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Search Results: 1 - 10 of 244656 matches for " Paul R. Gigante "
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Diameter bounded equal measure partitions of Ahlfors regular metric measure spaces
Giacomo Gigante,Paul Leopardi
Mathematics , 2015,
Abstract: The algorithm devised by Feige and Schechtman for partitioning higher dimensional spheres into regions of equal measure and small diameter is combined with David and Christ's construction of dyadic cubes to yield a partition algorithm suitable to any connected Ahlfors regular metric measure space of finite measure.
Complement Inhibition Promotes Endogenous Neurogenesis and Sustained Anti-Inflammatory Neuroprotection following Reperfused Stroke
Andrew F. Ducruet, Brad E. Zacharia, Sergey A. Sosunov, Paul R. Gigante, Mason L. Yeh, Justin W. Gorski, Marc L. Otten, Richard Y. Hwang, Peter A. DeRosa, Zachary L. Hickman, Paulina Sergot, E. Sander Connolly
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038664
Abstract: Background and Purpose The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent reports also implicate C3a in the modulation of tissue repair, suggesting that complement may influence both injury and recovery at later post-ischemic time-points. Methods To evaluate the effect of C3a-receptor antagonism on post-ischemic neurogenesis and neurological outcome in the subacute period of stroke, transient focal cerebral ischemia was induced in adult male C57BL/6 mice treated with multiple regimens of a C3a receptor antagonist (C3aRA). Results Low-dose C3aRA administration during the acute phase of stroke promotes neuroblast proliferation in the subventricular zone at 7 days. Additionally, the C3a receptor is expressed on T-lymphocytes within the ischemic territory at 7 days, and this cellular infiltrate is abrogated by C3aRA administration. Finally, C3aRA treatment confers robust histologic and functional neuroprotection at this delayed time-point. Conclusions Targeted complement inhibition through low-dose antagonism of the C3a receptor promotes post-ischemic neuroblast proliferation in the SVZ. Furthermore, C3aRA administration suppresses T-lymphocyte infiltration and improves delayed functional and histologic outcome following reperfused stroke. Post-ischemic complement activation may be pharmacologically manipulated to yield an effective therapy for stroke.
Stages of change for physical activity in adults from Southern Brazil: a population-based survey
Samuel C Dumith, Denise P Gigante, Marlos R Domingues
International Journal of Behavioral Nutrition and Physical Activity , 2007, DOI: 10.1186/1479-5868-4-25
Abstract: A population-based survey was undertaken in Pelotas, Southern Brazil, in 2005. An algorithm was applied to evaluate the SoC for PA, and PA was defined as being engaged in moderate-to-vigorous PA for at least 20 minutes on three times per week. The covariates collected in the questionnaire were: sex, age, skin color, marital status, education level, economic status, family income, smoking, body mass index (BMI) and self-reported health status. Data analyses were performed through Poisson and multinomial regression, taking the sampling design into account.Face-to-face interviews were applied to 3136 individuals, corresponding to a response rate of 93.5%. The prevalence across the stages was as follows: 38.3% in precontemplation, 13.0% in contemplation, 19.5% in preparation, 5.2% in action and 24.0% in maintenance. The elderly, married, smokers, and those with lower socioeconomic status were less likely to adopt, initiate and maintain regular PA.Despite the all benefits of PA, a high proportion of adults from Southern Brazil are physically inactive and do not present intention to engage in regular PA. The profile of those who are inactive but intend to do PA resembles those who are physically active. The findings of the present study can contribute to improve health behaviors and to plan health promotion strategies aimed at increasing the level of PA in the community.The effects of physical activity (PA) on health and disease are well established in the literature [1]. Despite the evidence, a large proportion of the population remains sedentary. For example, in the United States (US), 25% of adults are not active at all [1]. In Brazil, only 13% of adults reported being engaged in PA in their leisure time for at least 30 minutes in one or more days per week [2]. Therefore, any effort to increase PA levels could have a large potential impact on public health.However, PA is a complex behavior, and the incorporation of this habit cannot be summarized as an all-or-none phen
Epidemiologia das atividades físicas praticadas no tempo de lazer por adultos do Sul do Brasil
Dumith, Samuel C.;Domingues, Marlos R.;Gigante, Denise P.;
Revista Brasileira de Epidemiologia , 2009, DOI: 10.1590/S1415-790X2009000400014
Abstract: objectives: to describe types of leisure-time physical activities and to analyze the profile of their practitioners. methods: cross-sectional population-based survey comprising individuals aged 20 years or over, resident in pelotas, brazil. the outcome was the type of leisure physical activity performed in the week before the interview. crude and adjusted associations with demographic and socioeconomic characteristics and with body mass index (bmi) were conducted through chi-square and poisson regression, respectively. results: overall, 3,136 individuals were interviewed, of which 1,239 (40%) reported performing some leisure-time physical activity, corresponding to the denominator of this study. the great majority (91%) performed only one physical activity. walking was the most practiced, being reported by 57% of those engaged in some physical activity. the following most frequent activities were: soccer (14%), cycling (13%), weight lifting (8%), and gymnastics (6%). median of weekly frequency was 3 days, while median of daily duration was 60 minutes. more than a half (56%) reported performing physical activity with moderate-to-vigorous intensity. however, only 30% achieved the guidelines for adults and elderly. when the period of practice was considered, 53% were engaged in leisure physical activity for more than six months. the most common motivation was health reasons. conclusions: less than half of the investigated population was engaged in leisure-time physical activity. walking was the most frequent modality for every examined group. differences in the demographic and socioeconomic profile were observed according to the type of physical activity.
La nazione necessaria: Massimo d’Azeglio e il diritto di unirsi ovvero di dividersi
Claudio Gigante
Between , 2012,
Abstract: Nel contributo si propone un’interpretazione del pensiero politico di Massimo d’Azeglio, ricostruito attraverso i suoi principali pamphlets. Andando oltre le tradizionali sminuenti chiavi di lettura (all’insegna della bonomia e della “moderazione”) e discutendo le ragioni delle censure più gravi mosse a d’Azeglio (da Mazzini, poi da Gramsci) l’intervento si concentra sulla sua concezione della nazione e sul suo diritto a costituirsi e magari dissolversi. Un ragionamento che reca in sé le ragioni profonde del senso comune dell’identità nazionale e nel contempo i germi della sua possibile crisi.
In search of the lost sense. The return of the grand narrative:the case of Lyudmila Ulitskaya's Zelenyj ater (Imago)
Giulia Gigante
Slavica TerGestina , 2012,
Abstract: Lyudmila Ulitskaya's Zelenyj ater (Imago) is an interesting example of new realism, a trend which has been making its way in contemporary Russian literature and which expresses the need to understand the impact of historical events of the last century not only on everyday life of Russian people, but most of all on their inner life and human relationships. Ulitskaya is in search of the sense lost in the folds of history. She describes History through individual stories and makes it alive by evoking its atmosphere and sensitivity, writing about everything which was meaningful to those who had lived through it: the realia, the various social milieux, the people. The description of that period is made even more convincing by the insertion of autobiographical elements and by the liveliness of the characters of the novel. The latter impress themselves on our memory and the readers, perceiv-ing them as intelligible and close, tend, to an unpredictable extent, to feel part of the narration and get involved, soul and mind, in the outer and inner real-ity of its characters.
‘Fatta l’Italia, facciamo gli Italiani’. Appunti su una massima da restituire a d’Azeglio
Claudio Gigante
Incontri : Rivista Europea di Studi Italiani , 2011,
Abstract: ‘Fatta l’Italia, facciamo gli Italiani’ Notes on the reattribution of a maxim to d’Azeglio In the past few years, since the 1993 publication of a volume edited by Simonetta Soldani and Gabriele Turi, it has been taken as a given that the phrase that had traditionally been attributed to Massimo d’Azeglio (‘Fatta l’Italia, facciamo gli Italiani’) is in fact apocryphal. It was Ferdinando Martini, in 1896, who had ascribed it to the Piemontese statesman who had died thirty years prior, on the basis of a spurious passage that appeared in the contemporary edition of the Ricordi (‘s’è fatta l’Italia, ma non si fanno gl’Italiani’). The sentence, in reality, circulated earlier than was held by Martini. De Sanctis, in a series of lectures held at the University of Naples in 1872-1873, used the phrase to synthesize d’Azeglio’s thought, and in Leone Capri’s Italia vivente (1878) the maxim already appears in the form which would later be widely spread. However, what is relevant above all is the phrase that reappears in a similar form in various pieces by d’Azeglio himself (e.g., a passage of the Ricordi that is surely ‘authentic’, regarding Ettore Fieramosca reads: ‘Io pensavo [...] che bisogna far gli Italiani se si vuol avere l’Italia […]’) If not in the exact wording (and this point is also debatable), the maxim, interpreted opportunely, can, if only in spirit, be attributed to d’Azeglio.
László F ldényi, Dosto evski lit Hegel en Sibérie et fond en larmes
Giulia Gigante
Slavica Bruxellensia : Revue Polyphonique de Littérature, Culture et Histoire Slaves , 2009,
Abstract: Ce bref essai de László F ldényi, propose une lecture éclairante qui ouvre de nouvelles perspectives dans l'exégèse de la poétique de Dostoevskij. Le penseur hongrois, qui est un spécialiste de philosophie esthétique et professeur de littérature comparée à l'Université de Budapest, s'y engage dans une entreprise originale et passionnée qui na t de la conviction d'avoir deviné les uvres de Hegel que l'écrivain russe aurait lu pendant son exil à Semipalatinsk, un bourg du Sud de la Sibérie...
Ljudmila Ulitskaja, Daniel Stein, interprète
Giulia Gigante
Slavica Bruxellensia : Revue Polyphonique de Littérature, Culture et Histoire Slaves , 2010,
Abstract: L’ uvre, caractérisée par une rare intensité émotionnelle et une structure extrêmement complexe, narre une histoire vraie dans laquelle s’entremêlent tous les principaux événements dramatiques de l’Histoire du XXe siècle. Le Daniel du titre a donc réellement existé. Ljudmila Ulitskaja l’a rencontré par hasard il y a quinze ans et était, depuis lors, hantée par l’idée de raconter sa vie. Ulitskaja abandonne la narration linéaire qui caractérisait ses uvres précédentes et opte pour une forme d...
Fatores associados ao sedentarismo no lazer de adultos na coorte de nascimentos de 1982, Pelotas, RS
Azevedo,Mario R; Horta,Bernardo L; Gigante,Denise P; Victora,Cesar G; Barros,Fernando C;
Revista de Saúde Pública , 2008, DOI: 10.1590/S0034-89102008000900010
Abstract: objective: to assess factors associated to leisure-time physical activity and sedentary lifestyle. methods: prospective cohort study of people born in 1982 in the city of pelotas, southern brazil. data were collected at birth and during in a visit in 2004-5 when 77.4% of the cohort were evaluated, making a total of 4,297 people studied. information about leisure-time physical activity was collected using the international physical activity questionnaire. sedentary people were defined as those with weekly physical activity below 150 minutes. the following independent variables were studied: gender, skin color, birth weight, family income at birth and income change between birth and 23 years of age. poisson's regression with robust adjustment of variance was used for the assessment of risk factors of sedentary lifestyle. results: men reported 334 min of weekly leisure-time physical activity compared to 112 min among women. the prevalence of sedentary lifestyle was 80.6% in women and 49.2% in men. scores of physical activity increased as income at birth increased. those who were currently poor or who became poor during adult life were more sedentary. conclusions: leisure-time sedentary lifestyle in young adults was high especially among women. physical activity during leisure time is determined by current socioeconomic conditions.
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