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Search Results: 1 - 10 of 222254 matches for " Prakash C. Thakur "
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Sfrp5 Modulates Both Wnt and BMP Signaling and Regulates Gastrointestinal Organogensis in the Zebrafish, Danio rerio
Carsten Stuckenholz, Lili Lu, Prakash C. Thakur, Tae-Young Choi, Donghun Shin, Nathan Bahary
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062470
Abstract: Sfrp5 belongs to the family of secreted frizzled related proteins (Sfrp), secreted inhibitors of Wingless-MMTV Integration Site (Wnt) signaling, which play an important role in cancer and development. We selected sfrp5 because of its compelling expression profile in the developing endoderm in zebrafish, Danio rerio. In this study, overexpression of sfrp5 in embryos results in defects in both convergent extension (CE) by inhibition of non-canonical Wnt signaling and defects in dorsoventral patterning by inhibition of Tolloid-mediated proteolysis of the BMP inhibitor Chordin. From 25 hours post fertilization (hpf) to 3 days post fertilization (dpf), both overexpression and knockdown of Sfrp5 decrease the size of the endoderm, significantly reducing liver cell number. At 3 dpf, insulin-positive endodermal cells fail to coalesce into a single pancreatic islet. We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities.
Effect of mitomycin C-aided trabeculectomy on conjunctival goblet cell density
S Mukhopadhyay,SKD Thakur,J Dutta,R Prakash,C Shaw,DN Gangopadhyay,H Dutta,G Bhaduri
Nepalese Journal of Ophthalmology , 2012, DOI: 10.3126/nepjoph.v4i1.5854
Abstract: Introduction: Mitomycin C is gaining widespread popularity as an adjunctive with trabeculectomy, as it significantly increases the success rate of the procedure. But it is associated with serious sight-threatening complications. Materials and methods: Twenty eyes planned for trabeculectomy from the glaucoma clinic were enrolled for the study after obtaining an informed consent. The baseline impression cytology was taken. Ten eyes underwent trabeculectomy with mitomycin C (Group A) and the rest underwent trabeculectomy without any antimetabolites (Group B). Impression cytology samples were taken on months 1, 3, 6, 9 and 12. Results: In Group A, the difference between goblet cell density preoperatively and 12 month postoperatively was statistically significant (p < 0.0001). In Group B, the difference was not statistically significant. (p = 0.27). Conclusion: Mitomycin C, though used to augment the success rate of trabeculectomy, has deleterious effect on the conjunctival goblet cell population as is evident from the conjunctival impression cytology. DOI: http://dx.doi.org/10.3126/nepjoph.v4i1.5854 NEPJOPH 2012; 4(1): 68-72
Superconducting and critical properties of PrOFe0.9Co0.1As: effect of P doping
Shilpam Sharma,Jai Prakash,Gohil S. Thakur,A. T. Satya,A. Bharathi,A K Ganguli,C S Sundar
Physics , 2011, DOI: 10.1088/0953-2048/24/6/065020
Abstract: PrOFe0.9Co0.1As is known to be a superconductor with a TC of ~14 K. In an attempt to induce charge transfer and also induce chemical pressure between the FeAs and PrO layers we have synthesized for the first time oxypnictides of the type PrOFe0.9Co0.1As1-xPx (P doping at As sites). All the compounds crystallize in the tetragonal ZrCuSiAs type structure (space group = P4/nmm). The lattice parameters (a and c) decrease as expected on substitution of smaller phosphorous at the arsenic site in PrOFe0.9Co0.1As and a decrease in TC was observed on substitution of P ions at a low rate of 0.13K/at. % of P for x > 0.1. The irreversibility field (Hirr) and critical current density (JC), obtained using the AC susceptibility measurements was found to decrease monotonically with increasing 'P' concentration. 'Hirr' is observed to be much smaller than HC2, pointing to a very low pinning energy. The pinning potential obtained using both in-field transport and AC susceptibility measurements indicate a low value of ~40 meV and show no significant variation with P substitution.
Tandem repetitions in transcriptomes of some Solanaceae species  [PDF]
Atul Grover, Prakash C. Sharma
American Journal of Molecular Biology (AJMB) , 2012, DOI: 10.4236/ajmb.2012.22016
Abstract: Characterization of occurrence, density and motif sequence of tandem repeats in the transcribed regions is helpful in understanding the functional significance of these repeats in the modern genomes. We analyzed tandem repeats present in expressed sequences of thirteen species belonging to genera Capsicum, Nicotiana, Petunia and Solanum of family Solanaceae and the genus Coffea of Rubiaceae to investigate the propagation and evolutionary sustenance of these repeats. Tandem repeat containing sequences constituted 1.58% to 7.46% of sequences analyzed. Tandem repetitions of size 2, 15, 18 and 21 bp motifs were more frequent. Repeats with unit sizes 21 and 22 bp were also abundant in genomic sequences of potato and tomato. While mutations occurring in these repeats may alter the repeat number, genomes adjust to these changes by keeping the translated products unaffected. Surprisingly, in majority of the species under study, tandem repeat motif length did not exceed 228 bp. Conserved tandem repeat motifs of sizes 180, 192 and 204 bp were also abundant in the genomic sequences. Our observations lead us to propose that these tandem repeats are actually remnants of ancestral megasatellite repeats, which have split into multiple repeats due to frequent insertions over the course of evolution.
Options for Active Case Detection of Visceral Leishmaniasis in Endemic Districts of India, Nepal and Bangladesh, Comparing Yield, Feasibility and Costs
Shri Prakash Singh,Siddhivinayak Hirve ,M. Mamun Huda,Megha Raj Banjara,Narendra Kumar,Dinesh Mondal,Shyam Sundar,Pradeep Das,Chitra Kumar Gurung,Suman Rijal,C. P. Thakur,Beena Varghese,Axel Kroeger
PLOS Neglected Tropical Diseases , 2011, DOI: 10.1371/journal.pntd.0000960
Abstract: Background The VL elimination strategy requires cost-effective tools for case detection and management. This intervention study tests the yield, feasibility and cost of 4 different active case detection (ACD) strategies (camp, index case, incentive and blanket approach) in VL endemic districts of India, Nepal and Bangladesh. Methodology/Principal Findings First, VL screening (fever more than 14 days, splenomegaly, rK39 test) was performed in camps. This was followed by house to house screening (blanket approach). An analysis of secondary VL cases in the neighborhood of index cases was simulated (index case approach). A second screening round was repeated 4–6 months later. In another sub-district in India and Nepal, health workers received incentives for detecting new VL cases over a 4 month period (incentive approach). This was followed by house screening for undetected cases. A total of 28 new VL cases were identified by blanket approach in the 1st screening round, and used as ACD gold standard. Of these, the camp approach identified 22 (sensitivity 78.6%), index case approach identified 12 (sensitivity – 42.9%), and incentive approach identified 23 new VL cases out of 29 cases detected by the house screening (sensitivity – 79.3%). The effort required to detect a new VL case varied (blanket approach – 1092 households, incentive approach – 978 households; index case approach – 788 households had to be screened). The cost per new case detected varied (camp approach $21 – $661; index case approach $149 – $200; incentive based approach $50 – $543; blanket screening $112 – $629). The 2nd screening round yielded 20 new VL cases. Sixty and nine new PKDL cases were detected in the first and second round respectively. Conclusions/Significance ACD in the VL elimination campaign has a high yield of new cases at programme costs which vary according to the screening method chosen. Countries need the right mix of approaches according to the epidemiological profile, affordability and organizational feasibility.
Les alloantigènes sur les spermatozo?des des mammifères leur contr?le par le génome haplo?de
C Prakash
Genetics Selection Evolution , 1973, DOI: 10.1186/1297-9686-5-4-507
Design and Simulation of Phase-Locked Loop Controller Based Unified Power Quality Conditioner Using Nonlinear Loads
C. Prakash
International Journal of Power Electronics and Drive Systems , 2012, DOI: 10.11591/ijpeds.v2i4.376
Abstract: This project presents a power quality improvement of unified power quality conditioner (UPQC) to compensate current and voltage quality problems of sensitive loads. The UPQC consists of the series and shunt converter having a common dc link. The series converter mitigates voltage sag from the supply side and shunt converter eliminates current harmonics from the nonlimear load side. The developed controllers for series and shunt converters are based on a reference signal generation method (phase-locked loop). The dc link control strategy is based on the fuzzy-logic controllers. The conventional method using dq transformation to show the superiority of the proposed sag detection method. A fast sag detection method is also is presented. The efficiency of the proposed system is tested through simulation studies using the MATLAB/SIMULINK environment.
Identification of neuropeptides, flp-1 and flp-12 targeting neuromuscular system of rice root knot nematode (RRKN) Meloidogyne graminicola
Uma Rao,Prasoon Kumar Thakur,G Nagavara Prasad,,Prakash Banakar
Bioinformation , 2013,
Abstract: Root-knot nematodes (RKNs), Meloidogyne spp, are found in all temperate and tropical areas, and are among the most damaging plant pathogens worldwide. M. graminincola is an economically important root parasite on upland, lowland and deepwater rice. FMRFamide-like peptides (FLPs) play significant role as neurotransmitters or neuromodulators in the nervous system and proposed as one of the important targets for the plant parasitic nematode management. Therefore, for the first time, we have cloned and characterized two neuropeptide genes (flp-1 and flp-12) from the cDNA of preparasitic second stage juveniles of M. graminicola. The flp-12 contains putative 22 residue long signal peptide at N-terminal suggesting function as an extra-cellular protein. We have found highly conserved motif LFRGR in flp-1. These two flp genes could be interesting and potential targets for functional validation to explore their utility for designing management strategies.
Tenuazonic acid: a promising antitubercular principle from Alternaria alternate
Visalakchi Sonaimuthu,Swati Parihar,Jay Prakash Thakur,Suaib Luqman
Microbiology Research , 2011, DOI: 10.4081/mr.2011.e17
Abstract: Bioactivity guided isolation of dichloromethane extract of Alternaria alternata identified tenuazonic acid (1) as potentially active against Mycobacterium tuberculosis H37Rv, MIC at 250 μg/mL concentration. This active metabolite 1, was also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that this fungal metabolite showing antitubercular activity exhibited concentration dependent toxicity to human erythrocytes.
The Analysis Of Ionic Thermocurrent Spectrum
Devendra Prasad,A.N. Thakur,Jai Prakash
Indian Streams Research Journal , 2012,
Abstract: A new approach has been made for the analysis of ionic thermocurrent (ITC)spectrum. The involvement of different order of kinetics in ITC spectrum depends on theexperimental conditions of polarization and rate of rapid cooling, so the order of kineticsinvolved in the ITC spectrum does not represent any specific feature of the system underinvestigation. In suggested approach on the basis of generalized equation of ITCspectrum, Dielectric relaxation parameters, order of kinetics and approximate value ofdipoles per unit volume are evaluated
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