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Search Results: 1 - 10 of 3198 matches for " Pradeep Srivastava "
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Molecular Docking Studies of Myricetin and Its Analogues against Human PDK-1 Kinase as Candidate Drugs for Cancer  [PDF]
Shalini Singh, Pradeep Srivastava
Computational Molecular Bioscience (CMB) , 2015, DOI: 10.4236/cmb.2015.52004
Abstract: Phosphoinositide-dependent protein kinase-1 (PDK1), the class of serine threonine kinase, is a master regulator of the AGC family of kinases. It is a main component of the PI3K pathway. As it is reported that this pathway is most commonly, and this pathway is the most commonly deregulated among many cancers. So designing a selective inhibitor of PDK1 may have the efficacy as an anticancer agent. Herein, we describe our work focused on the structure based on screening of 95% similar analogues of Myricetin deposited in PubChem database as earlier studies have been suggested that myricetin acts as an anti cancer agent. Further molecular docking as well as the in silico ADMET studies are incorporated on these compounds to evaluate the binding and pharmacokinetic properties of these compounds. Due to low oral bioavailability, clinical use of myricetin is limited. Therefore this study is an attempt towards screening of structurally similar better compounds as compare with myricetin which can act as better inhibitor against PDK-1.
ELECTROSPUN BIOMATERIAL FOR BIOMEDICAL APPLICATION
Pooja Agarwal,Pradeep Srivastava
International Journal of Biomedical Research , 2013, DOI: 10.7439/ijbr.v2i3.91
Abstract: During the past two decades significant advances have been made in the development of biodegradable polymeric materials for biomedical applications. Nanostructured fibrous materials have been made more readily available in large part owing to recent advances in electrospinning and related technologies. Development of nanofibers by using the technique of electrospinning is having a new momentum. The nonwoven structure has unique features, including interconnected pores and a very large surface-to-volume ratio, which enable such nanofibrous scaffolds to have many biomedical and industrial applications, such as tissue engineering, wound dressing, enzyme immobilization and drug delivery. The chemical composition of electrospun membranes can be adjusted through the use of different polymers, In this paper, nanoscaffolds developed by using electrospinning and its applications in tissue engineering and drug delivery are reviewed.
ELECTROSPUN BIOMATERIAL FOR BIOMEDICAL APPLICATION
Pooja Agarwal,Pradeep Srivastava
International Journal of Biomedical Research , 2011, DOI: 10.7439/ijbr.v2i3.91
Abstract: During the past two decades significant advances have been made in the development of biodegradable polymeric materials for biomedical applications. Nanostructured fibrous materials have been made more readily available in large part owing to recent advances in electrospinning and related technologies. Development of nanofibers by using the technique of electrospinning is having a new momentum. The nonwoven structure has unique features, including interconnected pores and a very large surface-to-volume ratio, which enable such nanofibrous scaffolds to have many biomedical and industrial applications, such as tissue engineering, wound dressing, enzyme immobilization and drug delivery. The chemical composition of electrospun membranes can be adjusted through the use of different polymers, In this paper, nanoscaffolds developed by using electrospinning and its applications in tissue engineering and drug delivery are reviewed.
Combined 3D QSAR Based Virtual Screening and Molecular Docking Study of Some Selected PDK-1 Kinase Inhibitors
Shalini Singh,Pradeep Srivastava
Journal of Computational Medicine , 2014, DOI: 10.1155/2014/563080
Abstract: Phosphoinositide-dependent kinase-1 (PDK-1) is an important therapeutic target for the treatment of cancer. In order to identify the important chemical features of PDK-1 inhibitors, a 3D QSAR pharmacophore model was developed based on 21 available PDK-1 inhibitors. The best pharmacophore model (Hypo1) exhibits all the important chemical features required for PDK-1 inhibitors. The correlation coefficient, root mean square deviation (RMSD), and cost difference were 0.96906, 1.0719, and 168.13, respectively, suggesting a good predictive ability of the model (Hypo1) among all the ten pharmacophore models that were analyzed. The best pharmacophore model (Hypo1) was further validated by Fisher’s randomization method (95%), test set method , and the decoy set with the goodness of fit (0.73). Further, this validated pharmacophore model Hypo1 was used as a 3D query to screen the molecules from databases like NCI database and Maybridge. The resultant hit compounds were subsequently subjected to filtration by Lipinski’s rule of five as well as the ADMET study. Docking study was done to refine the retrieved hits and as a result to reduce the rate of false positive. Best hits will further be subjected to in vitro study in future. 1. Introduction Protein kinases are critical components of cellular signal transduction cascades [1]. Over 500 protein kinases in the human genome have been reported till date and they are considered as the second largest group of drug targets [2, 3]. Phosphoinositide-dependent kinase-1 (PDK-1), a 63?kDa serine/threonine kinase, is a major player in the PI3-kinase signaling pathway that regulates gene expression, cell cycle, growth, and proliferation [4–11]. PDK-1 is also termed as the ‘‘master kinase’’ because it phosphorylates highly conserved serine or threonine residues in the T-loop (or activation loop) of numerous AGC kinases, including PKB/AKT, PKC, p70S6K, SGK, and PDK-1 itself [12]. Although precise regulatory mechanisms vary, in the case of PKB/AKT, activation by PDK-1 is critically dependent on prior PI3 kinase activation and the presence of phosphatidylinositol-(3,4,5)-triphosphate (PIP3). A significant proportion (40–50%) of all tumors involve mutations in PIP3-3-phosphatase (PTEN) [13–15], which result in elevated levels of PIP3 and enhanced activation of PKB/AKT, p70S6K, and SGK. The inhibitors of PDK-1 could potentially provide valuable therapeutic agents for the treatment of cancer. Recognition process between ligand and model is based on spatial distribution of certain structural features of active site being complimentary
Pharmacognostic Evaluation and Antioxidant Activity of Urtica dioica L.  [PDF]
Vertika Khare, Pradeep Kushwaha, Shikhar Verma, Abhishek Gupta, Sharad Srivastava, AKS Rawat
Chinese Medicine (CM) , 2012, DOI: 10.4236/cm.2012.33021
Abstract: Background: Urtica dioica L. is a common Himalayan species which produces allergenic substances causing oedema and inflammation in humans. It has become a source of folk medicine for the treatment of many diseases. The leaves and roots both are used internally as a blood purifier and diuretic and an infusion of the plant is used for nasal and menstrual haemorrhage, diabetes, rheumatism, eczema, anaemia, hair loss, as an expectorant and antidiarrhoeal. Present study includes pharmacognostic evaluation, antioxidant activity and HPTLC analysis of Urtica dioica L. Methods: Pharmacognostic evaluation of aerial part of U. dioica has been performed as per Indian pharmacopoeia. In-vitro antioxidant evaluation of U. dioica has been performed using DPPH free radical scavenging activity. Ferulic acid, a potential phenolic antioxidant present in this species, has been studied through HPTLC. Results: U. dioica hydro-alcoholic extract shows positive results for antioxidant activity with IC50 value of 88.33 ± 2.88 μg/ml. Standard ascorbic acid showed IC50 value of 2.8 ± 0.62 μg/ml. Ferulic acid was identified at Rf 0.61 ± 0.01 and quantified to 0.73% in this species through CAMAG HPTLC analysis. Conclusion: The pharmacognostical parameters reported can be considered as quality standards of U. dioica in herbal industry. Hydro-alcoholic extract of U. dioica showed positive in vitro antioxidant activity. Presence of phenolic compound suggests that antioxidant activity may be due to ferulic acid content.
Lignin: Renewable Raw Material for Adhesive  [PDF]
Ravindra V. Gadhave, Shrray Srivastava, Prakash A. Mahanwar, Pradeep T. Gadekar
Open Journal of Polymer Chemistry (OJPChem) , 2019, DOI: 10.4236/ojpchem.2019.92003
Abstract: Biobased raw material like lignin used during manufacturing of wood and wood composite adhesive have been used extensively to replaced petro-chemical based adhesive because of their easy availability, low cost and biodegradability. Bio-based resources, such as lignin which is an abundant, constitute a rich source of hydroxyl functionality which is being considered as reactive raw material for the production of “adhesives”. Lignin is mainly used for production of wood and wood composite adhesives by blending with soy protein, grafting with another polymer and reacting with isocynates. In this review, lignin as suitable alternative raw material to conventional petroleum sourced materials used as a raw material for adhesives is discussed.
Feasibility of the Sar Technique on Quartz Sand of Terraces of NW Himalaya: A Case Study from Devprayag
Manoj Kumar Jaiswal, , Pradeep Srivastava, Jayant Kumar Tripathi, , Rafique Islam
Geochronometria , 2008, DOI: 10.2478/v10003-008-0015-8
Abstract: Optically Stimulated Luminescence (OSL) dating technique based on the Single Aliquot Regenerative dose (SAR) protocol is being used increasingly as a means of establishing sediment burial age in the late Quaternary studies. Thermal transfer, low and changing luminescence sensitivity of quartz grains of young sedimentary belts of the New Zealand Alps and the north-east Himalaya poses problems in using SAR protocol. Records of active tectonics and signatures of palaeo-climate are preserved in the Quaternary - Holocene terrace sediments. Therefore, to unfold the history of successive tectonic and palaeo-climate events, robust chronological technique is needed. Palaeoflood deposits in NW Lesser Himalayan region receive quartz from the weathering of various rock types such as quartzite and phyllite in the Alaknanda Basin. A series of tests e.g. dose recovery, preheat plateau, thermal recuperation and change in sensitivity, were performed to check the suitability of quartz grains collected from the terrace sediment of Devprayag of the NW Himalaya, for OSL studies. Inferences were drawn regarding the source of the quartz grains on the basis of the geochemistry and luminescence intensity of the terrace sediment. The study shows that though quartz from the North West Himalaya are low in luminescence intensity but the reproducibility of De value makes the quartz sand suitable for SAR dating technique. Relation between luminescence intensity with CIA values help to predict the provenance of quartz sand. Tests show that the quartz from NW Himalaya is suitable for SAR protocol in OSL.
Physical Growth Standards for Urban Adolescents (10-15 Years) from South Gujarat
Thakor Hitendra,Kumar Pradeep,Desai Vikas,Srivastava Ratan
Indian Journal of Community Medicine , 2000,
Abstract:
Obstructive sleep apnoea: A case-control study
Pradeep Kumar V,Bhatia M,Tripathi M,Srivastava A
Neurology India , 2003,
Abstract: Introduction: Obstructive sleep apnoea (OSA), is characterized by loud snoring and excessive daytime sleepiness. Though the gold standard for diagnosis is overnight polysomnography (PSG), sleep questionnaires have also been used to diagnose this with good predictive value. Material and Methods: A pre-designed proforma with clinical details, symptom-specific questions for diagnosis of OSA, and Epworth Sleepiness Scale (ESS) was administered to 20 patients presenting to the Sleep Disorder Clinic of our hospital and to 40 age and sex-matched relatives (control group). The students 't-test' and chi-square were used as the statistical tests. Results: There were 20 patients with a mean age of 41± 8 years, and 40 controls with a mean age of 41 ± 6 years (P=>0.05). Seven had family history of snoring in the study group and 3 in the control group (P=0.02). Four had met with road traffic accidents in the study group and none in the control group (P=0.001). The body mass index (BMI) was 29.9 (SD 4.4) in the study group and 24.5 (SD3.5) in the controls (P=0.001). The mean ESS was 13.3 ± 6 in the patients and 4.2+ 4 in the controls (P=0.001). A larger number of patients with OSA had hypertension: 5/20 vs. 3/40 (P=0.01). Conclusion: Patients with OSA had significantly higher BMI and ESS score, and were more likely to have hypertension and road traffic accidents. Increased awareness of this entity is essential.
Seasonal variation in abiotic factors and toxicity of thymol against the snail Lymnaea acuminata
Shefali Srivastava,Pradeep Kumar,V. K. Singh,Dinesh Kumar Singh
Journal of Biology and Earth Sciences , 2013,
Abstract: Toxicity of thymol against Lymnaea acuminata was conducted in each month of the year 2010-2011. The 24, 48, 72 and 96 h LC50 values of a molluscicide thymol were determined, with the concomitant estimation of levels of temperature, pH, dissolved oxygen, carbon dioxide and electrical conductivity, both in control and test water. On the basis of a 24h toxicity assay, it was observed that 24h LC50 value of 6.41 mg/l in month of May, was most effective in killing the snails, while the thymol was least effective in month of April, when its 24h LC50 was 15.25 mg/l. There was a significant positive correlation between LC50 of thymol and levels of carbon dioxide/ pH of water in corresponding months. On the contrary, a negative correlation was noted between LC50 of thymol and dissolved oxygen/ temperature of test water in the same months. In order to confirm that relationship between toxicity and abiotic factors is not coincidental, activity of acetylcholinesterase (AChE), acid phosphatase (ACP) and alkaline phosphatase (ALP) in the nervous tissue of control as well as sublethal thymol (60% of 24hLC50) treated snail, were assayed during each of the 12 months of the same year. A significant positive rank correlation was noted between AChE/ACP/ALP activity and corresponding sublethal treatment of thymol. Maximum inhibition of AChE, ACP and ALP activity was observed in the month of May. This study shows conclusively that the best time to control the L. acuminata population with thymol is during the month of May to July.
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