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Search Results: 1 - 10 of 12519 matches for " Paula Prazeres; "
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How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer
Hugo Prazeres,Joana Torres,Fernando Rodrigues,Joana P. Couto,Jo?o Vinagre,Manuel Sobrinho-Sim?es,Paula Soares
Journal of Thyroid Research , 2011, DOI: 10.4061/2011/678357
Abstract: The significance of RET in thyroid cancer comes from solid evidence that, when inherited, an RET activating mutation primes C-cells to transform into medullary carcinomas. Moreover, environmental exposure to radiation also induces rearranged transforming RET “isoforms” that are found in papillary thyroid cancer. The RET gene codes for a tyrosine kinase receptor that targets a diverse set of intracellular signaling pathways. The nature of RET point mutations predicts differences in the mechanisms by which the receptor becomes activated and correlates with different forms of clinical presentation, age of onset, and biological aggressiveness. A number of RET-targeting Tyrosine Kinase Inhibitors (TKIs) are currently undergoing clinical trials to evaluate their effectiveness in the treatment of thyroid cancer, and it is conceivable that the RET genotype may also influence response to these compounds. The question that now emerges is whether, in the future, the rational for treatment of refractory thyroid cancer will be based on the management of an abnormal RET signal. In this paper we address the RET-targeting TKIs and review studies about the signaling properties of distinct RET mutants as a means to predict response and design combinatorial therapies for the soon to be available TKIs. 1. The RET Tyrosine Kinase Receptor Targets a Diverse Spectrum of Intracellular Signaling Pathways RET (Rearranged during Transfection) encodes a membrane receptor tyrosine kinase (RTK) composed of four extracellular cadherin-like motifs and a cysteine-rich region, a transmembrane portion, and an intracellular domain with tyrosine kinase activity [1]. The RET signaling pathways are outlined in (Figure 1). RET signals through a ligand/coreceptor/RET multiprotein complex instead of the usual receptor/ligand binding. To date, several ligands of the glial-derived neurotrophic factor (GDNF) family, which include GDNF, artemin, neurturin, and persephin and a family of GPI-linked RET coreceptors (GFR1-4), have been identified [2]. The formation of ligand/coreceptor and RET complexes results in RET dimerization and triggers autophosphorylation at intracellular tyrosine residues. Phosphorylated tyrosine 687 (Y687), serine 696 (S696), Y752, Y791, Y806, Y809, Y826, Y864, Y900, Y905, Y928, Y952, Y981, Y1015, Y1029, Y1062, Y1090, and Y1096 constitute docking sites for numerous intracellular adaptor proteins such as RAC1-guanine exchange factor (GEF) [3], growth factor receptor-bound (GRB) docking proteins GRB7/10 [4], chicken Rous sarcoma virus oncogene (c-Src), focal adhesion kinase
Prevalência baixa de adenovírus em crian?as com diarreia em Belo Horizonte-MG
Duarte, Ricardo Jenner;Mendes, Edilberto Nogueira;Penna, Francisco José;Péret Filho, Luciano Amedée;Magalh?es, Paula Prazeres;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2012, DOI: 10.1590/S1676-24442012000400005
Abstract: introduction: several microorganisms, among them enteric adenovirus, are widely recognized as etiological agents of acute diarrhea. the association between adenovirus and the disease varies among geographical regions and is poorly known in brazil. objectives: to investigate the presence of adenovirus in stool samples from children with and without diarrhea in belo horizonte-mg. to study factors associated with enteric adenovirus infection. material and method: a qualitative immunochromatographic assay (kit vikia? rota-adeno, biomérieux) was performed to detect adenovirus antigens in stool samples from 268 children with acute diarrhea and 124 without diarrhea at hospital infantil jo?o paulo ii from january/2005 to december/2006. clinical, laboratory, and epidemiologic data were recorded in spss database (spss statistical package, ibm). results: adenovirus was detected in 16 samples (4.1%): 12 of them (4.5%) were from children with acute diarrhea and 4 of them (3.2%) from children without diarrhea. the viral infection was more prevalent among girls and the age distribution was homogenous. among the 16 children infected by adenovirus,11 (68.8%) were younger than 12 months old. however, no significant statistical difference was observed within the analyzed parameters. there was no seasonal distribution of adenovirus infection. conclusion: our data demonstrate that the prevalence of enteric adenovirus infection is low among children with diarrhea in belo horizonte-mg.
Associa o entre cagA e alelos do vacA de Helicobacter pylori e úlcera duodenal em crian as no Brasil
Ashour Abdussalam Ali Ramadam,Gusm?o Valquíria Ribeiro de,Magalh?es Paula Prazeres,Collares Guilherme Birchal
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2002,
Abstract: Helicobacter pylori é o principal agente de gastrite em seres humanos e fator de risco para úlcera péptica e cancer gástrico. A evolu o da infec o está relacionada a diversos fatores, inclusive bacterianos, como presen a de cagA e genótipo s1-m1 do vacA, associados com o desenvolvimento de úlcera e adenocarcinoma gástrico. O objetivo deste estudo foi investigar a associa o entre cagA e alelos do vacA em H. pylori isolado de crian as e relacionar os achados com a doen a apresentada pelo paciente. Foram estudadas 65 crian as (24 com úlcera duodenal e 41 sem úlcera gástrica ou duodenal). A pesquisa de cagA e de alelos do vacA foi feita por PCR em amostras da bactéria isoladas do est mago dos pacientes. Infec o mista foi identificada em dez (15,4%) crian as. Entre os pacientes com monoinfec o, o alelo s1 foi detectado em amostras isoladas de 40 (72,7%), e o m1 em 34 (61,8%). CagA foi identificado em H. pylori isolado de 38 (69,1%) pacientes. Foi observada associa o entre presen a de cagA e de genótipo s1-m1 (p = 10-7) e entre cagA e padr o s1-m1 com úlcera duodenal (p = 0,073 e p = 0,037, respectivamente). Em conclus o, infec o mista por H. pylori é comum em crian as brasileiras, e amostras da bactéria apresentando o alelo s1 e cagA s o as mais prevalentes no nosso meio. A concomitancia do alelo s1 do vacA e de cagA foi freqüentemente observada, e a associa o de amostras positivas de s1 e de cagA com úlcera duodenal foi confirmada neste trabalho.
Prevalence of Salmonella enterica in children aged less than 5 years with acute diarrhea and controls in Teresina-PI
Nunes, Maria do Rosário Concei??o Moura;Mendes, Edilberto Nogueira;Nunes, Jo?o Maurício Moura;Magalh?es, Paula Prazeres;Penna, Francisco José;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2012, DOI: 10.1590/S1676-24442012000200006
Abstract: we investigated the prevalence of salmonella enterica (se) among children (n = 400/250 with diarrhea) in teresina-pi from 2004 to 2007. se newport was isolated from two samples and o-c2-c3-nd, enteritidis, and muenchen serological variants were isolated from one sample each. se infection was more prevalent among children aged less than six months. increased fecal volume, 3-10 evacuations/day, vomit and fever were reported for all cases. resistance to nalidixic acid (nal) and sulphamethoxazole-trimethoprim (sxt) was ubiquitous. our data substantiate the need for monitoring se infections worldwide and the emergence of antimicrobial resistance.
Shigella in Brazilian children with acute diarrhoea: prevalence, antimicrobial resistance and virulence genes
Sousa, Mireille ?ngela Bernardes;Mendes, Edilberto Nogueira;Collares, Guilherme Birchal;Péret-Filho, Luciano Amedée;Penna, Francisco José;Magalh?es, Paula Prazeres;
Memórias do Instituto Oswaldo Cruz , 2013, DOI: 10.1590/S0074-02762013000100005
Abstract: diarrhoeal disease is still considered a major cause of morbidity and mortality among children. among diarrhoeagenic agents, shigella should be highlighted due to its prevalence and the severity of the associated disease. here, we assessed shigella prevalence, drug susceptibility and virulence factors. faeces from 157 children with diarrhoea who sought treatment at the children's hospital jo?o paulo ii, a reference children′s hospital in belo horizonte, state of minas gerais, brazil, were cultured and drug susceptibility of the shigella isolates was determined by the disk diffusion technique. shigella virulence markers were identified by polymerase chain reaction. the bacterium was recovered from 10.8% of the children (88.2% shigella sonnei). the ipah, iuc, sen and ial genes were detected in strains isolated from all shigellosis patients; set1a was only detected in shigella flexneri. additionally, patients were infected by shigella strains of different ial, sat, sen and set1a genotypes. compared to previous studies, we observed a marked shift in the distribution of species from s. flexneri to s. sonnei and high rates of trimethoprim/sulfamethoxazole resistance.
Antimicrobial resistance and plasmid detection in strains of the Bacteroides fragilis group
Avila-Campos, Mario Julio;Carvalho, Maria Auxiliadora Roque de;Magalh?es, Paula Prazeres;Damasceno, Carlos Américo Veiga;Chartone-Souza, Edmar;Cisalpino, Eduardo Osório;
Revista do Instituto de Medicina Tropical de S?o Paulo , 1993, DOI: 10.1590/S0036-46651993000100016
Abstract: resistant populations of the bacteroides fragilis group bacteria (two reference ones and two isolated from human and callithrix penicillata marmoset) were obtained by the gradient plate technique, to clindamycin, penicillin g, metronidazole and mercuric chloride. all the four tested strains were originaly susceptible to the four antimicrobial drugs at the breakpoint used in this study. mics determination for the four cultures gave constant values for each antimicrobial, on the several steps by the gradient plate technique. the intestinal human b. fragilis strains showed three dna bands, that could be representative of only two plasmids in the closed covalently circular (ccc) form with molecular weights of approximately 25 and 2.5 md. the results do not permit an association between the presence of plasmid in the human strain with the susceptibility to the studied drugs. the four strains were ?-lactamase negative in the two methods used, and no particular chromosomal genetic resistance marker was demonstred. the resistance (mic) observed, after contact with penicillin g and mercuric chloride, were two-fold in the four tested strains
Analysis of Functional Capacity and Postural Balance in Former Cutters Cane  [PDF]
Kaliane Pamponet Prazeres Bomfim, Jaqueline Silva Veloso, Mabel Barbosa Esteves
Occupational Diseases and Environmental Medicine (ODEM) , 2018, DOI: 10.4236/odem.2018.62005
Abstract: Background: Large-scale cane cultivation can promote health impacts of workers, resulting from weight bearing and repetitive movements. Musculoskeletal conditions can alter balance and increase risk of falls. Aim of Work: The objective of this study is to identify clinical characteristics and to correlate balance with functional capacity in ex-cane cutters. Methods: This was a descriptive exploratory study, 42 former workers of the cane cut, with mean age of 49 (±13) years, who were submitted to balance evaluation through the Berg Balance Scale (BSE) and the functional capacity was evaluated by the Incremental Shuttle Walk Test (ISWT). To investigate respiratory symptoms, the Medical Research Council questionnaire was used. Results: The individuals reached a mean of 52 points in BSE, considered low to moderate risk for falls and the average distance traveled of 446.2 (±188.5) meters, corresponding to 52.9% (±23.1) of the normal distance. Weak and negative correlations were found between changes in balance and exposure time (r2-0.16). Conclusion: It is concluded that excessive physical effort contributes to changes in the balance and, consequently, diminish functional capacity.
Asymptotics and regularity of flat solutions to fully nonlinear elliptic problems
Disson dos Prazeres,Eduardo Teixeira
Mathematics , 2013,
Abstract: In this work we establish local $C^{2,\alpha}$ regularity estimates for flat solutions to non-convex fully nonlinear elliptic equations provided the coefficients and the source function are of class $C^{0,\alpha}$. For problems with merely continuous data, we prove that flat solutions are locally $C^{1,\text{Log-Lip}}$.
Associa??o entre cagA e alelos do vacA de Helicobacter pylori e úlcera duodenal em crian?as no Brasil
Ashour, Abdussalam Ali Ramadam;Gusm?o, Valquíria Ribeiro de;Magalh?es, Paula Prazeres;Collares, Guilherme Birchal;Mendes, Edilberto Nogueira;Queiroz, Dulciene Maria de Magalh?es;Rocha, Gifone Aguiar;Rocha, Andreia Maria Camargos;Carvalho, Anfrisina Sales Teles;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2002, DOI: 10.1590/S1676-24442002000200003
Abstract: helicobacter pylori is now accepted as the most important agent of gastritis in humans and as a risk factor for ulcer disease and gastric carcinoma ethiopathogenesis. the outcome of the infection is associated with several factors, among them bacterial ones such as caga and vaca s1 genotype. we aimed to investigate the association between caga and vaca genotypes in h. pylori strains isolated from children and to correlate these findings with patient's disease. a total of 65 children (24 with duodenal ulcer and 41 without gastric or duodenal ulcer) were included in the study. caga and vaca alleles were identified by pcr in bacterium strains isolated from the gastric mucosa of the studied group. multiple-strain infection was detected in 10 (15.4%) patients. among children with nonmixed infection, s1 allele was found in h. pylori strains isolated from 40 (72.7%), and m1 allele in strains obtained from 34 (61.8%). caga was found in bacterium strains isolated from 38 (69.1%) patients. association between caga and s1-m1 genotype (p = 10-7), and between these genotypes and duodenal ulcer (p = 0.073 and p = 0.037, respectively) was observed. in conclusion, multiple-strain infection is frequent in brazilian children. h. pylori strains harbouring, simultaneously, caga and vaca s1-m1 genotypes are the most frequent in our pediatric population and are associated to ulcer disease.
Na costura do sapato, o desmanche das operárias: estudo das condi??es de trabalho e saúde das pespontadeiras da indústria de cal?ados de Franca, S?o Paulo, Brasil
Prazeres, Taísa Junqueira;Navarro, Vera Lucia;
Cadernos de Saúde Pública , 2011, DOI: 10.1590/S0102-311X2011001000006
Abstract: this study aimed to analyze associations between working conditions and health problems reported by women workers assigned to mechanical stitching in the footwear industry in franca, s?o paulo state, brazil. the qualitative study's theory and methodology were based on historical and dialectical materialism and combined sociological and ethnographic research techniques. data were collected with taped interviews, focusing on the workers' life and work stories, systematic observation of the work process, consultation of historical documents, and imagistic production. analysis of the data revealed the effects of work in mechanical stitching on the health of women workers employed in the factory and at home, who experience precarious labor conditions involving workday intensification and extension, preset production targets, job insecurity, and unhealthy workplaces.
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