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Search Results: 1 - 10 of 323352 matches for " Peter J. Novick "
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Analysis of SEC9 Suppression Reveals a Relationship of SNARE Function to Cell Physiology
Daniel C. Williams, Peter J. Novick
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005449
Abstract: Background Growth and division of Saccharomyces cerevisiae is dependent on the action of SNARE proteins that are required for membrane fusion. SNAREs are regulated, through a poorly understood mechanism, to ensure membrane fusion at the correct time and place within a cell. Although fusion of secretory vesicles with the plasma membrane is important for yeast cell growth, the relationship between exocytic SNAREs and cell physiology has not been established. Methodology/Principal Findings Using genetic analysis, we identified several influences on the function of exocytic SNAREs. Genetic disruption of the V-ATPase, but not vacuolar proteolysis, can suppress two different temperature-sensitive mutations in SEC9. Suppression is unlikely due to increased SNARE complex formation because increasing SNARE complex formation, through overexpression of SRO7, does not result in suppression. We also observed suppression of sec9 mutations by growth on alkaline media or on a non-fermentable carbon source, conditions associated with a reduced growth rate of wild-type cells and decreased SNARE complex formation. Conclusions/Significance Three main conclusions arise from our results. First, there is a genetic interaction between SEC9 and the V-ATPase, although it is unlikely that this interaction has functional significance with respect to membrane fusion or SNAREs. Second, Sro7p acts to promote SNARE complex formation. Finally, Sec9p function and SNARE complex formation are tightly coupled to the physiological state of the cell.
Silent Majority, Violent Majority: The Counter-Revolution in 70s Cinema
Peter Andrew Novick
Enthymema , 2012, DOI: 10.6092/2037-2426/2689
Abstract: There is one question, Inspector Callahan: Why do they call you ‘Dirty Harry’? Harry, it is explained, …Hates everybody: Limeys, Micks, Hebes, Fat Degos, Niggers, Honkies, Chinks…especially Spics . Don Siegel’s Dirty Harry (1971), famously labeled fascist by prominent film critic Pauline Kael, nonetheless represented something new and unique—the “Silent Majority’s” entry into liberal New Hollywood, a veritable counter-reformation to the new social movements having sprung up in the late Sixties and early Seventies. Far from the traditional American Right, however, and distinctly un-Fascist (in as much as the term means more than a simple epithet), these films acted to unite traditional European philosophy and revolutionary thought with organic conservative American tendencies, resulting in hybrid films which challenged the new social movements, while working within the medium of liberal New American Cinema. The article will address three themes from the era: violence and race in the city, revenge against “liberated women”, and fear and loathing of homosexuality. In each instance, using primary evidence from films and critical reviews from the Seventies and the present era, in addition to American and European theorists, the article will show how the counter-revolution in Seventies cinema failed to expunge the “revolutionary spirit” of the era. Rather, the Silent Majority’s visions of visual violence and reactionary values became part and parcel of the new liberated culture of the “Me Decade,” forever bounding the conservative celluloid revolt to the new cinematic culture.
Schizophrenia Outpatient Health Outcomes study: twelve-month findings
Novick D,Ascher-Svanum H,Haro JM,Bertsch J
Pragmatic and Observational Research , 2012,
Abstract: Diego Novick,1 Haya Ascher-Svanum,2 Josep Maria Haro,3 Jordan Bertsch,3 Michihiro Takahashi41Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly and Company, Indianapolis, IN; 3Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Eli Lilly and Company, Kobe, JapanBackground: The purpose of this study was to assess the 12-month outcomes associated with naturalistic antipsychotic treatment of patients participating in the Schizophrenia Outpatient Health Outcomes (SOHO) study.Methods: SOHO is a 3-year, prospective, observational study of the health outcomes associated with antipsychotic treatment in 10 European countries. The study included over 10,000 outpatients who were initiating or changing their antipsychotic medication. Medication use pattern, change in symptom severity, social functioning, and health-related quality of life were assessed, as well as rates of response, remission, treatment discontinuation, adverse events, and hospitalization.Results: Clinical Global Impression-Severity for Schizophrenia (CGI-SCH) and quality of life scores improved in all treatment cohorts. There were greater improvements in the CGI-SCH overall symptom score and in the CGI-SCH positive, negative, cognitive, and depressive symptom scores in the olanzapine and clozapine cohorts compared with other treatment cohorts. Changes were associated with an improvement in quality of life. Patients treated with olanzapine, quetiapine, and clozapine had better tolerability per extrapyramidal symptoms and sexual-related dysfunction measures compared with patients receiving risperidone, amisulpride, or typicals. Patients treated with olanzapine had greater weight gain than patients in all other treatment cohorts.Conclusion: Patients initiated on olanzapine and clozapine tend to have better outcomes at 12 months than patients initiated on other antipsychotics in routine outpatient clinical practice. Results should be interpreted conservatively due to the nonrandomized study design.Keywords: schizophrenia, treatment, outcomes, outpatient, remission, antipsychotics
Health care costs before and after diagnosis of depression in patients with unexplained pain: a retrospective cohort study using the United Kingdom General Practice Research Database
Reed C,Hong J,Novick D,Lenox-Smith A
ClinicoEconomics and Outcomes Research , 2013,
Abstract: Catherine Reed,1 Jihyung Hong,2 Diego Novick,1 Alan Lenox-Smith,3 Michael Happich41Global Health Outcomes, Eli Lilly and Company, Windlesham, Surrey, UK; 2Personal Social Services Research Unit, London School of Economics and Political Science, London, UK; 3Eli Lilly UK, Basingstoke, UK; 4Eli Lilly and Company, Bad Homburg, GermanyPurpose: To assess the impact of pain severity and time to diagnosis of depression on health care costs for primary care patients with pre-existing unexplained pain symptoms who subsequently received a diagnosis of depression.Patients and methods: This retrospective cohort study analyzed 4000 adults with unexplained pain (defined as painful physical symptoms [PPS] without any probable organic cause) and a subsequent diagnosis of depression, identified from the UK General Practice Research Database using diagnostic codes. Patients were categorized into four groups based on pain severity (milder or more severe; based on number of pain-relief medications and use of opioids) and time to diagnosis of depression (≤1 year or >1 year from PPS index date). Annual health care costs were calculated (2009 values) and included general practitioner (GP) consultations, secondary care referrals, and prescriptions for pain-relief medications for the 12 months before depression diagnosis and in the subsequent 2 years. Multivariate models of cost included time period as a main independent variable, and adjusted for age, gender, and comorbidities.Results: Total annual health care costs before and after depression diagnosis for the four patient groups were higher for the groups with more severe pain (£819–£988 versus £565–£628; P < 0.001 for all pairwise comparisons) and highest for the group with more severe pain and longer time to depression diagnosis in the subsequent 2 years (P < 0.05). Total GP costs were highest in the group with more severe pain and longer time to depression diagnosis both before and after depression diagnosis (P < 0.05). In the second year following depression diagnosis, this group also had the highest secondary care referral costs (P < 0.01). The highest drug costs were in the groups with more severe pain (P < 0.001), although costs within each group were similar before and after depression diagnosis.Conclusion: Among patients with unexplained pain symptoms, significant pain in combination with longer time from pain symptoms to depression diagnosis contribute to higher costs for the UK health care system.Keywords: depression, pain, cost, GPRD, UK
What Moser Could Have Asked: Counting Hamilton Cycles in Tournaments
Neil J. Calkin,Beth Novick,Hayato Ushijima-Mwesigwa
Mathematics , 2015,
Abstract: Moser asked for a construction of explicit tournaments on $n$ vertices having at least $(\frac{n}{3e})^n$ Hamilton cycles. We show that he could have asked for rather more.
La posición argentina en las tres conferencias mundiales de población
Susana Novick
Papeles de población , 1999,
Abstract: El artículo describe y estudia las posturas que los diferentes gobiernos nacionales presentaron a las tres conferencias mundiales sobre población realizadas durante los últimos 20 a os: Bucarest (1974), México (1984) y El Cairo (1994). Un análisis comparativo de los documentos oficiales elaborados en ocasión de estos eventos internacionales, colocados en el contexto histórico en el que aparecen, permite comprender la evolución observada en este específico tema. Es evidente la importancia creciente que los organismos internacionales han ido adquiriendo, desde las últimas décadas, en la formulación de las políticas internas de cada país, y la temática demográfica o poblacional no escapa a esta tendencia general.
Transformations and Challenges of Argentinean Migratory Policy in Relation to the International Context
Migraciones internacionales , 2012,
Abstract: El objetivo de este artículo es analizar las transformaciones recientes en la política migratoria argentina, a partir de la crisis de 2001, sobre la base de la producción normativa del Estado. En una primera parte se traza una rese a histórica abordada como marco y contexto en los que se interpretan los actuales procesos, sus continuidades y rupturas, subrayando la influencia del ámbito internacional en el proceso de gestación de la política migratoria --"desnacionalización" y "renacionalización"-- y los actores sociales que intervienen. Por último, se presentan los avances y retrocesos en esa política, así como las dificultades que deben superarse.
Planes versus proyectos: Algunos problemas constitutivos del Urbanismo Moderno. Buenos Aires (1910-1936). / Plan versus project: Some problems constituent of modern urbanism. Buenos Aires (1910-1936)
Novick, Alicia
Revista de Urbanismo , 2000, DOI: doi: 10.5354/0717-5051.2000.11787
Abstract: En este escrito, el centro de interés reside en la relación que se establece entre las ideas globales sobre la ciudad y las propuestas de intervención. A diferencia de las argumentaciones tradicionales que aducen el escaso impacto de los planes en la constitución del espacio urbano, nos interesa mostrar, que además de dar cuenta de las formas de pensar y de actuar sobre la ciudad en un momento dado, inciden directamente en su constitución./In this paper the focus lies in the relationship established between global ideas about the city and the proposed intervention. Unlike the traditional arguments that claim the limited impact of plans in the constitution of urban space, we want to show that, in addition to account for the ways of thinking and acting on the city at any given time, directly affect their constitution.
New Directions In Professional Development
Rebecca Novick
Education Policy Analysis Archives , 1996,
Abstract: There is increasing recognition that school reform and staff development are integrally related. Yet, despite a rich literature on adult learning and human development which supports teachers' need for a wide array of opportunities to construct their own understandings and theories in a collaborative setting, top down mandates have frequently left teachers out of the reform process. It is argued here that effective staff development should be tied directly to the daily life of classroom and grounded in the questions and concerns of teachers. Both a theory of pedagogy that advocates teaching for understanding and learning as understanding and a model of staff development based on practical knowledge enriched by critical reflection are discussed.
Población y Estado en Argentina de 1930 a 1943. Análisis de los discursos de algunos actores sociales: industriales, militares, obreros y profesionales de la salud
Susana Novick
Estudios Demográficos y Urbanos , 2008,
Abstract: Nuestro periodo de estudio muestra un clima surcado por crisis, paradojas y enfrentamientos, en un contexto en que germinan nuevos movimientos sociales. Se inicia con el primer golpe de Estado que quiebra el orden formal constitucional y provoca el derrumbe del proyecto liberal agroexportador junto con la restauración del conservadurismo de tintes nacionalistas. Estos vertiginosos cambios políticos y económicos son acompa ados desde lo demográfico con la ruptura de diversas tendencias: se hace visible el descenso de la fecundidad, los saldos migratorios europeos se vuelven negativos, se profundiza la migración interna y se inauguran los casamientos entre cónyuges que pertenecen a la primera generación de argentinos. La elite política aristocratizante muestra, en lo poblacional, una visión tradicional del rol de la mujer y una mirada racista de los flujos migratorios. En este trabajo indagamos el papel del Estado como receptor de las ideas, demandas y presiones que le exponían diferentes sectores sociales. Nos preguntamos cuáles eran los "problemas" y cuáles las "soluciones" que planteaban al Estado los industriales, los militares, los obreros y los profesionales de la salud pública sobre las variables demográficas; qué políticas formuló el Estado en respuesta a estos reclamos, y cuáles eran sus relaciones y discursos en el marco de los intensos debates poblacionales del periodo. Nuestro análisis nos exhibe un Estado firmemente interpelado, colocado en el centro de las discusiones sociales y capaz de formular un intervencionismo cuyo principal destinatario serían los sectores populares.
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