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Search Results: 1 - 10 of 43541 matches for " Paulo Camara Marques Pereira "
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Impact of Chagas Disease on Human Evolution: The Challenges Continue  [PDF]
Elaine Cristina Navarro, Paulo Camara Marques Pereira
Advances in Anthropology (AA) , 2013, DOI: 10.4236/aa.2013.34A001

Chagas disease affects 8 to 10 million people worldwide and, although most of them live in Latin America, there has been an increase in cases occurring in countries of Europe and North America although most of them live in Latin America. This study aims to describe the epidemiological situation in the present as well as government and research centers actions, particularly the study group of Chagas disease of the School of Medicine of Botucatu (FMB/UNESP)/Brazil.

Nutritional and Dietetic Profile of individuals with hepatitis C Perfil nutricional e dietético de indivíduos com hepatite C
Clisia Mara Carreira,Paulo Camara Marques Pereira
Semina : Ciências Biológicas e da Saúde , 2011,
Abstract: The aim of this study was to evaluate the dietary intake and the nutritional status of individuals infected with Hepatitis C virus both with and without antiviral treatment. The individuals were consisted of data into three groups: The Control Group (G1): 26 healthy individuals, Group 2 (G2): 30 individuals infected with hepatitis C without antiviral treatment and Group 3 (G3): 26 individuals with hepatitis C receiving antiviral treatment. The anthropometric index showed that the weight average and % of body fat from G1 and G2, as well as (BMI), Body Mass Index, from G2 and G3 were higher. The AST and ALT values in serum were enhanced at G2 and G3, though this is not a significant difference, considering p < 0,05. The mean energy intake (Kcal/day) and of protein (g/kg/d) was adequate. The carbohydrate mean intake was above the recommended, and % lipids mean was adequate, however G2 had a higher intake of lipids and fibers than G3 being statistically different, yet the amount of fibers intake was below the recommended in all three groups. In conclusion to that, the nutritional status of the individuals with hepatitis C is of overweight with high percent of body fat. This diagnosis can be an important risk factor to cardiovascular diseases and other associated complications besides directly affect the individual quality of life. O presente estudo avaliou a ingest o dietética e o estado nutricional de indivíduos com hepatite C com e sem tratamento antiviral. Os indivíduos participantes foram distribuídos em três grupos amostrais:Grupo Controle (G1) com 26 indivíduos saudáveis, Grupo 2 (G2) com 30 indivíduos com hepatite C sem tratamento antiviral, e Grupo 3 (G3) com 26 indivíduos com hepatite C em tratamento antiviral. Os indicadores antropométricos mostraram que a média de peso e porcentagem de gordura corpórea do G1 e G2 e o índice de massa corpórea do G2 e G3 estavam aumentados. Os valores séricos de ASTe ALT estiveram aumentados no G2 e G3 n o sendo essa diferen a significativa, considerando p < 0,05. A ingest o média energética (Kcal/dia) e de proteína (g/kg/d) estava adequada. O consumo médiode carboidrato foi acima do recomendado e a porcentagem média de lipídeo foi adequado, mas o G2 consumiu mais lipídeo e fibras que o G3 sendo estatisticamente diferentes; entretanto a quantidade defibras ingerida foi abaixo do recomendado nos três grupos. Conclui-se que o estado nutricional dos indivíduos com hepatite C é de sobrepeso. Uma vez tendo elevado percentual de gordura corpórea, essediagnóstico pode ser fator de risco importante para doen as cardiovascu
Microbiota intestinal de indivíduos que sofreram acidente ocupacional com materiais biológicos e que realizaram profilaxia anti-retroviral
Souza, Micheli Evangelista de;Pereira, Paulo Camara Marques;
Revista da Sociedade Brasileira de Medicina Tropical , 2007, DOI: 10.1590/S0037-86822007000600011
Abstract: the aim of this study was to evaluate the intestinal microbiota of individuals who had suffered occupational accidents and had received antiretrovirals. the study group consisted of 23 individuals between 18 and 45 years old, of whom 13 were blood donors and 10 had suffered occupational accidents. intestinal microflora, anthropometry and laboratory tests were evaluated before, after and 30 days after discontinuation of the medication. zidovudine plus lamivudine was used in association with nelfinavir for 70% of the individuals, with efavirenz for 20% and with ritonavir for 10%. nutritional, diet, laboratory and intestinal microbiota abnormalities were analyzed at three times: m1, not more than two days after starting prophylaxis; m2, on the last day of prophylaxis; and m3, 30 days after ending prophylaxis. nausea, vomiting and diarrhea were present in 50% at m2. overweight in 70%, malnutrition and eutrophy in 10% of the individuals remained unchanged during the study. transaminases, triglycerides and ldl-cholesterol because elevated at m2 and normalized 30 days after discontinuation of the medication. there were significant reductions in lactobacillus, bifidobacterium and bacteroides at the three times. the use of antiretrovirals caused a significant impact on the individuals? intestinal microbiota, without recovery after 30 days.
Intestinal microbiota of patients with bacterial infection of the respiratory tract treated with amoxicillin
Monreal, Maria Tereza Ferreira Duenhas;Pereira, Paulo Camara Marques;Lopes, Carlos Alberto de Magalh?es;
Brazilian Journal of Infectious Diseases , 2005, DOI: 10.1590/S1413-86702005000400005
Abstract: the intestinal tract harbors a huge diversity of metabolically-active aerobic and anaerobic bacteria that interact, forming a complex ecosystem. this microbiota has an important role in human metabolism, nutrition, immunity, and protection against colonization by pathogenic microorganisms. several factors can influence the intestinal microbiota; these include age, diet, inflammatory and infectious processes, and the use of antimicrobials. we investigated the influence of bacterial infection of the respiratory tract and of amoxicillin therapy on the normal intestinal microbiota of patients. bacterial infectious processes affecting the respiratory tract were found to influence the intestinal microbiota, significantly decreasing the number of colony-forming units (cfus) of bacteroides spp. and lactobacillus spp. per gram of feces. the use of amoxicillin also influenced the intestinal microbiota, significantly decreasing the cfu of bifidobacterium spp. and lactobacillus spp. /g of feces. changes in the composition of the intestinal microbiota need to be observed, since a decrease in the normal microorganisms can pose a number of hazards for hosts, including decreased resistance to colonization. with proper follow-up, health-care teams can minimize such hazards by implementing suitable therapy- and diet-related measures, thus reducing the occurrence of detrimental effects on the gastrointestinal ecosystem.
Clinical and nutritional profile of individuals with chagas disease
Geraix, Juliana;Ardisson, Lidiane Paula;Marcondes-Machado, Jussara;Pereira, Paulo Camara Marques;
Brazilian Journal of Infectious Diseases , 2007, DOI: 10.1590/S1413-86702007000400008
Abstract: chagas disease (cd), caused by the protozoan trypanossoma cruzi, affects approximately 18 million individuals in the americas, 5 million of which live in brazil. most chronic sufferers have either the indeterminate form of the disease, without organic compromise, or the cardiac or digestive forms. despite the importance of this disease, there is no information on the effect of nutrition on cd evolution. we evaluated the clinical-nutritional profile of individuals with cd treated at the tropical diseases nutrition out-patient clinic of the botucatu school of medicine, unesp. a retrospective cohort study was performed between 2002 and 2006, on 66 patients with serum and parasitological diagnosis of cd. epidemiological, clinical, nutritional, and biochemical data were collected, including gender, age, skin color, smoking, alcoholism, physical activity, weight, stature, body mass index, abdominal circumference, glycemia, and lipid profile. fifty-three percent were male and 47% female; 96% were white skinned. mean age was 49.6±6.36 years. the predominant form was indeterminate in 71%; smoking and drinking were recorded in 23% and 17%, respectively. sedentariness predominated in 83%, and 55% presented increased abdominal circumference. most, 94%, were overweight or obese. the biochemical exams revealed hyperglycemia in 12% and dyslipidemia in 74%. these findings suggest that the chagas population presents co-morbidities and risk factors for developing chronic non-transmissible diseases, including cardiovascular diseases, making cd evolution even worse.
Bezafibrate for the treatment of hypertriglyceridemia in HIV1-infected patients on highly active antiretroviral therapy
Geraix, Juliana;Souza, Micheli Evangelista de;Delatim, Francieli Cristina;Pereira, Paulo Camara Marques;
Brazilian Journal of Infectious Diseases , 2006, DOI: 10.1590/S1413-86702006000300001
Abstract: the use of highly active antiretroviral therapy (haart) in hiv-infected patients has been associated with the development of risk factors for cardiovascular diseases (cd) including dyslipidemia and insulin resistance, hypertriglyceridemia being the most frequent metabolic disturbance in these patients. fibrates are indicated when hypertriglyceridemia is accentuated and persists for over six months. we evaluated the efficacy and safety of bezafibrate for the treatment of hypertriglyceridemia in hiv-infected individuals on haart. all patients received 400mg/day of bezafibrate and were evaluated three times: mo (pre-treatment), m1 (one month after treatment), and m2 (six months after treatment). fifteen adult individuals, eight males and seven females with mean age = 41.2 ± 7.97 years and triglyceride serum levels > 400mg/dl were included in the study. smoking, alcohol ingestion and sedentarism rates were 50%, 6.66% and 60%, respectively. family history of cd, hypertension and diabetes mellitus was reported in 33.3%, 40% and 46.7% of the cases, respectively, while dyslipidemia was reported by only 13.3%. more than half of the patients were using a protease inhibitor plus a nucleotide analog transcriptase inhibitor. eutrophy and tendency toward overweight were observed at all three study time points. there were significant reductions in triglyceride serum levels from mo to m1 and from mo to m2. no significant changes were observed in the serum levels of creatine phosphokinase, hepatic enzymes, cd4+, cd8+ and viral load. therefore, bezafibrate seems to be safe and effective for the reduction of hypertriglyceridemia in hiv-infected patients on haart.
Evaluation of nutritional status in patients with endemic pemphigus foliaceus
Barraviera, Silvia Regina C. Sartori;Dillon, Neuza Lima;Curi, Paulo Roberto;Pereira, Paulo Camara Marques;Almeida, Dinah Borges de;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1995, DOI: 10.1590/S0036-46651995000100008
Abstract: sixteen patients with endemic pemphigus foliaceus were submitted to nutritional evaluation. ten had the localized form of the disease (group g1) and six the disseminated form (group g2). the patients were submitted to anthropometric measurements (weight, height, quetelét index, tricipital skin fold, subscapular skin fold, arm circumference, arm muscle circumference, arm area, arm muscle area, and arm adipose area) and to laboratory evaluation by protein electrophoresis. arm circumference, arm area and arm muscle area showed lower values in g2 than in g1. weight and arm muscle circumference tended to the lower in g2 than in g1. protein electrophoresis showed decreased albumin levels in both groups, with lower values in g2. overall analysis of the results permits us to conclude that patients with endemic pemphigus foliaceus present signs and symptoms of protein, but not calorie, malnutrition and that this malnutrition is more marked in patients with disseminated pemphigus foliaceus.
Paulo Marques,Potiguara Pereira
Revista do Departamento de Geografia , 1997, DOI: 10.7154/rdg.v0i11.188
Bayesian Analysis of Simple Random Densities  [PDF]
Paulo C. Marques F., Carlos A. de B. Pereira
Open Journal of Statistics (OJS) , 2014, DOI: 10.4236/ojs.2014.45037

A tractable nonparametric prior over densities is introduced which is closed under sampling and exhibits proper posterior asymptotics.

Predictive Analysis of Microarray Data  [PDF]
Paulo C. Marques F., Carlos A. de B. Pereira
Open Journal of Genetics (OJGen) , 2014, DOI: 10.4236/ojgen.2014.41009

Microarray gene expression data are analyzed by means of a Bayesian nonparametric model, with emphasis on prediction of future observables, yielding a method for selection of differentially expressed genes and the corresponding classifier.

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