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Search Results: 1 - 10 of 10907 matches for " Pierre Sirois "
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New Gene Therapy Strategies for the Deletion of Exon 44 of Dystrophin Gene Based on Gene Editing by TALENs  [PDF]
Ping Li, Yunzhi Pan, Alice S. S. Li, Aijuan Sun, Jia Zhang, H. L. Gao, Pierre Sirois, Kai Li
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.31001
Abstract:

Duchenne Muscular Dystrophy (DMD) is a severe childhood form of muscular dystrophy. Both the severe form and its milder form of Becker Muscular Dystrophy (BMD) are caused by the mutation of dystrophin gene. Different from some other genetic diseases such as hemophilia that can be treated by replacement therapy, there is no effective therapy for muscular dystrophy in conventional medication. Gene editing technology from the recently developed engineered nucleases such as TALENs has been successfully employed in genome modification of a variety of species, and will be applied in gene therapy of selected human diseases. The genetic basis of DMD and BMD indicates that DMD is a good target for gene therapy through returning the reading frame of dystrophin gene. Gene therapy strategies described here may apply to many other genetic diseases. Wider application of TALENs in gene therapy have the potential to dramatically prolong the lifespan of individuals with genetic diseases.

Cover changes, during the 1954-1990 period, in the alpine vegetation used by the Gaspesie Provincial Park caribou herd
Jean-Pierre Quellet,Luc Sirois,Jean Ferron
Rangifer , 1991,
Abstract:
Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis
Gabriel N Kaufman, Charlotte Zaouter, Barthélémy Valteau, Pierre Sirois, Florina Moldovan
Arthritis Research & Therapy , 2011, DOI: 10.1186/ar3338
Abstract: Osteoarthritis was surgically induced in male rats by transection of the right anterior cruciate ligament. Animals were subsequently treated with weekly intra-articular injections of specific peptide antagonists of ETA and/or BKB1. Hind limb nociception was measured by static weight bearing biweekly for two months post-operatively. Post-mortem, right knee joints were analyzed radiologically by X-ray and magnetic resonance, and histologically by the OARSI histopathology assessment system.Single local BKB1 antagonist treatment diminished overall hind limb nociception, and accelerated post-operative recovery after disease induction. Both ETA and/or BKB1 antagonist treatments protected joint radiomorphology and histomorphology. Dual ETA/BKB1 antagonism was slightly more protective, as measured by radiology and histology.BKB1 antagonism improves nociceptive tolerance, and both ETA and/or BKB1 antagonism prevents joint cartilage degradation in a surgical model of osteoarthritis. Therefore, they represent a novel therapeutic strategy: specific receptor antagonism may prove beneficial in disease management.Osteoarthritis (OA) is characterized by a progressive destruction of articular cartilage accompanied by subchondral bone remodeling, osteophyte formation, and synovial membrane inflammation [1]. Clinically, this disease progresses slowly and principally affects the hands and large weight-bearing joints. Pain is the primary complaint of patients with OA. Its etiology is multifactorial: subchondral bone can have micro-fractures, osteophytes can cause stretching of peri-osteal nerve endings, ligaments may be stretched, the joint capsule can be inflamed or distended, the synovium may be inflamed, and muscles may spasm [2]. Furthermore, neo-innervation of joint tissue concurrent with angiogenesis [3,4] may contribute to deep joint pain. Further understanding of the molecular mechanisms behind these effects should provide avenues towards targeted disease-modifying or -slowing t
Searches for SUSY Particles at HERA
Y. Sirois
Physics , 1996,
Abstract: Searches at the e-p collider HERA for supersymmetric partners of the Standard Model fermions are presented. Assuming R-parity conservation, selectrons and squarks of the Minimal Supersymmetric Standard Model are excluded for masses up to 65 GeV in a new region of the standard parameter space. Admitting in addition a R-parity violating Yukawa coupling $\lambda'$, squarks are sought through direct e-q fusion in a yet unexplored mass-coupling domain, taking into account all possible squark decays. Squark masses up to 240 GeV are excluded for $\lambda' \gtrsim \sqrt{4 \pi \alpha_{em}}$, depending only weakly on the free model parameters.
Searches For New Bosons Coupling To e-q Pairs At HERA And Other Colliders
Yves Sirois
Physics , 1999,
Abstract: The early observation at HERA of an excess of events compared to the expectation from the Standard Model in very short distance $e^+p$ deep-inelastic scattering processes has renewed the interest in the search for new physics which could manifest in electroweak-like interactions. New preliminary results from the H1 and ZEUS experiments making use of all available $e^+p$ data are reviewed here, with an emphasis on the search for new bosons possessing Yukawa couplings to lepton-quark pairs. The sensitivity of HERA to leptoquarks, and to squarks of R-parity violating supersymmetry, is confronted to existing indirect constraints from rare and forbidden semi-leptonic decays, atomic parity violation and neutrinoless double-beta decay, as well as to direct constraints from LEP and Tevatron colliders. The HERA and Tevatron colliders are found to offer exciting prospects for new physics, accessing yet unexplored domains of the mass-coupling plane. Possible striking manifestation of explicit lepton flavour violation is also discussed.
Current needs, the future of adolescents and young adults having sustained a moderate or severe Traumatic Brain Injury (TBI) and the potential of their social participation  [PDF]
Sirois Katia, Boucher Normand, Lepage Céline
Open Journal of Therapy and Rehabilitation (OJTR) , 2014, DOI: 10.4236/ojtr.2014.21009
Abstract: The general objective of this study is to identify the specific needs of youths who have suffered a moderate or severe traumatic brain injury (TBI) and their levels of life habit accomplishments. The secondary objective aims to identify how they view themselves in the future with regard to their life habits. Eighteen young persons with moderate or severe TBIs aged 14 to 20 completed questionnaires based on the Life-Habits questionnaire and elaborated on their current level of satisfaction and their visions of the future. Teenagers reported that maintaining good interpersonal relationships, being autonomous, fulfilling their responsibilities, warding off lone-liness, as well as being supported in their efforts to reach a satisfying response to their needs and concerns were their highest priorities. In order to increase their satisfaction related to life habits they suggest improving external factors, such as information concerning TBIs to their entourage. They see themselves as complete social participants in the future. Youths with moderate or severe TBIs identified their needs and envisioned their future to be like that of any other teenager and young adult. They hope to start a family and find a good job. They also identified strategies to improve their life habits.
Motivations for consulting complementary and alternative medicine practitioners: A comparison of consumers from 1997–8 and 2005
Fuschia M Sirois
BMC Complementary and Alternative Medicine , 2008, DOI: 10.1186/1472-6882-8-16
Abstract: Surveys were displayed in CAM and conventional medicine offices and clinics in Ontario, Canada in 1997–8 and again in 2005, and self-selected participants returned the surveys by mail.In 1997–8, 141 CAM consumers were identified from the 199 surveys returned, and 185 CAM consumers were identified from the 239 surveys returned in 2005. Five of the six CAM motivations were more likely to be endorsed by the 2005 CAM consumers compared to the 1997–8 CAM consumers (all p's < .0001). In 1997–8 the two top reasons for using CAM were that CAM allowed them to take an active role in their health (51.8%), and because conventional medicine was ineffective for their health problem (41.8%). In 2005, the treatment of the whole person (78.3%) was the top reason for using CAM followed by taking an active role in one's health (76.5%). The 2005 consumers were less educated, had slightly more chronic health complaints, had been using CAM for longer, and were more likely to consult chiropractors, reflexologists, and therapeutic touch practitioners than the 1997–8 consumers. Otherwise, the socio-demographic and health profiles of the two groups of CAM consumers were similar, as was their use of CAM.Compared to consumers in 1997–8, consumers in 2005 were more likely to endorse five of the six motivations for consulting CAM practitioners. A shift towards motivations focusing more on the positive aspects of CAM and less on the negative aspects of conventional medicine was also noted for the 2005 consumers. Findings suggest that CAM motivations may shift over time as public knowledge of and experience with CAM also changes.Interest in and use of complementary and alternative medicine (CAM) continues to rise in Canada and other developed nations, spurring interest into the motivations for CAM use. For example, in Canada, the use of CAM practitioners among the general population increased from 15% in 1994/5 to 20% in 2003 [1]. These rates are much lower than those generally found when CAM use
Search for Particles and Forces Beyond the Standard Model at HERA ep and Tevatron p\bar{p} Colliders
Masahiro Kuze,Yves Sirois
Physics , 2002, DOI: 10.1016/j.ppnp.2004.03.001
Abstract: A review of searches for physics beyond the Standard Model carried out at high energy lepton-hadron and hadron-hadron facilities is presented, with emphasis on topics of interest for future data taking at the upgraded Tevatron $p{\bar p}$ and HERA $ep$ colliders. The status and discovery prospects are discussed for leptoquarks, Technicolour and supersymmetry, forbidden lepton and quark flavour-changing processes, extra gauge bosons, excited states of composite fermions, generic contact interactions and extra compactified dimensions.
Validity Check of Mutual Inductance Formulas for Circular Filaments with Lateral and Angular Misalignments
Slobodan I. Babic;Frederic Sirois;Cevdet Akyel
PIER M , 2009, DOI: 10.2528/PIERM09060105
Abstract: In this paper we derived the formula for calculating the mutual inductance between circular filaments with lateral and angular misalignment by using the approach of the magnetic vector potential. The results obtained correspond to those of F. W. Grover, although the latter used the general formula given by the Neumann integral instead of a vector potential approach. However, the major purpose of this paper is to clarify some confusion introduced in previous works regarding the mutual inductance calculation between thin filamentary circular coils with parallel axes in air. This problem has been solved by Kim et al. (1997) using the magnetic vector potential, but unfortunately it leads to erroneous results, even for slight misalignments of the coils' center axes. This is why we chose to use the approach of the magnetic vector potential to show that, when properly derived, the results must indeed reduce to the well known F.W. Grover's formulas.
Lichen-Spruce Woodland Early Indicators of Ecological Resilience Following Silvicultural Disturbances in Québec’s Closed-Crown Forest Zone  [PDF]
Esteban Gonzalez, Fran?ois Hébert, Jean-Fran?ois Boucher, Pascal Sirois, Daniel Lord
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.43A094
Abstract:

Lichen woodlands (LW) located in the closed-crown boreal forest are not a successional stage moving towards a closed black spruce feathermoss stand (FM), but an alternative stable state, due to their previous forest history, and the occurrence of LWs located nearby closed-crown FM stands. Therefore, afforestation in those LWs through site preparation and plantation could shift back LW into FM stands. We implemented an experimental design with different combinations of silvicultural treatments in both site types (LW, FM). We monitored the evolution of plant diversity and the physiology of three bio-indicators (Picea mariana, Kalmia angustifolia, Rhododendron groenlandicum) in different microsites created by the silvicultural treatments. The return to the initial composition was noticed only two years after treatments, especially in the LW stands, thus indicating a higher level of early ecosystem resilience in LWs compared to FM stands. Mean species cover, especially in the FM stands, decreased the most in the skid trails created by logging, probably due to a lack of acclimation of bryophytes to open stand conditions. Conversely, ericaceous shrubs and lichens found in the LWs were already acclimated to open stand conditions, which give to LWs a restructuring advantage compared to FM plant communities after silvicultural treatments. Overall, FM and LW short-term resilience was similar, indicating equally efficient ecosystem reorganization in both stands. The comparable early resilience in managed LW and FM stands, in terms of plant biodiversity, contradicts the presumed fragility of LW stands, especially in this case where LWs are assumed to be an alternative stable state created by compound disturbances. Silvicultural treatments maintained the functional group diversity in LWs, a key element for ecosystem resilience. Therefore, this study support the idea that plantation following site preparation in LWs could be a valuable management strategy to reach several objectives, such as increasing forest carbon sinks.

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