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Search Results: 1 - 10 of 403048 matches for " Per M?lgaard "
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Asháninka medicinal plants: a case study from the native community of Bajo Quimiriki, Junín, Peru
Gaia Luziatelli, Marten S?rensen, Ida Theilade, Per Mlgaard
Journal of Ethnobiology and Ethnomedicine , 2010, DOI: 10.1186/1746-4269-6-21
Abstract: Fieldwork was conducted between July and September 2007. Data were collected through semi-structured interviews, collection of medicinal plants in the homegardens, forest walks, a walk along the river banks, participant observation, informal conversation, cross check through voucher specimens and a focus group interview with children.Four-hundred and two medicinal plants, mainly herbs, were indicated by the informants. The most important families in terms of taxa were Asteraceae, Araceae, Rubiaceae, Euphorbiaceae, Solanaceae and Piperaceae. Eighty-four percent of the medicinal plants were wild and 63% were collected from the forest. Exotics accounted to only 2% of the medicinal plants. Problems related to the dermal system, digestive system, and cultural belief system represented 57% of all the medicinal applications. Some traditional healers received non-indigenous customers, using their knowledge as a source of income. Age and gender were significantly correlated to medicinal plant knowledge. Children knew the medicinal plants almost exclusively by their Spanish names. Sixteen percent of the medicinal plants found in this community were also reported among the Yanesha of the Pasco Region.Despite the vicinity to a city, knowledge on medicinal plants and cultural beliefs are still abundant in this Asháninka Native Community and the medicinal plants are still available in the surroundings. Nevertheless, the use of Spanish names for the medicinal plants and the shift of healing practices towards a source of income with mainly non-indigenous customers, are signs of acculturation. Future studies on quantification of the use of medicinal plants, dynamics of transmission of ethno-medicinal knowledge to the young generations and comparison with available pharmacological data on the most promising medicinal plants are suggested.Peru is one of the twelve most biodiversity rich, or 'mega-diverse', countries of the world. Its combination of latitude and topography creates nume
Mapuche Herbal Medicine Inhibits Blood Platelet Aggregation
Susan Skanderup Falkenberg,Inge Tarnow,Alfonso Guzman,Per M lgaard,Henrik Toft Simonsen
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/647620
Abstract: 12 plant species traditionally used by the Mapuche people in Chile to treat wounds and inflammations have been evaluated for their direct blood platelet inhibition. Seven of the 12 tested plant species showed platelet inhibitory effect in sheep blood, and four of these were also able to inhibit the ADP- (5.0 M) and collagen- (2.0 g/mL) induced aggregations in human blood. These four species in respective extracts (in brackets) were Blechnum chilense (MeOH), Luma apiculata (H2O), Amomyrtus luma (DCM : MeOH 1 : 1) and Cestrum parqui (DCM : MeOH 1 : 1). The platelet aggregating inhibitory effects of A. luma (DCM : MeOH 1 : 1), and L. apiculata (H2O) were substantial and confirmed by inhibition of platelet surface activation markers.
Professionel folkelighed - om "Landet rundt" og "Dagens Danmark"
Per Jauert,Jan Mlgaard,Mogens Schmidt,Keld Vorup S?rensen
Massekultur & Medier , 1983,
Abstract: Professionel folkelighed - om "Landet rundt" og "Dagens Danmark"
Ethnopharmacological evaluation of radal (leaves of Lomatia hirsuta) and isolation of 2-methoxyjuglone
Henrik T Simonsen, Anne Adsersen, Louise Berthelsen, S?ren B Christensen, Alfonso Guzmán, Per Mlgaard
BMC Complementary and Alternative Medicine , 2006, DOI: 10.1186/1472-6882-6-29
Abstract: Along with the traditional tea, extracts of the leaves were screened for antifungal and toxic activities. The profile of secondary constituents was obtained using GC-MS.2-Methoxyjuglone was isolated from the leaves of Lomatia hirsuta and found to be active against the pathogenic fungus Candida albicans (MIC = 8 μg/mL). Cinnamic acid and vanillic acid were identified as major constituents in the tea by GC-MS. The tea was found not to be toxic against Artemia salina.The presence of phenolic acids with antimicrobial properties supports the traditional use of Radal, and encourages further studies.Lomatia hirsuta (Lam.) Diels ex Macbr. (Proteaceae) is a wild tree growing in Chile from Coquimbo to Chiloe (IV-X Regions). It is distributed from the sea to sub mountain zones through 700–1200 m of altitude. Other Lomatia species in Chile are L. ferruginea (Cav.) R.Br. and L. dentata (R. et P.) R. Br. L. hirsuta is also present in Argentina, Ecuador and Peru [1]. Products prepared from the leaves of L. hirsuta are used in traditional medicine in Chile the product is under the common name of "radal". A tea of radal is used for treatment of cough, bronchial troubles, and asthma [2]. In a preliminary screening in our laboratory, methanol extracts of the leaves, but not of the stem, revealed antifungal activity, in particular against Candida albicans [3], and since our previous phytochemical study of the leaves did not explain the antifungal activity, the present study was undertaken. C. albicans and Aspergillus fumigatus were chosen as test organisms, since these organisms increasingly cause severe infections in patients with reduced immune response, e.g. HIV [4]. Penicillium expansum were also chosen as a test organisms, since this was a well establish culture in our lab.An earlier study of L. hirsuta confirmed the presence of the hydroxycoumarins umbelliferone and scopoletin and the flavonoids quercetin, rhamnetin, iso-rhamnetin, and quercetrine [5]. An infusion of the leaves o
Asger Liebst: Tresserbilleder
Jan Mlgaard
Massekultur & Medier , 1983,
Higgs Critical Exponents and Conformal Bootstrap in Four Dimensions
Oleg Antipin,Esben Mlgaard,Francesco Sannino
Physics , 2014,
Abstract: We investigate relevant properties of composite operators emerging in nonsupersymmetric, four-dimensional gauge-Yukawa theories with interacting conformal fixed points within a precise framework. The theories investigated in this work are structurally similar to the standard model of particle interactions, but differ by developing perturbative interacting fixed points. We investigate the physical properties of the singlet and the adjoint composite operators quadratic in the Higgs field, and discover that the singlet anomalous dimension is substantially larger than the adjoint one. The numerical bootstrap results are then compared to precise four dimensional conformal field theoretical results. To accomplish this, it was necessary to calculate explicitly the crossing symmetry relations for the global symmetry group SU($N$)$\times$SU($N$).
Harnessing the potential clinical use of medicinal plants as anti-diabetic agents
Campbell-Tofte JI, M lgaard P, Winther K
Botanics: Targets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/BTAT.S17302
Abstract: rnessing the potential clinical use of medicinal plants as anti-diabetic agents Review (1726) Total Article Views Authors: Campbell-Tofte JI, M lgaard P, Winther K Published Date August 2012 Volume 2012:2 Pages 7 - 19 DOI: http://dx.doi.org/10.2147/BTAT.S17302 Received: 24 January 2012 Accepted: 23 April 2012 Published: 22 August 2012 Joan IA Campbell-Tofte,1 Per M lgaard,2 Kaj Winther1 1Department of Clinical Biochemistry, Frederiksberg University Hospital, Frederiksberg, Denmark; 2Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark Abstract: Diabetes is a metabolic disorder arising from complex interactions between multiple genetic and/or environmental factors. The characteristic high blood sugar levels result from either lack of the hormone insulin (type 1 diabetes, T1D), or because body tissues do not respond to the hormone (type 2 diabetes, T2D). T1D patients currently need exogenous insulin for life, while for T2D patients who do not respond to diet and exercise regimes, oral anti-diabetic drugs (OADs) and sometimes insulin are administered to help keep their blood glucose as normal as possible. As neither the administration of insulin nor OADs is curative, many patients develop tissue degenerative processes that result in life-threatening diabetes comorbidities. Several surveys of medicinal plants used as anti-diabetic agents amongst different peoples have been published. Some of this interest is driven by the ongoing diabetes pandemic coupled with the inadequacies associated with the current state of-the-art care and management of the syndrome. However, there is a huge cleft between traditional medicine and modern (Western) medicine, with the latter understandably demanding meaningful and scientific validation of anecdotal evidence for acceptance of the former. The main problems for clinical evaluation of medicinal plants with promising anti-diabetic properties reside both with the complexity of components of the plant materials and with the lack of full understanding of the diabetes disease etiology. This review is therefore focused on why research activities involving an integration of Systems Biology-based technologies of pharmacogenomics, metabolomics, and bioinformatics with standard clinical data, should be used for cost-effective validation of the safety and anti-diabetic efficacy of promising medicinal plants. The application of such approaches to studying entire mixtures of plant materials will ensure proper elucidation of novel therapies with improved mechanisms of action, as well as facilitate a personalized clinical use of medicinal plants as anti-diabetic agents.
The a theorem for Gauge-Yukawa theories beyond Banks-Zaks
Oleg Antipin,Marc Gillioz,Esben Mlgaard,Francesco Sannino
Physics , 2013, DOI: 10.1103/PhysRevD.87.125017
Abstract: We investigate the a theorem for nonsupersymmetric gauge-Yukawa theories beyond the leading order in perturbation theory. The exploration is first performed in a model-independent manner and then applied to a specific relevant example. Here, a rich fixed point structure appears including the presence of a merging phenomenon between non-trivial fixed points for which the a theorem has not been tested so far.
HLA Alleles Associated with Slow Progression to AIDS Truly Prefer to Present HIV-1 p24
José A. M. Borghans, Anne Mlgaard, Rob J. de Boer, Can Ke?mir
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000920
Abstract: Background The mechanism behind the association between human leukocyte antigen (HLA) molecules and the rate of HIV-1 disease progression is still poorly understood. Recent data suggest that “protective” HLA molecules, i.e. those associated with a low HIV-1 viral load and relatively slow disease progression, tend to present epitopes from the Gag capsid protein. Although this suggests that preferential targeting of Gag delays disease progression, the apparent preference for Gag could also be a side-effect of the relatively high immunogenicity of the protein. Methods and Findings To separate cause and effect, we predicted HIV-1 epitopes from the whole genome of HIV-1, and found that protective HLA alleles have a true preference for the p24 Gag protein, while non-protective HLA alleles preferentially target HIV-1 Nef. In line with this, we found a significant negative correlation between the predicted affinity of the best-binding p24 epitopes and the relative hazard of HIV-1 disease progression for a large number of HLA molecules. When the epitopes targeted by protective HLA alleles were mapped to the known p24 structure, we found that mutations in these epitopes are likely to disturb the p24 dimer structure, which is expected to severely reduce the fitness of the virus. Conclusions Our results suggest that the intrinsic preference of different HLA molecules to present p24 peptides explains why some HLA molecules are more protective than others.
A Perturbative Realization of Miransky Scaling
O. Antipin,S. Di Chiara,M. Mojaza,E. Mlgaard,F. Sannino
Physics , 2012, DOI: 10.1103/PhysRevD.86.085009
Abstract: Near conformal dynamics is employed in different extensions of the standard model of particle interactions as well as in cosmology. Many of its interesting properties are either conjectured or determined using model computations. We introduce a relevant four dimensional gauge theory template allowing us to investigate such dynamics perturbatively. The gauge theory we consider is quantum chromodynamics with the addition of a meson-like scalar degree of freedom as well as an adjoint Weyl fermion. At the two-loop level, and in the Veneziano limit, we firmly establish the existence of several fixed points of which one is all directions stable in the infrared. An interesting feature of the model is that this fixed point is lost, within the perturbatively trustable regime, by merging with another fixed point when varying the number of quark flavors. We show the emergence of the Miransky scaling and determine its properties. We are also able to determine the walking region of the theory which turns out to be, at large number of colors, about 12% of the conformal window. Furthermore, we determine highly relevant quantities for near conformal dynamics such as the anomalous dimension of the fermion masses.
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