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Search Results: 1 - 10 of 340953 matches for " Paulo Tannús; "
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In vivo magnetic resonance imaging tracking of C6 glioma cells labeled with superparamagnetic iron oxide nanoparticles
Mamani, Javier Bustamante;Malheiros, Jackeline Moraes;Cardoso, Ellison Fernando;Tannús, Alberto;Silveira, Paulo Henrique;Gamarra, Lionel Fernel;
Einstein (S?o Paulo) , 2012, DOI: 10.1590/S1679-45082012000200009
Abstract: objective: the aim of the current study was to monitor the migration of superparamagnetic iron oxide nanoparticle (spion)-labeled c6 cells, which were used to induce glioblastoma tumor growth in an animal model, over time using magnetic resonance imaging (mri), with the goal of aiding in tumor prognosis and therapy. methods: two groups of male wistar rats were used for the tumor induction model. in the first group (n=3), the tumors were induced via the injection of spion-labeled c6 cells. in the second group (n=3), the tumors were induced via the injection of unlabeled c6 cells. prussian blue staining was performed to analyze the spion distribution within the c6 cells in vitro. tumor-inducing c6 cells were injected into the right frontal cortex, and subsequent tumor monitoring and spion detection were performed using t2- and t2*-weighted mri at a 2t field strength. in addition, cancerous tissue was histologically analyzed after performing the mri studies. results: the in vitro qualitative evaluation demonstrated adequate distribution and satisfactory cell labeling of the spions. at 14 or 21 days after c6 injection, a spion-induced t2- and t2*-weighted mri signal reduction was observed within the lesion located in the left frontal lobe on parasagittal topography. moreover, histological staining of the tumor tissue with prussian blue revealed a broad distribution of spions within the c6 cells. conclusion: mri analyses exhibit potential for monitoring the tumor growth of c6 cells efficiently labeled with spions.
Hepatite por propiltiouracil: apresenta??o de dois casos com evolu??es diversas
Gon?alves Júnior, Jo?o C.;Oliveira, Rodrigo de A.;Carvalho, Ademar M. de;Jorge, Paulo Tannús;
Arquivos Brasileiros de Endocrinologia & Metabologia , 1999, DOI: 10.1590/S0004-27301999000200010
Abstract: the authors present two cases of ptu-associated hepatotoxicity which had different outcome. one patient developed jaundice and altered transaminases, that disappeared after the discontinuation of ptu. the other patient presented with upper gastrointestinal bleeding, hepatic failure and died soon after the admission. laboratory evaluation showed negative sorology for viral hepatitis in both cases. the authors highlight the importance of the orientation of the patient about the possibility of developing jaundice during the use of ptu and in cases of hepatotoxicity they orient the immediate withdraw of the drug and clinical follow-up.
Avalia??o da associa??o entre doen?a auto-imune de tireóide e urticária cr?nica idiopática
Feibelmann, Taciana C.M.;Gon?alves, Fabrícia Torres;Daud, Mariana Salom?o;Jorge, André de Sousa;Mantese, S?nia A.O.;Jorge, Paulo Tannús;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2007, DOI: 10.1590/S0004-27302007000700009
Abstract: several studies found a higher prevalence of autoimmune thyroid disease (atd) in patients with chronic urticaria (cu). this relationship may be due to the possible autoimmune etiology in up to one third of the cases of chronic idiopathic urticaria (ciu). however, the frequency of atd ranged from 1.14% to 28.6%. the study began by determining whether there is an association between atd and cu, in a population seen at the same clinic. we compared the frequency of anti-thyroid antibodies and thyroid dysfunction in 49 patients with ciu (group 1) and 112 controls (group 2). in order to support the result found, we studied the prevalence of ciu in 60 patients with atd (group 3) and compared with 29 patients who had non-immune thyroid disease (nitd) (group 4). we did not find a statistical difference for the presence of anti-thyroid antibodies or thyroid dysfunction between groups 1 and 2 (12.24% x 9.82% and 12.24% x 7.14%, respectively). the same occurred for the presence of ciu among groups 3 and 4 (3.33% x 3.44%). in our study it was not possible to demonstrate a relationship between atd and ciu, which means that different populations may present a higher or lower degree of association between these illnesses.
Discordancia entre IGF-1 e GH pós-sobrecarga de glicose no rastreamento de acromegalia em paciente com macroprolactinoma: relato de caso e revis?o sobre o tema
Gon?alves, Fabrícia Torres;Feibelmann, Taciana C. Maia;Fernandes, Maria Luiza M. P.;Fonseca, Alessandra R.C.;Arantes, Henrique Pierotti;Jorge, Paulo Tannús;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2007, DOI: 10.1590/S0004-27302007000300020
Abstract: we describe a patient with macroprolactinoma and discrepant insulin-like growth factor (igf-1) concentration (elevated) and growth hormone (gh) values during a 75 g oral glucose tolerance test (normal), that were measured to evaluate the co-secretion of gh by tumor. with the bromocriptin use, the patient achieved normalization of prolactin, but persisted with high levels of igf1, suggesting to be subclinical acromegaly. after the development of new more sensitive gh assays, cases of discrepant gh and igf-1 results have been observed and taken to some authors to suggest that gh nadir concentration during 75 g ogtt used to acromegaly diagnosis and treatment could be lower than values considered currently normal. thus, if this is confirmed, subclinical and oligosymptomatic acromegaly cases could have earlier diagnoses.
Questions of Logic, Philosophy, and Linguistics
Marcio Chaves-Tannús
Principia : an International Journal of Epistemology , 2011,
Abstract: There were in the past, just as there are in the present, several diverse attempts to establish a unique theory capable of identifying in all natural languages a similar, invariable basic structure of a logical nature. If such a theory exists, then there must be principles that rule the functioning of these languages and they must have a logical origin. Based on a work by the French linguist, Oswald Ducrot, entitled D’un mauvais usage de la logique, this paper aims to present in a concise manner two of the above mentioned attempts. They were elaborated in diverse epochs and different arguments were put forward to support them. The first attempt was in XVII century France and its theoretic basis was the renowned ‘Port-Royal Logic’. The second attempt is recent and its theoretic support comes from Contemporary Logic.
Primary pigmented nodular adrenocortical disease associated with Carney complex: case report and literature review
Gon?alves, Fabrícia Torres;Feibelmann, Taciana Carla Maia;Mendes, Cínthia Monteiro;Fernandes, Maria Luiza Mendon?a Pereira;Miranda, Geraldo Henrique Gouvêa de;Gouvêa, Agostinho Pinto;Jorge, Paulo Tannús;
Sao Paulo Medical Journal , 2006, DOI: 10.1590/S1516-31802006000600007
Abstract: context: carney complex (cnc), a familial multiple neoplasm syndrome with dominant autosomal transmission, is characterized by tumors of the heart, skin, endocrine and peripheral nervous system, and also cutaneous lentiginosis. this is a rare syndrome and its main endocrine manifestation, primary pigmented nodular adrenal disease (ppnad), is an uncommon cause of adrenocorticotropic hormone-independent cushing's syndrome. case report: we report the case of a 20-year-old patient with a history of weight gain, hirsutism, acne, secondary amenorrhea and facial lentiginosis. following the diagnosing of cnc and ppnad, the patient underwent laparoscopic bilateral adrenalectomy, and she evolved with decreasing hypercortisolism. screening was also performed for other tumors related to this syndrome. the diagnostic criteria, screening and follow-up for patients and affected family members are discussed.
In silico evolutionary analysis of Helicobacter pylori outer membrane phospholipase A (OMPLA)
Vollan Hilde S,Tanns Tone,Yamaoka Yoshio,Bukholm Geir
BMC Microbiology , 2012, DOI: 10.1186/1471-2180-12-206
Abstract: Background In the past decade, researchers have proposed that the pldA gene for outer membrane phospholipase A (OMPLA) is important for bacterial colonization of the human gastric ventricle. Several conserved Helicobacter pylori genes have distinct genotypes in different parts of the world, biogeographic patterns that can be analyzed through phylogenetic trees. The current study will shed light on the importance of the pldA gene in H. pylori. In silico sequence analysis will be used to investigate whether the bacteria are in the process of preserving, optimizing, or rejecting the pldA gene. The pldA gene will be phylogenetically compared to other housekeeping (HK) genes, and a possible origin via horizontal gene transfer (HGT) will be evaluated through both intra- and inter-species evolutionary analyses. Results In this study, pldA gene sequences were phylogenetically analyzed and compared with a large reference set of concatenated HK gene sequences. A total of 246 pldA nucleotide sequences were used; 207 were from Norwegian isolates, 20 were from Korean isolates, and 19 were from the NCBI database. Best-fit evolutionary models were determined with MEGA5 ModelTest for the pldA (K80 + I + G) and HK (GTR + I + G) sequences, and maximum likelihood trees were constructed. Both HK and pldA genes showed biogeographic clustering. Horizontal gene transfer was inferred based on significantly different GC contents, the codon adaptation index, and a phylogenetic conflict between a tree of OMPLA protein sequences representing 171 species and a tree of the AtpA HK protein for 169 species. Although a vast majority of the residues in OMPLA were predicted to be under purifying selection, sites undergoing positive selection were also found. Conclusions Our findings indicate that the pldA gene could have been more recently acquired than seven of the HK genes found in H. pylori. However, the common biogeographic patterns of both the HK and pldA sequences indicated that the transfer occurred long ago. Our results indicate that the bacterium is preserving the function of OMPLA, although some sites are still being evolutionarily optimized.
Characterizing water fingering phenomena in soils using magnetic resonance imaging and multifractal theory
A. Posadas, R. Quiroz, A. Tannús, S. Crestana,C. M. Vaz
Nonlinear Processes in Geophysics (NPG) , 2009,
Abstract: The study of water movement in soils is of fundamental importance in hydrologic science. It is generally accepted that in most soils, water and solutes flow through unsaturated zones via preferential paths or fingers. This paper combines magnetic resonance imaging (MRI) with both fractal and multifractal theory to characterize preferential flow in three dimensions. A cubic double-layer column filled with fine and coarse textured sand was placed into a 500 gauss MRI system. Water infiltration through the column (0.15×0.15×0.15 m3) was recorded in steady state conditions. Twelve sections with a voxel volume of 0.1×0.1×10 mm3 each were obtained and characterized using fractal and multifractal theory. The MRI system provided a detailed description of the preferential flow under steady state conditions and was also useful in understanding the dynamics of the formation of the fingers. The f(α) multifractal spectrum was very sensitive to the variation encountered at each horizontally-oriented slice of the column and provided a suitable characterization of the dynamics of the process identifying four spatial domains. In conclusion, MRI and fractal and multifractal analysis were able to characterize and describe the preferential flow process in soils. Used together, the two methods provide a good alternative to study flow transport phenomena in soils and in porous media.
Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells
Lars L Eftang, Ying Esbensen, Tone M Tanns, Ida RK Bukholm, Geir Bukholm
BMC Microbiology , 2012, DOI: 10.1186/1471-2180-12-9
Abstract: Interleukin-8 was the most significantly up-regulated gene and appears to play a paramount role in the epithelial cell response to H. pylori infection and in the pathological processes leading to gastric disease. MAPK and NF-kappaB cellular pathways were powerfully activated, but did not seem to explain the impressive IL-8 response. There was marked up-regulation of TP53BP2, whose corresponding protein ASPP2 may interact with H. pylori CagA and cause marked p53 suppression of apoptosis. Other regulators of apoptosis also showed abberant regulation. We also identified up-regulation of several oncogenes and down-regulation of tumor suppressor genes as early as during the first 24 h of infection. H. pylori OMPLA phase variation did not seem to influence the inflammatory epithelial cell gene response in this experiment.In whole genome analysis of the epithelial response to H. pylori exposure, IL-8 demonstrated the most marked up-regulation, and was involved in many of the most important cellular response processes to the infection. There was dysregulation of apoptosis, tumor suppressor genes and oncogenes as early as in the first 24 h of H. pylori infection, which may represent early signs of gastric tumorigenesis. OMPLA+/-did not affect the acute inflammatory response to H. pylori.H. pylori is well established as the primary cause of peptic ulcer disease and the initiator of the multistep cascade leading to gastric adenocarcinoma. Although gastric cancer is the fourth most common cancer worldwide and second only to lung cancer in causing cancer related deaths [1], there are remarkable differences in the distribution of this disease between western and eastern countries. The decrease in gastric cancer parallels H. pylori prevalence in the western world, but this phenomenon does not completely explain the great geographical differences in gastric cancer distribution. The reason why only 1-2% of H. pylori-infected individuals develop gastric malignancies remains unexplain
Manganese-enhanced magnetic resonance imaging in the acute phase of the pilocarpine-induced model of epilepsy
Malheiros, Jackeline Moraes;Longo, Beatriz Monteiro;Tannús, Alberto;Covolan, Luciene;
Einstein (S?o Paulo) , 2012, DOI: 10.1590/S1679-45082012000200023
Abstract: magnetic resonance images are useful in the study of experimental models of temporal lobe epilepsy. the manganese-enhanced mri (memri) technique is of interest since it combines the effects caused by manganese on the increased contrast in activated cell populations, when competing with calcium in synaptic transmission. thus, the purpose of this study was to investigate the temporal evolution of the contrast related to manganese in the acute phase of temporal lobe epilepsy induced by systemic pilocarpine and compare it to the expression of the c-fos protein. during this phase, the intensity of the memri signal was analyzed at three different time points (5, 15 or 30 minutes) after the onset of status epilepticus (se). the group that was maintained in status epilepticus for 30 minutes showed a decrease in intensity of the signal in ca1 and the dentate gyrus (dg). there were no differences between the control group and the other groups treated with pilocarpine. the expression of the protein, c-fos, in the same animals showed that even in the short-duration status epilepticus (5 minutes), there was already maximal cellular activation in subregions of the hippocampus (dg, ca1 and ca3). under the experimental conditions tested, our data suggest that the memri signal was not sensitive for the identification of detectable variations of cell activation in the acute phase of the pilocarpine model. our findings are not consistent with the idea that manganese contrast reflects primarily alterations in cellular activity during se when other signal-modifying elements can act.
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