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Search Results: 1 - 10 of 23633 matches for " Paul Tingey "
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A Needs-Based Rheumatologist Education Program on Treating to Target in Psoriatic Arthritis and Spondyloarthropathy: Insights and Challenges  [PDF]
Janet Pope, Linda Wang, Paul Tingey, Angela Montgomery, Art Karasik, Pauline Boulos, Vandana Ahluwalia, Maggie Larche, Sara Haig, Nikhil Chopra, Gina Rohekar, Sherry Rohekar
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2017, DOI: 10.4236/ojra.2017.71005
Abstract: Objectives: To determine if comparative practice data and education for rheumatologists would change physician behavior for monitoring and treating psoriatic arthritis (PsA) and spondyloarthritis (SpA). Methods: Participating rheumatologists each performed a chart audit on 20 patients with PsA and SpA. Accredited education (determined by a survey and chart audits) and results of chart audits (comparing to other rheumatologists) were provided for each participant (intervention). Eight months later, a repeat chart audit by each participant was conducted on another 20 PsA and SpA patients. Changes in measurements collected, treatment given and patient characteristics pre and post intervention were analyzed. Results: Nine rheumatologists received the intervention. At baseline, most routinely monitored PsA and SpA for clinical and laboratory markers. In PsA, there was no change post-intervention in performing SJC (96%), TJC (91%), ESR (70%), CRP (73%), and CDAI (25%). In SpA, there were increased measurements of inflammatory markers (54% pre vs. 61% post for CRP), more NSAID use and decreased physical exam measures and HAQ but no significant changes. There were no major treatment differences pre and post intervention including NSAIDs, DMARDs and biologics. Conclusions: The rheumatologists frequently performed measurements of disease activity, did not change significantly with educational intervention so there may have been little room for improvement and many patients were already in a low disease state. Calculation of composite scores did not increase in PsA. The validity of physical exam and BASDAI as a measurement of disease activity were noted as concerns in applying a treat-to-target approach in SpA. Significance and Innovation: This study did not show a significant change in behavior for rheumatologists who had education based on care gaps and needs assessment in psoriatic arthritis and spondyloarthropathy. The rheumatologists identified that disease activity is difficult to determine with usual care in SpA and thought some measures lacked validity.
应用生命表进行马铃薯粘腺毛品系对桃蚜抗性的分析
夏基康,WardM.Tingey
南京农业大学学报 , 1986, DOI: 10.7685/j.issn.1000-2030.1986.03.005
Abstract: 桃蚜(Myzuspersicae)有翅型和无翅型所产后代生活在粘腺毛马铃薯杂交后代D888-4、MH_4-5盆栽植株上的存活率、生长历期与生殖力均显著地低于感性对照品种Superior植株。在适温(22―15℃)或高温(33―18℃)下的Superior植株上,有翅型后代的r_m均大于无翅型的后代。在D888-4和MH_4-5上,两蚜型后代的r_m均接近或等于零。
Sequence characterization of hypervariable regions in the soybean genome: leucine-rich repeats and simple sequence repeats
Barros, Everaldo G. de;Tingey, Scott;Rafalski, J. Antoni;
Genetics and Molecular Biology , 2000, DOI: 10.1590/S1415-47572000000200029
Abstract: the genetic basis of cultivated soybean is rather narrow. this observation has been confirmed by analysis of agronomic traits among different genotypes, and more recently by the use of molecular markers. during the construction of an rflp soybean map (glycine soja x glycine max) the two progenitors were analyzed with over 2,000 probes, of which 25% were polymorphic. among the probes that revealed polymorphisms, a small proportion, about 0.5%, hybridized to regions that were highly polymorphic. here we report the sequencing and analysis of five of these probes. three of the five contain segments that encode leucine-rich repeat (lrr) sequence homologous to known disease resistance genes in plants. two other probes are relatively at-rich and contain segments of (a)n/(t)n. dna segments corresponding to one of the probes (a45-10) were amplified from nine soybean genotypes. partial sequencing of these amplicons suggests that deletions and/or insertions are responsible for the extensive polymorphism observed. we propose that genes encoding lrr proteins and simple sequence repeat region prone to slippage are some of the most hypervariable regions of the soybean genome.
Sequence characterization of hypervariable regions in the soybean genome: leucine-rich repeats and simple sequence repeats
Barros Everaldo G. de,Tingey Scott,Rafalski J. Antoni
Genetics and Molecular Biology , 2000,
Abstract: The genetic basis of cultivated soybean is rather narrow. This observation has been confirmed by analysis of agronomic traits among different genotypes, and more recently by the use of molecular markers. During the construction of an RFLP soybean map (Glycine soja x Glycine max) the two progenitors were analyzed with over 2,000 probes, of which 25% were polymorphic. Among the probes that revealed polymorphisms, a small proportion, about 0.5%, hybridized to regions that were highly polymorphic. Here we report the sequencing and analysis of five of these probes. Three of the five contain segments that encode leucine-rich repeat (LRR) sequence homologous to known disease resistance genes in plants. Two other probes are relatively AT-rich and contain segments of (A)n/(T)n. DNA segments corresponding to one of the probes (A45-10) were amplified from nine soybean genotypes. Partial sequencing of these amplicons suggests that deletions and/or insertions are responsible for the extensive polymorphism observed. We propose that genes encoding LRR proteins and simple sequence repeat region prone to slippage are some of the most hypervariable regions of the soybean genome.
Endo-(1,4)-β-Glucanase gene families in the grasses: temporal and spatial Co-transcription of orthologous genes1
Margaret Buchanan, Rachel A Burton, Kanwarpal S Dhugga, Antoni J Rafalski, Scott V Tingey, Neil J Shirley, Geoffrey B Fincher
BMC Plant Biology , 2012, DOI: 10.1186/1471-2229-12-235
Abstract: The endo-(1,4)-β-glucanase gene families from barley (Hordeum vulgare), maize (Zea mays), sorghum (Sorghum bicolor), rice (Oryza sativa) and Brachypodium (Brachypodium distachyon) range in size from 23 to 29 members. Phylogenetic analyses show variations in clade structure between the grasses and Arabidopsis, and indicate differential gene loss and gain during evolution. Map positions and comparative studies of gene structures allow orthologous genes in the five species to be identified and synteny between the grasses is found to be high. It is also possible to differentiate between homoeologues resulting from ancient polyploidizations of the maize genome. Transcript analyses using microarray, massively parallel signature sequencing and quantitative PCR data for barley, rice and maize indicate that certain members of the endo-(1,4)-β-glucanase gene family are transcribed across a wide range of tissues, while others are specifically transcribed in particular tissues. There are strong correlations between transcript levels of several members of the endo-(1,4)-β-glucanase family and the data suggest that evolutionary conservation of transcription exists between orthologues across the grass family. There are also strong correlations between certain members of the endo-(1,4)-β-glucanase family and other genes known to be involved in cell wall loosening and cell expansion, such as expansins and xyloglucan endotransglycosylases.The identification of these groups of genes will now allow us to test hypotheses regarding their functions and joint participation in wall synthesis, re-modelling and degradation, together with their potential role in lignocellulose conversion during biofuel production from grasses and cereal crop residues.Plant (1,4)-β-glucan endohydrolases are members of the GH9 family of glycosyl hydrolases [1] (http://www.cazy.org/ webcite) and are commonly known as cellulases. Enzymes of this group will catalyse the hydrolysis of (1,4)-β-glucosyl linkages in so
SNP frequency, haplotype structure and linkage disequilibrium in elite maize inbred lines
Ada Ching, Katherine S Caldwell, Mark Jung, Maurine Dolan, Oscar Smith, Scott Tingey, Michele Morgante, Antoni J Rafalski
BMC Genetics , 2002, DOI: 10.1186/1471-2156-3-19
Abstract: We examined the frequency and distribution of DNA polymorphisms at 18 maize genes in 36 maize inbreds, chosen to represent most of the genetic diversity in U.S. elite maize breeding pool. The frequency of nucleotide changes is high, on average one polymorphism per 31 bp in non-coding regions and 1 polymorphism per 124 bp in coding regions. Insertions and deletions are frequent in non-coding regions (1 per 85 bp), but rare in coding regions. A small number (2–8) of distinct and highly diverse haplotypes can be distinguished at all loci examined. Within genes, SNP loci comprising the haplotypes are in linkage disequilibrium with each other.No decline of linkage disequilibrium within a few hundred base pairs was found in the elite maize germplasm. This finding, as well as the small number of haplotypes, relative to neutral expectation, is consistent with the effects of breeding-induced bottlenecks and selection on the elite germplasm pool. The genetic distance between haplotypes is large, indicative of an ancient gene pool and of possible interspecific hybridization events in maize ancestry.Direct analysis of genetic variation at the DNA sequence level at many loci became possible in recent years due to improvements in sequencing technology. High throughput genotyping methods, including DNA chips, allele-specific PCR and primer extension approaches make single nucleotide polymorphisms (SNPs) especially attractive as genetic markers [1-3].If a whole-genome scan is to be undertaken, trait mapping by allele association requires high marker density [4-7] which could be provided by SNPs. Recent detailed analysis of allelic diversity at the maize Dwarf8 gene, which indicated association with flowering time [8], is an example of association approach using candidate genes. SNPs may also be used for mapping expressed sequence tags (ESTs) in defined segregating populations and for the integration of genetic and physical (contig) maps, which contain EST-derived landmarks.While po
Complex Regulation by Apetala2 Domain-Containing Transcription Factors Revealed through Analysis of the Stress-Responsive TdCor410b Promoter from Durum Wheat
Omid Eini, Nannan Yang, Tatiana Pyvovarenko, Katherine Pillman, Natalia Bazanova, Natalia Tikhomirov, Serik Eliby, Neil Shirley, Shoba Sivasankar, Scott Tingey, Peter Langridge, Maria Hrmova, Sergiy Lopato
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058713
Abstract: Expression of the wheat dehydrin gene Cor410b is induced several fold above its non-stressed levels upon exposure to stresses such as cold, drought and wounding. Deletion analysis of the TdCor410b promoter revealed a single functional C-repeat (CRT) element. Seven transcription factors (TFs) were shown to bind to this CRT element using yeast one-hybrid screens of wheat and barley cDNA libraries, of which only one belonged to the DREB class of TFs. The remaining six encoded ethylene response factors (ERFs) belong to three separate subfamilies. Analysis of binding selectivity of these TFs indicated that all seven could bind to the CRT element (GCCGAC), and that three of the six ERFs could bind both to the CRT element and the ethylene-responsive GCC-box (GCCGCC). The TaERF4 subfamily members specifically bound the CRT element, and did not bind either the GCC-box or DRE element (ACCGAC). Molecular modeling and site-directed mutagenesis identified a single residue Pro42 in the Apetala2 (AP2) domain of TaERF4-like proteins that is conserved in monocotyledonous plants and is responsible for the recognition selectivity of this subfamily. We suggest that both DREB and ERF proteins regulate expression of the Cor410b gene through a single, critical CRT element. Members of the TaERF4 subfamily are specific, positive regulators of Cor410b gene expression.
A Model for the Quantization of the Hall Resistance in the Quantum Hall Effect  [PDF]
Paul Bracken
Journal of Modern Physics (JMP) , 2010, DOI: 10.4236/jmp.2010.13023
Abstract: Some aspects of anyon physics are reviewed with the intention of establishing a model for the quantization of the Hall conductance. A single particle Schrödinger model is introduced and coupled with a constraint equation formulated from the anyon picture. The Schrödinger equation-constraint system can be converted to a single nonlinear differential equation and solutions for the model can be produced.
Exposure to Oil during Meiosis Results in Alterations in Meiotic Chromosomes that are Similar to Age-Related Changes in the Nematode Caenorhabditis elegans  [PDF]
Paul Goldstein
Journal of Environmental Protection (JEP) , 2010, DOI: 10.4236/jep.2010.13027
Abstract: Exposure of young C. elegans nematodes to three different concentrations of oil resulted in changes in the meiotic chromosomes, nucleus, nucleolus, and nuclear envelope associations. Such alterations decreased the viability and fertility of this organism which was used as a biological model. The morphological changes in the “young” group were similar to nematodes that were senescent and post-reproductive. Comparison of meiotic chromosomes at the pachytene stage of meiosis from young, old, and oil-exposed wild-type hermaphrodites were made following three-dimensional electron microscopy reconstruction of serial ultrathin sections. Age-related and oil-exposure related changes included: 1) Induced condensation of chromatin with increased variance in length of chromosomes; 2) Changes in nuclear and nucleolar volume; 3) Increased density of the nucleoplasm; and 4) Absence of Disjunction Regulator Regions, resulting in the loss of control of the segregation of the X-chromosome into gametes during meiosis. Abnormal clustering of the telomeric ends of the chromosomes was present on the nuclear envelope affecting the segregation of the chromosomes during meiosis.
The Processing of Pictures and Written Words: A Perceptual and Conceptual Perspective  [PDF]
Paul Miller
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.27109
Abstract: The present study examines similarities and differences in the processing of drawings and their corresponding names. For this purpose, students were asked to determine as fast as possible the identicalness of two pictures as opposed to the identicalness of their written Hebrew names. Twenty-eight Hebrew native speakers from the fifth grade participated in the experiment. Findings suggest that the human information processing system optimizes the processing of information (words, drawings, etc.) according to specific task requirements or task constraints. Stimulus type per se does not seem to determine the depth of its processing, nor does it seem to directly trigger particular modalities of encoding (perceptual, linguistic, semantic). Finally, the findings warrant the conclusion that superiority effects related to the processing of written words and pictorial stimuli reflect artifacts of task requirements rather than inherent characteristics of stimuli.
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