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Search Results: 1 - 10 of 65767 matches for " Paulo Roberto;Santos "
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Comparison of quality of life between hemodialysis patients waiting and not waiting for kidney transplant from a poor region of Brazil
Santos, Paulo Roberto;
Jornal Brasileiro de Nefrologia , 2011, DOI: 10.1590/S0101-28002011000200008
Abstract: introduction: there are few data about the quality of life (qol) level among patients undergoing hemodialysis (hd) and not eligible for kidney transplant. objective: the qol level was compared between hd patients waiting and not waiting for kidney transplant. methods: we included 161 end-stage renal disease patients undergoing hd, during april, 2009. all patients were older than 18 years old, had been on hd at least three months, and had no previous transplantation. to measure qol, the sf-36 was used. we also collected data about death and transplants in the 12 months after april, 2009. qol scores were compared by analysis of variance with covariates. results: patients not awaiting transplantation were older (53.7 versus 36.3 years old; p < 0.001), more often had diabetes (15.8 versus 4.7%; p = 0.032) and hypertension (35.5 versus 12.9%; p < 0.001), and had no lupus (0 versus 4.7%; p = 0.001). they also presented lower creatinine levels (11.5 versus 13.5 mg/dl; p = 0.001) and were submitted to a lower dose of dialysis, estimated by kt/v (1.6 versus 2.0; p = 0.026). patients not awaiting transplant died more often in the following 12 months (21.1 versus 5.9%; p = 0.005). adjusted mean scores were lower among patients not awaiting transplant regarding six dimensions of qol: functional capacity (42.0 versus 53.4; p = 0.022), physical limitation (29.9 versus 49.2; p = 0.030); pain (45.0 versus 64.0; p = 0.003), social aspects (56.3 versus 75.9; p = 0.003), emotional aspects (45.1 versus 79.0; p = 0.001), and mental health (50.1 versus 64.3; p = 0.004). conclusions: patients undergoing hd and not awaiting transplant are at risk of poor qol level, mainly regarding role-emotional and role-physical aspects. we recommend psychological approaches and physical rehabilitation for this group of patients.
O papel do fisiologista desportivo no futebol: para quê & por quê?
Silva, Paulo Roberto Santos;
Revista Brasileira de Medicina do Esporte , 2000, DOI: 10.1590/S1517-86922000000400008
Abstract: sports physiology is still considered a relatively new specialty in soccer. small wonder, thus, that a sports physiologist, with his function and formation, is a personage unknown to most people engaged in this sport, for they are unable to characterize his role as a specialized professional in a soccer team. so it is important to lay stress on the fact that the work of such specialist in this area is directly connected with the trainer, as he performs, among others, duties like: 1) team work, conveying constant information about the players’ functional condition to the technical commission; 2) systematic evaluation of the athletes; 3) longitudinal follow-up to the functional adaptation resulting from the training to which athletes are submitted; 4) investigation and reflection capacity regarding several aspects of the soccer (football) game. consequently, it is logical to infer that a sports physiologist requires ample knowledge of the scientific methodologies about functional evaluation and sport training, apart from specific mastery of bioenergetic concepts aimed at the soccer (football) game, so as to allow to identify the kind of effort and, starting from there, adequate methods for the development of the soccer (football) players’ training program. in conclusion, the sports physiologist is essentially a professional concerned with health, whose function is more and more educational and intended to contribute to the improvement of the scientific information that every community must possess about several health aspects of the human body and, particularly, about the performance of exercises.
Depression and quality of life of hemodialysis patients living in a poor region of Brazil
Santos, Paulo Roberto;
Revista Brasileira de Psiquiatria , 2011, DOI: 10.1590/S1516-44462011000400005
Abstract: objective: to determine the correlation between depression and quality of life (qol) of patients in hemodialysis (hd). method: one hundred and sixty six patients over 18 years of age who had been in hd for at least three months and had no history of transplant. qol was assessed using the sf-36. to categorize depression, a score > 10 was used on the 10-item version of the center for epidemiologic studies depression scale (ces-d). comparisons between depressed and nondepressed patients were performed using the chi-square test, student's t-test, and mann-whitney test. multiple regression was performed to assess the predictive variables of patients' qol. results: symptoms of depression were found in 13 (7.8%) patients. the only variable that differed among depressed patients was qol. depressed patients presented lower scores in vitality (40.7 vs. 57.3; p = 0.010), role-emotional (25.6 vs. 62.5; p = 0.006), and mental health (50.1 vs. 65.4; p = 0.023). regression analysis demonstrated that depression was a predictor of role-emotional (or = 0.981, ci = 0.967-0.996; p = 0.010) and mental health (or = 0.970, ci = 0.946-0.996; p = 0.022). conclusion: depressed patients experience a poor qol because, in addition to their chronically affected physical aspects, they also feel limited in the mental dimensions, which usually have the highest score among non-depressed hd patients.
Rela??o do sexo e da idade com nível de qualidade de vida em renais cr?nicos hemodialisados
Santos, Paulo Roberto;
Revista da Associa??o Médica Brasileira , 2006, DOI: 10.1590/S0104-42302006000500026
Abstract: background: the stagnant mortality rate of the last decade and the increased prevalence of aged people among hemodialysis patients motivated the present study to determine the relation of gender and age with the quality of life (ql) of patients with chronic kidney failure treated with hemodialysis. methods: from the sample of 107 individuals who underwent regular hemodialysis in a dialysis unit in the interior of the state of ceará, brazil, the medical outcomes study questionnaire 36-item short form health survey (sf-36) was used to assess quality of life. pearson's correlation coefficient was used to calculate and to test the linear correlation between age and the score generated by the sf-36. the score for gender was compared by the t test and the mann-whitney when indicated. results: there was no difference between the score related to gender. there was no negative and linear correlation between age and the dimensions of ql named: physical functioning (r=-0.289, p=0.003), physical role (r=-0.224, p=0.020), body pain (r=0.252, p=0.008), general health (r=-0.245, p<0.001), vitality (r=-0.334, p<0.001) and social functioning (r=-0.270, p=0.005). there was no correlation between age and the dimensions: role of emotions (r=-0.149, p=0.125) and mental health (r=-0.158, p=0.103). conclusion: gender did not correlate with the level of ql among chronic hemodialysis patients, while there was a linear and negative correlation between age and the dimensions relating to the physical aspect of the ql.
Uma abordagem arquivística: os documentos de um laboratório das ciências biomédicas
Santos, Paulo Roberto Elian dos;
História, Ciências, Saúde-Manguinhos , 2012, DOI: 10.1590/S0104-59702012000100016
Abstract: this article addresses archival methods, techniques, and practices for managing documents generated by scientific activity, using field research carried out at an instituto oswaldo cruz laboratory at the funda??o oswaldo cruz as a reference. based on an analysis combining an archival studies approach with elements of the sociology of science, we believe that the models and instruments of archival knowledge are subordinate to the assumptions of historical research or social memory. they also serve a technical rationality aligned with empirical organization practices that confront the more complex archival reality, leading archival science to negate its foundations and theoretical principles.
Pilocarpus spp.: a survey of its chemical constituents and biological activities
Santos, Ana Paula;Moreno, Paulo Roberto Hrihorowitsch;
Revista Brasileira de Ciências Farmacêuticas , 2004, DOI: 10.1590/S1516-93322004000200002
Abstract: pilocarpus species have been exploited as the only source of the imidazole alkaloid pilocarpine (used in glaucoma treatment), since its isolation up to the present. almost all pilocarpusspecies are native from brazil. because of the medicinal importance of pilocarpine, several of them are in the path of extinction. other secondary metabolites, such as coumarins, flavonoids and terpenes, were described for pilocarpusspecies. in this review the secondary metabolites, other than pilocarpine, isolated from pilocarpusspecies and their biological activities were compiled. although the variety of structures and the importance of the biological activities described in literature for pilocarpusspecies this is an unexploited field of research in natural products and pharmacology.
The CD133/1+ cell subset from human subcutaneous adult fat retains hemogenic potential  [PDF]
Camila Santos de Moraes, Paulo Roberto Albuquerque Leal, Daniel Fabiano Ferreira, Fernando Serra, Eliana Abdelhay, Claudia Sondermann Freitas
Stem Cell Discovery (SCD) , 2012, DOI: 10.4236/scd.2012.22006
Abstract: Research has shown that cells from adult fat tissue can effect long-term blood reconstitution. Fat-derived multipotentiality was ascribed to CD34+ perivascular populations from its prominent microvasculature, that represent mostly non-hemogenic, mesenchymal cells, although this tissue contains a CD34+45+ subset committed to a hemogenic fate. Here, in order to analyze cell subsets presenting hemogenic capabilities within fat, CD133/1+ and pericytes, the latter defined by CD140b (PDGFRb, Platelet-Derived Growth Factor Receptor Beta) expression, were immunomagnetically selected from stromal-vascular fractions (SVF). In Vitro Colony Forming Unit (CFU) assays were negative for CD140b+ pericytes and positive for CD133/1+ cells when a prolonged CFU assay was performed, revealing fat as another store of primitive progenitors that retain hemogenic potential.
N-acetyltransferase 2: Slow, intermediate or fast? A booming question of the molecular epidemiology in cancer research  [PDF]
Giuliano Di Pietro, Sandra Rocha Gadelha, Sandra Mara Bispo Sousa, Paulo Roberto Santana de Melo, Fabricio Rios Santos
Open Journal of Genetics (OJGen) , 2012, DOI: 10.4236/ojgen.2012.24028
Abstract: Throughout history, humanity has referred to reactions occurring with food, plants and, recently, medicines or drugs. The increase in pulmonary tuberculosis cases and the availability of treatment showed that genetic human differences can interfere in the capacity to metabolize drugs. There are remarkable genetic polymorphisms of N-acetyltransferase 2 (NAT2) activity that have been associated with different levels of susceptibility to developing many kinds of cancers. This review considers the field as an open window for the application of molecular epidemiology tools that led to the development of pharmacogenomics. We cover historical data and the most recent knowledge about NAT2 genetic polymorphisms and its distribution in different populations, which is an important concept being incorporated in epidemiological studies of cancer risk. We present up to date information about these studies, including meta-analysis based on the NAT2 distribution in different types of cancer. A critical broad at advances in NAT2 research, high-lighting recent studies related to NAT2 alleles in cancer susceptibility. Although there are multifactorial aspects involved in cancer risk, the variability in NAT2 allelic frequency can be related to carcinogenesis through alterations in the metabolic rate after exposure to carcinogens.
Conex?es de conhecimento e posturas tecnológicas das firmas: evidências da aglomera??o industrial de petróleo e gás da Bacia de Campos
Silvestre, Bruno dos Santos;Dalcol, Paulo Roberto Tavares;
Gest?o & Produ??o , 2007, DOI: 10.1590/S0104-530X2007000200003
Abstract: the present work analyses the results of empirical research involving ten firms that are part of the oil and gas industrial agglomeration in the productive region of the campos basin (rj). the firms involved in this study operate in areas of intense technological dynamism providing products and services of high technological complexity to operators in this region. two groups of firms were given special attention: well equipment suppliers (wet christmas trees) and well service suppliers (well technology). a hybrid model for agglomeration analysis was developed, which uses elements from the clusters approach and innovation systems (sectoral and technological). the aim of this work was to determine the formation process and the agglomeration characterization and to understand, from the perspective of the knowledge system and the technological approaches of the firms, how the technological changes, recently applied to the campos basin, are implemented and what the origins of such changes are. as a secondary objective, this study has attempted to verify whether geographic agglomeration is a factor that favors innovation by the firms located there. results have shown evidence of the existence of a group of firms in which geographical proximity has a positive influence on innovative activities.
Indu??o floral de limeiras ácidas 'Tahiti' submetidas a baixas temperaturas
Santos, Dierlei dos;Siqueira, Dalmo Lopes de;Cecon, Paulo Roberto;
Ciência Rural , 2011, DOI: 10.1590/S0103-84782011000300006
Abstract: the research was realized to quantify the need for accumulation hours under low temperatures to the acid lime 'tahiti' flowering, without water application and beyond evaluating gas exchange and chlorophyll a fluorescence under low temperature and light. the experiment was conducted in vi?osa-mg, brazil, with plants from acid lime 'tahiti' grafted on rangpur lime grown in pots of 12 liters. the design was completely randomized with seven treatments and four replicates with one plant per plot. from 02/01/2008 until 04/30/2008, four plants were taken from each growth chamber (cc) (temperatures: 16/12°c (day/night); air humidity: 70%; photoperiod: 10 hours; photosynthetic photon flux density: 100μmol m-2 s-1) to 15 days and taken to a greenhouse (cv) without environmental control, totaling seven dates of transfer. exposure of plants to low temperatures, under controlled conditions, does not cause significant changes in the characteristics of chlorophyll a fluorescence, but caused 80% of reduction in gas exchange. this reduction does not hurt the flowering plants. plants exposed to no-induced conditions only issued vegetative shoots, while those submitted to lower temperatures, the greater was the exposure time, the greater was the number of flowers sent.
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