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Search Results: 1 - 10 of 177298 matches for " Pedro F Costa;Diniz "
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C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults
Alline M. Beleigoli, Eric Boersma, Maria de Fátima H. Diniz, Pedro G. Vidigal, Maria Fernanda Lima-Costa, Antonio L. Ribeiro
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075809
Abstract: Background New biomarkers may aid in preventive and end-of-life decisions in older adults if they enhance the prognostic ability of traditional risk factors. We investigated whether C-reactive protein (CRP) and/or B-type natriuretic peptide (BNP) improve the ability to predict overall mortality among the elderly of the Bambuí, Brazil Study of Aging when added to traditional risk factors. Methods From 1997 to 2007, 1,470 community-dwelling individuals (≥60 years) were followed-up. Death was ascertained by continuous verification of death certificates. We calculated hazard ratios per 1 standard deviation change (HR) of death for traditional risk factors only (old model), and traditional risk factors plus CRP and/or BNP (new models) and assessed calibration of the models. Subsequently, we compared c-statistic of each of the new models to the old one, and calculated integrated discriminative improvement (IDI) and net reclassification improvement (NRI). Results 544 (37.0%) participants died in a mean follow-up time of 9.0 years. CRP (HR 1.28, 95% CI 1.17-1.40), BNP (HR 1.31 95% CI 1.19-1.45), and CRP plus BNP (HR 1.26, 95% CI 1.15-1.38, and HR 1.29, 95% CI 1.16-1.42, respectively) were independent determinants of mortality. All models were well-calibrated. Discrimination was similar among the old (c-statistic 0.78 [0.78-0.81]) and new models (p=0.43 for CRP; p=0.57 for BNP; and p=0.31 for CRP plus BNP). Compared to the old model, CRP, BNP, and CRP plus BNP models led to an IDI of 0.009 (p<0.001), -0.005 (p<0.001) and -0.003 (p=0.84), and a NRI of 0.04 (p=0.24), 0.07 (p=0.08) and 0.06 (p=0.10), respectively. Conclusions Despite being independent predictors of long-term risk of death, compared to traditional risk factors CRP and/or BNP led to either a modest or non-significant improvement in the ability of predicting all-cause mortality in older adults.
Environmental influences on antibody-enhanced dengue disease outcomes
Diniz, Daniel Guerreiro;F?ro, César Augusto Raiol;Turiel, Maíra C Pereira;Sosthenes, Marcia CK;Demachki, Samia;Gomes, Giovanni Freitas;Rego, Carla M Damasceno;Magalh?es, Marina Cutrim;Pinho, Brunno Gomes;Ramos, Juliana Pastana;Casseb, Samir M Moraes;Brito, Maysa de Vasconcelos;Silva, Eliana Vieira Pinto da;Nunes, Marcio Roberto Teixeira;Diniz, José Antonio Pican?o;Cunningham, Colm;Perry, Victor Hugh;Vasconcelos, Pedro F Costa;Diniz, Cristovam W Pican?o;
Memórias do Instituto Oswaldo Cruz , 2012, DOI: 10.1590/S0074-02762012000800010
Abstract: because an enriched environment (ee) enhances t-cell activity and t-lymphocytes contribute to immunopathogenesis during heterologous dengue virus (denv) infections, we hypothesised that an ee increases dengue severity. to compare single serotype (ss) and antibody-enhanced disease (aed) infections regimens, serial intraperitoneal were performed with denv3 (genotype iii) infected brain homogenate or anti-denv2 hyperimmune serum followed 24 h later by denv3 (genotype iii) infected brain homogenate. compared aed for which significant differences were detected between the ee and impoverished environmental (ie) groups (kaplan-meyer log-rank test, p = 0.0025), no significant differences were detected between the ss experimental groups (kaplan-meyer log-rank test, p = 0.089). survival curves from ee and ie animals infected with the aed regimen were extended after corticoid injection and this effect was greater in the ee than in the ie group (kaplan-meyer log-rank test, p = 0.0162). under the aed regimen the ee group showed more intense clinical signs than the ie group. dyspnoea, tremor, hunched posture, ruffled fur, immobility, pre-terminal paralysis, shock and death were associated with dominant t-lymphocytic hyperplasia and presence of viral antigens in the liver and lungs. we propose that the increased expansion of these memory t-cells and serotype cross-reactive antibodies facilitates the infection of these cells by denv and that these events correlate with disease severity in an ee.
Rela??es intergovernamentais e descentraliza??o: uma análise da implementa??o do SUAS em Minas Gerais
Costa, Bruno Lazzarotti Diniz;Palotti, Pedro Lucas de Moura;
Revista de Sociologia e Política , 2011, DOI: 10.1590/S0104-44782011000200015
Abstract: according to existing literature on public policy, the decentralization of social policies within federative contexts should promote the compatibility of the autonomy of federal entities with the need for political coordination toward the fulfillment of common goals. in the case of welfare assistance in brazil, there is the additional challenge of building a proper field for state intervention capable of moving beyond clientelism, philanthropy and institutional fragmentation. this paper seeks an understanding of the role of institutional arrangements and the induction promoted by central governments in the recent municipalization of welfare assistance in the state of minas gerais, focusing on two initiatives: preparing municipalities to deal with the sistema único de assistência social (unified system of social assistance - suas) and the implementation of the centros de referência da assistência social (centers of reference of social assistance - cras). our research was based on administrative records and on official reports and publications, interviews with technicians in the field and a series of secondary data. our major conclusions maintain that the formal rules of and commitment to decentralization at federal and state levels were relevant in explaining the scope and format of suas implementation in minas gerais, a process that is still underway at present.
A proposta curricular para o ensino de ciências e programas de saúde: uma síntese e detalhamento para o ciclo básico
Costa, Fátima Neves do Amaral;Casagrande, Lisete Diniz Ribas;
Paidéia (Ribeir?o Preto) , 1994, DOI: 10.1590/S0103-863X1994000100003
Abstract: the paper begins with a shintesis of the science and health programs curriculum proposal, worked up by the pedagogic studies ans norms coordination (cenp), from the bureau of education in s?o paulo state, brazil. the proposal's theoretical foudation on social-historic premises is also showed, toghether with the difficulties for the traditionally prepared teacher to work with it. finally, the paper discusses the possible contribution of the educator-nurse professional, on the improvement of helth themes of the proposal (1992), especially for the school. (basic cicle)
Lista de cigarritas (Hemiptera: Cicadellidae) de Cusco, Perú Checklist of leafhoppers (Hemiptera: Cicadellidae) from Cusco, Peru
Juan F. Costa,Pedro W. Lozada
Revista Peruana de Biología , 2011,
Abstract: Se presenta una lista de cigarritas registradas para Cusco, conteniendo 111 géneros y 203 especies. Esta lista incluye especies citadas en la literatura y también de material depositado en la colección de la Universidad Nacional de San Antonio Abad del Cusco. Las cigarritas identificadas por los autores fueron colectadas de 8 provincias de Cusco: Anta, Calca, Canchis, Cusco, La Convención, Paucartambo, Quispicanchi y Urubamba. We present a list of leafhoppers recorded for Cusco, containing 111 genera and 203 species. This list includes species cited in taxonomic literature and also from material housed in the collections of the Universidad Nacional de San Antonio Abad del Cusco. The leafhoppers identified by the authors were collected from 8 provinces of Cusco: Anta, Calca, Canchis, Cusco, La Convención, Paucartambo, Quispicanchi and Urubamba.
Microalbuminuria and Kidney Disease Risk in HIV Patients Taking Combined Antiretroviral Therapy  [PDF]
Huylmer Lucena Chaves, Mayanna Pinho Batista, Adriana de Menezes Gomes, Amanda Antunes Costa, André Tigre Lima, Vinícius Diniz Arcelino do Ceará, Pedro Rubens Araújo Carvalho, Linna Albuquerque Sampaio, Fabrício de Maicy Bezerra, Melissa Soares Medeiros
World Journal of AIDS (WJA) , 2014, DOI: 10.4236/wja.2014.42029

Objectives: This study proposes to evaluate risk factors for kidney disease in HIV patients treated chronically and correlate with microalbuminuria measurements. Methods: Review charts and analyses of microalbuminuria in subgroup of HIV patients treated at Ceara/Brazil. Results: 149 patients, 69.1% male, mean 38.5 years old, infection mean 86.8 months. Mean Creatinine Clearance 110.2%, Creatinine 0.97, Urea 27.76 mg/dl, CD4+ 600.37 cels/mm3 and detectable viral load 530.59 copies with 61.7% undetectable. Mean Dosages of microalbuminuria/24h 147, 46 ± 820, 45 (N = 48) and microalbuminuria (mg/dl) 32.05 ± 85.25 (N = 43). Kidney Diseases Classification analyses evidenced 6.4% patients in stages ≥3 and 6.2% presented altered Microalbuminuria/24h. Patients using Tenofovir (TDF) 27.27% had Stage 2 and protease inhibitors (PI) had 4.1% in Stage 3. Proteinuria was observed in 5% stage ≥3. Association PI/TDF had 4.1% in Stage 3. No statistical difference between CD4 > or < 350 cels/mm3 and microalbuminuria/24h > 300 mg (p = 0.69); detectable/undetectable viral load and microalbuminuria/24h (p = 0.63) or stage ≥3 (p = 0.17); relation to Diabetes or arterial hypertension and microalbuminuria 24 h (p = 0.5 and p = 0.21); relation stage ≥3 and microalbuminuria/24h (p = 0.33); relation HIV diagnoses >/< 60 months and stage ≥3 (p = 0.51); or microalbuminuria/24h and TDF (p = 0.4), PI (p = 1), TDF/PI (p = 0.69), Atazanavir (p = 0.4) or Lopinavir/r (p = 1) regimens. There was statistical significance comparing age > or < 50 years and stage ≥3 (p = 0.001) without difference with age > or < 50 years and microalbuminuria/24h (p = 0.55) or microalbuminuria mg/d (p = 0.32). Relating comorbidities risk (Diabetes Mellitus plus Systemic Arterial Hypertension) to Kidney Diseases, it was found that 55.5% patients in Stage 3 or above with comorbidities compared with 15% with comorbidities in lower stages (P = 0.005).

Sex-dependent foraging effort and vigilance in coal-crested finches, Charitospiza eucosma (Aves: Emberizidae) during the breeding season: evidence of female-biased predation?
Diniz, Pedro;
Zoologia (Curitiba) , 2011, DOI: 10.1590/S1984-46702011000200003
Abstract: sexual dimorphism in birds is often attributed to sexual selection, but another interpretation suggests the evolution of this phenomenon by natural selection. predation may be an important selective pressure, acting mainly on females. in this study, i tested the latter hypothesis on the coal-crested finch (charitospiza eucosma oberholser, 1905) in a neotropical savanna of the central brazil (cerrado). i used capture methods for ascertaining the sex ratio in the population, and focal observations to gather behavioral data. my results show that the sex ratio is skewed toward males (1:1.39). males were more vigilant, vocalized for longer periods of time, and used higher perches than females. females foraged more, spent more time on parental care and remained on the ground for longer periods than males. these results support the 'foraging effort hypothesis, suggesting that females are more preyed upon because they spend more time foraging. ultimately, this may reflect the fact that females invest more on parental care than males. the sex-dependent parental investment may favor the evolution of different antipredator strategies in males and females: the camouflage in females as a less efficient strategy than vigilance in males.
Micronutrientes e sódio num solo cultivado com maracujazeiro amarelo, com a aplica o de biofertilizante supermagro e potássio Micronutrients and sodium in a soil cultivated with yellow passion fruit, with application of “supermagro” biofertilizer and potassium
Lourival F. Cavalcante,Artenisa C. Rodrigues,Adriana A. Diniz,Pedro D. Fernandes
Revista Brasileira de Ciências Agrárias , 2011, DOI: 10.5039/agraria.v6i3a781
Abstract: Um experimento de campo foi executado, no período de mar o/2005 a fevereiro/2007, no município de Remígio, PB, para avaliar o efeito do biofertilizante supermagro (esterco fresco de bovino + água + macro e micro nutrientes), aplicado ao solo na forma líquida, sobre os teores de micronutrientes e sódio no solo. O trabalho consistiu na combina o de dois fatores: doses de supermagro, diluído em água na raz o de 1:4 (0, 1, 2, 3 e 4 L por planta), combinadas à aduba o de K2O (com e sem K2O), oriundo de cloreto de potássio, compondo um fatorial 5 x 2, no delineamento experimental em blocos casualizados, com três repeti es. A aplica o de supermagro, independentemente da adi o de K2O, promoveu aumento dos teores de boro, cobre, manganês e zinco, mas n o interferiu nos conteúdos de ferro e sódio no solo. A field experiment was carried out during the period from March/2005 to February/2007, in the municipality of Remígio, Paraíba State, Brazil, in order to evaluate the action of the “supermagro” biofertilizer (fresh bovine manure + water + macro and micronutrients) applied on the soil in liquid form, on the contents of soil micronutrients and sodium. The treatments were distributed in randomized blocks, with three repetitions, using the factorial design 5 x 2, consisting of levels of “supermagro” biofertilizer diluted in water in a 1:4 proportion (0, 1, 2, 3 and 4 L per plant), combined with K2O fertilization (with and without K2O), obtained from potassium chloride. The biofertilizer application on the soil in treatments without and with K2O, increased the contents of boron, copper, manganese and zinc on the soil, but had no effects on sodium and iron content.
Physicians and Conflicts of Interest  [PDF]
Deborah Pimentel, Maria-Jésia Vieira, Jo?o Pedro Declerc F. S. Neves, Manoel Juvenal da Costa-Neto, Laís Costa Souza Oliveira
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.516128

In medical practice, the most commonly observed conflicts of interest are the ones existing in the relations between professionals and industries linked to health or between the former and health services. These relations are no longer a partnership in search of the best to be offered to patients and tend to take up a commercial role, in a seduction game where, each one, in their own manner, seeks benefits. The purpose of this study is to analyze the existence of these conflicts of interest, in an exploratory and qualitative study, with physician focal groups. The results were grouped in two categories: benefits received by physicians and the justifications provided by them for the establishment of these partnerships. The most common benefits are: percentages over orthoses and prosthetics received by the industry; discounts and credits on rent or condominium fees for exam indications and procedures; rewards offered by the pharmaceutical industry for the indication of their products. Physicians have pointed out as main determinants for ethical missteps that involve conflicts of interest, the character and family formation as well as the lack of denunciations. The fact that efficient and widespread laws for resolution of conflicts of interest do not exist makes it necessary to recognize their existence with mechanisms of management and transparency, perhaps as the only way to avoid negative interference in physician behavior.

Application of a double-enrichment procedure for microsatellite isolation and the use of tailed primers for high throughput genotyping
Diniz, Fábio Mendon?a;Iyengar, Arati;Lima, Paulo Sarmanho da Costa;Maclean, Norman;Bentzen, Paul;
Genetics and Molecular Biology , 2007, DOI: 10.1590/S1415-47572007000300014
Abstract: the number of microsatellite loci and their allelic diversity contribute to increase accuracy and informativity of genetic estimates, however, the isolation of microsatellite loci is not only laborious but also quite expensive. we used (gata)n and (gaca)n tetranucleotide probes and single- and double-enrichment hybridization to construct and screen a genomic library with an increased proportion of dna fragments containing repeat motifs. repeats were found using both types of hybridization but the double-enrichment procedure recovered sequences of which 100% contained (gata)n and (gaca)n motifs. microsatellite loci primers were then designed with an m13r-tail or cag-tag to produce scorable pcr products with minimal stutter. the approach used in this study suggests that double-enrichment is a worthwhile strategy when isolating repeat motifs from eukaryotic genomes. moreover, the use of tailed microsatellite primers provides increased resolution for compound microsatellite loci, with a significant decrease in costs.
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