering preterm (both by spontaneous vaginal delivery and caesarean sectioning) as compared to those delivering at term. In contrast, placental MMP-9 levels in preterm pregnancies was higher (p<0.05) in women with spontaneous vaginal delivery while lower (p<0.05) in women delivering by caesarean sectioning. Low placental DHA was associated with higher placental MMP-9 levels. Our study suggests a differential effect of mode of delivery on the levels of MMPs from placenta. Further this study suggests a negative association of DHA and the levels of MMP-9 in human placenta although the mechanisms need further study.
Effects of Altered Maternal Folic Acid, Vitamin B12 and Docosahexaenoic Acid on Placental Global DNA Methylation Patterns in Wistar Rats
Asmita Kulkarni,Kamini Dangat,Anvita Kale,Pratiksha Sable,Preeti Chavan-Gautam,Sadhana Joshi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017706
Abstract: Potential adverse effects of excess maternal folic acid supplementation on a vegetarian population deficient in vitamin B12 are poorly understood. We have previously shown in a rat model that maternal folic acid supplementation at marginal protein levels reduces brain omega-3 fatty acid levels in the adult offspring. We have also reported that reduced docosahexaenoic acid (DHA) levels may result in diversion of methyl groups towards DNA in the one carbon metabolic pathway ultimately resulting in DNA methylation. This study was designed to examine the effect of normal and excess folic acid in the absence and presence of vitamin B12 deficiency on global methylation patterns in the placenta. Further, the effect of maternal omega 3 fatty acid supplementation on the above vitamin B12 deficient diets was also examined. Our results suggest maternal folic acid supplementation in the absence of vitamin B12 lowers plasma and placental DHA levels (p<0.05) and reduces global DNA methylation levels (p<0.05). When this group was supplemented with omega 3 fatty acids there was an increase in placental DHA levels and subsequently DNA methylation levels revert back to the levels of the control group. Our results suggest for the first time that DHA plays an important role in one carbon metabolism thereby influencing global DNA methylation in the placenta.
On the study of phase-space analysis of fragments produced in heavy-ion collisions
Sakshi Gautam,Preeti Bansal
Physics , 2011,
Abstract: Effect of momentum-dependent interactions and broader Gaussian is investigated on the emission of various fragments formed in a heavy-ion reaction. We also study the corresponding structure details of those fragments for broader Gaussian and momentum-dependent interactions. We find that nucleons forming the fragments belong to same region of the phase space
Phase-space analysis of fragments formed in heavy-ion collisions
Sakshi Gautam,Preeti Bansal
Physics , 2011,
Abstract: We study the effect of momentum-dependent interactions and a broader Gaussian on multifragmentation. We also look into the details of the fragment structure for a broader Gaussian and momentum-dependent interactions. We find that nucleons forming the fragments belong to same region of the phase space.
DNA Microarrays in Herbal Drug Research
Preeti Chavan,Kalpana Joshi,Bhushan Patwardhan
Evidence-Based Complementary and Alternative Medicine , 2006, DOI: 10.1093/ecam/nel075
Abstract: Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts.
Molecular Significance of lon and cpxR Genes in the Pathogenicity of Salmonella  [PDF]
Rahul M. Nandre, Preeti Mahajan
Open Journal of Animal Sciences (OJAS) , 2015, DOI: 10.4236/ojas.2015.54045
Abstract: The important foodborne zoonotic pathogen Salmonella causes gastroenteritis. The dynamics of host-pathogen Salmonella interaction and infection might enhance the development of novel tar-geted preventative measures and drug regimens. The lon and cpxR are virulence associated genes, which have an important role in the Salmonella pathogenesis. However, the deletions of lon and cpxRlead to the construction of genetically engineered live Salmonella vaccine candidate. In this review, lon and cpxR genes are focused for their involvement in Salmonella pathogenesis. Furthermore, the importance of these genes was briefly emphasized during the construction of Salmonella vaccine candidate.
Florid manifestions of recurrent herpes genitalis in seronegative patient
Nisarg Chavan,Manjyot Gautam,Sharmila Patil
Indian Journal of Sexually Transmitted Diseases , 2008,
Familial distal renal tubular acidosis presenting as acute quadriparesis
Zaki Syed,Chavan Vishal,Nagotkar Leena,Shanbag Preeti
Saudi Journal of Kidney Diseases and Transplantation , 2010,
Forensic Investigations & Frauds Detection (Related To Forensic Accounting)
Ranjana M. Chavan
Golden Research Thoughts , 2012, DOI: 10.9780/22315063
Abstract: The ICAI has defined auditing “the independent examination of financial information of any entity , whether profit oriented or not and irrespective of its size or legal form, when such an examination is conducted with view to express an opinion thereon.”
Ranjana M.Chavan
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Microfinance sector has grown rapidly over the past few decades. Nobel Laureate Muhammad Yunus is credited with laying the foundation of the modern MFIs with establishment of Grameen Bank, Bangladesh in 1976. Today it has evolved into a vibrant industry exhibiting a variety of business models. The microfinance sector is having a healthy growth rate, there have been a number of concerns related to the sector, like grey areas in regulation, transparent pricing, low financial literacy etc. In addition to these concerns there are a few emerging concerns like cluster formation, insufficient funds, multiple lending and over-indebtedness which are arising because of the increasing competition among the MFIs.
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