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Search Results: 1 - 10 of 53794 matches for " Pei-Hong Shen "
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Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations
Orna Levran, Olaoluwakitan Awolesi, Pei-Hong Shen, Miriam Adelson, Mary Jeanne Kreek
Human Genomics , 2012, DOI: 10.1186/1479-7364-6-2
Origin of matter in the universe
Gu, Pei-Hong
High Energy Physics - Phenomenology , 2007, DOI: 10.1016/j.physletb.2007.08.095
Abstract: We extend the standard model with two iso-singlet color triplet scalars, one singlet real scalar and one singlet fermion. The new fields are odd under an unbroken Z_2 discrete symmetry while the standard model particles are even. The decays of the singlet real scalar into three standard model quarks (antiquarks) with three singlet antifermions (fermions), which explicitly violate the baryon number, will become effective after the electroweak phase transition and then produce the observed baryon asymmetry in the universe through the loop diagram involving the exchange of the W gauge boson. The singlet fermion can serve as the candidate for cold dark matter. In our model, all new particles with masses below the TeV scale can be detected by the forthcoming collider experiments or the next generation experiments for neutron-antineutron oscillations.
Multi-component dark matter with magnetic moments for Fermi-LAT gamma-ray line
Gu, Pei-Hong
High Energy Physics - Phenomenology , 2013,
Abstract: We propose a model of multi-component dark matter with magnetic moments to explain the 130 GeV gamma-ray line hinted by the Fermi-LAT data. Specifically, we consider a U(1)_X dark sector which contains two vector-like fermions besides the related gauge and Higgs fields. A very heavy messenger scalar is further introduced to construct the Yukawa couplings of the dark fermions to the heavy [SU(2)]-singlet leptons in the SU(3)_c \times SU(2)_L \times SU(2)_R \times U(1)_{B-L} left-right symmetric models for universal seesaw. A heavier dark fermion with a very long lifetime can mostly decay into a lighter dark fermion and a photon at one-loop level. The dark fermions can serve as the dark matter particles benefited from their annihilations into the dark gauge and Higgs fields. In the presence of a U(1) kinetic mixing, the dark matter fermions can be verified by the ongoing and forthcoming dark matter direct detection experiments.
Parity: from strong CP problem to dark matter, neutrino masses and baryon asymmetry
Gu, Pei-Hong
High Energy Physics - Phenomenology , 2013,
Abstract: We show that in an SU(3)_c\times [SU(2)_L\times U(1)_Y]\times [SU(2)'_R\times U(1)'_Y] framework, the parity symmetry motivated by solving the strong CP problem without resorting to an axion can predict a dark matter particle with a mass around 302 GeV. This dark matter candidate can be directly detected in the presence of a U(1)_Y\times U(1)'_Y kinetic mixing. Furthermore, our model can accommodate a natural way to simultaneously realize an inverse-linear seesaw for neutrino masses and a resonant leptogenesis for baryon asymmetry.
Unified picture for Dirac neutrinos, dark matter, dark energy and matter-antimatter asymmetry
Gu, Pei-Hong
High Energy Physics - Phenomenology , 2007, DOI: 10.1016/j.physletb.2008.02.030
Abstract: We propose a unified scenario to generate the masses of Dirac neutrinos and cold dark matter at the TeV scale, understand the origin of dark energy and explain the matter-antimatter asymmetry of the universe. This model can lead to significant impact on the Higgs searches at LHC.
Characterization of a Novel Serine Protease Inhibitor Gene from a Marine Metagenome
Cheng-Jian Jiang,Zhen-Yu Hao,Rong Zeng,Pei-Hong Shen,Jun-Fang Li,Bo Wu
Marine Drugs , 2011, DOI: 10.3390/md9091487
Abstract: A novel serine protease inhibitor (serpin) gene designated as Spi1C was cloned via the sequenced-based screening of a metagenomic library from uncultured marine microorganisms. The gene had an open reading frame of 642 base pairs, and encoded a 214-amino acid polypeptide with a predicted molecular mass of about 28.7 kDa. The deduced amino acid sequence comparison and phylogenetic analysis indicated that Spi1C and some partial proteinase inhibitor I4 serpins were closely related. Functional characterization demonstrated that the recombinant Spi1C protein could inhibit a series of serine proteases. The Spi1C protein exhibited inhibitory activity against α-chymotrypsin and trypsin with K i values of around 1.79 × 10 ?8 and 1.52 × 10 ?8 M, respectively. No inhibition activity was exhibited against elastase. Using H-D-Phe-Pip-Arg-pNA as the chromogenic substrate, the optimum pH and temperature of the inhibition activity against trypsin were 7.0–8.0 and 25 °C, respectively. The identification of a novel serpin gene underscores the potential of marine metagenome screening for novel biomolecules.
A New Ionizing-radiation Resistant Strain WGR702 Isolated, Identified, and Radioresistant Character

SUN Ji-Hua,SHEN Pei-Hong,WU Bo,

微生物学通报 , 2008,
Abstract: 从辐射污染的土壤中分离到一株新的耐辐射菌WGR702.该菌为革兰氏阳性球菌,直径1.5 μm~2.5μm.菌体呈粉红色、能运动、兼性厌氧及不产孢子.其生长温度和pH范围分别为10℃~35℃和pH 5.0~10.0.(G C)mol%含量为60.5%.UV和γ射线辐射检测表明WGR702具有很强的耐辐射性.16S rDNA序列(EU315117)分析表明,菌株 WGR702与沙雷氏菌属(Serratia)菌株16S rDNA序列有很高相似性(94.79%~98.53%),但与沙雷氏菌属已报道菌株最大不同点是菌株WGR702细胞为球状,且革兰氏阳性.结合形态、生理生化特征分析表明菌株WGR702可能是沙雷氏菌属(Serratia)的一个新种.
Common Genetic Origins for EEG, Alcoholism and Anxiety: The Role of CRH-BP
Mary-Anne Enoch, Pei-Hong Shen, Francesca Ducci, Qiaoping Yuan, Jixia Liu, Kenneth V. White, Bernard Albaugh, Colin A. Hodgkinson, David Goldman
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003620
Abstract: The resting EEG is a dynamic index of cortical activation, cognitive function and consciousness and is therefore an intermediate phenotype for many behaviors in which arousal is implicated such as anxiety and alcoholism. We performed a dense whole genome linkage scan using 3878 unlinked SNPs in a large pedigree derived from a population isolate sample of 328 Plains American Indians. Alpha (8–13 Hz), theta (4–8 Hz) and beta (13–30 Hz) EEG power was heritable (0.58–0.27) and stable over a 2 year period (r = 0.82–0.53). Genetic correlations between frequency bands were high (0.75). Linkage peaks for EEG power in all three frequency bands converged on chromosome 5q13-14 with genome-wide significant LOD scores of 3.5 (empirical p<0.0001) for alpha and beta power. A logical candidate gene, corticotropin releasing hormone-binding protein (CRH-BP), was located at the apex of these convergent linkage peaks. CRH-BP was significantly associated with alpha power in the Plains Indians and also in a replication sample of 188 Caucasians. Moreover, the same SNPs and haplotypes, located within the CRH-BP haplotype block, were also associated with anxiety disorders in the Plains Indians and alcohol use disorders in the Caucasians. CRH-BP modulates CRH which influences cortical and hippocampal EEG activity and is the primary mediator of the neuroendocrine stress response. Our results suggest a likely role for CRH-BP in stress-related alcoholism and highlight the use of the resting EEG as an intermediate phenotype for arousal-related behaviors such as anxiety and addiction.
miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level
Shen-meng Gao, Chong-yun Xing, Chi-qi Chen, Si-si Lin, Pei-hong Dong, Fu-jun Yu
Journal of Experimental & Clinical Cancer Research , 2011, DOI: 10.1186/1756-9966-30-110
Abstract: K562 and HL-60 cells were transfected with pRS-15/16 or pRS-E, cell growth were measured by CCK-8 assay and direct cell count. Meanwhile WT1 protein and mRNA level were measured by Western blotting and quantitative real-time PCR.In this study we found that over-expression of miR-15a/16-1 significantly inhibited K562 and HL-60 cells proliferation. Enforced expression of miR-15a/16-1 in K562 and HL-60 cells significantly reduced the protein level of WT1 but not affected the mRNA level. However enforced expression of miR-15a/16-1 can not reduce the activity of a luciferase reporter carrying the 3'-untranslated region(3'UTR) of WT1. Silencing of WT1 by specific siRNA suppressed leukemic cells proliferation resembling that of miR-15a/16-1 over-expression. Anti-miR-15a/16-1 oligonucleotides (AMO) reversed the expression of WT1 in K562 and HL-60 cells. Finally, we found a significant inverse correlation between miR-15a or miR-16-1 expression and WT1 protein levels in primary acute myeloid leukemia (AML) blasts and normal controls.These data suggest that miR-15a/16-1 may function as a tumor suppressor to regulate leukemic cell proliferation potentially by down-regulating the WT1 oncogene. However WT1 is not directly targeted by miR-15a/16-1 through miRNA-mRNA base pairing, therefore more study are required to understand the mechanism by which miR-15a/16-1 downregulate WT1.MicroRNAs (miRNAs) are non-coding regulatory RNAs of 21 to 25 nucleotides and regulate most of basal progress such as cell proliferation, survival, apoptosis, and differentiation by triggering either translational repression or mRNA degradation[1-3]. Recently an increasing number of data have demonstrated that almost 50% of miRNAs are located at or close to fragile sites of regions. This regions are known to be amplified or deleted in human cancer[4]. miRNAs may function as tumor suppressor genes or potential oncogenes during the initiation and progression of cancer[5]. The function of some miRNAs is depen
The Functional DRD3 Ser9Gly Polymorphism (rs6280) Is Pleiotropic, Affecting Reward as Well as Movement
Jonathan Savitz, Colin A. Hodgkinson, Chantal Martin-Soelch, Pei-Hong Shen, Joanna Szczepanik, Allison Nugent, Peter Herscovitch, Anthony A. Grace, David Goldman, Wayne C. Drevets
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054108
Abstract: Abnormalities of motivation and behavior in the context of reward are a fundamental component of addiction and mood disorders. Here we test the effect of a functional missense mutation in the dopamine 3 receptor (DRD3) gene (ser9gly, rs6280) on reward-associated dopamine (DA) release in the striatum. Twenty-six healthy controls (HCs) and 10 unmedicated subjects with major depressive disorder (MDD) completed two positron emission tomography (PET) scans with [11C]raclopride using the bolus plus constant infusion method. On one occasion subjects completed a sensorimotor task (control condition) and on another occasion subjects completed a gambling task (reward condition). A linear regression analysis controlling for age, sex, diagnosis, and self-reported anhedonia indicated that during receipt of unpredictable monetary reward the glycine allele was associated with a greater reduction in D2/3 receptor binding (i.e., increased reward-related DA release) in the middle (anterior) caudate (p<0.01) and the ventral striatum (p<0.05). The possible functional effect of the ser9gly polymorphism on DA release is consistent with previous work demonstrating that the glycine allele yields D3 autoreceptors that have a higher affinity for DA and display more robust intracellular signaling. Preclinical evidence indicates that chronic stress and aversive stimulation induce activation of the DA system, raising the possibility that the glycine allele, by virtue of its facilitatory effect on striatal DA release, increases susceptibility to hyperdopaminergic responses that have previously been associated with stress, addiction, and psychosis.
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