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Search Results: 1 - 10 of 175257 matches for " Peter B;Manrique-Due?as "
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Valor pronóstico del inmunofenotipo en la respuesta temprana de la leucemia aguda linfoblástica pre-B en ni?os
Correa-González, Lourdes Cecilia;Mandeville, Peter B;Manrique-Due?as, Javier;Alejo-González, Francisco;Salazar-Martínez, Abel;Pérez-Ramírez, Oscar de Jesús;Hernández-Sierra, Juan Francisco;
Gaceta médica de México , 2005,
Abstract: objective: to determine the prognostic value of pre b immunophenotype and its variants on early treatment response among of acute pediatric lymphoblast leukemia. patients and methods: a case control study nested in a cohort was carried out with male and female patients 15 years and younger with recently diagnosed pre b lymphoblast leukemia. a panel of b, t, monoclonal antibodies of the myelo monocytic and megakaryocytic cell type was used. response was assessed by bone marrow aspiration 14 days post treatment. results: 54 patients were included. the median age was 7 years (2 months - 14 years) median leukocyte count was 13,450/mm3 (1200-986,000/mm3). we identified 29 cases with late pre b immune phenotype, 19 cases with common pre b and 6 cases with early pre b immunophenotype. eleven patients also displayed myeloid antigens. a significant association (p=0.034) was found between early treatment response and the presence of myeloid antigens. no association was found between the pre b immunophenotype, age and leukocyte count with early treatment response (p=0.264). conclusions: we need to pay special emphasis on early treatment response in children with lymphoblast leukemia as our study did not corroborate the common finding that clinical factors and immune phenotype can be predictive factors.
Intervention Effects on Adolescent Physical Activity in the Multicomponent SPACE Study: A Cluster Randomized Controlled Trial
Mette Toftager, Lars B. Christiansen, Annette K. Ersb?ll, Peter L. Kristensen, Pernille Due, Jens Troelsen
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099369
Abstract: Background Multicomponent school-based interventions have the potential to reduce the age-related decline in adolescents' physical activity (PA), yet there is not consistent evidence to guide non-curricular and school environment interventions. The aim of this study was to assess the effectiveness of a multicomponent environmental school-based intervention, designed to reduce the age-related decline in PA among adolescents. Methods A cluster randomized controlled trial was conducted with 7 intervention and 7 control schools. Baseline measurements were carried out in spring 2010 with 2 years of follow-up. A total of 1,348 students (11–13 years, in grade 5 and 6) enrolled in the study at baseline. The 14 schools included in the study were located in the Region of Southern Denmark. The intervention consisted of organizational and physical changes in the school environment with a total of 11 intervention components. The primary outcome measure was overall PA (cpm, counts per minute) and was supported by analyses of time spent in MVPA, and time spent sedentary. Furthermore, a secondary outcome measure was PA in school time and during recess. PA was measured using accelerometer (Actigraph GT3X). Results A total of 797 students completed the trial and had valid accelerometer data. No significant difference was found for overall PA with an adjusted difference of ?19.1 cpm (95% CI: ?93, 53) or for school time activity with an adjusted difference of 6 cpm (95% CI: ?73, 85). A sensitivity analysis revealed a positive significant intervention effect of PA in recess with an adjusted difference of 95 cpm. Conclusions No evidence was found of the overall effect of a non-curricular multicomponent school-based intervention on PA among Danish adolescents. The intervention was positively associated with PA during school time and recess, however, with small estimates. Lack of effect on overall PA could be due to both program theory and different degrees of implementation. Trial Registration www.Controlled-Trials.com ISRCTN79122411
Simpatectomía toracoscópica: una revisión de la literatura
Bejarano,B.; Manrique,M.;
Neurocirugía , 2010, DOI: 10.4321/S1130-14732010000100001
Abstract: introduction: since its first description by kux in 1954, the thoracic endoscopic (thoracoscopic) sympathectomy has rendered the open techniques obsolete in the treatment of the hyperhidrosis and other sympathetic-related diseases. aim: the goal of this article is to present a critical review of the current indications, results and complications of the endoscopic thoracic sympathectomy. material and methods: an extensive search and review of published papers on the thoracoscopic sympathectomy was undertaken. results: the thoracoscopic sympathectomy has evolved as a therapeutic choice in patients with focal hyperhidrosis, pain syndromes and peripheral vascular disorders, particularly. the results, recurrences and complications are similar to the previously established open procedures; nevertheless, the morbidity, the hospital stay and the time to return to activities of daily living are substantially reduced. the highest success and satisfaction rates (over 95%) were observed among patients treated for focal hyperhidrosis. conclusions: the success and complication rates of thoracoscopic sympathectomy are comparable to those of open techniques, with an easier postoperative period and an earlier return to labor and daily living.
Simpatectomía toracoscópica: una revisión de la literatura Thoracoscopic sympathectomy: a literature review
B. Bejarano,M. Manrique
Neurocirugía , 2010,
Abstract: Introducción: Desde su primera descripción en 1954 por Kux, la simpatectomía torácica endoscópica (toracoscópica) ha vuelto obsoletas a las técnicas abiertas en el tratamiento de la hiperhidrosis y otras patologías relacionadas con el sistema nervioso simpático. Objetivo: El propósito de este artículo es presentar una revisión crítica de las indicaciones actuales, resultados y complicaciones de la simpatectomía torácica endoscópica. Material y métodos: Se llevó a cabo una búsqueda y revisión exhaustiva de trabajos publicados sobre la simpatectomía toracoscópica. Resultados: La simpatectomía toracoscópica se ha desarrollado como una opción terapéutica en pacientes con hiperhidrosis focal, síndromes dolorosos y trastornos vasculares periféricos, fundamentalmente. Los resultados, recurrencias y complicaciones son equivalentes a los procedimientos abiertos previamente establecidos; sin embargo, la morbilidad, la estancia hospitalaria y el tiempo en volver a la vida diaria se reducen sustancialmente. Las mayores tasas de éxito y de satisfacción (más del 95%) se obtienen en sujetos tratados por hiperhidrosis focal. Conclusiones: Las tasas de éxito y de complicación de la simpatectomía endoscópica son similares a las de las técnicas abiertas, siendo mejor tolerado el postoperatorio y más precoz el retorno a la vida cotidiana y laboral. Introduction: Since its first description by Kux in 1954, the thoracic endoscopic (thoracoscopic) sympathectomy has rendered the open techniques obsolete in the treatment of the hyperhidrosis and other sympathetic-related diseases. Aim: The goal of this article is to present a critical review of the current indications, results and complications of the endoscopic thoracic sympathectomy. Material and methods: An extensive search and review of published papers on the thoracoscopic sympathectomy was undertaken. Results: The thoracoscopic sympathectomy has evolved as a therapeutic choice in patients with focal hyperhidrosis, pain syndromes and peripheral vascular disorders, particularly. The results, recurrences and complications are similar to the previously established open procedures; nevertheless, the morbidity, the hospital stay and the time to return to activities of daily living are substantially reduced. The highest success and satisfaction rates (over 95%) were observed among patients treated for focal hyperhidrosis. Conclusions: The success and complication rates of thoracoscopic sympathectomy are comparable to those of open techniques, with an easier postoperative period and an earlier return to labor and daily living.
Relación entre el efecto Mozart y la prueba de solución de problemas misioneros y caníbales
Rojas Corredor,Juliana; Soler Salazar,María Claudia; Moreno Due?as,Nancy; Sáiz Bravo,Nicolás; Manrique Jaime,Otto;
Universitas Psychologica , 2005,
Abstract: relation between mozart effect and problem solving test missionaries and cannibals was explored in female students with ages between 17 and 20 years old. this relation was measured with the interactive task missionaries and cannibals and the mozart’s sonata para dos pianos k448. statistical analysis with 0.05 significance level showed differences between control and experimental group; also when significance level was increased to 0.01 (confidence of 99%) the test continue showing an association between test solution missionaries and cannibals and mozart effect.
Fungal infection-related mortality versus total mortality as an outcome in trials of antifungal agents
Anne K Due, Helle K Johansen, Peter C G?tzsche
BMC Medical Research Methodology , 2006, DOI: 10.1186/1471-2288-6-40
Abstract: As an estimate of bias we used relative risk of death in those patients the authors considered had not died from fungal infection. Our sample consisted of 69 trials included in four systematic reviews of prophylactic or empirical antifungal treatment in patients with cancer and neutropenia we have published previously.Thirty trials met the inclusion criteria. The trials comprised 6130 patients and 869 deaths, 220 (25%) of which were ascribed to fungal infection. The relative risk of death was 0.85 (95% CI 0.75–0.96) for total mortality, 0.57 (95% CI 0.44–0.74) for fungal mortality, and 0.95 (95% CI 0.82–1.09) for mortality among those who did not die from fungal infection.We could not support the hypothesis that use of disease specific mortality introduces bias in antifungal trials on cancer patients as our estimate of the relative risk for mortality in those who survived the fungal infection was not increased. We conclude that it seems to be reliable to use fungal mortality as the primary outcome in trials of antifungal agents. Data on total mortality should be reported as well, however, to guard against the possible introduction of harmful treatments.Disease specific mortality is often used as outcome rather than total mortality in clinical trials. This approach assumes that the classification of cause of death is unbiased. However, a comparison of noncancer death rates in cancer patients with noncancer death rates in a matched population showed that use of cancer specific mortality may underestimate the mortality related to cancer, and that treatment-related deaths seemed to have been omitted from cancer mortality [1]. A review of cancer screening trials also identified inconsistencies between disease specific mortality and all-cause mortality [2], and it has been shown that biased misclassification of cause of death can give a spurious advantage to aggressive cancer treatments over less aggressive treatments [3].For antifungal agents, a higher incidence of bacte
ACTUALIDAD EN EL DIAGNóSTICO Y MANEJO DEL ACRETISMO PLACENTARIO
Due?as G,Ornar; Rico 0,Hugo; Rodríguez B,Mario;
Revista chilena de obstetricia y ginecología , 2007, DOI: 10.4067/S0717-75262007000400011
Abstract: placenta accreta supposes a special situation that increases the fetal and maternal mo rb i mortality of considerable form. thanks all new arrival methods as the image of magnetic resonance, the cystoscopy, serum markers, doppler ultrasound, etc., the prenatal diagnostic is feasible. the management of placenta accreta of traditional form supposes a multidisciplinary approach form hysterectomy execution, involving general surgeons, oncogynecologist or urogynecologist. some authors have proposed the conservative management as an adequate solution in certain cases, whether with the use of several drugs including chemotherapy or expectant form. nevertheless, not yet solid evidence exists if the surgical traditional approach or the conservative management is the best option
El deterioro cognitivo: un factor a tener en cuenta en la evaluación e intervención de pacientes con dolor crónico
Ojeda,B.; Salazar,A.; Due?as,M.; Failde,I.;
Revista de la Sociedad Espa?ola del Dolor , 2011,
Abstract: chronic pain constitutes a serious public health problem due to its high prevalence and the social and personal consequences. the presence of chronic pain has been associated with mild cognitive impairment, especially in patients with fibromyalgia and neuropathic pain, and it has been also related with other disease like anxiety, depression, sleep disorders and the use of certain drugs, usually taken on these patients. this document revises the complex issue of the cognitive process and the several elements that comprise it. likewise, we review the different mechanisms by which pain affect cognitive process and the way it could be affected by other disease, or by drugs commonly used on treatment. it is necessary to assess mild cognitive impairment on chronic pain patients, in order to prevent the develop and the evolution of cognitive disease to a more severe impairment, as well as help to improve therapeutic response to pain and increase health related quality of life of patients.
ACTUALIDAD EN EL DIAGNóSTICO Y MANEJO DEL ACRETISMO PLACENTARIO
Ornar Due?as G,Hugo Rico 0,Mario Rodríguez B
Revista Chilena de Obstetricia y Ginecología , 2007,
Abstract: El acretismo placentario es una entidad que incrementa considerablemente la morbimortalidad materna y fetal. Gracias al advenimiento de nuevos métodos diagnósticos como la resonancia magnética, la cistoscopia, los marcadores séricos, el ultrasonido doppler, etc., el diagnóstico prenatal es factible. El manejo del acretismo placentario de forma tradicional supone la realización de histerectomía multidisci-plinaria, involucrando a cirujanos generales, oncoginecólogos o uroginecólogos. Algunos autores han propuesto al manejo conservador como una solución adecuada en ciertos casos, ya sea con el uso de diversos medicamentos que incluyen quimioterápicos o bien de forma expectante. Sin embargo, aún no existe evidencia sólida que determine si el manejo conservador o tradicional es el mejor Placenta accreta supposes a special situation that increases the fetal and maternal mo rb i mortality of considerable form. Thanks all new arrival methods as the image of magnetic resonance, the cystoscopy, serum markers, doppler ultrasound, etc., the prenatal diagnostic is feasible. The management of placenta accreta of traditional form supposes a multidisciplinary approach form hysterectomy execution, involving general surgeons, oncogynecologist or urogynecologist. Some authors have proposed the conservative management as an adequate solution in certain cases, whether with the use of several drugs including chemotherapy or expectant form. Nevertheless, not yet solid evidence exists if the surgical traditional approach or the conservative management is the best option
El deterioro cognitivo: un factor a tener en cuenta en la evaluación e intervención de pacientes con dolor crónico Cognitive impairment: a factor to consider in the assesment and intervention of chronic pain patients
B. Ojeda,A. Salazar,M. Due?as,I. Failde
Revista de la Sociedad Espa?ola del Dolor , 2011,
Abstract: El dolor crónico constituye un grave problema de salud pública, dada su elevada prevalencia y las consecuencias personales y sociales que produce. La presencia de dolor crónico se ha asociado con un deterioro cognitivo leve, sobre todo en los pacientes afectados por fibromialgia o dolor neuropático, habiéndose relacionado esto con la concurrencia en estos pacientes, de otros procesos, como la ansiedad, la depresión, los trastornos del sue o y el consumo de ciertos fármacos, todos ellos habituales en los pacientes con dolor crónico. En esta revisión, hacemos un repaso del complejo proceso de la cognición así como de los distintos elementos que lo integran. Asimismo, revisamos los mecanismos mediante los que el dolor crónico puede afectar el proceso de la cognición y el modo en el que este puede verse afectado por la concurrencia de otras patologías, o por los fármacos habitualmente utilizados para su tratamiento. Finalmente se plantea la necesidad de evaluar el deterioro cognitivo en los pacientes con dolor crónico, con el objetivo de evitar la progresión de la enfermedad cognitiva hacia un cuadro de deterioro más grave, así como de contribuir a mejorar la respuesta terapéutica al dolor y el aumento de la calidad de vida de los pacientes. Chronic pain constitutes a serious public health problem due to its high prevalence and the social and personal consequences. The presence of chronic pain has been associated with mild cognitive impairment, especially in patients with fibromyalgia and neuropathic pain, and it has been also related with other disease like anxiety, depression, sleep disorders and the use of certain drugs, usually taken on these patients. This document revises the complex issue of the cognitive process and the several elements that comprise it. Likewise, we review the different mechanisms by which pain affect cognitive process and the way it could be affected by other disease, or by drugs commonly used on treatment. It is necessary to assess mild cognitive impairment on chronic pain patients, in order to prevent the develop and the evolution of cognitive disease to a more severe impairment, as well as help to improve therapeutic response to pain and increase health related quality of life of patients.
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