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Search Results: 1 - 10 of 27779 matches for " Praveen Kumar Gupta "
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Sero-Prevalence of Paratuberculosis (Johne's Disease) in Cattle Population of South-Western Bangalore Using ELISA Kit  [PDF]
Anvita Gupta, Sobha M. Rani, Pushpa Agrawal, Praveen Kumar Gupta
Open Journal of Veterinary Medicine (OJVM) , 2012, DOI: 10.4236/ojvm.2012.24031
Abstract: Johne's disease or paratuberculosis is a chronic mycobacterial infection that affects cattle, sheep, goats and other ruminants, adversely, leading to huge economic losses throughout the world. The estimation of sero-prevalence of this disease in the cattle population of south-western Bangalore, Karnataka, using an immunological assay and statistical analyses, was the objective of this study. One of the diagnostic tools used to detect an antigen or an antibody in animal serum or milk is the Enzyme Linked Immuno-Sorbent Assay, which has been widely used in the research and diagnosis of animal and human diseases as its accuracy is of nanogram-picogram/milliltre level. In the present study, indirect-ELISA was used to diagnose and estimate the sero-prevalence of paratuberculosis in cattle showing diarrhoea and/or anaemia, at 5 local dairy farms in south-west Bangalore, India. Out of 350 bovine serum samples, 53 (15.14%) were positive, 55 milk samples out of 300 were found positive (18.33%) for antibody against Johne's disease by indirect ELISA. The positive samples were then confirmed by direct smear examination of dung by Ziehl-Neelsen staining. Statistical analyses were carried out to indicate the seroprevalence of Johne's disease in the cattle population of this region to be 15 ± 10%, taking a confidence interval of 95%. The results emphasize the need to prevent the further spread of infection to other susceptible animals and humans as the causative organism, Mycobacterium avium subsp. paratuberculosis is implicated in Crohn's disease, an irritable bowel syndrome in humans.
Giant Loose Body of Knee Joint Presenting as Accessory Patella
—A Case Report
 [PDF]

Praveen Kumar Pandey, Inder Pawar, Jyoti Gupta, Raaghav Rai Verma
Open Journal of Orthopedics (OJO) , 2015, DOI: 10.4236/ojo.2015.58031
Abstract: Loose bodies are freely floating fragments of cartilage or bone inside the knee joint space. This is commonly seen in association with degenerative joint disease (DJD), direct or indirect trauma, synovial chondromatosis, osteochondritis dissecans (OCD) and size of the loose body may vary from few millimeters to few centimeters. Patients with loose bodies in knee joint presented to orthopaedists with knee pain, swelling and restricted movement, with intermittent locking or catching of the joint. This is managed surgically most of the times when it becomes symptomatic. The surgical technique most commonly utilized is arthroscopy. Open arthrotomy should be done when the loose bodies are very large/numerous/located in posterior joint space. In review of literature, we found very few cases of giant loose body in knee joint due to DJD reported in last 70 years. We are hereby reporting our case of 60-year-old male with a giant loose body of same size as of patella in the supra-patellar pouch of left knee joint and managed by arthrotomy to remove the giant loose body. Post-operatively patient recovered significantly over the period of 6-week follow-up. In conclusion, giant loose body should be removed through arthrotomy and all such cases should be thoroughly evaluated to diagnose the cause of giant loose body.
INFLUENCE OF SLIP CONDITION ON PERISTALTIC TRANSPORT OF A VISCOELASTIC FLUID WITH FRACTIONAL BURGER'S MODEL
Dharmendra TRIPATHI,Praveen Kumar GUPTA,Subir Das
Thermal Science , 2011, DOI: tsci1102501t
Abstract: The investigation is to explore the transportation of a viscoelastic fluid with fractional Burgers' model by peristalsis through a channel under the influence of wall slip condition. This analysis has been carried out under the assumption of long wavelength and low Reynolds number. An approximate analytical solution of the problem is obtained by using Homotopy Analysis method (HAM). It is assumed that the cross-section of the channel varies sinusoidally along the length of channel. The expressions for axial velocity, volume flow rate and pressure gradient are obtained. The effects of fractional parameters α and β, material constants λ1, λ2, λ3, slip parameter k and Φ amplitude on the pressure difference and friction force across one wavelength are discussed numerically and with the help of illustrations.
GREEN PHARMACY: AN ALTERNATIVE AND COMPLEMENTARY MEDICINE
Neeta Shivakumar*, Pushpa Agrawal and Praveen Kumar Gupta
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: The people in India have an outstanding knowledge of medicinal plants acquired over centuries. A passion for studying medicinal plants is evident both in folk and scholarly traditions. The indigenous mode of understanding and using plants is different from the modern scientific way. It includes botanical, medical and astrological elements. This is the basis of green pharmacy. Indians obviously care for medicinal plants because they know so many of them, so much about them and have worked extensively on their application. It is a remarkable fact that the use of medicinal plants is still a living tradition in the form of a million village-based folk carriers. These traditional birth attendants, bonesetters, herbal healers and wandering monks are invisible to policy makers and therefore not taken into account as a public health resource. Apart from these specialised folk healers there are also millions of women and elders with traditional knowledge of food and nutrition and herbal home-remedies. However, the revitalisation of this vast and diverse folk tradition does not appear on the Governments agenda. Here is an attempt to introduce these traditional knowledge with an emphasis of Nevadensin that holds a promising substance to cure many of the diseases naturally.
A REVIEW ON XYLOOLIGOSACCHARIDES
Gupta Praveen Kumar,Agrawal Pushpa,Hegde Prabha
International Research Journal of Pharmacy , 2012,
Abstract: Xylan is an important structural component of plant biomass left in agricultural wastes. It is the most abundant of all of the hemicellulosic materials in the world. A number of economically valuable products such as xylose and xylitol can be made from Xylan, but one category of emerging importance is Xylooligosaccharides (XOS). Xylans are present not only in wood but also in various other plants such as grasses, cereals, and herbs. They constitute 5-35% of the dry tissues of lignocellulosic materials and occur up to 50% in some cereal grains. Non-digestible oligosaccharides are low molecular weight carbohydrates of intermediate in nature between simple sugars and polysaccharides. They can be obtained by direct extraction from natural sources or produced by chemical processes hydrolyzing polysaccharides or by enzymatic and chemical synthesis from disaccharides. XOS have great prebiotic potential and can be incorporated into many food products. XOS seem to exert their nutritional bene ts in various animal species, which by definition have an intestinal tract populated by a complex, bacterial intestinal ecosystem.
Effect Of Daily And Alternate Day Iron & Folic Acid Supplementation To Pregnant Females On The Weight Of The Newborn
Grover Vijay,Aggarwal O.P,Gupta Anita,Kumar Praveen
Indian Journal of Community Medicine , 1998,
Abstract: Research question: What is the effect of IFA supplementation when given daily and on alternate days? Objective: To study the effect of daily and alternate day IFA supplementation. Study design: Intervention study. Setting: Rural health center of Gazipur village in east Delhi under deptt, of PSM, University College of Medical Sciences, Delhi. Participants: Pregnant females with period of gestation 20 ±4 weeks registering during Jan. to Dec. 94. Sample size: 120 pregnant females. Study variables: Birth weight. Results: Total 120 pregnant females were studied. 64 were put on daily (Group I) and 56 on alternate day (group II) IFA supplementation. In group I, 7 (10.9%) babies had birth weight less than 2.5 Kg as compared to 3 (5.3%) in Group II. However, the difference between the two groups regarding the birth weight was not statistically significant (p=0.489). Supplementation of IFA in Group II caused fewer adverse effects compared to Group I. Alternate day IFA supplementation may be an alternate to daily IFA in cases of non-compliance due to adverse effects without adversely affecting the outcome of pregnancy.
Chaotic Properties on Time Varying Map and Its Set Valued Extension  [PDF]
Ayub Khan, Praveen Kumar
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.33051
Abstract: Every autonomous dynamical system X, finduces a set-valued dynamical system \"\"on the space of compact subsets of X. In this paper we have investigated some chaotic relations between a nonautonomous dynamical system and its set valued extension.
Interferon Alpha Characterization and Its Comparative Expression in PBM Cells of Capra hircus and Antelope cervicapra Cultured in the Presence of TLR9 Agonist
Ramesh Doreswamy,Mohini Saini,Devendra Swarup,Vivek Kumar Singh,Suchitra Upreti,Asit Das,Praveen K. Gupta
Molecular Biology International , 2010, DOI: 10.4061/2010/573426
Abstract: TLR9 plays pivotal role in innate immune responses through upregulation of costimulatory molecules and induction of proinflammatory cytokines like type I interferons including interferon alpha (IFNA). The present study characterized IFNA cDNA and predicted protein sequences in goat and black buck. Response of the PBM cells to TLR9 agonist CpG ODN C and Phorbol Myristate Acetate (PMA) was evaluated by realtime PCR. IFNA coding sequences were amplified from leukocyte cDNA and cloned in pGEMT-easy vector for nucleotide sequencing. Sequence analysis revealed 570?bp, IFNA ORF encoding 189 amino acids in goat and black buck. Black buck and goat IFNA has 92.1% to 94.7% and 93% to 95.6% similarity at nucleotide level, 86.3% to 89.5% and 70.9% to 91.6% identity at amino acid level with other ruminants, respectively. Nonsynonymous substitutions exceeding synonymous substitutions indicated IFNA evolved through positive selection among ruminants. In spite of lower total leukocyte count, the innate immune cells like monocytes and neutrophils were more in black buck compared to goat. In addition, CpG ODN C-stimulated PBM cells revealed raised IFNA transcript in black buck than goat. These findings indicate sturdy genetically governed immune system in wild antelope black buck compared to domestic ruminant goat. 1. Introduction TLR9 emerged as a robust pathogen recognition receptor of innate immune system in the present decade and is known to be present in the endosomal membrane of the Plasmacytoid dendritic cells [pDCs], macrophages, and B- cells where it functions as a known sensor for bacterial, viral, fungal, and parasitic foreign DNA [1]. pDCs have been proved as powerful natural Interferon alpha (IFNA) secreting cells in mouse, human, and porcine in response to bacterial/viral (unmethylated cytosine-guanine) CpG motifs via TLR9 signaling [2–4]. Unmethylated CpG motifs or pathogen derived DNA rich in CpG motifs are known to be the cognate agonists for TLR9. In response to TLR9 signaling, several downstream co-stimulatory molecules and cytokines like Type I interferons (IFN), IFN- , Interleukins IL1, IL6, IL10, IL12, and IL18, involved in evoking the adaptive immune system optimally against the invading pathogen, are produced. Among the type I IFNs, IFNA (leukocyte) is of prime importance as earliest cytokine activating macrophages and NK cells to collectively bring Th1 response. TLR9 signaling is involved in recognizing and stimulating the adaptive immune system against the invading pathogen like blood protozoan in Leishmania major [5], Trypanosoma cruzi [6].
Morning cortisol is lower in obese individuals with normal glucose tolerance
Praveen EP, Sahoo JP, Kulshreshtha B, Khurana ML, Gupta N, Dwivedi SN, Kumar G, Ammini AC
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy , 2011, DOI: http://dx.doi.org/10.2147/DMSO.S23915
Abstract: rning cortisol is lower in obese individuals with normal glucose tolerance Original Research (3750) Total Article Views Authors: Praveen EP, Sahoo JP, Kulshreshtha B, Khurana ML, Gupta N, Dwivedi SN, Kumar G, Ammini AC Published Date September 2011 Volume 2011:4 Pages 347 - 352 DOI: http://dx.doi.org/10.2147/DMSO.S23915 Edavan P Praveen1, Jaya Prakash Sahoo1, Bindu Kulshreshtha2, Madan L Khurana3, Nandita Gupta1, Sada Nand Dwivedi3, Guresh Kumar3, Ariachery C Ammini1 1Department of Endocrinology, All India Institute of Medical Sciences, 2Ram Manohar Lohia Hospital, 3Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India Background: There is no consensus on the role of cortisol in the pathogenesis of obesity and metabolic syndrome (MS). This cross-sectional study aimed to analyze the relationship of morning plasma cortisol and adrenocorticotropic hormone (ACTH) levels with body mass index (BMI) and glucose tolerance. Subjects and methods: The sample frame was the “Offspring of individuals with diabetes study” database. A total of 358 offspring of individuals with type 2 diabetes mellitus (T2DM) and 287 individuals without a known family history of T2DM were recruited for the study. Subjects who were ≥10 years of age were selected from the database for analysis. Subjects with T2DM were excluded. All participants underwent a 75 g oral glucose tolerance test (OGTT), and blood samples were collected at 0, 30, 60, and 120 minutes for glucose, insulin and C-peptide. Plasma cortisol, ACTH, and lipid profile were estimated from the fasting sample. Results: Four hundred and ninety-five participants (305 males [62%] and 190 females [38%]) were included in the analysis. ACTH and cortisol levels were higher in normal-weight subjects than in overweight/obese subjects. Both ACTH and cortisol increased as fasting plasma glucose increased. Cortisol levels were significantly lower in offspring of T2DM subjects with MS than in offspring of T2DM subjects without MS. When adjusted for BMI, the significance was marginal. In males, cortisol levels were negatively correlated with early insulin secretion during OGTT (insulinogenic index [0–30]) and positively with waist circumference and serum high-density lipoprotein cholesterol. In females, fasting glucose and systolic blood pressure were significantly and positively correlated. Conclusion: Body weight was correlated negatively with morning plasma cortisol and ACTH, whereas fasting glucose was correlated positively.
IN SILICO MODELLING AND DRUG DESIGN – A REVIEW
Gupta Praveen kumar,Agrawal Pushpa,Shivakumar Neeta,Hiremath Suhasini.B
International Research Journal of Pharmacy , 2011,
Abstract: Bioinformatics and Computational biology is an interdisciplinary field that applies the techniques of computer science, applied mathematics and statistics to address biological problems. Research in computational biology often overlaps with systems biology. Major research efforts in the field include sequence alignment, gene finding, genome assembly, protein structure alignment, protein structure prediction, prediction of gene expression and protein-protein interactions, and the in silico drug modelling. Drug discovery is an intense, lengthy and interdisciplinary endeavour. It is mostly portrayed as a linear, consecutive process that starts with target and lead discovery, followed by lead optimization and pre-clinical in vivo and in vitro studies to determine if such compounds satisfy a numbers of pre-set criteria for initiating clinical developments. In silico methods help in identifying drug targets via bioinformatics tools. They can be used to analyze the target structures for possible binding sites, generate candidate molecules, check for their drug likeness, dock these molecules with the target, rank them according to their binding affinities and further optimize the molecules to improve binding characteristics.
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