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Search Results: 1 - 10 of 506 matches for " Petar Alaupovic "
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Sex differences in HDL ApoC-III in American Indian youth
Blackett Piers R,Khan Sohail,Wang Wenyu,Alaupovic Petar
Biology of Sex Differences , 2012, DOI: 10.1186/2042-6410-3-18
Abstract: Background Since American Indians are predisposed to type 2 diabetes (DM2) and associated cardiovascular risk, Cherokee boys and girls (n = 917) were studied to determine whether BMI Z (body mass index Z score) is associated with the apoC-III (apolipoprotein C-III) content of HDL (high density lipoprotein), a previously reported predictor of DM2. Methods An ad hoc cross-sectional analysis was conducted on a previously studied cohort. Participants were grouped by gender-specific age groups (5 to 9, 10 to 14 and 15 to 19 years). ApoA-I (apolipoprotein A-I) and HDL apoC-III were assayed by electroimmunoassay. ApoC-III was measured in whole plasma, and in HDL to determine the molar proportion to apoA-I. General linear models were used to assess association. Results The HDL apoC-III to apoA-I molar ratio increased by BMI Z quartile in girls aged 10–14 years (p < 0.05 for linear trend, p < 0.05 for difference in BMI Z quartile IV vs. I to III) and aged 15–19 years (p < 0.05 for trend). In boys the increase by BMI Z occurred only at ages 15–19 years (p < 0.01 for trend and for quartile difference). Conclusions ApoC-III showed an obesity-related increase relative to apoA-I during adolescence beginning in girls aged 10 to 14 years and in boys aged 15 to 19 years. The earlier changes in girls may alter HDL’s protective properties on the β-cell and contribute to their increased risk for DM2.
Influence of Peripheral Artery Disease and Statin Therapy on Apolipoprotein Profiles
Andrew W. Gardner,Petar Alaupovic,Donald E. Parker,Polly S. Montgomery,Omar L. Esponda,Ana I. Casanegra
International Journal of Vascular Medicine , 2013, DOI: 10.1155/2013/548764
Abstract: Apolipoprotein B is a stronger predictor of myocardial infarction than LDL cholesterol, and it is inversely related to physical activity and modifiable with exercise training. As such, apolipoprotein measures may be of particular relevance for subjects with PAD and claudication. We compared plasma apolipoprotein profiles in 29 subjects with peripheral artery disease (PAD) and intermittent claudication and in 39 control subjects. Furthermore, we compared the plasma apolipoprotein profiles of subjects with PAD either treated ( ) or untreated ( ) with statin medications. For the apolipoprotein subparticle analyses, subjects with PAD had higher age-adjusted Lp-B:C ( ) and lower values of Lp-A-I:A-II ( ) than controls. The PAD group taking statins had lower age-adjusted values for apoB ( ), Lp-A-II:B:C:D:E ( ), Lp-B:E + Lp-B:C:E ( ), Lp-B:C ( ), and Lp-A-I ( ) than the untreated PAD group. Subjects with PAD have impaired apolipoprotein profiles than controls, characterized by Lp-B:C and Lp-A-I:A-II. Furthermore, subjects with PAD on statin medications have a more favorable risk profile, particularly noted in multiple apolipoprotein subparticles. The efficacy of statin therapy to improve cardiovascular risk appears more evident in the apolipoprotein sub-particle profile than in the more traditional lipid profile of subjects with PAD and claudication. This trial is registered with ClinicalTrials.gov NCT00618670. 1. Introduction Peripheral artery disease (PAD) is a highly prevalent medical condition, [1] and it is associated with high prevalence of coexisting vascular diseases in the coronary, cerebral, and renal arteries [2, 3]. Consequently, PAD is a deadly [4, 5] and costly disease [6]. Many patients with PAD are physically limited by ambulatory leg pain [7, 8], resulting in baseline ambulatory and physical dysfunction [9, 10], low physical activity [11, 12], and poor health-related quality of life [13]. Although PAD is considered by many to be a benign disease, as 70 to 80% of patients have stable claudication that does not progress to worsening claudication or critical limb ischemia [2], PAD patients have increased rates of functional decline and mobility loss compared to those without PAD [14], leading to higher rates of hospitalization and loss of independence [15]. We have previously found that cardiovascular risk factors, such as dyslipidemia, are associated with impaired ambulation and vascular function in subjects with PAD and claudication [16, 17]. Dyslipidemia is typically evident by an elevation in low-density lipoprotein cholesterol (LDL-C).
Oxidative Stress and Inflammation in Renal Patients and Healthy Subjects
Diana M. Lee, Kenneth W. Jackson, Nicholas Knowlton, Joshua Wages, Petar Alaupovic, Ola Samuelsson, Aso Saeed, Michael Centola, Per-Ola Attman
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022360
Abstract: The first goal of this study was to measure the oxidative stress (OS) and relate it to lipoprotein variables in 35 renal patients before dialysis (CKD), 37 on hemodialysis (HD) and 63 healthy subjects. The method for OS was based on the ratio of cholesteryl esters (CE) containing C18/C16 fatty acids (R2) measured by gas chromatography (GC) which is a simple, direct, rapid and reliable procedure. The second goal was to investigate and identify a triacylglycerol peak on GC, referred to as TG48 (48 represents the sum of the three fatty acids carbon chain lengths) which was markedly increased in renal patients compared to healthy controls. We measured TG48 in patients and controls. Mass spectrometry (MS) and MS twice in tandem were used to analyze the fatty acid composition of TG48. MS showed that TG48 was abundant in saturated fatty acids (SFAs) that were known for their pro-inflammatory property. TG48 was significantly and inversely correlated with OS. Renal patients were characterized by higher OS and inflammation than healthy subjects. Inflammation correlated strongly with TG, VLDL-cholesterol, apolipoprotein (apo) C-III and apoC-III bound to apoB-containing lipoproteins, but not with either total cholesterol or LDL-cholesterol. In conclusion, we have discovered a new inflammatory factor, TG48. It is characterized with TG rich in saturated fatty acids. Renal patients have increased TG48 than healthy controls.
Mean-Value Theorems for Harmonic Functions on the Cube in Rn  [PDF]
Petar Petrov
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.511062
Abstract: Let \"\"be a hypercube in Rn. We prove theorems concerning mean-values of harmonic and polyharmonic functions on In(r), which can be considered as natural analogues of the famous Gauss surface and volume mean-value formulas for harmonic functions on the ball in and their extensions for polyharmonic functions. We also discuss an application of these formulas—the problem of best canonical one-sided L1-approximation by harmonic functions on In(r).
Numerical Analysis of the Magnetic Field of High-Current Busducts and GIL Systems
Petar Sarajcev
Energies , 2011, DOI: 10.3390/en4122196
Abstract: This paper presents a numerical computation method for determining the magnetic field of high-current busducts of circular cross-section geometry, based on the subdivision of the busduct phase conductors and screens into the conductor filaments and the subsequent application of the mesh-current method, with the aid of the geometric mean distance method. The mathematical model takes into account the skin effect and the proximity effects, as well as the complete electromagnetic coupling between phase conductors and metal enclosures ( i.e., screens) of the single-phase isolated busduct system (of circular cross-section geometry). This model could be readily applied to the computation of the magnetic field of the Gas Insulated Transmission Lines (GIL) as well.
Value of Ultrasound Machine Settings Optimization for Better Diagnosis of Focal Liver Lesions
Petar Avramovski
Macedonian Journal of Medical Sciences , 2009, DOI: 10.3889/MJMS.1857-5773.2009.0048
Abstract: Background. Focal liver lesions and metastasis can be very hard to localize. For best imaging, customizing of several settings of the machine are necessary: brightness, contrast, probe frequency, focusing, dynamic range, time gain compensation, flow area, flow gain, sample volume, angle, peak repetitive frequency, filter adjusting and parallelogram of region of interest. Aim. The aim of this study is to examine the influence of adjusted or not adjusted ultrasound scanner in diagnosing of focal liver lesions. Material and methods. The study involves 129 patients from the group of focal liver lesions including a broad spectrum of benign, malignant, and infectious aetiologies. We made ultrasound examination with automatic factory settings of ultrasound machine parameters and after that all off them were examined with manual settings of the scanner. Results. The results obtained from "auto" and "manual" mode settings were compared with CT and MRI imaging as a gold standard. In auto mode false positive results were seen in patients with hiperechoic metastases understood like FNH, patients with hipoechoic metastases treated like haemangioma, patients with anechoic metastases and patients with abscesses treated like cysts. Conclusion. Manual mode ultrasound procedure is more accurate in detection of focal liver parenchymal lesions because of reduced specificity in auto mode compared with higher specificity and small percentage of false positive results within manually adjusted scanner. We show the great value of best performance manual setting of the scanner in liver parenchymal focal lesions detecting.
Macedonia between nationalism(s) and multiculturalism: The framework agreement and its multicultural conjectures
Atanasov Petar
Sociologija , 2003, DOI: 10.2298/soc0304303a
Abstract: This paper deals with the nationalism(s) and multiculturalism in the Macedonian society, and the multicultural democracy contingency within Macedonian practice. Furthermore, it shed lights on the implementation of the Framework Agreement after the conflict of 2001 seen through the national and multicultural paradigm In addition the paper attempts to correlate the class and the ethnicity in Macedonian socialist pre- ethnic period, with the transition processes and current Macedonian state-of-affairs The paper argues that the management of ethnic differences must reconcile the two nationalisms and in opposite direction, the 'battle' for the resources and symbols between Macedonians and Albanians will reinforce the affections toward their own national (ethnic) identity.
Disarrangement: Dominant symptom of traumatized people in Serbia
Opali? Petar
Sociologija , 2008, DOI: 10.2298/soc0804417o
Abstract: The psychopathological status of 175 subjects from Belgrade and wider surroundings was examined. Out of them, 70 subjects had somatic trauma (26 war traumas and 44 somatic peacetime traumas); 45 subjects had mental trauma, and 60 had no trauma. The following instruments were used: PTSD-Scale, Brief Eysenck's Personality Inventory, General Health Questionnaire (GHQ-60) and Late Effect of Accidental Injury (LEAIQ), as well as appropriate statistical procedures (ANOVA, discriminative analysis, linear correlation). In qualitative terms, the majority of symptoms were conversive, the first of which was disarrangement. In quantitative terms, the symptoms of general neuroticism were most frequent in the subgroup of subjects with somatic war traumas, then in the subgroup with mental traumas in peacetime, and finally in the subgroup of subjects with somatic peacetime traumas. In the subgroup of mentally traumatised subjects, the PTSD symptoms were most frequent.
Development of the sociology of mental disorders: An overview
Opali? Petar
Sociologija , 2007, DOI: 10.2298/soc0701001o
Abstract: In the introduction the social character of mental disorders is discussed. In the second part the contribution of individual authors and their works to the development of sociology of mental disorders in European countries and the USA is described, with special emphasis on the sociogenesis of mental disorders. There follows an overview of the theories of Comte, Durkheim Halbwachs, Meyer and Eliot, Goffman, Parsons, Foucault, as well as representatives of anti-psychiatry (Laing, Basaglia and Szasz) and Freudo-Marxists (Reich, Fromm etc), to contemporary authors of relevant textbooks (Gallagher, Eaton, Cocherham etc). The study of the sociology of mental disorders in Serbia is briefly sketched.
Clinical sociologist in psychiatry: The professional bridge between the sociology and psychiatry
Opali? Petar
Sociologija , 2007, DOI: 10.2298/soc0702117o
Abstract: In the first section of the paper the profession of clinical sociologist in relation to other related professions in psychiatry is defined. Then various aspects of the position of clinical sociologist in a psychiatric institution, as well as specific features of various functions and roles of clinical sociologist in psychiatry and medicine are discussed. The conclusion points to some contradictions inherent in this profession. Advantages to be gained by introducing the profession of clinical sociologist in psychiatric institutions in our country are identified.
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