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Search Results: 1 - 10 of 14 matches for " Prahalad Sooknanan "
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The Role of Technology in the Marketing Communications Industry: An Exploratory Study of the Impact of North American Influence on Local Business in Trinidad and Tobago  [PDF]
Prahalad Sooknanan, Karen Crichlow
Advances in Journalism and Communication (AJC) , 2014, DOI: 10.4236/ajc.2014.23009
Abstract: New communication technologies such as the Internet are causing sweeping changes within the global marketing communications industry. Therefore, the implications of e-marketing for business in Trinidad and Tobago are profound as seen in a national plan to address this need. This study examines the efforts of local businesses and consumers to get on the e-marketing bandwagon already commonplace in the U.S. Two surveys were conducted among local businesses and local consumers to determine their readiness and/or success. In spite of governmental efforts to expand Internet capabilities, lethargy and lack of access still plague local businesses. This contrasts with local consumers who are more receptive to e-marketing expressing an increasing demand for online information. It is therefore imperative for the T&T government to address the deficiencies in its ICT plan so that local businesses and consumers can catch up with the rest of the world before the gap widens to a point where it becomes impossible to do so.
The Impact of Computer Mediated Communication (CMC) on Productivity and Efficiency in Organizations: A Case Study of an Electrical Company in Trinidad and Tobago  [PDF]
Kenrick Bob, Prahalad Sooknanan
Advances in Journalism and Communication (AJC) , 2014, DOI: 10.4236/ajc.2014.22005
Abstract: This study investigates how computer mediated communication (CMC) and the electronic mailing system in particular have impacted on productivity and efficiency not to mention interpersonal interaction and increased use of technology in the organization. An electricity company was chosen for the case study since it had achieved approximately 78% computerization and networking of its office staff. Following the judgemental sampling technique to identify the organization, random sampling was used to select a sample size of 100 respondents. A questionnaire survey with sixteen items was self-administered over a one-week period. The results showed that 73% of the respondents agreed that CMC enhanced their overall productivity and efficiency while 27% differed. However, while the findings revealed that the introduction of CMC increased its use as a whole, it impacted negatively on interpersonal relationships among respondents.
Diffusion of Technology for Organizational Effectiveness: An Exploratory Study of the Procurement Department of a Multi-National Energy Company in Trinidad and Tobago  [PDF]
Prahalad Sooknanan, Jim Leung Chee
Advances in Journalism and Communication (AJC) , 2014, DOI: 10.4236/ajc.2014.24014
Abstract: This study investigates the diffusion of technology within a homogenous corporate cultural context according to age and educational level to determine how these variables determine the rate of diffusion. Based on the findings, the conventional communication models seem to apply. Specifically, the study shows that in the particular organizational context, age and education level impact on diffusion of technology. Younger and higher educated individuals seem to have a greater affinity to communication and use new communication technologies in their personal lives as well as professional lives which lend itself to possible early adoption or innovation. The study concludes, in the particular context, while hiring younger and more educated staff can possibly enhance the innovation and adoption process, it is perhaps equally, if not more important, to engage innovators from the wider organization to hasten the diffusion process.
A comprehensive review of the genetics of juvenile idiopathic arthritis
Sampath Prahalad, David N Glass
Pediatric Rheumatology , 2008, DOI: 10.1186/1546-0096-6-11
Abstract: Juvenile idiopathic arthritis rers to a group of chronic arthropathies of childhood[1]. According to the International League of Associations for Rheumatology criteria, JIA comprises seven subtypes[2]. These include systemic JIA (sJIA), oligoarticular JIA, rheumatoid factor (RF)-negative polyarticular JIA, RF-positive polyarticular JIA, enthesitis related arthritis (ERA), psoriatic arthritis and undifferentiated JIA. The relatively homogeneous subtypes of JIA share clinical features with other chronic autoimmune disorders such as rheumatoid arthritis (RA), psoriasis or spondyloarthropathies [3]. Autoimmune disorders are relatively common in the population, estimated to have a prevalence of about ~5% in the US. While clinical and laboratory features distinguish many of these autoimmune disorders, there is accumulating evidence to support the hypothesis that clinically distinct autoimmune phenotypes share common genetic susceptibility factors. In this review, we will examine the genetic factors that underlie JIA susceptibility, and discuss some of the genetic factors that underlie multiple autoimmune phenotypes.All subtypes of JIA are characterized by persistent joint swelling caused by an accumulation of synovial fluid and thickening of the synovial lining. There is evidence to support the involvement of different components of the immune system in the etiopathogenesis of JIA. The synovial tissue contains various inflammatory cells including neutrophils, plasma cells, dendritic cells and a high proportion of activated T-cells [4-6]. The recruitment of pro-inflammatory cells into the synovium of a child with JIA is believed to be mediated by chemokines that selectively attract Th1 T-cells [7-9]. These T-cells are characterized by the production of interleukin (IL)-2, interferon-γ, and tumor necrosis factor (TNF)-β. Many other autoimmune disorders including RA, inflammatory bowel disease (IBD), psoriasis, and type 1 diabetes mellitus (T1DM) are also associated with Th1
The fortune at the bottom of the pyramid
Coimbatore Krishnarao Prahalad,Stuart L. Hart
Revista Eletr?nica de Estratégia e Negócios , 2010,
Abstract: This article is based on a 1998 working paper from the authors. It was originally published in Strategy+Business n. 26, first quarter 2002, and is one of the basis for the CK Prahalad best seller of the same title. Tha article argues about the possibility and opportunity to transform the bottom of the pyramid market in a profitable market.
Life and Death in a Gang-A Mathematical Model of Gang Membership
Donna Marie Giselle Comissiong,Joanna Sooknanan,Balswaroop Bhatt
Journal of Mathematics Research , 2012, DOI: 10.5539/jmr.v4n4p10
Abstract: There is increasing gang membership worldwide, but few mathematical models are available describing the growth of gangs in a population. A mathematical model consisting of a system of four coupled, nonlinear ordinary differential equations is used to divide a population into four groups based on gang affiliation. Demographics and vertical transmission are included in the model. One of the main findings of this research is the conditions under which the gang members become extinct. Bifurcation analyses shows the existence of extquotedblleft tipping points extquotedblright in the murder rates, gang recruitment rates and the imprisonment and deterrence rates.
Criminals Treated as Predators to Be Harvested: A Two Prey One Predator Model with Group Defense, Prey Migration and Switching
Donna Marie Giselle Comissiong,Joanna Sooknanan,Balswaroop Bhatt
Journal of Mathematics Research , 2012, DOI: 10.5539/jmr.v4n4p92
Abstract: A mathematical model is formulated and analysed to study the dynamics of a one predator - two prey eco-system using the logistic equation in which the predator switches between habitats and is being harvested. Constant effort and Constant yield harvesting functions are applied to the predators. The Constant effort strategy as opposed constant yield strategy may lead to an additional equilibrium in which the predators are extinct, whereas in the Constant yield stategy the only equilibrium is the coexistence one. In both cases, computer simulations are performed to study the effects of various parameters on the dynamics of the system. These studies show that depending on parameter values, a stable equilibrium or a limit cycle orbit is possible with both harvesing types.
Retinoic Acid Mediates Regulation of Network Formation by COUP-TFII and VE-Cadherin Expression by TGFβ Receptor Kinase in Breast Cancer Cells
Priya Prahalad,Sivanesan Dakshanamurthy,Habtom Ressom,Stephen W. Byers
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010023
Abstract: Tumor development, growth, and metastasis depend on the provision of an adequate vascular supply. This can be due to regulated angiogenesis, recruitment of circulating endothelial progenitors, and/or vascular transdifferentiation. Our previous studies showed that retinoic acid (RA) treatment converts a subset of breast cancer cells into cells with significant endothelial genotypic and phenotypic elements including marked induction of VE-cadherin, which was responsible for some but not all morphological changes. The present study demonstrates that of the endothelial-related genes induced by RA treatment, only a few were affected by knockdown of VE-cadherin, ruling it out as a regulator of the RA-induced endothelial genotypic switch. In contrast, knockdown of the RA-induced gene COUP-TFII prevented the formation of networks in Matrigel but had no effect on VE-cadherin induction or cell fusion. Two pan-kinase inhibitors markedly blocked RA-induced VE-cadherin expression and cell fusion. However, RA treatment resulted in a marked and broad reduction in tyrosine kinase activity. Several genes in the TGFβ signaling pathway were induced by RA, and specific inhibition of the TGFβ type I receptor blocked both RA-induced VE-cadherin expression and cell fusion. Together these data indicate a role for the TGFβ pathway and COUP-TFII in mediating the endothelial transdifferentiating properties of RA.
Susceptibility to childhood onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of five genetic risk variants
Prahalad Sampath,Brown Milton,Thompson Susan D,Zwick Michael
Pediatric Rheumatology , 2012, DOI: 10.1186/1546-0096-10-s1-a116
Abstract:
Role of Sox-9, ER81 and VE-Cadherin in Retinoic Acid-Mediated Trans-Differentiation of Breast Cancer Cells
Yoshimi Endo, Kamla Deonauth, Priya Prahalad, Becky Hoxter, Yuelin Zhu, Stephen W. Byers
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002714
Abstract: Many aspects of development, tumor growth and metastasis depend upon the provision of an adequate vasculature. This can be a result of regulated angiogenesis, recruitment of circulating endothelial progenitors and/or vascular trans-differentiation. The present study demonstrates that treatment of SKBR-3 breast cancer cells with retinoic acid (RA), an important regulator of embryogenesis, cancer and other diseases, stimulates the formation of networks in Matrigel. RA-treatment of SKBR-3 cells co-cultured with human umbilical vein endothelial cells resulted in the formation of mixed structures. RA induces expression of many endothelial genes including vascular endothelial (VE) cadherin. VE-cadherin was also induced by RA in a number of other breast cancer cells. We show that RA-induced VE-cadherin is responsible for the RA-induced morphological changes. RA rapidly induced the expression of Sox-9 and ER81, which in turn form a complex on the VE-cadherin promoter and are required to mediate the transcriptional regulation of VE-cadherin by RA. These data indicate that RA may promote the expression of endothelial genes resulting in endothelial-like differentiation, or provide a mechanism whereby circulating endothelial progenitor cells could be incorporated into a growing organ or tumor.
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