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Search Results: 1 - 10 of 537957 matches for " Peggy A O'Day "
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Speciation and fate of trace metals in estuarine sediments under reduced and oxidized conditions, Seaplane Lagoon, Alameda Naval Air Station (USA)
Susan Carroll, Peggy A O'Day, Brad Esser, Simon Randall
Geochemical Transactions , 2002, DOI: 10.1186/1467-4866-3-81
Abstract: The fate of these metals during dredging was evaluated by comparing in situ geochemistry with that of sediments oxidized by seawater in laboratory experiments. Cadmium and zinc pose the greatest hazard from dredging because their sulfides were highly reactive in seawater. However, their dissolved concentrations under oxic conditions were limited eventually by sorption to or co-precipitation with an iron (oxy)hydroxide. About 50% of the reacted CdS and 80% of the reacted ZnS were bonded to an oxide-substrate at the end of the 90-day oxidation experiment. Lead and chromium pose a minimal hazard from dredging because they are bonded to relatively insoluble carbonate, phosphate, phyllosilicate, or oxide minerals that are stable in seawater. These results point out the specific chemical behavior of individual metals in estuarine sediments, and the need for direct confirmation of metal speciation in order to constrain predictive models that realistically assess the fate of metals in urban harbors and coastal sediments.A recent evaluation of sediment contamination of surface waters in the United States by the US Environmental Protection Agency identified 96 watersheds, mostly urban harbors, containing metal and/or organic chemical contents that are potentially hazardous to aquatic biota.[1] These harbors and coastal sediments are contaminated from past and present industrial and military waste disposal practices. One such example is the estuary sediments of the East Outfall Site of the Seaplane Lagoon, at the former Naval Air Station (NAS) Alameda located on an island in San Francisco Bay, USA (Fig. 1). The most abundant metals in the sediments are cadmium, lead, chromium, zinc, copper, and nickel. Concentrations of these metal contaminants above background levels in San Francisco Bay result from a 57 year history of military and industrial activity at this site. From 1940 to 1975, the Seaplane Lagoon received about 300 million gallons of waste-water from industrial and st
Surface complexation model for strontium sorption to amorphous silica and goethite
Susan A Carroll, Sarah K Roberts, Louise J Criscenti, Peggy A O'Day
Geochemical Transactions , 2008, DOI: 10.1186/1467-4866-9-2
Abstract: Strontium surface complexation equilibrium constants determined in this study combined with other alkaline earth surface complexation constants are used to recalibrate a predictive model based on Born solvation and crystal-chemistry theory. The model is accurate to about 0.7 log K units. More studies are needed to determine the dependence of alkaline earth sorption on ionic strength and dissolved carbonate and sulfate concentrations for the development of a robust surface complexation database to estimate alkaline earth sorption in the environment.Ion sorption to mineral and amorphous solids has long been recognized as a process that controls the composition of trace elements in water. This process is particularly important for the transport of contaminants in the Earth's surface environment where sorption may retard transport by removing the contaminant from a mobile aqueous phase to a more stationary solid phase. Efforts to describe sorption in complex geological settings has evolved from a purely empirical approach in which distribution coefficients (Kd) are a measure of the total amount of specific ion between the solid and aqueous phases for a complex solution and solid matrix specific to a contaminated site. Although this approach provides a direct measure of the ability of the solid matrix to sequester the contaminant from a specific solution, its empirical nature does not allow it to be applied outside of the specific parameters of the contaminated site. Another approach measures thermodynamic surface complexation constants which describe sorption as a series of specific reactions between dissolved ions and surface sites. In principle, thermodynamic data from several single mineral and element experiments can be combined to build a model that represents the complex systems found in nature, especially when coupled with aqueous speciation, mineral solubility, and kinetic databases. However an internally consistent surface complexation database for a wide range
Long-term cost-effectiveness of atypical antipsychotics in the treatment of adults with schizophrenia in the US
O'Day K,Rajagopalan K,Meyer K,Pikalov A
ClinicoEconomics and Outcomes Research , 2013,
Abstract: Ken O'Day,1 Krithika Rajagopalan,2 Kellie Meyer,1 Andrei Pikalov,2 Antony Loebel21Xcenda, Palm Harbor, FL, 2Sunovion Pharmaceuticals, Marlborough, MA, USABackground: The purpose of this study was to evaluate the long-term cost-effectiveness (including hospitalizations and cardiometabolic consequences) of atypical antipsychotics among adults with schizophrenia.Methods: A 5-year Markov cohort cost-effectiveness model, from a US payer perspective, was developed to compare lurasidone, generic risperidone, generic olanzapine, generic ziprasidone, aripiprazole, and quetiapine extended-release. Health states included in the model were patients: on an initial atypical antipsychotic; switched to a second atypical antipsychotic; and on clozapine after failing a second atypical antipsychotic. Incremental cost-effectiveness ratios (ICERs) assessed incremental cost/hospitalization avoided. Effectiveness inputs included discontinuations, hospitalizations, weight change, and cholesterol change from comparative clinical trials for lurasidone and for aripiprazole, and the Clinical Antipsychotic Trials of Intervention Effectiveness for other comparators. Atypical antipsychotic-specific relative risk of diabetes obtained from a retrospective analysis was used to predict cardiometabolic events per Framingham body mass index risk equation. Mental health costs (relapsing versus nonrelapsing patients) and medical costs associated with cardiometabolic consequences (cardiovascular events and diabetes management) were obtained from published sources. Atypical antipsychotic costs were estimated from Red Book prices at dose(s) reported in clinical data sources used in the model (weighted average dose of lurasidone and average dose for all other comparators). Costs and outcomes were discounted at 3%, and model robustness was tested using one-way and probabilistic sensitivity analyses.Results: Ziprasidone, olanzapine, quetiapine extended-release, and aripiprazole were dominated by other comparators and removed from the comparative analysis. ICER for lurasidone versus risperidone was $25,884/relapse-related hospitalization avoided. At a $50,000 willingness-to-pay threshold, lurasidone has an 86.5% probability of being cost-effective, followed by a 7.2% probability for olanzapine, and 6.3% for risperidone. One-way sensitivity analysis showed the model is sensitive to lurasidone and generic risperidone hospitalization rates.Conclusion: Generic risperidone is the least costly atypical antipsychotic. Lurasidone is more costly and more effective than risperidone and is cost-effective at
Mechanized design of the process of production of the garlic sauce in a foods company
Londo?o D,Peggy A; Mieres Pitre,Alberto; Clemente Y,Ynes M;
Revista Técnica de la Facultad de Ingeniería Universidad del Zulia , 2007,
Abstract: this work was centered in the mechanized design of the process of production of the garlic sauce in a company located in carabobo state. table of cause and effect, way analysis and fault effect and pareto diagram were done to identify the variables that have influence in the diminution of the viscosity of the product and to obtain the cause of potentials faults. measures were made of the water hardness and the viscosity of the product, where it was observed that as increased the hardness viscosity diminished. we obtained that the hardness of the water occupies 79% of the faults next by the time of mixed. in the design of mechanized process, they were incorporated jumbled hoppers to facilitate the handling of materials, a line of packaging for the presentation of a gallon and other equipment that didn?t exist. with the proposal of the new design the time of the process was reduced from 100 to 40 minutes.
Dise o mecanizado del proceso de producción de la salsa de ajo en una empresa de alimentos Mechanized design of the process of production of the garlic sauce in a foods company
Peggy A Londo?o D,Alberto Mieres Pitre,Ynes M Clemente Y
Revista Técnica de la Facultad de Ingeniería Universidad del Zulia , 2007,
Abstract: El trabajo se centró en el dise o mecanizado del proceso de producción de la salsa de ajo en una empresa local ubicada en el estado Carabobo. Se realizó una tabla de causa y efecto, análisis de modo y efecto de falla y diagrama de Pareto, para identificar las variables influyentes en la disminución de la viscosidad del producto y así obtener las causas de fallas potenciales. Se hicieron medidas de la dureza del agua y de la viscosidad del producto, donde se observó que a medida que aumentaba la dureza disminuía la viscosidad. Se obtuvo que la dureza del agua ocupa el 79% de las fallas seguida por el tiempo de mezclado. En el dise o del proceso mecanizado se incorporaron tolvas para facilitar el manejo de materiales, la línea de envasado para la presentación de galón y otros equipos que no existían. Con la propuesta del nuevo dise o el tiempo del proceso es reducido de 100 a 40 minutos. This work was centered in the mechanized design of the process of production of the garlic sauce in a company located in Carabobo state. Table of cause and effect, way analysis and fault effect and Pareto diagram were done to identify the variables that have influence in the diminution of the viscosity of the product and to obtain the cause of potentials faults. Measures were made of the water hardness and the viscosity of the product, where it was observed that as increased the hardness viscosity diminished. We obtained that the hardness of the water occupies 79% of the faults next by the time of mixed. In the design of mechanized process, they were incorporated jumbled hoppers to facilitate the handling of materials, a line of packaging for the presentation of a gallon and other equipment that didn’t exist. With the proposal of the new design the time of the process was reduced from 100 to 40 minutes.
Established Risk Factors Account for Most of the Racial Differences in Cardiovascular Disease Mortality
Sean O. Henderson, Christopher A. Haiman, Lynne R. Wilkens, Laurence N. Kolonel, Peggy Wan, Malcolm C. Pike
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0000377
Abstract: Background Cardiovascular disease (CVD) mortality varies across racial and ethnic groups in the U.S., and the extent that known risk factors can explain the differences has not been extensively explored. Methods We examined the risk of dying from acute myocardial infarction (AMI) and other heart disease (OHD) among 139,406 African-American (AA), Native Hawaiian (NH), Japanese-American (JA), Latino and White men and women initially free from cardiovascular disease followed prospectively between 1993–1996 and 2003 in the Multiethnic Cohort Study (MEC). During this period, 946 deaths from AMI and 2,323 deaths from OHD were observed. Relative risks of AMI and OHD mortality were calculated accounting for established CVD risk factors: body mass index (BMI), hypertension, diabetes, smoking, alcohol consumption, amount of vigorous physical activity, educational level, diet and, for women, type and age at menopause and hormone replacement therapy (HRT) use. Results Established CVD risk factors explained much of the observed racial and ethnic differences in risk of AMI and OHD mortality. After adjustment, NH men and women had greater risks of OHD than Whites (69% excess, P<0.001 and 62% excess, P = 0.003, respectively), and AA women had greater risks of AMI (48% excess, P = 0.01) and OHD (35% excess, P = 0.007). JA men had lower risks of AMI (51% deficit, P<0.001) and OHD (27% deficit, P = 0.001), as did JA women (AMI, 37% deficit, P = 0.03; OHD, 40% deficit, P = 0.001). Latinos had underlying lower risk of AMI death (26% deficit in men and 35% in women, P = 0.03). Conclusion Known risk factors explain the majority of racial and ethnic differences in mortality due to AMI and OHD. The unexplained excess in NH and AA and the deficits in JA suggest the presence of unmeasured determinants for cardiovascular mortality that are distributed unequally across these populations.
Secretory Protein mRNA Finds Another Way Out
Kira E. O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0050330
Abstract:
Shedding Light on Animal Cryptochromes
Kira E. O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0060168
Abstract:
Completing the Candida Loop
Kira O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0050270
Abstract:
Gut Reaction: Pyrosequencing Provides the Poop on Distal Gut Bacteria
Kira O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0060295
Abstract:
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