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Search Results: 1 - 10 of 436 matches for " Pradipta;Guha "
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Non tuberculous mycobacteria and toxoplasma co-infection of the central nervous system in a patient with AIDS
Sardar, Partha;Bandyopadhyay, Dipanjan;Roy, Deeptarka;Guha, Pradipta;Guha, Goutam;Banerjee, Amit Kumar;
Brazilian Journal of Infectious Diseases , 2009, DOI: 10.1590/S1413-86702009000600011
Abstract: new-onset seizures are frequent manifestations in patients infected with human immunodeficiency virus (hiv). we describe the clinical and radiological findings in an 25yr old aids patient presenting with new onset seizures as the primary manifestation of cerebral toxoplasmosis and non tuberculous mycobacterial [ntm] co-infection. cranial computed tomography showed a subtle ventricular dilatation whereas magnetic resonance imaging disclosed prominent temporal horn. toxoplasma tachyzoites and rapidly growing mycobacteria were recovered from csf. seizures were complex partial in nature and refractory to antiepileptic therapy.
Single Nucleotide Polymorphism Network: A Combinatorial Paradigm for Risk Prediction
Puspita Das Roy, Dhriti Sengupta, Anjan Kr Dasgupta, Sudip Kundu, Utpal Chaudhuri, Indranil Thakur, Pradipta Guha, Mousumi Majumder, Roshni Roy, Bidyut Roy
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074067
Abstract: Risk prediction for a particular disease in a population through SNP genotyping exploits tests whose primary goal is to rank the SNPs on the basis of their disease association. This manuscript reveals a different approach of predicting the risk through network representation by using combined genotypic data (instead of a single allele/haplotype). The aim of this study is to classify diseased group and prediction of disease risk by identifying the responsible genotype. Genotypic combination is chosen from five independent loci present on platelet receptor genes P2RY1 and P2RY12. Genotype-sets constructed from combinations of genotypes served as a network input, the network architecture constituting super-nodes (e.g., case and control) and nodes representing individuals, each individual is described by a set of genotypes containing M markers (M = number of SNP). The analysis becomes further enriched when we consider a set of networks derived from the parent network. By maintaining the super-nodes identical, each network is carrying an independent combination of M-1 markers taken from M markers. For each of the network, the ratio of case specific and control specific connections vary and the ratio of super-node specific connection shows variability. This method of network has also been applied in another case-control study which includes oral cancer, precancer and control individuals to check whether it improves presentation and interpretation of data. The analyses reveal a perfect segregation between super-nodes, only a fraction of mixed state being connected to both the super-nodes (i.e. common genotype set). This kind of approach is favorable for a population to classify whether an individual with a particular genotypic combination can be in a risk group to develop disease. In addition with that we can identify the most important polymorphism whose presence or absence in a population can make a large difference in the number of case and control individuals.
Iodocyclization of Diallyl-Dihydroxy Naphthalenes Using N-Iodosuccinimide vs Molecular Iodine in Aqueous Micelle  [PDF]
Pradipta Kumar Basu, Amrita Ghosh
International Journal of Organic Chemistry (IJOC) , 2013, DOI: 10.4236/ijoc.2013.33022
Abstract: A number of doubly-fused [1,2] naphthodifurans have been synthesized from the corresponding diallyl-dihydroxy naphthalene precursors involving N-iodosuccinimide in acetonitrile and also by molecular iodine in aqueous micelle using CTAB as surfactant. The electrophilic cyclization occurs regioselectively by a 5-exo-trig mode of cyclization.
Correspondence in relation to the case report "Capnography as an aid in localizing the phrenic nerve in brachial plexus surgery. Technical note." published in May issue of Journal of Brachial Plexus and Peripheral Nerve Injury
Pradipta Bhakta
Journal of Brachial Plexus and Peripheral Nerve Injury , 2008, DOI: 10.1186/1749-7221-3-20
Abstract: Journal of Brachial Plexus and Peripheral Nerve Injury 2008, 3:14 (22 May 2008)Dear Editors,I want to thank the authors for this article explaining this innovative technique to identify phrenic nerve intraoperatively. This may be applied a good technique as replacement of currently available means. But after going through the article I found some doubts related to the actual correlation of diaphragmatic contraction with electrical stimulation of phrenic nerve.Authors have used an intravenous based anesthesia for their cases without muscle relaxation. They have not mentioned anything about the dose of the drug used or monitoring the depth or adequacy of anesthesia. Nor they mentioned anything about intraoperative ventilatory technique during maintenance of anesthesia. From the pattern of the capnogram presented in the report, I can assume that probably a controlled ventilatory technique was used in all the cases [1]. Authors have assumed that notches in the alveolar plateau part (phase III) of capnogram were because of diaphragmatic contraction elicited by electrical stimulation. But there are several reasons of appearance of notch in phase III of capnogram namely curare cleft, hiccup, premature respiratory effort by the patient during mechanical ventilation etc [1-3]. Though curare cleft is out of question in these cases, but premature respiratory effort provoked by painful electrical stimulation in the scenario of inadequate anesthesia and analgesia should have been considered as a possibility [1-3]. It is very well known that any electrical stimulation above 1–2 mA is very painful [4]. That is why it is advised to start electrical stimulation with lowest possible current and to increase it until stimulation is obtained. Though some or most of these painful responses can be reduced or abolished by use of anesthesia, painful stimulation like this under inadequate anesthesia can manifest as hemodynamic imbalance as well as premature respiratory effort. Appearance of
The Mazur Intersection Property and Farthest Points
Pradipta Bandyopadhyay
Mathematics , 1994,
Abstract: K.\ S.\ Lau had shown that a reflexive Banach space has the Mazur Intersection Property (MIP) if and only if every closed bounded convex set is the closed convex hull of its farthest points. In this work, we show that in general this latter property is equivalent to a property stronger than the MIP. As corollaries, we recapture the result of Lau and characterize the w*-MIP in dual of RNP spaces.
Data Path Processing in Fast Programmable Routers
Pradipta De
Computer Science , 2004,
Abstract: Internet is growing at a fast pace. The link speeds are surging toward 40 Gbps with the emergence of faster link technologies. New applications are coming up which require intelligent processing at the intermediate routers. Switches and routers are becoming the bottlenecks in fast communication. On one hand faster links deliver more packets every second and on the other hand intelligent processing consumes more CPU cycles at the router. The conflicting goals of providing faster but computationally expensive processing call for new approaches in designing routers. This survey takes a look at the core functionalities, like packet classification, buffer memory management, switch scheduling and output link scheduling performed by a router in its data path processing and discusses the algorithms that aim to reduce the performance bound for these operations. An important requirement for the routers is to provide Quality of Service guarantees. We propose an algorithm to guarantee QoS in Input Queued Routers. The hardware solution to speed up router operation was Application Specific Integrated Circuits (ASICs). But the inherent inflexibility of the method is a demerit as network standards and application requirements are constantly evolving, which seek a faster turnaround time to keep up with the changes. The promise of Network Processors (NP) is the flexibility of general-purpose processors together with the speed of ASICs. We will study the architectural choices for the design of Network Processors and focus on some of the commercially available NPs. There is a plethora of NP vendors in the market. The discussion on the NP benchmarks sets the normalizing platform to evaluate these NPs.
Quantum Information Processing Using the Exchange Interaction  [PDF]
M. Guha Majumdar
Journal of Quantum Information Science (JQIS) , 2018, DOI: 10.4236/jqis.2018.84010
Abstract: In this paper, I propose new models of quantum information processing using the exchange interaction in physical systems. The partial SWAP operator that can be realized using the exchange interaction is used as the underlying resource for defining models of quantum computation, quantum communication, quantum memory and decoherence-free subspaces. Given the non-commutativity of these operators (for adjacent operators operating on a common qubit), a number of quantum states and entanglement patters can be obtained. This zoo of states can be classified, due to the parity constraints and permutation symmetry of the states, into invariant subspaces that are used for the definition of some of the applications in this paper.
Predicting Viscosity of Limestone–Water Slurry  [PDF]
Pradipta Kumar Senapati, Dibakar Panda, Ashutosh Parida
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2009, DOI: 10.4236/jmmce.2009.83018
Abstract: The rheological behavior of limestone–water slurry samples was investigated for different volume concentrations, particle size distribution and slurry temperature. Experiments were conducted over a range of volumetric solids concentration (Q= 0.20 - 0.46) in shear rate range of 1-300 s-1. The slurry showed Newtonian behavior up to a volumetric solids concentration of 37.8 vol. %, beyond which the slurry was highly pseudoplastic in nature and fitted excellently to a non-Newtonian Power law model. The relative viscosity (Nr) of the mixture slurry, defined as the suspension viscosity over the viscosity of the suspending medium was found to be increasing exponentially when Q exceeds 0.404. By adopting an experimental approach, the rheological data indicated that Q might reach 0.462. Using the ( 1-Nr-1/2 ) -Q relationship proposed by Liu, the theoretical maximum solids fraction (Qm) was evaluated as Qm= 0.504 for the given slurry samples and was then used to predict the relative viscosity (Nr) by some existing models. Five empirical models namely; Liu, Dabak et al., Krieger-Dougherty, Mooney and Chong et al. were considered for the purpose. Liu’s model better predicted the relative viscosity and thus would be helpful in evaluating the hydraulic parameters accurately for design of limestone slurry pipelines operating at high concentrations.
Accurate Calculation of the Density of States near the Ground-State Energy of the Peptides Met-Enkephalin and with the Wang-Landau Method: Lessons Learned
Priya Singh,Pradipta Bandyopadhyay
Journal of Atomic, Molecular, and Optical Physics , 2012, DOI: 10.1155/2012/782806
Abstract: The Wang-Landau method estimates the relative density of states (DOS) by performing random walk in energy space. However, estimation of the DOS near the ground state minimum is highly challenging because of the dearth of states in the low-energy region compared to that at the high-energy region. Ideally the derivative of the logarithm of the DOS with respect to energy, which is proportional to the inverse of temperature, should become steeper with decrease in energy. However, in actual estimation of the DOS for molecular systems, it is nontrivial to achieve this. In the current work, the accuracy of the Wang-Landau method in estimating the DOS near the ground state minimum is investigated for two peptides, Met-enkephalin and (Alanine)5. It has been found that the steepness of the DOS can be achieved if the correct ground state energy is found, the bin used to discretize the energy space is extremely small (0.1 kcal/mol was used in the current case) and the energy range used to estimate the DOS is small. The findings of this work can help in devising new protocols for calculating the DOS with high accuracy near the ground state minimum for molecular systems.
Theoretical Modelling for the Ground State Rotamerisation and Excited State Intramolecular Proton Transfer of 2-(2’-hydroxyphenyl)oxazole, 2-(2’-hydroxyphenyl)imidazole, 2-(2’-hydroxyphenyl)thiazole and Their Benzo Analogues
Pradipta Purkayastha,Nitin Chattopadhyay
International Journal of Molecular Sciences , 2003, DOI: 10.3390/i4060335
Abstract: Two series of compounds, one comprising of 2-(2′-hydroxyphenyl)benzoxazole (HBO), 2-(2′-hydroxyphenyl)benzimidazole (HBI), 2-(2′-hydroxyphenyl)benzothiazole (HBT), and the other of 2-(2′-hydroxyphenyl)oxazole (HPO), 2-(2′-hydroxyphenyl)imidazole (HPI) and 2-(2′-hydroxyphenyl)thiazole (HPT) are susceptible to ground state rotamerization as well as excited state intramolecular proton transfer (ESIPT) reactions. Some of these compounds show experimental evidence of the existence of two ground state conformers. Out of these two one undergoes ESIPT reaction leading to the formation of the tautomer. The two photophysical processes, in combination, result in the production of a number of fluorescence bands each one of which corresponding to a particular species. Semiempirical AM1-SCI calculations have been performed to rationalize the photophysical behaviour of the compounds. The calculations suggest that for the first series of compounds, two rotational isomers are present in the ground state of HBO and HBI while HBT has a single conformer under similar circumstances. For the molecules of the other series existence of rotamers depends very much on the polarity of the environment. The potential energy curves (PEC) for the ESIPT process in different electronic states of the molecules have been generated theoretically. The simulated PECs reveal that for all these systems the IPT reaction is unfavourable in the ground state but feasible, both kinetically and thermodynamically, in the S1 as well as T1 states.
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