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Search Results: 1 - 10 of 11008 matches for " Pierre Togo "
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Results of Combined Chemotherapy and External Beam Radiotherapy for Unilateral Intra-Orbital Retinoblastoma—A Multi-Institutional Study from Mali  [PDF]
Boubacar Togo, Fousseyni Traore, Konimba Diabaté, Fatou Sylla, A?chata Tall, Affiatou Simaga, Bakarou Kamaté, Hawa Diall, Pierre Togo, Abdoul Karim Doumbia, Pierre Bey, Francis Eshun
Open Journal of Pediatrics (OJPed) , 2019, DOI: 10.4236/ojped.2019.91005
Abstract: Retinoblastoma (RB) treatment aims at saving the life and preserving useful vision. In most low-income countries, because of delays in diagnosis, advanced disease presentation is quite common. This prospective study aimed at evaluating the treatment results of orbital RB with regards to overall survival rate of the patients treated with chemotherapy and radiotherapy. The study was performed from 01 November 2011 to 31 December 2015 in the paediatric oncology unit of Gabriel Touré Teaching Hospital, Bamako, Mali and The Institute of Tropical Ophthalmology of Africa (IOTA), Bamako, Mali. All intra-orbital non-metastatic RB cases not previously treated by chemotherapy or radiotherapy were included in this study. Fourteen patients were included into the study. Median age was 2 years, and sex ratio 2.5 (M = 10; F = 4). Right eye (n = 12, 85.7%) was more often affected than left eye (n
Epidemiological and Clinical Study of Cardiac Diseases in the Pediatric Department of the University Hospital Gabriel Touré (UH GT), Bamako (Mali)  [PDF]
Maiga Belco, Ba Hamidou Oumar, Sacko Karamoko, Dembélé Adama, Sanogo Nouhoum, Cissé Mohamed Elmouloud, Togo Pierre, Diakité Abdoul Aziz, Dicko-Traoré Fatoumata, Sylla Mariam
World Journal of Cardiovascular Diseases (WJCD) , 2018, DOI: 10.4236/wjcd.2018.87032
Abstract: Introduction: Children’s heart disease is a major public health problem in developing countries and especially in Mali. The purpose of our work was to determine frequency, different types of heart disease and their short term evolution in the pediatric department. Methods: We performed a retrospective study among children aged 0 to 15 years, hospitalized in the pediatric department from January to December 2015 and whose diagnosis was confirmed using trans-thoracic echocardiography. Results: We included 103 cases of heart disease out of a total of 8613 admissions in the pediatric department, giving an hospital prevalence of 1.2%. Mean age was 4.1 years (from 1 day to 15 years) and children under 5 years were the most affected with 73.80% of cases. Male predominance was noted (sex ratio = 1.2). Respiratory distress was the most common circumstance of discovery (93.20%). Cardiac murmur and tachycardia were the most common cardiac signs with respectively 88.35% and 83.50%. Congenital heart disease accounted for 70.87% and was dominated by ventricular septal defect (VSD) with 30.13%. Acquired heart disease (29.13% of the sample) was dominated by mitral regurgitation (MR) with 56.67%. Mortality rate was 31.9% for congenital heart disease and 11.1% for acquired heart disease. Conclusion: children’s heart disease is responsible for high mortality. Early detection improves the management of this pathology, which remains frequent.
Preparation of α-Bromoketones and Thiazoles from Ketones with NBS and Thioamides in Ionic Liquids  [PDF]
Yuhta Izumisawa, Hideo Togo
Green and Sustainable Chemistry (GSC) , 2011, DOI: 10.4236/gsc.2011.13010
Abstract: Ketones smoothly reacted with NBS in the presence of a catalytic amount of ptoluenesulfonic acid to give α-bromoketones in good yields in typical ionic liquids, such as [bmim]PF6 and [bmpy]Tf2N, and the ionic liquids could be repeatedly used for the same reaction after the extraction of the α-bromoketones. Then, the one-pot conversion of ketones into thiazoles by the treatment with NBS, and subsequently with thioamides could be also carried out in [bmim]PF6 and [bmpy]Tf2N, respectively Thus, [bmim]PF6 and [bmpy]Tf2N could be used as recyclable reaction media for the preparation α-bromoketones and thiazoles from ketones.
Structure Refinement of Mn-Substituted LiMnxFe1-xPO4  [PDF]
Masakazu Togo, Atsushi Nakahira
Materials Sciences and Applications (MSA) , 2018, DOI: 10.4236/msa.2018.96039
Abstract: For Mn substituted LiMnxFe1-xPO4 synthesized by hydrothermal process, the structural differences caused by Mn substitution were characterized by SEM, ICP, XRD, XAFS, and FT-IR. In this study, by using XAFS advantageous to the atomic selectivity, the local structure of MeO6 octahedral was investigated. From ICP, Mn composition in the products was similar to Mn addition amount, and the peak shifts of XRD patterns with increasing Mn addition were observed. The lattice constants refined by Rietveld analysis were a = 1.0338 ± 5 nm, b = 0.5995 ± 4 nm and c = 0.4696 ± 1 nm in LiFePO4, and it was expanded linearly with increasing Mn addition. Fe-O bond distance, which was calculated by curve fitting of the radius distribution function of LiMnxFe1-xPO4, was 0.208 nm smaller than 0.214 nm of Mn-O bond. In addition, MeO6 octahedral expansion was affected to PO4 vibrational structure from FT-IR spectra.
Post-Infectious Acute Glomerulonephritis in Child: Epidemiological, Clinical and Evolutionary Aspects in Gabriel Touré Teaching Hospital in Mali  [PDF]
Mariam Sylla, Fatoumata Dicko-Traoré, Abdoul Karim Doumbia, Aminata Coulibaly, Abdoul Aziz Diakité, Modibo Sangaré, Pierre Togo, Fousseyni Traoré, Amadou Touré, Djènèba Konaté, Karamoko Sacko, Belco Maiga, Fatoumata Léonie Diakité, Lala N’Drainy Sidibé, Mohamed Elmouloud Cissé, Adama Dembélé, Hawa Diall, Oumar Coulibaly, Ibrahim Hamadou, Leyla Maiga, Issiaka Koné, Boubacar Togo, Toumani Sidibé
Open Journal of Pediatrics (OJPed) , 2018, DOI: 10.4236/ojped.2018.84036
Abstract: Introduction: Acute post-infectious glomerulonephritis (APIGN) can be serious due to its complications that still occur in our countries. In this work, we aimed to study the epidemiological, clinical, biological and evolutionary aspects of APIGN. Patients and methods: We conducted a retrospective, descriptive study from January 1st, 2015 to December 31st, 2017 in the pediatric ward of the Gabriel Touré Teaching Hospital in Bamako. All children hospitalized for APIGN were included. Results: In two years, we included 10 children aged 7 years old on average; all from low socioeconomic backgrounds. The sex ratio was 1.5. On average, the children spent 15.8 days before our consultation. Edema was the main reason for consultation. We found a history of infection and high blood pressure in 30% each, and renal failure in 10% of the children. Hematuria and proteinuria were detected in 100% and 90%, respectively. Hypocomplementemia was observed in 66.6%. One third of the children had a positive antistreptolysin O. The average duration of hospital stay was 11.2 days. The evolution was favorable in 90%. Kidney failure was the leading cause of death. Conclusion: Acute post-infectious glomerulonephritis is still a reality in our context. Emphasis should be put on its prevention by improving the hygienic conditions, detection and the management of
Acute Pneumonia Characteristics in Children under Five Years of Age in Bamako, Mali  [PDF]
Fatoumata Dicko-Traoré, Abdoul Karim Doumbia, Mariam Sylla, Mariatou Traoré, Djènèba Konaté, Fatoumata Léonie Diakité, Karamoko Sacko, Belco Maiga, Hawa Diall, Oumar Coulibaly, Pierre Togo, Fousseyni Traoré, Abdoul Aziz Diakité, Yacouba Toloba
Open Journal of Pediatrics (OJPed) , 2019, DOI: 10.4236/ojped.2019.91002
Abstract: Pneumonia is the most common cause of mortality in child under five years of age. The objective of the study was to assess socio-demographic and clinical characteristics of children under 5 hospitalized for pneumonia. Material and method: We conducted a 6 months prospective study from June 1st, 2016 to December 31st, 2016 in the general pediatric service in the Pediatric Department of Gabriel Touré Teaching Hospital in Bamako, the capital city of Mali. Result: We have selected 63 cases of pneumonia according to our definition criteria, i.e. 2.2% of hospitalizations for children aged 1 to 59 months. The average age was 14 months. Infants under 2 years accounted for 82.53%. The sex ratio was 1.2. Seventy eight percent came from an unfavorable socio-economic background. The majority of mothers were uneducated (71.42%). Breastfeeding was exclusive up to 6 months in 50.79% of patients. Vaccination according to the national program was not up to date in 27% of patients. The average consultation time was 18 days. On admission, 81% of
Cell Membrane Disruption Stimulates NO/PKG Signaling and Potentiates Cell Membrane Repair in Neighboring Cells
Tatsuru Togo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042885
Abstract: Resealing of a disrupted plasma membrane at the micron-diameter range requires Ca2+-regulated exocytosis. Repeated membrane disruptions reseal more quickly than the initial wound, and this potentiation of membrane resealing persists for at least 24 hours after the initial wound. Long-term potentiation of membrane resealing requires CREB-dependent gene expression, which is activated by the PKC- and p38 MAPK-dependent pathway in a wounded cell. The present study demonstrates that membrane resealing is potentiated in both wounded and neighboring cells in MDCK cells. Wounding of cells expressing CREB133, a mutant variant of CREB, does not show the potentiated response of cell membrane resealing in either wounded or neighboring cells. Furthermore, wounding of cells induces CREB phosphorylation, not only in wounded cells, but also in neighboring cells. Inhibition of the nitric oxide/PKG signaling pathway suppresses CREB phosphorylation in neighboring cells, but not in wounded cells. The potentiation of membrane resealing in neighboring cells is suppressed if the nitric oxide/PKG pathway is inhibited during the initial wound. Together, these results suggest that the nitric oxide/PKG pathway stimulates CREB phosphorylation in neighboring cells so that subsequent cell membrane disruptions of the neighboring cells reseal more quickly.
Is the Walking Campaign Effective for Depressive Symptoms?  [PDF]
Setsuko Taneichi, Fumiharu Togo, Tsukasa Sasaki
Open Journal of Psychiatry (OJPsych) , 2014, DOI: 10.4236/ojpsych.2014.44047

Aim: The aim of this study is to examine the effect of walking 10,000 steps per day on depressive symptoms for the company employees and their spouses in Japan. Method: Subjects were recruited from the participants of a walking campaign carried out by a Japanese company where the goal was to achieve 600,000 steps in 60 days. Among 221 subjects who participated in the campaign, 176 subjects (79.6%) agreed to participate in the present study. Sociodemographics and other information including depressive symptoms were assessed using a questionnaire. Result: Out of the 171 participants, 125 achieved the goal (73.1%). In the achiever’s group, the GHQ-12 score was significantly reduced at the end of the campaign compared with the non-achiever’s group. Exercise habit and the less overtime work (<45 hours past 1 month) at the baseline were significantly associated with the achievement of the goal. Conclusion: The achievement of 600,000 steps in 60 days is correlated with the improvement of depressive symptoms and the achievement of this goal might be related with the exercise habit and less overtime work before the campaign.

Factors of Nephroblastomas’ Relapse in Children at the Academic Hospital Gabriel Toure, Bamako, Mali  [PDF]
Djénèba Konaté, Coulibaly Yacaria, Doumbia Abdoul Karim, Doumbia Aliou, Amadou Issa, Oumar M. Coulibaly, Traoré Fousseyni, K. Traoré, Kamaté Bénoi, Djiré Mamadou Kassoum, Coulibaly Youssouf, Traoré Abdramane, Togo Pierre, Koné Oumou, Togo Boubacar
Open Journal of Pediatrics (OJPed) , 2020, DOI: 10.4236/ojped.2020.101012
Abstract: Introduction:The factors of nephroblastomas’ relapse are a set of elements playing a role in the reappearance of cancer cells in the same place of the kidney or in other regions of the body after a 5-year remission.Objectives:?To determine the frequency and the factors of nephroblastomas’ relapse in the pediatric oncology unit and pediatric surgery of the academic hospital Gabriel Touré. Materials and methods:?This was a retrospective study carried out from January 1, 2005 to December 31, 2019 in all children treated for nephroblastoma relapses in the pediatric oncology unit and in the pediatric surgery service.Results:?In 15 years, we have managed 182 cases of nephroblastoma, of which 128 cases were declared in complete remission after 5 years and 12 cases presented a recurrence. The relapses factors were: capsular break, intraoperative tumor rupture, presence of an associated malformation, surgery without neoadjuvant chemotherapy and tumor surgical stage (p?<0.05). Patients’ age at diagnosis, sex, number of neoadjuvant and adjuvant chemotherapy sessions and histological type were not decisive (p> 0.05).Conclusion:?Relapses are more and more frequent in cases of nephroblastoma. The correct use of the protocol would avoid these recurrences.
Appendicular Abscess in the Service of General Surgery at the Teaching Hospital Gabriel Toure, Bamako, Mali  [PDF]
Madiassa Konate, Traore Amadou, Coulibaly Yacaria, Dembele Bakary Tiéntigui, Karembe Boubacar, Keita Soumaila, Amadou Issa, Mangane Moustaphissa, Diop Thierno Madani, Almeimoune Abdoul Hamidou, Togo Adégné Pierre, Kante Lassana, Traore Alhassane, Maiga Amadou, Bah Amadou, Sidibe Boubacaryoro, Diamoutene Kolo, Tolo Maimouna, Samake Moussa, Mounimezié Diarra, Diakite Ibrahim, Diallo Gangaly
Surgical Science (SS) , 2018, DOI: 10.4236/ss.2018.98033
Abstract: Objectives: To determine hospital frequency and to write the diagnostic and therapeutic aspects of appendicular abscess in adults in the General Surgery Department of teaching Hospital Gabriel Touré from 2005 to 2017. Material and Methods: This was a retrospective study conducted from January 1, 2005 to December 31, 2017 in the General Surgery De-partment of Gabriel Touré University Hospital in all patients with appen-dicular abscess. Results: In 13 years, 1420 cases of acute appendicitis have been reported, including 105 cases of appendicular abscess (7.4%). Mean age of the patients was 32 years with extremes of 16 years and 70 years. Abdominal pain and fever were present in all patients. Pain sat in the right iliac fossa in 73.3% and was epigastric in 11.4%. In almost all cases abdominal defense was present (97.1%). There was generalized abdominal contracture in 2.8% of cases. Average duration of evolution was 27 days with extremes of 1 day and 60 days. Ultrasonography was performed in 42.6% of cases and found peri-appendicular effusion in 29 cases (27.6%). 90 incisions were made by incision of Mac Burney, 8 by median umbilical, 7 by midline above and below umbilical. The amount of fluid aspirated was greater than 100 cc in 47 patients. We performed an appendectomy with appendicular stump burying followed by washing plus drainage of the abdominal cavity in 65 patients. Morbidity rate was 14.3%. No deaths were recorded. Average duration of hospitalization was 6.5 days with extremes of 2 days and 26 days.
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