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Search Results: 1 - 10 of 47947 matches for " Paulo Francisco Guerreiro;Moreira "
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Prevalência da doen?a do refluxo gastroesofágico em pacientes com fibrose pulmonar idiopática
Bandeira, Cristiane Dupont;Rubin, Adalberto Sperb;Cardoso, Paulo Francisco Guerreiro;Moreira, José da Silva;Machado, Mirna da Mota;
Jornal Brasileiro de Pneumologia , 2009, DOI: 10.1590/S1806-37132009001200004
Abstract: objective: to determine the prevalence of gastroesophageal reflux disease (gerd) and to evaluate its clinical presentation, as well as the esophageal function profile in patients with idiopathic pulmonary fibrosis (ipf). methods: in this prospective study, 28 consecutive patients with ipf underwent stationary esophageal manometry, 24-h esophageal ph-metry and pulmonary function tests. all patients also completed a symptom and quality of life in gerd questionnaire. results: in the study sample, the prevalence of gerd was 35.7%. the patients were then divided into two groups: gerd+ (abnormal ph-metry; n = 10) and gerd- (normal ph-metry; n = 18). in the gerd+ group, 77.7% of the patients presented at least one typical gerd symptom. the ph-metry results showed that 8 (80%) of the gerd+ group patients had abnormal supine reflux, and that the reflux was exclusively in the supine position in 5 (50%). in the gerd+ and gerd- groups, respectively, 5 (50.0%) and 7 (38.8%) of the patients presented a hypotensive lower esophageal sphincter, 7 (70.0%) and 10 (55.5%), respectively, presenting lower esophageal dysmotility. there were no significant differences between the groups regarding demographic characteristics, pulmonary function, clinical presentation or manometric findings. conclusions: the prevalence of gerd in the patients with ipf was high. however, the clinical and functional characteristics did not differ between the patients with gerd and those without.
Bronquiectasias: aspectos diagnósticos e terapêuticos Estudo de 170 pacientes
Moreira, José da Silva;Porto, Nelson da Silva;Camargo, José de Jesus Peixoto;Felicetti, José Carlos;Cardoso, Paulo Francisco Guerreiro;Moreira, Ana Luiza Schneider;Andrade, Cristiano Feijó;
Jornal de Pneumologia , 2003, DOI: 10.1590/S0102-35862003000500003
Abstract: background: bronchiectasis is a frequently found disease in medical practice in brazil leading to significant morbidity and decrease in quality of life of the affected individuals. objectives: to study diagnostic and therapeutic aspects in a series of hospitalized patients with bronchiectasis in a department of pulmonary diseases. method: signs, symptoms, microbiological and radiographic data, and therapeutic results were studied in 170 hospitalized patients between 1978 and 2001 - females 62.4%, males 37.6%, and aged from 12 to 88 years (mean age 36.8 yrs). previous history of pneumonia in childhood was detected in 52.5% of the patients, tuberculosis in 19.8%; 8.8% had bronchial asthma, and 2 had kartagener's syndrome. results: the most common symptoms were cough (100.0%), expectoration (96.0%) and pulmonary rales (66.0%). the pulmonary lesions were unilateral in 46.5% of the cases. pneumococcus, h. influenzae or mixed flora were found in 85.0% of the examined sputa. all 170 patients received antibiotics and postural drainage, and 88 of them (younger and with a higher functional reserve) were also submitted to pulmonary resections (82 unilateral and 6 bilateral). two deaths occurred, and repetitive hospitalizations were more frequent among the clinically treated patients. the follow up showed that most of the surgically treated patients had significant symptoms improvement and rarely needed to be re-hospitalized. conclusions: in the majority of the patients, lung resection surgery improved permanently the prolonged bronchopulmonary symptoms of patients with bronchiectasis, differently from the patients who received only clinical treatment.
As novas perspectivas do transplante de pulm o: da preserva o convencional à perfus o pulmonar ex vivo com recondicionamento pulmonar New perspectives in lung transplantation: from conventional preservation to ex vivo lung perfusion and lung reconditioning
Paulo Francisco Guerreiro Cardoso
Jornal Brasileiro de Pneumologia , 2009, DOI: 10.1590/s1806-37132009001100001
Termoplastia br?nquica: relato do primeiro tratamento endoscópico de asma na América Latina
Rubin, Adalberto Sperb;Cardoso, Paulo Francisco Guerreiro;
Jornal Brasileiro de Pneumologia , 2008, DOI: 10.1590/S1806-37132008000100011
Abstract: bronchial thermoplasty is a new bronchoscopic procedure that delivers radiofrequency energy to the airway and potentially reduces the smooth muscle-mediated bronchoconstriction. we report the case of a 48-year-old man with persistent moderate asthma submitted to bronchial thermoplasty. the treatment increased the forced expiratory volume in one second, increased the number of symptom-free days, reduced the use of relief medications, and improved the juniper asthma quality of life scale score. in this patient, bronchial thermoplasty was well tolerated and safe. this was the first bronchial thermoplasty performed in latin america. at 12 months after the procedure, the results were encouraging in terms of its potential benefits in patients with difficult-to-control asthma.
Termoplastia br?nquica em asma
Rubin, Adalberto Sperb;Cardoso, Paulo Francisco Guerreiro;
Jornal Brasileiro de Pneumologia , 2010, DOI: 10.1590/S1806-37132010000400018
Abstract: currently available treatments for asthma provide satisfactory control of the disease in most cases. however, a significant number of patients do not respond to such treatments (i.e., do not achieve effective symptom relief). one novel approach to treating asthma is bronchial thermoplasty, in which the airway smooth muscle is specifically and directly treated. this procedure delivers radiofrequency energy to the airways in order to reduce smooth muscle-mediated bronchoconstriction. in this article, we present the thermoplasty technique, summarizing the results of the major randomized clinical trials of the procedure, as well as discussing its mechanisms of action and potential adverse effects. we also propose strategies for the future clinical use of this new treatment.
Carcinoma mucoepidermóide
Jornal de Pneumologia , 2002, DOI: 10.1590/S0102-35862002000600009
Abstract: mucoepidermoid carcinoma is an uncommon neoplasm of the tracheobronchial tree, of unknown etiology. its preferred endobronchial location often results in respiratory symptoms such as obstruction of the airways and lung diseases of slow recovery. they usually are slow growing tumors although they may present an aggressive behavior with local invasion and lymph node metastases depending on their histopathologic characteristics. the mainstay therapy is complete surgical resection either by means of lobectomy or by lung sparing procedures such as bronchotomy and bronchoplasty. prognosis depends upon the degree of cellular differentiation of the tumors. the authors report a case of this rare neoplasia and describe the clinical and radiographic characteristics, and the surgical treatment.
Ventila??o líquida: revis?o da literatura
Jornal de Pneumologia , 2002, DOI: 10.1590/S0102-35862002000600011
Abstract: new methods of ventilation are being studied in different settings of pulmonary insufficiency in which the ultimate goal is to improve gas exchange and to minimize aggression to the lung parenchyma. the use of liquid perfluorocarbons administered directly in the airways has been ostensibly studied in pulmonary lesion models and in some clinical essays with good results relating to gas exchange, ventilatory mechanics, and anti-inflammatory properties. pfcs are substances with low surface tension, high density, they are not soluble in water, and allow for high diffusion of oxygen and carbonic gas. they act by recruiting collapsed alveoli, improving the gas exchange, protecting pulmonary architecture, and they wash out alveoli debris. this review article focuses on the different liquid ventilation strategies with perfluorocarbons, and provides information on the state of the art of liquid ventilation.
Ventila o líquida: revis o da literatura
Jornal de Pneumologia , 2002,
Abstract: Atualmente, novas alternativas de ventila o têm sido estudadas em quadros de insuficiência respiratória, com o objetivo de melhorar a oxigena o e minimizar a agress o ao parênquima pulmonar. A utiliza o de perfluorocarbonos líquidos administrados diretamente na via aérea vem sendo ostensivamente estudada em modelos de les o pulmonar e em alguns ensaios clínicos, demonstrando bons resultados com rela o à troca gasosa, mecanica ventilatória e propriedades antiinflamatórias. Os PFCs s o substancias que possuem baixa tens o superficial, alta densidade, s o insolúveis em água, além de permitirem alta difus o de oxigênio e gás carb nico. Esses compostos atuam recrutando alvéolos colapsados, melhorando a oxigena o, protegendo a arquitetura pulmonar e atuando como carreadores de impurezas, limpando a superfície alveolar de resíduos da degrada o celular. Neste artigo de revis o s o apresentadas as diferentes modalidades ventilatórias com perfluorocarbonos e fornecidas informa es sobre a utiliza o e o estado atual da ventila o líquida.
Carcinoma mucoepidermóide
Jornal de Pneumologia , 2002,
Abstract: O carcinoma mucoepidermóide é uma neoplasia infreqüente da árvore traqueobr nquica e de etiologia ainda indeterminada. Sua localiza o endobr nquica preferencial freqüentemente causa sintomas respiratórios obstrutivos e pneumopatias de resolu o lenta. Normalmente, s o tumores de crescimento lento, mas que podem apresentar comportamento agressivo, com invas o local e metástases para linfonodos, dependendo das suas características histopatológicas. O tratamento de elei o é o cirúrgico, com ressec o completa, seja através de lobectomia ou broncotomia e broncoplastia. O prognóstico dependerá do grau de diferencia o celular desses tumores. Relata-se um caso dessa rara neoplasia descrevendo suas características clínicas, radiológicas e o tratamento cirúrgico.
Modifica??o da técnica de alotransplante pulmonar unilateral em ratos*
Sánchez, Pablo Gerardo;Martins, Lucas Krieger;Martins, Frederico Krieger;Schimer, Ricardo;Cardoso, Paulo Francisco Guerreiro;Andrade, Cristiano Feijó;
Jornal Brasileiro de Pneumologia , 2007, DOI: 10.1590/S1806-37132007000400015
Abstract: the increasing demand in transplantation research requires efficient and less expensive animal models in order to obtain reliable results that are reproducible in larger animal models and, ultimately, applied clinically. the model of unilateral left lung transplantation in rats has proven to be a useful alternative for those purposes. we demonstrate a technical modification of this model, which consists of the isolation and ligation of the contralateral (right) pulmonary artery, allowing blood circulation exclusively in the transplanted lung. this model is feasible and reproducible. however, the short survival time restricts the assessment of the transplanted lung to a maximum period of three hours.
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