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Search Results: 1 - 10 of 3296 matches for " Poh Lim "
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Design and Construction of Microstrip UWB Antenna with Time Domain Analysis
Ka-Sing Lim;Manimaran Nagalingam;Chue-Poh Tan
PIER M , 2008, DOI: 10.2528/PIERM08051903
Abstract: In this paper, a compact design and construction of microstrip Ultra Wide Band (UWB) antenna is proposed. The proposed antenna has the capability ofop erating between 4.1 GHz to 10 GHz. The antenna parameter in frequency domain analysis have been investigated to show its capability as an effective radiating element. Furthermore, time domain Gaussian pulse excitation analysis in UWB systems is also demonstrated in this paper. As a result, the simulation results demonstrated reasonable agreement with the measurement results and good ultra-wideband linear transmission performance has also been achieved in time domain.
Proteome-Wide Profiling of the MCF10AT Breast Cancer Progression Model
Lee Yee Choong,Simin Lim,Poh Kuan Chong,Chow Yin Wong,Nilesh Shah,Yoon Pin Lim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011030
Abstract: Mapping the expression changes during breast cancer development should facilitate basic and translational research that will eventually improve our understanding and clinical management of cancer. However, most studies in this area are challenged by genetic and environmental heterogeneities associated with cancer.
Surveillance for Clostridium difficile Infection: ICD-9 Coding Has Poor Sensitivity Compared to Laboratory Diagnosis in Hospital Patients, Singapore
Monica Chan,Poh Lian Lim,Angela Chow,Mar Kyaw Win,Timothy M. Barkham
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015603
Abstract: Clostridium difficile infection (CDI) is an increasingly recognized nosocomial infection in Singapore. Surveillance methods include laboratory reporting of Clostridium difficile toxin assays (CDTA) or use of International Classification of Diseases, 9th Revision (ICD-9) discharge code 008.45. Previous US studies showed good correlation between CDTA and ICD-9 codes. However, the use of ICD-9 codes for CDI surveillance has not been validated in other healthcare settings.
Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma
Weijie Poh, Winnie Wong, Huimin Ong, Myat Aung, Seng Lim, Boon Chua, Han Ho
Molecular Cancer , 2012, DOI: 10.1186/1476-4598-11-14
Abstract: Quantitative real-time PCR analysis identified frequent elevation of KLB gene expression in HCC tumors relative to matched non-tumor tissue, with a more than two-fold increase correlating with development of multiple tumors in patients. KLB-silencing in Huh7 cells decreased cell proliferation and suppressed FGFR4 downstream signaling. While transient repression of KLB-FGFR4 signaling decreased protein expression of alpha-fetoprotein (AFP), a HCC diagnostic marker, prolonged inhibition enriched for resistant HCC cells exhibiting increased liver stemness.Elevated KLB expression in HCC tissues provides further credence to the oncogenic role of increased FGFR4 signaling in HCC progression and represents a novel biomarker to identify additional patients amenable to anti-FGFR4 therapy. The restricted tissue expression profile of KLB, together with the anti-proliferative effect observed with KLB-silencing, also qualifies it as a specific and potent therapeutic target for HCC patients. The enrichment of a liver stem cell-like population in response to extended KLB-FGFR4 repression necessitates further investigation to target the development of drug resistance.With approximately 680,000 deaths in 2008, hepatocellular carcinoma (HCC) ranks third worldwide in cancer-related mortalities [1]. The majority of HCC patients present at advanced stages where curative surgical treatments are not applicable and face median survival of less than a year [2]. Moreover, traditional systemic chemotherapies have produced no significant survival benefit in advanced HCC patients [3]. Consequently, novel therapies for unresectable HCC are urgently needed to address this grim prognosis.Recently, there has been increasing interest in developing molecular-targeted therapies that can discriminate between cancer cells and their non-neoplastic counterparts by targeting proteins overexpressed in tumors. The approval of sorafenib, a multi-targeted tyrosine kinase inhibitor, for the treatment of advance
Multi-Dimensional Features Reduction of Consistency Subset Evaluator on Unsupervised Expectation Maximization Classifier for Imaging Surveillance Application
Chue-Poh TAN,Ka-Sing LIM,Weng-Kin LAI (Dr.)
International Journal of Image Processing , 2008,
Abstract: This paper presents the application of multi dimensional feature reduction ofConsistency Subset Evaluator (CSE) and Principal Component Analysis (PCA)and Unsupervised Expectation Maximization (UEM) classifier for imagingsurveillance system. Recently, research in image processing has raised muchinterest in the security surveillance systems community. Weapon detection is oneof the greatest challenges facing by the community recently. In order toovercome this issue, application of the UEM classifier is performed to focus onthe need of detecting dangerous weapons. However, CSE and PCA are used toexplore the usefulness of each feature and reduce the multi dimensional featuresto simplified features with no underlying hidden structure. In this paper, we takeadvantage of the simplified features and classifier to categorize images objectwith the hope to detect dangerous weapons effectively. In order to validate theeffectiveness of the UEM classifier, several classifiers are used to compare theoverall accuracy of the system with the compliment from the features reduction ofCSE and PCA. These unsupervised classifiers include Farthest First, DensitybasedClustering and k-Means methods. The final outcome of this researchclearly indicates that UEM has the ability in improving the classification accuracyusing the extracted features from the multi-dimensional feature reduction of CSE.Besides, it is also shown that PCA is able to speed-up the computational timewith the reduced dimensionality of the features compromising the slight decreaseof accuracy.
Expatriates ill after travel: Results from the Geosentinel Surveillance Network
Lim Poh-Lian,Han Pauline,Chen Lin H,MacDonald Susan
BMC Infectious Diseases , 2012, DOI: 10.1186/1471-2334-12-386
Abstract: Background Expatriates are a distinct population at unique risk for health problems related to their travel exposure. Methods We analyzed GeoSentinel data comparing ill returned expatriates with other travelers for demographics, travel characteristics, and proportionate morbidity (PM) for travel-related illness. Results Our study included 2,883 expatriates and 11,910 non-expatriates who visited GeoSentinel clinics ill after travel. Expatriates were more likely to be male, do volunteer work, be long-stay travelers (>6 months), and have sought pre-travel advice. Compared to non-expatriates, expatriates returning from Africa had higher proportionate morbidity (PM) for malaria, filariasis, schistosomiasis, and hepatitis E; expatriates from the Asia-Pacific region had higher PM for strongyloidiasis, depression, and anxiety; expatriates returning from Latin America had higher PM for mononucleosis and ingestion-related infections (giardiasis, brucellosis). Expatriates returning from all three regions had higher PM for latent TB, amebiasis, and gastrointestinal infections (other than acute diarrhea) compared to non-expatriates. When the data were stratified by travel reason, business expatriates had higher PM for febrile systemic illness (malaria and dengue) and vaccine-preventable infections (hepatitis A), and volunteer expatriates had higher PM for parasitic infections. Expatriates overall had higher adjusted odds ratios for latent TB and lower odds ratios for acute diarrhea and dermatologic illness. Conclusions Ill returned expatriates differ from other travelers in travel characteristics and proportionate morbidity for specific diseases, based on the region of exposure and travel reason. They are more likely to present with more serious illness.
Failure to prescribe pneumocystis prophylaxis is associated with increased mortality, even in the cART era: results from the Treat Asia HIV observational database
Lim Poh-Lian,Zhou Jialun,Ditangco Rossana A,Law Matthew G
Journal of the International AIDS Society , 2012, DOI: 10.1186/1758-2652-15-1
Abstract: Background Pneumocystis jiroveci pneumonia (PCP) prophylaxis is recommended for patients with CD4 counts of less than 200 cells/mm3. This study examines the proportion of patients in the TREAT Asia HIV Observational Database (TAHOD) receiving PCP prophylaxis, and its effect on PCP and mortality. Methods TAHOD patients with prospective follow up had data extracted for prophylaxis using co-trimoxazole, dapsone or pentamidine. The proportion of patients on prophylaxis was calculated for each calendar year since 2003 among patients with CD4 counts of less than 200 cells/mm3. The effect of prophylaxis on PCP and survival were assessed using random-effect Poisson regression models. Results There were a total of 4050 patients on prospective follow up, and 90% of them were receiving combination antiretroviral therapy. Of those with CD4 counts of less than 200 cells/mm3, 58% to 72% in any given year received PCP prophylaxis, predominantly co-trimoxazole. During follow up, 62 patients developed PCP (0.5 per 100 person-years) and 169 died from all causes (1.36/100 person-years). After stratifying by site and adjusting for age, CD4 count, CDC stage and antiretroviral treatment, those without prophylaxis had no higher risk of PCP, but had a significantly higher risk of death (incident rate ratio 10.8, p < 0.001). PCP prophylaxis had greatest absolute benefit in patients with CD4 counts of less than 50 cells/mm3, lowering mortality rates from 33.5 to 6.3 per 100 person-years. Conclusions Approximately two-thirds of TAHOD patients with CD4 counts of less than 200 cells/mm3 received PCP prophylaxis. Patients without prophylaxis had significantly higher mortality, even in the era of combination ART. Although PCP may be under-diagnosed, these data suggest that prophylaxis is associated with important survival benefits.
The Significance of HIV ‘Blips’ in Resource-Limited Settings: Is It the Same? Analysis of the Treat Asia HIV Observational Database (TAHOD) and the Australian HIV Observational Database (AHOD)
Rupa Kanapathipillai, Hamish McManus, Adeeba Kamarulzaman, Poh Lian Lim, David J. Templeton, Matthew Law, Ian Woolley
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086122
Abstract: Introduction Magnitude and frequency of HIV viral load blips in resource-limited settings, has not previously been assessed. This study was undertaken in a cohort from a high income country (Australia) known as AHOD (Australian HIV Observational Database) and another cohort from a mixture of Asian countries of varying national income per capita, TAHOD (TREAT Asia HIV Observational Database). Methods Blips were defined as detectable VL (≥ 50 copies/mL) preceded and followed by undetectable VL (<50 copies/mL). Virological failure (VF) was defined as two consecutive VL ≥50 copies/ml. Cox proportional hazard models of time to first VF after entry, were developed. Results 5040 patients (AHOD n = 2597 and TAHOD n = 2521) were included; 910 (18%) of patients experienced blips. 744 (21%) and 166 (11%) of high- and middle/low-income participants, respectively, experienced blips ever. 711 (14%) experienced blips prior to virological failure. 559 (16%) and 152 (10%) of high- and middle/low-income participants, respectively, experienced blips prior to virological failure. VL testing occurred at a median frequency of 175 and 91 days in middle/low- and high-income sites, respectively. Longer time to VF occurred in middle/low income sites, compared with high-income sites (adjusted hazards ratio (AHR) 0.41; p<0.001), adjusted for year of first cART, Hepatitis C co-infection, cART regimen, and prior blips. Prior blips were not a significant predictor of VF in univariate analysis (AHR 0.97, p = 0.82). Differing magnitudes of blips were not significant in univariate analyses as predictors of virological failure (p = 0.360 for blip 50–≤1000, p = 0.309 for blip 50–≤400 and p = 0.300 for blip 50–≤200). 209 of 866 (24%) patients were switched to an alternate regimen in the setting of a blip. Conclusion Despite a lower proportion of blips occurring in low/middle-income settings, no significant difference was found between settings. Nonetheless, a substantial number of participants were switched to alternative regimens in the setting of blips.
Radiation of the Red Algal Parasite Congracilaria babae onto a Secondary Host Species, Hydropuntia sp. (Gracilariaceae, Rhodophyta)
Poh-Kheng Ng, Phaik-Eem Lim, Siew-Moi Phang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097450
Abstract: Congracilaria babae was first reported as a red alga parasitic on the thallus of Gracilaria salicornia based on Japanese materials. It was circumscribed to have deep spermatangial cavities, coloration similar to its host and the absence of rhizoids. We observed a parasitic red alga with morphological and anatomical features suggestive of C. babae on a Hydropuntia species collected from Sabah, East Malaysia. We addressed the taxonomic affinities of the parasite growing on Hydropuntia sp. based on the DNA sequence of molecular markers from the nuclear, mitochondrial and plastid genomes (nuclear ITS region, mitochondrial cox1 gene and plastid rbcL gene). Phylogenetic analyses based on all genetic markers also implied the monophyly of the parasite from Hydropuntia sp. and C. babae, suggesting their conspecificity. The parasite from Hydropuntia sp. has a DNA signature characteristic to C. babae in having plastid rbcL gene sequence identical to G. salicornia. C. babae is likely to have evolved directly from G. salicornia and subsequently radiated onto a secondary host Hydropuntia sp. We also recommend the transfer of C. babae to the genus Gracilaria and propose a new combination, G. babae, based on the anatomical observations and molecular data.
Eliminating Spectral Distinguishability in Ultrafast Spontaneous Parametric Down-conversion
Hou Shun Poh,Jiaqing Lim,Ivan Marcikic,Antia Lamas-Linares,Christian Kurtsiefer
Physics , 2009, DOI: 10.1103/PhysRevA.80.043815
Abstract: Generation of polarization-entangled photon pairs with a precise timing through down-conversion of femtosecond pulses is often faced with a degraded polarization entanglement quality. In a previous experiment we have shown that this degradation is induced by spectral distinguishability between the two decay paths, in accordance with theoretical predictions. Here, we present an experimental study of the spectral compensation scheme proposed and first implemented by Kim et al. in 2002. By measuring the joint spectral properties of the polarization correlations of the photon pairs, we show that the spectral distinguishability between the down-converted components is eliminated. This scheme results in a visibility of 97.9+/-0.5% in the polarization basis without any spectral filtering.
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