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Search Results: 1 - 10 of 33546 matches for " Paula Alejandra Boero;Cristina "
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Conceito de responsabilidade social de gestores e empregados
Lom?naco, José Fernando Bitencourt;Cabral, Caio Parada;Ulasowicz, Carla;Quinelato, Patrícia Thomasio;Villagran, Paula Alejandra Boero;Cristina, Tereza;Zampieri, Rangel Credidio;
Psicologia: Ciência e Profiss?o , 2012, DOI: 10.1590/S1414-98932012000100016
Abstract: this research evaluated the conception of social responsibility of employees and administrators from some companies that participate in the national politics of integration of the person with disability. the subjects were 57 people divided into two groups: employees and administrators. the group of administrators was formed by 19 professionals of human resources and the group of employees was formed by 38 professionals with disability. the subjects were asked to write associations related to social responsibility in 90 seconds. the responses were grouped in eight categories: concern about the environment, social inclusion, solidarity, respect, social compromise, positive feelings and attitudes, collectivity and other responses. the chi-squared statistical analysis allowed the rejection of the null hypothesis with a high level of probability. it was checked that the bigger number of responses related to the concept of social responsibility was concentrated in social inclusion, positive feelings and attitudes and concern about the environment categories that, together, represented a little more than the half (52%) of the total responses. aiming to evaluate the association degree between the administrators’ and the employees’ responses the spearman’s rank-order correlation coefficient was calculated. the results allowed the identification of a net of concepts related to the concept of social responsibility, as it was foreseen by one of the theories of concept formation: the theoretical vision.
Valores y actitudes socialmente responsables en universitarios chilenos
Gracia Navarro,Paula Boero,Gladys Jiménez,Liliana Tapia
Calidad en la Educación , 2012,
Abstract: Socially-responsible values and attitudes in Chilean universitystudentsGracia Navarro,1 Paula Boero,2 Gladys Jiménez,3 Liliana Tapia,4 Reinier Hollander,5 Arturo Escobar,6 Margarita Baeza,7 álvaro EspinaABSTRACTAs a contribution to comprehension of the socially responsible behaviour in college students, this study tries to identify their values and attitudes towards social responsibility; to determine differences according to gender, promotion and career areas and to identify the relationship among values, attitudes towards social responsibility and a socially responsible behaviour. It surveyed 2.876 students from six Chilean universities by CAVSR and CACSR (Project MECESUP UCO0303, 2004-2008).Results show a very positive and significant relation among values, attitudes and socially responsible behaviour, commitment with values and attitudes that are closer to college student experiences andless commitment with those linked to social wellbeing, citizenship, democracy and participation. There are significant differences according to gender, promotion and career areas. As a conclusion, there is a need to stimulate educational practices that activate less preponderant values and promote positive attitudes towards them in order to achieve a social responsibility full exercise.Keywords: values, attitude, social responsibility, college students1 Universidad de Concepción. Concepción, Chile. Contacto: gnavarro@udec.cl2-7 Universidad de La Frontera3 Pontificia Universidad Católica de Valparaíso4 Universidad de Valparaíso5 Universidad del Bío-Bío6 Universidad Austral de Chile
A Mitochondrial Kinase Complex Is Essential to Mediate an ERK1/2-Dependent Phosphorylation of a Key Regulatory Protein in Steroid Biosynthesis
Cecilia Poderoso, Daniela P. Converso, Paula Maloberti, Alejandra Duarte, Isabel Neuman, Soledad Galli, Fabiana Cornejo Maciel, Cristina Paz, María C. Carreras, Juan J. Poderoso, Ernesto J. Podestá
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0001443
Abstract: ERK1/2 is known to be involved in hormone-stimulated steroid synthesis, but its exact roles and the underlying mechanisms remain elusive. Both ERK1/2 phosphorylation and steroidogenesis may be triggered by cAMP/cAMP-dependent protein kinase (PKA)-dependent and-independent mechanisms; however, ERK1/2 activation by cAMP results in a maximal steroidogenic rate, whereas canonical activation by epidermal growth factor (EGF) does not. We demonstrate herein by Western blot analysis and confocal studies that temporal mitochondrial ERK1/2 activation is obligatory for PKA-mediated steroidogenesis in the Leydig-transformed MA-10 cell line. PKA activity leads to the phosphorylation of a constitutive mitochondrial MEK1/2 pool with a lower effect in cytosolic MEKs, while EGF allows predominant cytosolic MEK activation and nuclear pERK1/2 localization. These results would explain why PKA favors a more durable ERK1/2 activation in mitochondria than does EGF. By means of ex vivo experiments, we showed that mitochondrial maximal steroidogenesis occurred as a result of the mutual action of steroidogenic acute regulatory (StAR) protein –a key regulatory component in steroid biosynthesis-, active ERK1/2 and PKA. Our results indicate that there is an interaction between mitochondrial StAR and ERK1/2, involving a D domain with sequential basic-hydrophobic motifs similar to ERK substrates. As a result of this binding and only in the presence of cholesterol, ERK1/2 phosphorylates StAR at Ser232. Directed mutagenesis of Ser232 to a non-phosphorylable amino acid such as Ala (StAR S232A) inhibited in vitro StAR phosphorylation by active ERK1/2. Transient transfection of MA-10 cells with StAR S232A markedly reduced the yield of progesterone production. In summary, here we show that StAR is a novel substrate of ERK1/2, and that mitochondrial ERK1/2 is part of a multimeric protein kinase complex that regulates cholesterol transport. The role of MAPKs in mitochondrial function is underlined.
Graves’ Disease as a Late Manifestation of Immune Reconstitution Syndrome after Highly Active Antiretroviral Therapy in an HIV-1 Infected Patient  [PDF]
Evelin Mingote, Agustina Urrutia, Alejandra Viteri, Cristina Faingold, Carla Musso
World Journal of AIDS (WJA) , 2013, DOI: 10.4236/wja.2013.33024

Context: Highly active antiretroviral therapy (HAART) inhibits the HIV replication and consequently increases CD4 levels and decreases viral load. This immune system improvement can trigger various immunological phenomena, entity called Immune Reconstitution Syndrome (IRS). Graves’ disease is a late Immune Reconstitution consequence. Patient: We report the case of a 48 years old man with HIV infection who developed Graves’ disease three years after he was on effective HAART because of the Immune Reconstitution Syndrome. At presentation he had a very low CD4 T-cell count (17 cells/μL). When he started HAART he presented a lipodystrophy syndrome. HAART was changed because of the persistent low CD4-T cells count (less than 100 cell/μL). Afterwards serum lipid levels began to decrease and that was the first manifestation of Graves’ disease, which was diagnosed when CD4 T-cells increased up to 343 cell/μL. Our patient developed Graves’ disease 36 months after initiating effective HAART with protease inhibitors which was coincident with viral suppression and a rise of CD4 T cells. Conclusion: The most immunosuppressed patients with a CD4 T cell count less than 100 cells/μL are at greatest risk for the development of Immune Reconstitution Syndrome after HAART initiation. We conclude that clinicians will have to consider the importance of the early diagnosis of thyroid disease to bring an adequate treatment.

Nutritional Composition of Ten Persimmon Cultivars in the “Ready-to-Eat Crisp” Stage. Effect of Deastringency Treatment  [PDF]
Pedro Novillo, Cristina Besada, Li Tian, Almudena Bermejo, Alejandra Salvador
Food and Nutrition Sciences (FNS) , 2015, DOI: 10.4236/fns.2015.614135
Abstract: Traditionally persimmons have been consumed over-ripened to avoid astringency perception. However, the introduction of new technology that removes astringency while preserving fruit firmness has allowed the commercialization of “ready-to-eat crisp” fruits. Several studies have evaluated the nutritional composition of over-ripened persimmons and have claimed that they are a good source of primary and secondary metabolites that are favourable for human health. Yet very little is known about the nutritional composition of persimmons in the “ready-to-eat crisp” stage. In this context, we determined the main nutritional compounds in ten popular persimmon cultivars, including astringent cultivars (“Rojo Brillante”, “Tone Wase”, “Giboshi”, “Kaki Tipo”, “Aizumishirazu-A”, “Giombo”, “Hachiya”) and non-astringent cultivars (“O’gosho”, “Hana Fuyu” and “Jiro”). To this end, fruits were harvested when their texture was firm, and soluble polyphenols content, total antioxidant capacity and main sugars, organic acids and carotenoids were evaluated. In those astringent cultivars at harvest, the changes in nutritional compounds associated with applying deastringency treatment with high CO2 concentration were determined. Our results revealed the main sugars (glucose, fructose and sucrose), organic acids (citric acid, malic acid and succinic) and carotenoids (β-cryptoxanthin, lutein, violoxanthin, zeaxanthin, and β-carotene) present in the flesh of crisp persimmons. At harvest the content of these metabolites vastly varied among cultivars; astringent cultivars showed higher soluble polyphenols and greater antioxidant capacity, and presented higher contents of sugars and organic acids than non-astringent ones. The deastringency treatment applied to astringent cultivars resulted in a drastic loss of soluble polyphenols and total antioxidant capacity, and induced changes in carotenoids and sugars composition.
The Study of Species in the Era of Biodiversity: A Tale of Stupidity
Ferdinando Boero
Diversity , 2010, DOI: 10.3390/d2010115
Abstract: Research policies ensuing from the Convention on Biological Diversity made huge funds available to study biodiversity. These were mostly dedicated to projects aimed at providing services to taxonomy via information and technology, or to develop “modern”, i.e., molecular, approaches to taxonomy. Traditional taxonomy was overly neglected and is in serious distress all over the world. It is argued that both novel and traditional ways to study biodiversity are essential and that the demise of traditional taxonomy (based on phenotypes) in the era of biodiversity is the result of an unwise policy, mainly fostered by portions of the scientific community that aim at taking total advantage of the funds dedicated to the study of biodiversity.
Appointing university professors in Italy, the need for a change
Boero F
Forest@ , 2008, DOI: -
Abstract: The Italian university system is in crisis due to unwise policies, both in the recruitment of professors and in the design of curricula. Professors are appointed by careful procedures privileging formal accomplishments and disregarding substance. The reform of university curricula lowered the quality of undergraduate courses, re-aligning them with those of other countries, but this was not counterbalanced by a parallel upgrade of Italian PhD courses.
Information and technology are not enough: we need also knowledge and science.
Ferdinando Boero
SCIRES-IT : SCIentific RESearch and Information Technology , 2011, DOI: 10.2423/i22394303v1n1p3
Abstract: En The era of Information and Technology has changed our life, allowing those who can access an internet connection to consult an almost unlimited number of sites covering almost all topics. It is difficult, however, to distinguish reliable information from unreliable one. The data posted in the web might be very precise while lacking accuracy. It is very important that information is based on solid knowledge, like the one guaranteed by peer-reviewed scientific journals. It is argued, with some examples, that the current policy of Information availability throught the internet is not based on sufficient knowledge. More reliability is available at the sites of scientific journals, but they often require a subscription and enforce copyright restrictions, so hampering the spread of knowledge which is the basis of scientific "publication" (i.e. the delivery of the results of science to the public). It L'era della Tecnologia dell'Informazione ha cambiato la nostra vita, permettendo a chi abbia una connessione internet di consultare un numero illimitato di siti che coprono quasi tutti gli argomenti. E' difficile, tuttavia, distinguere le informazioni attendibili da quelle inattendibili. I dati pubblicati nella rete possono essere molto precisi ma mancare completamente di accuratezza. E' molto importante che le informazioni siano basate su solide conoscenze, come quella garantita dalla revisione dei pari (peer-review) utilizzata dalle riviste scientifiche. Questo lavoro suggerisce, con alcuni esempi, che la politica corrente di disponibilità di informazioni attraverso internet non è basata su sufficiente conoscenza. Una maggiore attendibilità è disponibile sui siti delle riviste scientifiche, ma essi spesso richiedono un abbonamento e impongono restrizioni basate sul copyright, impedendo così la diffusione delle conoscenze che è alla base delle "pubblicazioni" scientifiche (cioè della disponibilità pubblica dei risultati della ricerca scientifica).
Gracia Navarro, Paula Boero, Gladys Jiménez, Liliana Tapia, Reinier Hollander, Arturo Escobar, Margarita Baeza y álvaro Espina
Calidad en la Educación , 2010,
Abstract: This research was aimed to study frequency and intention of socially accountable behaviour in 5515 students from six Chilean universities. It used the CACSR questionnaire (Davidovich, Espina, Navarro, 2005) composed by two scales measuring 10 categories of behaviour and 3 categories of intention. Results showed a low self-attribution of socially accountable behaviour because only one(SocialInteraction) out of these ten categories fulfils the requirements: frequency and benefit for everybody.These results reflect an impoverishment on the identity formation and a devaluation of interpersonal relationships based on ethical considerations of justice and care. Consequently, there is a progressive disinterest in the concept of welfare for everybody and an increasing possibility of social damage. It is critical to implement strategies to counteract the identified weaknesses and promote the formation of responsible citizens for social welfare.
A voz dos quilombos: na senda das vocalidades afro-brasileiras
Vilas, Paula Cristina;
Horizontes Antropológicos , 2005, DOI: 10.1590/S0104-71832005000200009
Abstract: this article presents a reflection on the vocality in traditional cultural performances. the research begun with a fieldwork from 1998 to 2003 in the maroons community of pombal, state of goias, brazil. the starting point is the concept of vocality as formulated by zumthor, embracing orality and an "en-bodied" vocal dimension. the concept of performance as an analytical category, cuts across the fieldwork, the local making, and the result of this research with the accomplishment of a play as a retribution to the community. the classic formulation of austin enables the study of phonematic and sound aspects as meanings, within an "aesthetics of opacity" as pointed by j. j. carvalho. the local vocality will be considered in the field of afro-brazilian vocalities, in the special contingent process of the brazilian state recognizing pombal as a "quilombo", arisen in the salience of the ties established with the community along the research.
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