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Search Results: 1 - 10 of 2555 matches for " Pharmacotherapeutic intervention "
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Classification and treatment of different stages of alzheimer’s disease using various machine learning methods
Sandhya Joshi,Vibhudendra Simha G.G.,Deepa Shenoy P.,Venugopal K.R.
International Journal of Bioinformatics Research , 2010,
Abstract: There has been a steady rise in the number of patients suffering from Alzheimer’s disease (AD)all over the world. Medical diagnosis is an important but complicated task that should be performedaccurately and efficiently and its automation would be very useful. The patient’s records are collected fromNational Institute on Aging, USA. The Sample consisted of initial visits of 496 subjects seen either as controlor as patients. Patients were concerned about their memory at the National Institute on Aging. It alsoconsisted of patients and caregiver interviews. This research work presents different models for theclassification of different stages of Alzheimer’s disease using various machine learning methods such asNeural Networks, Multilayer Perceptron, Bagging, Decision tree, CANFIS and Genetic algorithms. Theclassification accuracy for CANFIS was found to be 99.55% which was found to be better when compared toother classification methods. Based on the outcome of classification accuracies, various management andtreatment strategies such as pharmacotherapeutic and non pharmacotherapeutic interventions for mild,moderate and severe AD were elucidated, which can be of enormous use for the medical professionals indiagnosis and treatment of AD.
Propuesta de adaptación de la hoja de historia farmacoterapéutica del método Dáder para aprendices
Carvalho Amarante,Laila; Sanae Shoji,Luci; Freitas,Kátia Michele; Radighieri Rascado,Ricardo; Silva,Lara Cristina; Moreira Marques,Luciene Alves;
Revista Cubana de Farmacia , 2012,
Abstract: introduction: freitas & marques proposed a sheet of pharmacotherapeutical history (sph) in 2008: the dáder adaptation (da). objective: this study was aimed at evaluating the applicability of da compared with dáder. methods: the sheets of pharmacotherapeutical history (sph) were applied to chronic users of drugs by pharmacy students. at the end, interviewers attributed scores ranged from 0 to 5 points to various aspects of their applicability. the completeness or not of the collected data was also evaluated. results: the two sph were equivalent, because there was no statistically significant difference for the three questions about the applicability. conclusions: in the context of pharmaceutical care, this new sheet of pharmacotherapeutical history offers possibilities to choose the one that best fits the needs of the pharmacist.
Assessment of quality of generics in cardiology: reality and possibilities
V.V. Yakusevich
Rational Pharmacotherapy in Cardiology , 2005,
Abstract: Wide presence of original drugs’ copies, the so-called “generics”, on the pharmaceutical market is analyzed. The positive side of this expansion is connected with the lower price of generics, which makes it possible to decrease the costs of treatment. From the other side with the advent of big number of copies of the original drugs it becomes more difficult to assess the quality of each particular generic. Russian legislation in the field of registration allows selling in the country almost all drugs, which have at least minimal similarity to the original. The problem of pre-registration studies of bioequivalency of original and analogue drugs, therapeutical equivalency is widely observed. Concrete proposals of how to prevent the overflow of the Russian market with the generics with the unproved efficacy and safety are considered.
Avalia??o econ?mica do seguimento farmacoterapêutico em pacientes com diabetes melito tipo 2 em farmácias comunitárias
Correr, Cassyano Januário;Pontarolo, Roberto;Wiens, Astrid;Rossignoli, Paula;Melchiors, Ana Carolina;Radominski, Rosana;Fernandez-Llimós, Fernando;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2009, DOI: 10.1590/S0004-27302009000700006
Abstract: objective: assess economics results of pharmacotherapeutic follow-up (pf) in patients with diabetes mellitus type 2 in community pharmacies from additional health system. methods: in a prospective clinic study, 161 patients were divided into two groups, of which only one group received pf for 12 months. from the results, we calculated data of effectiveness and costs. the primary endpoint was the economic evaluation pf by using an indicator of effectiveness (changes in glycated hemoglobin), which was related to the costs of pharmaceutical care. secondary endpoints were values of blood pressure, waist circumference and body mass index of patients, also related to costs of pharmaceutical care. results: a real reduction of 1.3% of hba1 was observed in the pf group, in comparison to control group. the annual cost of the reduction in 1% in hba1 values in the pf group patients was $45.15. this feature to improve the control of type 2 diabetic patients can be implemented with annual investments of about $225.76 per patient, using pf and monitoring of blood glucose test. conclusions: it is possible to reduce the hba1 values to desired levels by using pf. this can be considered an additional resource for the attainment of metabolic control, resulting in this study a cost of $37.62 per patient, per year, to reduce 1% in the hba1 values.
Drug-related problems observed in a pharmaceutical care service, Belo Horizonte, Brazil
Nascimento, Yone de Almeida;Carvalho, Wania da Silva;Acurcio, Francisco de Assis;
Brazilian Journal of Pharmaceutical Sciences , 2009, DOI: 10.1590/S1984-82502009000200018
Abstract: this present observational, longitudinal, and non-concurrent study was developed with the purposes of evaluate the profile of patients attended by a pharmacotherapeutic follow-up service and describe the drug-related problems (drps) found over there; determine the proportion of drps between the health problems presented by the studied population, classifying them and identifying the situations related with their appearance. the study was developed at the school pharmacy of newton paiva university center, belo horizonte, mg, during the period from 2001 november up to 2003 november. ninety seven patients have been evaluated, the majority of female sex (66.0%), with up to 8 years of scholarship (45.4%), mean age of 56.7 ± 13.0 years; mean of 4 ± 2 diagnosed diseases; 7 ± 6 complaints and 4 ± 2 medications per patient. nine hundred and twelve health problems have been identified: 56.5% uncontrolled. from the uncontrolled problems, 380 (73.6%) were drps and between these, 81 (21.3%) were risks for drp. from the 97 followed-up patients, 89 (91.7%) have presented at least one drp during the follow-up. the more frequent drps were related to effectiveness (53.2%), to necessity (25.2%) and to safety (21.6%). a great number of uncontrolled problems was observed, as well as the possibility to resolve them by means of pharmaceutical care, indicating so the resolutive potential of this practice.
Contribui??o do uso de medicamentos para a admiss?o hospitalar
Mastroianni, Patrícia de Carvalho;Varallo, Fabiana Rossi;Barg, Marina Souza;Noto, Ana Regina;Galduróz, José Carlos Fernandez;
Brazilian Journal of Pharmaceutical Sciences , 2009, DOI: 10.1590/S1984-82502009000100020
Abstract: according to the word health organization, adverse drug reactions (adr) are any harmful and non intentional answer which occurred in doses normally used in human beings. the adr can be responsible for 2.4% to 11.5% of hospital admissions. therefore, this study aimed at knowing the admitted patient′s demographic profile due to possible adr, identifying the most frequent drugs and complaints, and evaluating the incidence of hospital admission related to drug use. patients who were 18 years old or more and were admitted during a period of one month to a medical clinical of a general hospital were interviewed for one month about drug use before being admitted, as well as regarding to the complaint which led them to hospital. these information were analyzed according to official data, like micromedex? and who criteria as well. it was observed that the admission due to drug use occurred in most part of the cases in elderly [47.5% (66/139)] and women [62% (87/139)]. the most frequent drugs used were: omeprazole (16), analgesics (31), antihypertensive (31), simvastatin (7) and formoterol fumarate (6), and the symptoms were normally associated to the digestive (20.5%), circulatory (20.2%), respiratory (18.2%) and central nervous systems (13.9%). it was estimated that 15.5% (139/897) of the hospital admission occurred possibly due to the drug use. the data found by present study suggests some strategies in order to prevent adr in the context of primary health care services, such as monitoring drug therapy, manly for patients with chronic diseases, elderly and polimedicated people; and pharmaceutical care including dispensation and purchasing of the drugs, a lot of them dispensed over the counter (otc).
Aspectos clínicos y farmacoterapéuticos de la infección del tracto urinario. Revisión estructurada
CES Medicina , 2011,
Abstract: objective: the urinary tract infections (uti) are more frequent infection after respiratory infectious diseases. it is therefore considered necessary to have systematic and updated information to help improve drug therapy outcomes and reduce morbidity and mortality associated with this infection. the aim of this study was to perform a structured review of clinical and pharmacotherapeutic aspects of urinary tract infections. methods: we conducted a structured review of urinary tract infection in pubmed/medline of articles published in english and spanish, between 2007and 2010, in humans, with access to full text. search terms were: "urinary tract infections" and (classification or epidemiology or complications or physiology or physiopathology or drug therapy) in title/abstract field. the information was complemented both by a specific search of colombia scielo database, using the terms: urinary tract infections and urinary tract infection, and by review of references cited in relevant articles. the information is organized into the following sections: classification, epidemiological, risk factors, etiology, clinical presentation, diagnosis, drug therapy, prophylaxis and resistance. relevant aspects are presented and current urinary tract infection (uti) related to its classification, epidemiology, risk factors, etiology, clinical presentation, diagnosis, drug therapy, prophylaxis and antibiotic resistance. results: we present some relevant and current aspects of the urinary tract infection related to its classification, epidemiology, risk factors, etiology, clinical presentation, diagnosis, drug therapy, prophylaxis, and antibiotic resistance. conclusions: the review of health problems common in the population, such as the uti, offers the ability of update and outline an approach based pharmacotherapy based on the proper use of medicines, in order to reduce the likelihood of treatment failure and resistance of microorganisms. in colombia, the epidemiological and drug
Acompanhamento farmacoterapêutico dos pacientes com leucemia mieloide cr?nica em uso de mesilato de imatinibe na Universidade Federal do Ceará
Aquino, Sterfen S.;Gon?alves, Romélia P.;Silva, Lilianne B.;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009005000048
Abstract: chronic myeloid leukemia (cml) is a genetic disorder of unknown etiology characterized by increased and unregulated growth of myeloid precursor cells in the bone marrow. cml is associated with a characteristic chromosomal translocation known as the philadelphia chromosome. this is a descriptive observational study of cml patients in the walter cantídio university hospital, federal university of ceará, brazil. the aim of the study was to investigate the efficacy and common side effects of imatinib mesylate therapy. twenty- six patients were included in the study: 9 in the chronic phase (34.61%), 6 in the accelerated phase (23.08%) and 11 in blast crises (42.31 %). the cases in the chronic phase had previous intolerance to interferon alpha (ifn- α). complete hematological responses were observed in 7 patients: 5 in the chronic phase, 1 in the accelerated phase and 1 in blast crisis. during the first year of treatment, 4 patients in the chronic phase presented complete cytogenetic responses. one of these patients subsequently lost response. no patient in the accelerated phase or blast crisis showed complete cytogenetic response. complete molecular response was confirmed in 1 patient in the chronic phase. among the 18 patients who were alive at the end of the study, only 4 patients (22.22%) had no complaint. the most commonly reported adverse events were: edema (50%), adynamia (33.33%), bone and / or joint pain (33.33%), headaches (27.78%), cramps (16,67%), diarrhea (16.67%), insomnia (16.67%), itching (16.67%), ecchymosis (11.11%), nauseas (11.11%), epigastric pain (5.55%), erythema (5.55%), shedding of tears (5.55%), dehydration of the skin and lips (5.55%), rush (5.55%), and sweating (5.55%). a minority of patients evolved with imatinib resistance. newer drugs and trials are being developed to overcome resistance and to increase responsiveness to tyrosine- kinase inhibitors.
Adverse reactions to oxacillin in hospitalized children: a prospective study
Souza, Mariana de Oliveira Brizeno de;Araújo, Maria da Concei??o Castro de;Santiago, Raquel Araújo de;Coelho, Helena Lutéscia Luna;Fonteles, Marta Maria de Fran?a;
Revista Brasileira de Saúde Materno Infantil , 2007, DOI: 10.1590/S1519-38292007000100007
Abstract: objectives: follow-up of children exposed to oxacillin during hospitalization focusing on adverse reactions. methods: patients were selected from the pediatric wards of two hospitals in fortaleza (hospital universitário walter cantídio-huwc and hospital infantil albert sabin-hias) from the first oxacillin prescription with a prospective cohort study between october, 2000 and july, 2001 (huwc) and july/2001 and march, 2002 (hias). patients' follow-up was performed by daily visits to the wards and medical charts and prescription analysis. suspected oxacillininduced adverse reactions (oxar cases) were notified and classified according to causality and severity. related statistic tests were completed. results: of the 130 patients exposed to oxacillin, 27 had oxar (20.8%). fever was the most frequent reaction (50%) followed by rash (35.7%). the majority of reactions were considered probable, for oxacillin was the only medication involved and 92.6% of the cases had moderate severity with the need of therapeutic interventions caused by oxar. a significant relation between oxacillin exposure time and oxar was determined as well as hospitalization time and the appearance of adverse reactions. exposure time over 14 days to oxacillin was established as a risk factor for oxar (relative risk = 5.49). conclusions: careful administration of oxacillin in children is recommended with established treatment duration. empiric and prolonged use must be avoided.
Manokaran Kalaiselvi,Duraisamy Gomathi,Balasubramaniam Vidya,Chandrasekar Uma
International Research Journal of Pharmacy , 2012,
Abstract: Ananas comosus (L.) Merrill is belonging to the family Bromeliaceae which act as an anti-inflammatory, antitumor effect. The present study is aimed to appraise the antioxidant potential and Fourier transform infrared spectroscopy (FTIR) analysis in Ananus comosus peel. The enzymatic and non enzymatic antioxidants profiles were analyzed in fresh peel of pineapple with the standard protocols and the FTIR was applied and Infrared spectrum in mid infrared region 4000–400 cm–1 was used for discriminating and to identify various functional groups present in the ethanolic extract of Ananus comosus. The fresh peel shows the significant amount of antioxidants and the FTIR analysis also found the presence of amino acids, alkenes, nitrates, nitrites, ethers, esters, aldehydes, alkynes, aromatic compounds, organic halogen compounds, carbohydrates, sulphur derivatives and polysaccharides. In conclusion, the results presented in the peel of Ananus comosus have strong antioxidant content which may be act as good pharmacotherapeutic agents in future.
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