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Search Results: 1 - 10 of 2444 matches for " Per Kristiansson "
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Pregnancy related back pain, is it related to aerobic fitness? A longitudinal cohort study
Eva Thorell, Per Kristiansson
BMC Pregnancy and Childbirth , 2012, DOI: 10.1186/1471-2393-12-30
Abstract: A cohort of pregnant women, recruited from maternal health care centers in central Sweden, were examined regarding estimated peak oxygen uptake by cycle ergometer test in early pregnancy, reported physical activity prior to pregnancy, basic characteristics, back pain during pregnancy and back pain postpartum.Back pain during the current pregnancy was reported by nearly 80% of the women. At the postpartum appointment this prevalence was 40%. No association was displayed between estimated peak oxygen uptake and incidence of back pain during and after pregnancy, adjusted for physical activity, back pain before present pregnancy, previous deliveries, age and weight. A significant inverse association was found between estimated peak oxygen uptake and back pain intensity during pregnancy and a direct association post partum, in a fully adjusted multiple linear regression analysis.Estimated peak oxygen uptake and reported physical activity in early pregnancy displayed no influence on the onset of subsequent back pain during or after pregnancy, where the time sequence support the hypothesis that poorer physical deconditioning is not a cause but a consequence of the back pain condition. The mechanism for the attenuating effect of increased oxygen uptake on back pain intensity is uncertain.Chronic medical conditions are in focus for the development of strategies aimed at improving population health worldwide. This is also true for chronic pain conditions leading to impaired or non-existent ability to exercise, as physical inactivity is associated with development of chronic diseases. Musculoskeletal disorders constitute an estimated 90% of all chronic pain, of which back pain contributes to a high extent.During pregnancy there is a remarkably increased prevalence of low back pain, as compared with the non-pregnant state. Prevalence rates between 61% and 88% of back pain with onset during current pregnancy are reported, as compared with one-year prevalence of back pain, irresp
Predicting functional upstream open reading frames in Saccharomyces cerevisiae
Selpi, Christopher H Bryant, Graham JL Kemp, Janeli Sarv, Erik Kristiansson, Per Sunnerhagen
BMC Bioinformatics , 2009, DOI: 10.1186/1471-2105-10-451
Abstract: In this paper, a new computational approach to predicting functional uORFs in the yeast Saccharomyces cerevisiae is presented. Our approach is based on inductive logic programming and makes use of a novel combination of knowledge about biological conservation, Gene Ontology annotations and genes' responses to different conditions. Our method results in a set of simple and informative hypotheses with an estimated sensitivity of 76%. The hypotheses predict 301 further genes to have 398 novel functional uORFs. Three (RPC11, TPK1, and FOL1) of these 301 genes have been hypothesised, following wet-experiments, by a related study to have functional uORFs. A comparison with another related study suggests that eleven of the predicted functional uORFs from genes LDB17, HEM3, CIN8, BCK2, PMC1, FAS1, APP1, ACC1, CKA2, SUR1, and ATH1 are strong candidates for wet-lab experimental studies.Learning based prediction of functional uORFs can be done with a high sensitivity. The predictions made in this study can serve as a list of candidates for subsequent wet-lab verification and might help to elucidate the regulatory roles of uORFs.Different genes are expressed differently in different places, at different times and in different amounts. Misregulation of gene expression can cause an abnormality, leading to disease(s) or even cancer [1]. Therefore, a complete understanding of gene regulation is important; one step towards this is to elucidate the roles of post-transcriptional regulatory elements.Upstream open reading frames (uORFs) are among the post-transcriptional regulatory elements that may be present in the 5' untranslated region (UTR) of mRNA [2] (Figure 1). A 5' UTR region is the region between transcription start site and the main coding sequence (CDS). A uORF is identified by the presence of both a start codon before (i.e., upstream of) the start codon of the CDS, and an in-frame stop codon. Research has revealed that the frequency of transcribed uORFs is higher in genes w
Access to health care in relation to socioeconomic status in the Amazonian area of Peru
Charlotte Kristiansson, Eduardo Gotuzzo, Hugo Rodriguez, Alessandro Bartoloni, Marianne Strohmeyer, G?ran Tomson, Per Hartvig
International Journal for Equity in Health , 2009, DOI: 10.1186/1475-9276-8-11
Abstract: Cross-sectional study design included household interviews. Caregivers of 780 children aged 6–72 months in Yurimaguas and 793 children of the same age in Moyobamba were included in the study. Caregivers were interviewed on health care seeking strategies (public/private sectors; formal/informal providers), and medication for their children in relation to reported symptoms and socio-economic status. Self-reported symptoms were classified into illnesses based on the IMCI algorithm (Integrated Management of Childhood Ilness). Wealth was used as a proxy indicator for the economic status. Wealth values were generated by Principal Component Analysis using household assets and characteristics.Significantly more caregivers from the least poor stratum consulted health professionals for cough/cold (p < 0.05: OR = 4.30) than the poorest stratum. The poorest stratum used fewer antibiotics for cough/cold and for cough/cold + diarrhoea (16%, 38%, respectively) than the least poor stratum (31%, 52%, respectively). For pneumonia and/or dysentery, the poorest used significantly fewer antibiotics (16%) than the least poor (80%).The poorest seek less care from health professionals for non-severe illnesses as well as for severe illnesses; and treatment with antibiotics is lacking for illnesses where it would be indicated. Caregivers frequently paid for health services as well as antibiotics, even though all children in the study qualified for free health care and medicines. The implementation of the Seguro Integral de Salud health insurance must be improved.Following health reforms in the 1980s and 1990s, many Latin-American countries moved from universal coverage (free health care financed by public funds) towards cost recovery initiatives utilizing, for example, user fees and social insurances [1-3]. However, user fees have been shown to represent an important barrier to accessing health services, especially for poor people[4]. Strategies including fee exemption – aimed at mitigating
Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals
Sven Nelander, Erik Larsson, Erik Kristiansson, Robert M?nsson, Olle Nerman, Mikael Sigvardsson, Petter Mostad, Per Lindahl
BMC Genomics , 2005, DOI: 10.1186/1471-2164-6-68
Abstract: In a screen that covered ~40 per cent of all annotated protein-coding genes, we identified 21 co-expressed gene clusters with statistically supported sharing of cis-regulatory sequence elements. 66 predicted cases of over-represented transcription factor binding motifs were validated against the literature and fell into three categories: (i) previously described cases of gene battery-like regulation, (ii) previously unreported cases of gene battery-like regulation with some support in a limited number of genes, and (iii) predicted cases that currently lack experimental support. The novel predictions include for example Sox 17 and RFX transcription factor binding sites that were detected in ~10% of all testis specific genes, and HNF-1 and 4 binding sites that were detected in ~30% of all kidney specific genes respectively. The results are publicly available at http://www.wlab.gu.se/lindahl/genebatteries webcite.21 co-expressed gene clusters were enriched for a total of 66 shared cis-regulatory sequence elements. A majority of these predictions represent novel cases of potential co-regulation of functionally coupled proteins. Critical technical parameters were evaluated, and the results and the methods provide a valuable resource for future experimental design.To understand how gene expression is coordinated to produce hundreds of cell phenotypes from an identical complement of genes is a principal challenge in mammalian genome research. A commonly suggested model for terminal differentiation in metazoans is that the core features of the cellular phenotype are mediated by a set of genes that is regulated as a gene battery, i.e. a set of functionally coupled genes that are activated by similar cis- and trans-acting regulators [1-3]. Although the gene battery is an idealized concept, concrete examples of gene battery-like regulation have been found in for example muscle subtypes [4-7], megakaryocytes [8], the epidermis [9] and lymphocytes [10,11].A key step in the eluci
Scalar Field Corrections to AdS_4 Gravity from Higher Spin Gauge Theory
Fredric Kristiansson,Peter Rajan
Physics , 2003, DOI: 10.1088/1126-6708/2003/04/009
Abstract: We compute the complete contribution to the stress-energy tensor in the minimal bosonic higher spin theory in D=4 that is quadratic in the scalar field. We find arbitrarily high derivative terms, and that the total sign of the stress-energy tensor depends on the parity of the scalar field.
Wound String Scattering in NCOS Theory
Fredric Kristiansson,Peter Rajan
Physics , 2000, DOI: 10.1016/S0370-2693(01)00204-0
Abstract: We calculate the amplitude for a non-excited closed string with nonzero winding number to scatter from a D-string with a near critical E field. We go to the NCOS limit and observe that we get the same result if we adopt another approach put forward by Gomis and Ooguri.
Understanding the Contributing Factors to Nighttime Crashes at Freeway Mainline Segments  [PDF]
Hongyun Chen, Kristiansson Fanny
Journal of Transportation Technologies (JTTs) , 2019, DOI: 10.4236/jtts.2019.94028
Abstract: This study investigated the crash contributing factors to the injury outcomes and the characteristics of the night time crashes at freeway mainline segments. Multinomial logit model (MNL) was selected to estimate the explanatory variables at a 95% confidence level. The six-year crash data (2005-2010) were obtained in the State of Florida, USA and five injury level outcomes, no injury, possible injury, non-incapacitating injury, capacitating injury, and fatal injury, were considered. The no injury level was selected as the baseline category.
浙江大学学报(农业与生命科学版) , 2000,
Abstract: Oilseed rape seeds (Brassica napus L.) harvested from mature plants require only imbibition of water and a suitable temperature. Despite this absence of primary dormancy, there is evidence that rapeseeds, due to the induction of secondary dormancy, are able to persist in the field for up to 10 years, and thus can emerge as volunteer plants in later crops. In addition, volunteers originate from seeds shed before and during harvest. The level of seed losses is influenced by the timing and technique of harvest, and can reach several thousand seeds per m2. As a consequence of both these effects, problems from volunteer rape occur frequently in subsequent crops.   Volunteer rape has been particularly troublesome in broad-leaved crops. It is a highly competitive weed and due to its prolonged period of emergence, timing of herbicide application is sometimes a problem. Volunteer rape can contaminate the sown crop resulting in heterogenous mixtures of seeds. This not only affects breeding and the production of seed crops, but can also affect growers when they switch from one type or quality of rape to another, or if they grow different rape qualities in one rotation, e.g., rapeseed for human consumption in the normal rotation and rapeseed for industrial use on set-aside land. The problem will not disappear with the introduction of herbicide resistant oilseed rape, as there are no indications that seeds of these cultivars will not have the potential to persist. The ability of rapeseed to persist in the soil for a long time and at high percentages also has to be taken into account in risk assessment of genetically manipulated rape, as rape can escape in space by pollen transfer or in time via the soil seedbank. Although hybridization between oilseed rape and wild crucifers is infrequent, it does occur. Traits, such as herbicide resistance or pest and disease resistance, if transferred into wild plants have the potential to alter the agro-ecosystem significantly.……
Isolated populations and complex disease gene identification
Kati Kristiansson, Jussi Naukkarinen, Leena Peltonen
Genome Biology , 2008, DOI: 10.1186/gb-2008-9-8-109
Abstract: Over the past few years, understanding how genetic variation in individuals and in populations contributes to the biological pathways involved in determining human traits and mechanisms of disease has become a reachable goal for genetic research. Following on from the achievements in molecular studies of monogenic disorders, recent studies have used strategies of hypothesis-free fine mapping of genes and loci to identify underlying factors in common complex diseases with major impacts on public health. These diseases, which include cancers, coronary heart disease, schizophrenia, autism and multiple sclerosis, arise from complex interactions between environmental factors and variation in several different genes. Until recently, detection of the genes underlying these diseases met with only limited success, but the past two years have witnessed the identification of more than 100 well established loci. These successes mainly involved the collection of very large study cohorts for any individual trait and international collaborations on an unprecedented scale [1].The detection of genes underlying common complex diseases might not always need large global population samples. Samples of individuals from genetically isolated populations, or 'population isolates', have already proved immensely useful in the identification of rare recessive disease genes. Such genes are only detectable in isolated populations with a limited number of founders, where rare disease alleles are enriched, thus resulting in homozygote individuals affected by the disease. Impressive accomplishments in disease-locus mapping and gene identification using genome-wide scans of only a handful of affected individuals in such populations have been reported, typically based on linkage analyses and homozygosity scanning [2,3]. It is becoming increasingly apparent that studies locating genes underlying complex phenotypes also benefit from the study of samples from homogeneous populations with a limited numb
A Qualitative Study of Individual and Organizational Learning through Physiotherapists’ Participation in a Research Project  [PDF]
Petra Dannapfel, Anneli Peolsson, Per Per Nilsen
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.59071

The need for evidence-based practice has been recognized by physiotherapy organizations over the past decades. Earlier studies have documented facilitators and barriers that affect the use and implementation of evidence-based practice. Less is known about what kind of interventions might be useful to implement evidence-based practice. This study explores what physiotherapists learn through participation in a research project relevant to their professional development towards achieving a more evidence-based physiotherapy practice. To what extent this learning was transferred to colleagues for organizational learning is also examined. This study was set in Sweden, where health care is publicly funded. Patients do not need a referral from a physician to consult a physiotherapist. Eleven interviews were conducted with physiotherapists who had participated in a randomized, controlled, multicenter, physiotherapy intervention investigating neck-specific exercise for patients with whiplash disorder. Gadamer’s hermeneutics was used to analyze the data. The physiotherapists described a range of learning experiences from their project participation, including instrumental learning (the concrete application of knowledge to achieve changes in practice) and conceptual learning (changes in knowledge, understanding or attitudes). The research project enabled the physiotherapists to develop new treatment techniques for broader application and extend their competence in techniques already known (instrumental learning). The physiotherapists believed that project participation enhanced their overall competence as physiotherapists, increased their job motivation and strengthened their self-confidence and self-efficacy (conceptual learning). Physiotherapists’ participation in the research project yielded many individual learning experiences, fostered positive attitudes to research and was conducive to achieving a more research-informed physiotherapy practice. Participation was associated with a deeper understanding of the challenges involved in conducting research. The transfer from individual learning to the wider organization in terms of organizational learning was limited.

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