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Search Results: 1 - 10 of 32281 matches for " Peter Hjelmstrom "
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Elevated Plasma Levels but Decreased Platelet-Associated Expression of LIGHT in Patients with Acute Atherothrombotic Stroke  [PDF]
Guangzhi Liu, Yang He, Tingting Yang, Hong Jiang, Yajuan Xiang, Qi Zhang, Xiangjun He, Peter Hjelmstrom, Xuguang Gao
World Journal of Neuroscience (WJNS) , 2014, DOI: 10.4236/wjns.2014.44042
Abstract: Background: As a member of the tumor necrosis factor superfamily (TNFSF), LIGHT (TNFSF14) is expressed by a variety of immune cells and exists in membrane-bound and soluble forms. Recently, LIGHT was found to be associated with platelets and released upon activation. Activation of endothelia cells by recombinant LIGHT protein results in pro-inflammatory and pro-thrombotic changes. Several studies have reported increased plasma levels of LIGHT in patients with stroke and cardiovascular diseases. However, the form-associated roles of LIGHT in ischemic atherosclerotic stroke remain unclear. Mater?als and Methods: In this study, the platelet LIGHT expression and soluble LIGHT protein were analyzed by flow cytometry and enzyme-linked immunosorbent assay (ELISA) in peripheral blood of patients with acute ischemic atherosclerotic stroke, asymptomatic carotid stenosis (ACS) and normal controls. RESULTS: During the initial 24 h after onset, the stroke patients had decreased LIGHT expression on their platelets (5.9% ± 4.9%) and increased plasma LIGHT levels (36.1 ± 21.0 pg/ml) as compared with normal controls (9.5% ± 3.0%, p < 0.05; 20.4 ± 13.4 pg/ml, p < 0.05). Moreover, the platelet LIGHT expression correlated with total plaque area in the stroke patients (r = 0.4572, p = 0.0247). Conclus?ons: The dysregulated LIGHT expression reflects a persistent chronic inflammatory
Natural Rights, Morality, and the Law  [PDF]
Drum Peter
Beijing Law Review (BLR) , 2011, DOI: 10.4236/blr.2011.21004
Abstract: It is argued that despite attempts to discount the importance of natural rights for morality, they are fundamental to it; therefore, so too are natural rights to the legitimacy of the law.
Price Stability and the Growth Maximizing Rate of Inflation for Ghana  [PDF]
Peter Quartey
Modern Economy (ME) , 2010, DOI: 10.4236/me.2010.13021
Abstract: Monetary policy in Ghana, which is typical of many central banks, over the years, has focused on ensuring price stability or low inflation. The aim of the policy of price stability is to provide a stable environment for real sector activities to flourish. However, the outcome of the policy on real sector activities has not been subjected to any empirical investigation and this forms the focus of the study. For instance, the Central Bank has focused on single digit inflation and whether such a low rate is growth maximizing is yet to be ascertained. The study therefore investigates the revenue maximizing and the ‘growth maximizing’ rate of inflation for Ghana using data from Bank of Ghana and WDI. The study finds that economic performance is higher under low inflation era than when inflation is high. It also established the revenue maximizing rate of inflation using the Laffer curve approach is lower than the growth maximizing rate of inflation. Also, from the results, it can be deduced that the single digit inflation target set by the Central bank is not growth maximizing.
Aristotle’s Definition of Place and of Matter  [PDF]
Peter Drum
Open Journal of Philosophy (OJPP) , 2011, DOI: 10.4236/ojpp.2011.11006
Abstract: The accuracy of Aristotle’s definition of place is defended in terms of his form-matter theory. This theory is in turn defended against the objectionable notion that it entails matter is ultimately characterless.
Adapted Caussinus-Mestre Algorithm for Networks of Temperature series (ACMANT)  [PDF]
Peter Domonkos
International Journal of Geosciences (IJG) , 2011, DOI: 10.4236/ijg.2011.23032
Abstract: Any change in technical or environmental conditions of observations may result in bias from the precise values of observed climatic variables. The common name of these biases is inhomogeneity (IH). IHs usually appear in a form of sudden shift or gradual trends in the time series of any variable, and the timing of the shift indicates the date of change in the conditions of observation. The seasonal cycle of radiation intensity often causes marked seasonal cycle in the IHs of observed temperature time series, since a substantial portion of them has direct or indirect connection to radiation changes in the micro-environment of the thermometer. Therefore the magnitudes of temperature IHs tend to be larger in summer than in winter. A new homogenisation method (ACMANT) has recently been developed which treats in a special way the seasonal changes of IH-sizes in temperature time series. The ACMANT is a further development of the Caussinus-Mestre method, that is one of the most effective tool among the known homogenising methods. The ACMANT applies a bivariate test for searching the timings of IHs, the two variables are the annual mean temperature and the amplitude of seasonal temperature-cycle. The ACMANT contains several further innovations whose efficiencies are tested with the benchmark of the COST ES0601 project. The paper describes the properties and the operation of ACMANT and presents some verification results. The results show that the ACMANT has outstandingly high performance. The ACMANT is a recommended method for homogenising networks of monthly temperature time series that observed in mid- or high geographical latitudes, because the harmonic seasonal cycle of IH-size is valid for these time series only.
Random but System-Wide Unique Unlinkable Parameters  [PDF]
Peter Schartner
Journal of Information Security (JIS) , 2012, DOI: 10.4236/jis.2012.31001
Abstract: When initializing cryptographic systems or running cryptographic protocols, the randomness of critical parameters, like keys or key components, is one of the most crucial aspects. But, randomly chosen parameters come with the intrinsic chance of duplicates, which finally may cause cryptographic systems including RSA, ElGamal and Zero-Knowledge proofs to become insecure. When concerning digital identifiers, we need uniqueness in order to correctly identify a specific action or object. Unfortunately we also need randomness here. Without randomness, actions become linkable to each other or to their initiator’s digital identity. So ideally the employed (cryptographic) parameters should fulfill two potentially conflicting requirements simultaneously: randomness and uniqueness. This article proposes an efficient mechanism to provide both attributes at the same time without highly constraining the first one and never violating the second one. After defining five requirements on random number generators and discussing related work, we will describe the core concept of the generation mechanism. Subsequently we will prove the postulated properties (security, randomness, uniqueness, efficiency and privacy protection) and present some application scenarios including system-wide unique parameters, cryptographic keys and components, identifiers and digital pseudonyms.
Enlarged cauda equina nerve roots in Cerebrotendinous Xanthomatosis  [PDF]
Peter Kalina
Open Journal of Clinical Diagnostics (OJCD) , 2011, DOI: 10.4236/ojcd.2011.13006
Abstract: CXT is a rare inherited autosomal recessive lipid storage disease due to the impaired metabolic pathway of cholesterol secondary to a deficiency in 27- sterol hydroxylase, an enzyme in the synthesis of chenodeoxycholic acid (CDCA), a primary bile acid. Abnormal bile acid synthesis leads to elevated plasma Cholestanol (a derivative of cholesterol) accumulation, especially in the lens, central nervous system (CNS) and tendons.
Spinal Cord Compression by Thoracic Vertebral Hemangioma—A Case Report  [PDF]
Peter Kalina
Open Journal of Medical Imaging (OJMI) , 2012, DOI: 10.4236/ojmi.2012.21005
Abstract: A 68 year old with lower extremity numbness, vibratory sensation loss, coldness and burning of his feet, unsteady gait, frequent falls and a sensory level had an MRI demonstrating aT7 and T8 vertebral body/posterior element lesion with epidural extension, cord compression and foraminal extension (Figures 1-5). Decompressive laminectomy/resection confirmed vertebral hemangioma, a common benign neoplasm that typically remains asymptomatic, found incidentally in 10% of the population. Progressive vertebral body hemangiomas may cause cord or nerve root compression due to epidural tumor extension, expanded bone, hematoma or fracture. Radiographs demonstrate course vertical striations caused by thick trabeculae. CT in indolent lesions demonstrates fat density while compressive lesions demonstrate soft tissue density. Indolent lesions follow fat signal on MRI; symptomatic lesions are T1 isointense/T2 hyperintense. Work-up for aggressive hemangiomas includes angiography to determine vascularity, identify feeding/draining vessels and identify blood supply to the cord. Biopsy helps differentiate hemangioma, lymphoma, myeloma or metastasis. Management of symptomatic hemangiomas includes vertebroplasty for pain, radiation for pain, compression or pre-op and decompressive laminectomy for epidural disease. Embolization of feeding vessels may be performed pre-op or may be curative. Hemangioma causing cord compression and neurologic symptoms by extraosseous extension is much less common than benign hemangioma. Imaging features may suggest potential for progression.
Tay-Sachs and French Canadians: A Case of Gene-Culture Co-evolution?  [PDF]
Peter Frost
Advances in Anthropology (AA) , 2012, DOI: 10.4236/aa.2012.23016
Abstract: Tay-Sachs, an inherited neurological disorder, is unusually common among French Canadians from eastern Quebec. Two alleles are responsible, one being specific to the north shore of the St. Lawrence and the other to the south shore. This pattern of convergent evolution suggests the presence of a selection pressure limited to eastern Quebec. Both alleles probably arose after the British conquest of Quebec in 1759 or at least were uncommon previously. To explain the high incidence of Tay-Sachs among Ashkenazi Jews, some authors have invoked heterozygote advantage, i.e., heterozygous individuals enjoy a higher rate of neuronal growth, and thus greater learning capacity, without the neurological deterioration of homozygous individuals. Such an advantage would have helped Ashkenazim perform the mental effort required for work in trade and crafts. A similar situation may have developed in eastern Quebec, where the relative scarcity of British and American merchants made it easier for French Canadians to enter occupations that required literacy, numeracy, and future time orientation.
Electing an All-Party, Proportional, Power-Sharing Coalition, a Government of National Unity  [PDF]
Peter Emerson
Open Journal of Political Science (OJPS) , 2013, DOI: 10.4236/ojps.2013.32009
Abstract:

There are many instances when a group of people might want to choose a committee, a fixed number of individuals to undertake a particular collective function. At their AGM or annual conference, residents in a community group, shareholders of a limited company, members of a trades union, and those of a political party, may all want to elect an executive: one person to be chair, another secretary, a third treasurer, etc. All these posts require different talents and all the individual office bearers undertake necessary but separate functions for the successful operation of that committee. In like manner, a parliament may choose to elect a government of national unity (GNU). The only voting procedure so far devised by which a given electoratethose concerned at an AGM or members of parliament (MPs)may elect, not only those whom they wish to be in cabinet, but also the ministerial posts in which each of those chosen will then serve, is the matrix vote. This paper describes 1) an experiment held at the Political Studies Association of Ireland (PSAI), undergraduate conference in Dublin on 23rd June 2012 inwhich participants, role playing as members of the Irish parliament, elected a GNU; and 2) the matrix vote methodology, such that others may also employ this voting system. An obvious instance would be for the election of an all-party power-sharing executive in a post-conflict zone.

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