oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 18 )

2018 ( 50 )

2017 ( 60 )

2016 ( 66 )

Custom range...

Search Results: 1 - 10 of 29259 matches for " Pedro Sanchez-Cruz "
All listed articles are free for downloading (OA Articles)
Page 1 /29259
Display every page Item
Synthesis and Evaluation of Folate-Conjugated Phenanthraquinones for Tumor-Targeted Oxidative Chemotherapy  [PDF]
Ajay Kumar, Venkatesh Chelvam, Mahalingam Sakkarapalayam, Guo Li, Pedro Sanchez-Cruz, Natasha S. Pi?ero, Philip S. Low, Antonio E. Alegria
Open Journal of Medicinal Chemistry (OJMC) , 2016, DOI: 10.4236/ojmc.2016.61001
Abstract: Almost all cells are easily killed by exposure to potent oxidants. Indeed, major pathogen defense mechanisms in both animal and plant kingdoms involve production of an oxidative burst, where host defense cells show an invading pathogen with reactive oxygen species (ROS). Although cancer cells can be similarly killed by ROS, development of oxidant-producing chemotherapies has been limited by their inherent nonspecificity and potential toxicity to healthy cells. In this paper, we describe the targeting of an ROS-generating molecule selectively to tumor cells using folate as the tumor-targeting ligand. For this purpose, we exploit the ability of 9,10-phenanthraquinone (PHQ) to enhance the continuous generation of H2O2 in the presence of ascorbic acid to establish a con-stitutive source of ROS within the tumor mass. We report here that incubation of folate receptor-expressing KB cells in culture with folate-PHQ plus ascorbate results in the death of the cancer cells with an IC50 of ~10 nM (folate-PHQ). We also demonstrate that a cleavable spacer linking folate to PHQ is significantly inferior to a noncleavable spacer, in contrast to most other folate-targeted therapeutic agents. Unfortunately, no evidence for folate-PHQ mediated tumor regression in murine tumor models is obtained, suggesting that unanticipated impediments to generation of cytotoxic quantities of ROS in vivo are encountered. Possible mechanisms and potential solutions to these unanticipated results are offered.
Holographic kinetic k-essence model
Norman Cruz,Pedro F. Gonzalez-Diaz,Alberto Rozas-Fernandez,Guillermo Sanchez
Physics , 2008, DOI: 10.1016/j.physletb.2009.07.028
Abstract: We consider a connection between the holographic dark energy density and the kinetic k-essence energy density in a flat FRW universe. With the choice $c\geq1$, the holographic dark energy can be described by a kinetic k-essence scalar field in a certain way. In this paper we show this kinetic k-essential description of the holographic dark energy with $c\geq1$ and reconstruct the kinetic k-essence function F(X).
Almost sure convergence and asymptotical normality of a generalization of Kesten's stochastic approximation algorithm for multidimensional case
Pedro Cruz
Statistics , 2011,
Abstract: It is shown the almost sure convergence and asymptotical normality of a generalization of Kesten's stochastic approximation algorithm for multidimensional case. In this generalization, the step increases or decreases if the scalar product of two subsequente increments of the estimates is positive or negative. This rule is intended to accelerate the entrance in the `stochastic behaviour' when initial conditions cause the algorithm to behave in a `deterministic fashion' for the starting iterations.
One-dimensional elliptic equation with concave and convex nonlinearities
Justino Sanchez,Pedro Ubilla
Electronic Journal of Differential Equations , 2000,
Abstract: We establish the exact number of positive solutions for the boundary-value problem $$displaylines{ -(|u'|^{m-2} u')'=lambda u^q + u^pquad hbox{in }(0,1)cr u(0)= u(1)=0,, }$$ where $0leq q < m- 1 < p$ and $lambda$ is positive.
C-reactive protein in aortic valve disease
Pedro L Sanchez, Anna Mazzone
Cardiovascular Ultrasound , 2006, DOI: 10.1186/1476-7120-4-37
Abstract: Aortic stenosis (AS) is at present time the most frequent valvulopaty in developed countries, and as life expectancy increases, the incidence and prevalence of AS will also rise fundamentally at the expense of the degenerative form.The scientific interest of this valvar disorder was parked for many years, as the image tools necessary to quantify it are at our disposal and we have a certain agreement of the clinical moment for indicating the valve replacement. Nevertheless, in the past years different studies have demonstrated a common pathogenic mechanism between degenerative AS and atherosclerosis [1-3]. This is consistent with histopathological evidence that the lesions in AS involve active cellular processes that have classical "response to injury features", namely inflammatory infiltrates containing macrophages, T cells, and smooth muscle cells [4]. Therefore, investigators have needed only a half turn of the head to transfer the early past experience of blood markers of inflammation in the atherosclerosis setting to the AS scenario.C-reactive protein (CRP) is the marker of inflammation most widely studied in patients with coronary artery disease and hence has become the marker of reference for any other inflammatory-based disease [5]. On this basis, CRP has emerged as a leading candidate for a better understanding of AS pathogenesis, for predicting AS progression, and for driving therapies in AS.The first study showing increased CRP levels in patients with degenerative AS was published by Galante et al, in 2001 [6]. They compared serum CRP levels of 68 consecutive patients with severe degenerative trileaflet AS and absence of coronary atherosclerotic lesions admitted for elective cardiac surgery with 92 healthy controls. CRP levels were higher in patients with AS than in controls (0.85 ± 1.42 vs. 0.39 ± 0.50; p = 0.0001). They also showed an independent association of CRP with AS; the odds ratio for the disease according to CRP levels were 2.62 (95% confidence
Retraction: C-reactive protein in aortic valve disease
Pedro L Sanchez, Anna Mazzone
Cardiovascular Ultrasound , 2006, DOI: 10.1186/1476-7120-4-42
Abstract: The correct version of the article [2] had previously been published in Cardiovascular Ultrasound.The authors have agreed that the preliminary version [1] should be retracted.
C-reactive protein in degenerative aortic valve stenosis
Pedro L Sanchez, AnnaMaria Mazzone
Cardiovascular Ultrasound , 2006, DOI: 10.1186/1476-7120-4-24
Abstract: Degenerative aortic stenosis (AS) is at present time the most frequent valvulopaty in developed countries, and as life expectancy increases, the incidence and prevalence of AS will also rise fundamentally at the expense of the degenerative form.The scientific interest of this valvar disorder was parked for many years, as the image tools necessary to quantify it are at our disposal and we have a certain agreement of the clinical moment for indicating the valve replacement. Nevertheless, in the past years different studies have demonstrated a common pathogenic mechanism between degenerative AS and atherosclerosis [1-3]. This is consistent with histopathological evidence that the lesions in AS involve active cellular processes that have classical "response to injury features", namely inflammatory infiltrates containing macrophages, T cells, and smooth muscle cells [4]. Therefore, investigators have needed only a half turn of the head to transfer the early past experience of blood markers of inflammation in the atherosclerosis setting to the AS scenario.C-reactive protein (CRP) is the marker of inflammation most widely studied in patients with coronary artery disease and hence has become the marker of reference for any other inflammatory-based disease [5]. On this basis, CRP has emerged as a leading candidate for a better understanding of AS pathogenesis, for predicting AS progression, and for driving therapies in AS.The first study showing increased CRP levels in patients with degenerative AS was published by Galante et al, in 2001 [6]. They compared serum CRP levels of 68 consecutive patients with severe degenerative trileaflet AS and absence of coronary atherosclerotic lesions admitted for elective cardiac surgery with 92 healthy controls. CRP levels were higher in patients with AS than in controls (0.85 ± 1.42 vs. 0.39 ± 0.50; p = 0.0001). They also showed an independent association of CRP with AS; the odds ratio for the disease according to CRP levels was 2.62 (95%
Erratum: Impact of stem cells in craniofacial regenerative medicine
Pedro A. Sanchez-Lara
Frontiers in Physiology , 2013, DOI: 10.3389/fphys.2013.00219
Abstract:
Análisis estructural del sector azucarero y el etanol del Valle del Cauca
Cruz Aguilar,Pedro L.;
Cuadernos de Administración (Universidad del Valle) , 2010,
Abstract: analysis of the sector tries to demonstrate that following the international price of sugar above 16 cents a pound, the sugar industry will count on coordinating mechanisms that will allow them to direct their production of cane sugar to the link in the productive chain which will produce the greatest profit margin will produce, without having to increase the number of acres planted in proportion to the increase in sugar exported. this consolidated the sugar industry as one of the driving forces of the colombian economy, but to date has forced the government to lower the percentage of ethanol fuel in gasoline from 10 to 8 percent and casts doubt on the implementation of decrees which substantially increase the percentage of alcohol fuel for engines of 2000 cms3.
LA REFORMA DEL ESTADO DE LAS AUTONOMíAS
Pedro Cruz Villalón
Revista d'Estudis Autonòmics i Federals , 2006,
Abstract: In this article, its author analyzes some of the top current issues on the politicaland legal definition of the Spanish territorial model of state. From thisperspective, the author considers that there are some aspects of the territorialorganization of the state that have neither been tackled properly, norhave been approached from a problem-solving perspective. As a consequence,these aspects have ended up generating structural resistances to the full developmentof political decentralization in Spain. Thus, first of all, the authorsustains that there have been no significant changes on the territorial modelof state since its foundation in 1978; according to the author, thus, the1978 territorial status quo has hardly changed over all this period. Under thispremise, the author studies what he calls the “re-foundation” of the territorialdistribution of power in Spain, that is, the re-definition of the Stateof the Autonomous Communities.Secondly, he advocates for the need to provide a detailed definition of thede facto territorial model of State. In this sense he strongly criticizes theterritorial model of State that would result from both the process leadingto the reform of the Statute of Autonomy of Catalonia and the constitutionalreform proposed by Central Government. Thirdly, he states the importance of dealing with the different political and legal challenges arising fromthe current political debates on the territorial matter, as well as the need tofurther develop a federal paradigm which could serve as a reference for thefuture.
Page 1 /29259
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.