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Search Results: 1 - 10 of 4013 matches for " Pooja Patel "
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Feasibility studies on in vitro mass-scale propagation of Indian Ashwagandha (Withania somnifera) cultivars for commercial purpose
Pooja Patel,R. Krishnamurthy
Journal of Pharmacognosy and Phytochemistry , 2013,
Abstract: The explants with higher regeneration potential raised through in vitro germination of seeds of two genotypes of Withania somnifera namely: WS-100 and WS-134 were cultured on MS basal media fortified with 0.6mg/ml BAP and 0.4 mg/ml IAA. Culture medium MS + 0.2 mg/l BAP + 30.0 gm/l sucrose + 7.5 gm/l agar, induced callus in higher frequencies in both the varieties. While in multiple shooting, maximum shoots were observed in WS 100 with MS+0.2 mg/lit BAP+0.2 mg/lit IAA and in WS 134 with MS+0.3mg/l BAP + 0.2 mg/l IAA. Higher in vitro rooting response was achieved on rooting medium MS + 5.0 mg/1 IBA + 25.0 gm/1 sucrose + 7.5 gm/1 agar in WS 100 and in WS 134 with MS +0.6 mg/l BAP+ 2.5 mg/1 IBA + 25.0 gm/1 sucrose + 7.5 gm/1 agar. In terms of in vitro genotypic response, genotype WS-100 was found significantly superior to WS-134 for the most of the attributes investigated. Regenerated plantlets were established successfully in the field after primary and secondary hardening. The present investigation brought out possibility of mass-scale in vitro (micropropagation) production of Indian Ashwagandha cultivars.
Lung Hyperinflation Is Associated with Pulmonary Exacerbations in Adults with Cystic Fibrosis  [PDF]
Kosal Seng, Lynn Fukushima, Pooja Patel, Arteen Pirverdian, Adupa Rao, Joseph Milic-Emili, Ahmet Baydur
Open Journal of Respiratory Diseases (OJRD) , 2016, DOI: 10.4236/ojrd.2016.62004
Abstract: Background: Forced expiratory volume 1 second (FEV1) has traditionally been used as a readily available marker of health in adult cystic fibrosis (CF). However, due to the obstructive nature of this disease, it is possible that lung hyperinflation could be more closely related to disease severity than is FEV1. The purpose of this study was to determine if hyperinflation is more closely associated with quality of life, functional status, and pulmonary exacerbations than FEV1 in patients with CF. Methods: Sixty-eight adult patients with CF were evaluated in this retrospective study. We used IC and functional residual capacity (FRC) and their ratios to total lung capacity (TLC) as measures of lung hyperinflation. We used bivariate correlations and backwards regression analysis to assess possible associations between FEV1, lung hyperinflation, and measures of disease severity including questionnaire based quality of life, pulmonary exacerbation frequency, and mortality. The respiratory component of the Cystic Fibrosis Questionnaire–Revised (CRQ-R-Respiratory) was used as a measure of quality of life. Results: Both FEV1 and IC were negatively correlated with pulmonary exacerbations over a 3 year period (p = 0.004, r2 = 0.127; p < 0.001, r2 = 0.307, respectively), while FRC/TLC correlated positively with exacerbations (p = 0.007). Backwards regression analysis showed that among pulmonary function variables, IC had the strongest relationship with exacerbations over 3 years. A lower CFQ-R-Respiratory score was associated with greater mortality (p = 0.005). However, no statistically significant relationships were found between lung function and mortality. Conclusions: FEV1 and lung hyperinflation-as measured by IC and FRC/TLC-are both associated with pulmonary exacerbation frequency. This suggests that chronic dynamic hyperinflation contributes significantly to disease severity in adult cystic fibrosis.
Liposome: A Novel Aerosol Carrier of Doxophylline in Treatment of Chronic Asthma & Chronic Obstructive Pulmonary Disease
Monika Oberoi,Pooja Choudhry,Kuldeep Singh Patel,Prince Jain
International Journal of Biomedical Research , 2013, DOI: 10.7439/ijbr.v3i7.473
Abstract: The aim of the present research work is to develop liposomal dry powder inhaler of doxophylline by double hydration method to increase the entrapment efficiency of this hydrophilic drug. In this formulation, PVP coated mannitol and the mannitol were used as a cryoprotectant and a carrier respectively. Doxophylline, a new methylxanthine derivative, chemically designated as 7-(1,3-dixolan-2-yl-methyl) theophylline, is a more potent bronchodilator than theophylline, which is associated with a wide range of adverse effects accounting for poor compliance and high dropout rates. Powder inhaler formulation of the drug was characterized by angle of repose, compressibility index and in vitro aerosolization properties using Anderson cascade impactor including fine particle dose (212.9+7.2), fine particle fraction (21.69+1.21), % dispersibility (62.34+3.5) and % emission (72.1+0.13) at a flow rate of 28.3 lit/m for 10 seconds using 10 capsules for each determinations. The optimized formulations were subjected to stability studies at 2-8oC, RT, and 40oC for 3 months. The stability studies of LDPI were determined in terms of their visual appearance (surface characteristics and colour changes) and PDRE. The in vivo study was carried out by gamma scintigraphy and that showed better retention of doxophylline in liposomal formulation as compared to the controlled release formulation.
Pooja Choudhry,kuldeep singh patel,Prince kumar jain,Monika Arora
International Journal of Biomedical and Advance Research , 2012, DOI: 10.7439/ijbar.v3i11.466
Abstract: In an effort to reduce production costs, a simple, direct compression delayed release formulation consisting of pantoprazole was investigated. Pantoprazole is a proton pump inhibitor belongs to group of benzimidazole. It is very efficient for the treatment of gastric and duodenum ulcers. Even in solid state pantoprazole is sensitive to heat, humidity, light and especially to substances containing an acidic group. For such types of drugs, enteric coating added to the formulation tends to avoid the stomach's acidic exposure, delivering them instead to a basic pH environment where they do not degrade, and give their desired action. Subcoating is desirable to protect the enteric coating. Opadry and Acryl-EZE systems have been utilized for subcoating and enteric coating respectively. Delayed-release tablets with good physical, mechanical and technological properties were obtained with use of different combinations of diluents, binders, superdisintegrants and lubricants. A comparative kinetic study of the present tablets and commercial tablets was established. The value for the similarity factor (f2 = 71.6) suggested that the dissolution profile of the present two delayed-release oral dosage forms are similar. Hixona€“Crowell (erosion) kinetic profiles were achieved
Analysis of X-knife and surgery in treatment of arteriovenous malformation of brain
Patel Pooja,Vyas Rakesh,Bhavsar Devang,Suryanarayan U
Journal of Cancer Research and Therapeutics , 2008,
Abstract: Background: The goal of treatment in arteriovenous malformation (AVM) is total obliteration of the AVM, restoration of normal cerebral function, and preservation of life and neurological function. Aim: To analyze the results of X-knife and surgery for AVM of the brain. The endpoints for success or failure were as follows: success was defined as angiographic obliteration and failure as residual lesion, requiring retreatment, or death due to hemorrhage from the AVM. Materials and Methods: From May 2002 to May 2007, 54 patients were enrolled for this study. Grade I AVM was seen in 9%, grade II in 43%, grade III in 26%, grade IV in 9%, and grade V in 13%. Thirty-eight patients were treated by microsurgical resection out of which Grade I was seen in 5 patients, Grade II was seen in 17 patients, Grade III was seen in 9 patients and Grade V was seen in 7 patients. Rest of the sixteen patients were treated by linear accelerator radiosurgery out of which Grade II was seen in 6 patients, Grade III was seen in 5 patients and Grade IV was seen in 5 patients. The follow up was in range of 3-63 months. In follow up, digital subtraction angiography/ magnetic resonance angiography (DSA/MRA) was performed 3 months after surgery and 1 year and 2 years after stereotactic radiosurgery (SRS). Results: Among the patients treated with X-knife, 12/16 (75%) had proven angiographic obliteration. Complications were seen in 4/16 (25%) patients. Among the patients treated with microsurgical resection, 23/38 (61%) had proven angiographic obliteration. Complications (both intraoperative and postoperative) were seen in 19/38 (50%) patients. Conclusions: Sixty-one percent of patients were candidates for surgical resection. X-knife is a good modality of treatment for a low-grade AVM situated in eloquent areas of the brain and also for high-grade AVMs, when the surgical risk and morbidity is high.
Development of Oral Sustained Release Rifampicin Loaded Chitosan Nanoparticles by Design of Experiment
Bhavin K. Patel,Rajesh H. Parikh,Pooja S. Aboti
Journal of Drug Delivery , 2013, DOI: 10.1155/2013/370938
Abstract: Objective. The main objective of the present investigation was to develop and optimize oral sustained release Chitosan nanoparticles (CNs) of rifampicin by design of experiment (DOE). Methodology. CNs were prepared by modified emulsion ionic gelation technique. Here, inclusion of hydrophobic drug moiety in the hydrophilic matrix of polymer is applied for rifampicin delivery using CN. The 23 full-factorial design was employed by selecting the independent variables such as Chitosan concentration ( ), concentration of tripolyphosphate ( ), and homogenization speed ( ) in order to achieve desired particle size with maximum percent entrapment efficiency and drug loading. The design was validated by checkpoint analysis, and formulation was optimized using the desirability function. Results. Particle size, drug entrapment efficiency, and drug loading for the optimized batch were found to be 221.9?nm, 44.17 ± 1.98% W/W, and 42.96 ± 2.91% W/W, respectively. In vitro release data of optimized formulation showed an initial burst followed by slow sustained drug release. Kinetic drug release from CNs was best fitted to Higuchi model. Conclusion. Design of Experiment is an important tool for obtaining desired characteristics of rifampicin loaded CNs. In vitro study suggests that oral sustained release CNs might be an effective drug delivery system for tuberculosis. 1. Introduction In spite of the absolute number of incident TB cases falling globally, tuberculosis (TB) continues to be the leading cause of mortality worldwide and has also been considered to be an occupational disease in the health care setup [1]. One of the major problems in the current treatment of tuberculosis is the noncompliance to prescribed regimens, primarily because treatment of TB involves continuous, frequent multiple drug dosing. Adherence to treatment and the outcome of therapy could be improved with the introduction of long-duration drug formulations releasing the antitubercular agents in a slow and sustained manner [2]. Polymer-based drug delivery systems like polymeric nanoparticles have achieved a potential position in the controlled release of therapeutic agents [3]. Polymeric nanoparticles are solid colloidal particles with diameters ranging from 1 to 1000?nm [4]. They consist of macromolecular materials in which the active ingredient is dissolved, entrapped, encapsulated, and adsorbed or chemically attached. The fate of nanoparticles in the gastrointestinal tract has extensively been investigated [5–7]. Sustained release cross-linked polymeric nanoparticles enable improvement of drug
Ultrasonic Speed and Related Acoustical Parameters of 1,1 -Binaphthalene-2,2 -diyl Diacetate Solutions at 308.15 K
Pooja P. Adroja,S. P. Gami,J. P. Patel,P. H. Parsania
Journal of Chemistry , 2011, DOI: 10.1155/2011/869594
Role of fibreoptic bronchoscopy and CT guided FNAC in diagnostic evaluation of Non resolving Pneumonia with special emphasis on clinical outcome
Bhupendra Kumar Jain, Pooja Sharma, Ashok Bajpai, Satish Motiwale, Nikhilesh Pasari, Deepika Patel
Asian Journal of Medical Sciences , 2015, DOI: 10.3126/ajms.v6i3.10727
Abstract: Background: Nonresolving pneumonia is a pneumonia with a delayed or slow resolution of radiographic infiltrates or clinical symptoms despite adequate treatment with antibiotics for a minimum period of 10 days. Fibreoptic bronchoscopy (FOB) and CT guided FNAC has a specific role in diagnosis of Non resolving pneumonia. Aims and Objectives: To assess the diagnostic efficacy of fibreoptic bronchoscopy (FOB) and computed tomography (CT)- guided fi ne needle aspiration cytology (FNAC) in evaluation of non-resolving or slowly resolving pneumonia with special emphasis on clinical outcome. Material and Methods: The study was designed as a prospective observational study. We reviewed FOB in Sixty-five consecutive patients of Non-resolving pneumonia admitted under Respiratory Medicine unit of Sri aurobindo medical college and PG Institute Indore from June 2012 to May 2014. We also reviewed role of CT guided FNAC in selected case where FOB result was inconclusive. Result: Out of total Sixty-five case of non resolving pneumonia, Fifty-two patient (81%) were diagnosed with the help of FOB and Eleven patients (91%) were diagnosed with help of CT guided FNAC out of Twelve patient subjected for procedure. Conclusion: FOB should be the first option before CT-guided FNAC in evaluating non-resolving pneumonia. Both the procedures were safe and no major complication was observed. DOI: http://dx.doi.org/10.3126/ajms.v6i3.10727 ? Asian Journal of Medical Sciences Vol.6(3) 2015 66-71
Study on Causal Association between FDI and Its Determinants in Taiwan  [PDF]
Shailender Singh, Pooja Jain
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.815213
Abstract: A vital role is played by FDI (Foreign Direct Investment) in enhancing the growth and economic status of the country. Most of the countries in the developing phase depend on FDI to foster their economy as they were facing the scarcity of hard cash for their development process. High growth performance experienced by Taiwan economy largely relies on the FDI; to attract the foreign capital inflows the Taiwan government work on many policies. But the most important factors which influence and attract the foreign capital inflows are in academic debate. On the basis of macroeconomic theory knowledge, this research paper will shed light on the econometric analysis on the data of Taiwans total foreign direct investment and factors influencing it, which contains exchange rate, inflation rate, Taiwan stock exchange index, import, and business income tax during the years of 1998 to 2013.
Initial Experience with Robotic Retropubic Urethropexy Compared to Open Retropubic Urethropexy
Pooja R. Patel,Mostafa A. Borahay,Audrey R. Puentes,Ana M. Rodriguez,Jessica Delaisse,Gokhan S. Kilic
Obstetrics and Gynecology International , 2013, DOI: 10.1155/2013/315680
Abstract: Study Objective. To compare the clinical outcomes of robotic retropubic urethropexy versus open retropubic urethropexy. Design. Retrospective case-control study (II-2). Setting. University Hospital. Patients. All patients who underwent robotic retropubic urethropexy from 1/1/12 to 6/1/12 by a single gynecologic surgeon were included in the case series. The control cases consisted of the last five consecutive open retropubic urethropexies performed by the same surgeon. Main Results. A total of 10 patients (5 robotic cases and 5 open cases) were included in this study. Both groups were similar with respect to age, BMI, and obstetrical history. Mean hospital stay length and mean EBL were overall less for robotic cases than for open cases (1.2 days versus 2.6 days; 169?mL versus 300?mL). One of the 5 patients who underwent the open approach and 2 of the 5 patients who underwent the robotic approach sustained a minor intraoperative complication. All but one patient from each group experienced resolution of incontinence after the procedure. Two of the patients who underwent the open approach had postoperative complications. Conclusions. Robotic retropubic urethropexy may be a feasible alternative to open retropubic urethropexy. A larger study is necessary to support our observations. 1. Introduction Minimally invasive surgery has gained tremendous popularity over the recent decades. This popularity is due to several advantages associated with robotic surgery versus laparotomy, which include magnification resulting in better visualization, decreased blood loss and need for blood transfusions, shorter hospital stay and postoperative recovery, decreased postoperative pain, and decreased risk of infections [1–6]. Even more recently, robotic surgery has gained popularity due to improved precision and surgeon comfort when compared to laparoscopy. As experience and comfort with robotic surgery have increased, the robot is being used now for more comples surgeries, including urogynecologic procedures such as the retropubic urethropexies (i.e., Burch colposuspensions). Pelvic organ prolapse (POP) is becoming a more prominent problem, especially given the aging US population. The estimated lifetime risk of surgery for stress urinary incontinence or POP is 11%; however, this is likely an underestimate of the general population as it is based on hospital data [6]. The current literature surprisingly lacks information on experiences with robotic retropubic urethropexy in comparison to retropubic urethropexy associated with laparotomy (i.e., open retropubic urethropexy).
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