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Search Results: 1 - 10 of 371031 matches for " Paul P. G. Hodiamont "
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Screening for Personality Disorders: A Comparison of the Dimensional NEO-FFI with the Categorical SAPAS-SR  [PDF]
Sara Germans, Alexander Rath, Guus L. Van Heck, Paul P. G. Hodiamont
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.42016

In psychiatric outpatients, the usefulness of the dimensional NEO-FFI as a screening instrument for personality disorders (PDs) was compared with the categorical screening instrument SAPAS-SR using the SCID-II as the gold standard. Major research questions are: 1) is the NEO-FFI a useful screening instrument for PDs? 2) does the NEO-FFI outperform a categorical screening instrument (SAPAS-SR)? 3) does combining both instruments improve the screening results? Extreme raising on Big Five personality trait domains (NEO-FFI) domain scores were examined in relation to the presence and the number of PDs as diagnosed, with to the SCID-II. Additionally, the NEO-FFI, in conjunction with a short self-report screening instrument (SAPAS-SR), was analysed with respect to sensitivity and specificity for screening of PDs. According to the SCID II, 97 patients (50%) were suffering from a PD. The majority of them had no (35.9%) or only one (40%) extreme score on one of the Big Five personality domains. There were no significant relationships between separate extreme traits on PD or five factor profiles, as proposed in the literature, and the presence of a SCID-II PD. Comparisons of the NEO-FFI with the SAPAS-SR showed no significant relationships. Using both screeners in conjunction resulted in an increase in specificity and the number of correctly classified cases at the expense, however, of the sensitivity. Correlation and regression analyses showed that personality traits are statistically significant predictors for each of the12 PDs. However, the associations between NEO-FFI scores and the DSM-VI-TR PD criteria were rather modest. Support could not be obtained for the view that separate extreme scores on basic personality traits or combinations of such scores in five-factor profiles will provide adequate screening possibilities for PDs. The SAPAS-SR has better screening potential than the NEO-FFI or the SAPAS-SR and the NEO-FFI together.

Validation of two informant-based screening instruments for personality disorders in a psychiatric outpatient population
Sara Germans,Guus L.Van Heck,Paul PG Hodiamont,Danielle Elshoff
Journal of Hospital Administration , 2012, DOI: 10.5430/jha.v2n2p133
Abstract: Purpose: The predictive validity of two informant-based screening instruments for personality disorders (PDs), the Standardized Assessment of Personality (SAP) and a short eight-item version (SAPAS-INF), were studied in 103 Dutch psychiatric outpatients, using the SCID-II as the ‘gold standard’. Methods: All patients and their informants were interviewed separately and independently by different interviewers who were unaware of the results in the other conditions. Results: According to the SCID-II, 66 patients had at least one personality disorder (PD). The SAP correctly classified 72% of all participants in the category PD present/absent. The sensitivity and specificity were 69% and 76%, respectively. The positive and negative predictive values were 84% and 58%. The SAPAS-INF, using a cut-off score of 3, correctly classified 70%; the sensitivity and specificity were 76% and 58%, respectively. The positive and the negative predictive values were 77% and 57%. Conclusion: These results show that the informant-based SAP as well as the shorter informant-based SAPAS-INF are adequate; though rather moderate screening instruments for identifying PD. The SAP and the SAPAS-INF, however, both performed worse than the SAPAS-SR, which is based on the patient’s self-report. Therefore, it is concluded that the SAP or the SAPAS-INF can be used as a satisfactory screening instruments for the presence/absence of PD in those cases where patients themselves are unable to provide the required information.
Acute renal failure caused by pheniramine maleate induced rhabdomyolysis: An unusual case
Paul G,Sood P,Paul B,Puri S
Indian Journal of Critical Care Medicine , 2009,
Abstract: Antihistamines are easily available over-the-counter medications, which are frequently involved in overdoses. The usual course is accompanied by the anticholinergic effects of these agents. We report a case of a suicide attempt in a young male, where ingestion of antihistamine pheniramine maleate was complicated by nontraumatic rhabdomyolysis and oliguric acute renal failure. Rhabdomyolysis and acute renal failure is a rarely reported but potentially serious complication among patients who present to the emergency after intentional overdoses making recognition and prompt intervention essential. We also describe the potential mechanism of muscle injury in antihistamine overdose.
Pure red cell aplasia with phenytoin following traumatic brain injury
Paul G,Sood P,Berry A,Paul B
Neurology India , 2011,
From insulin detemir to glargine: Effect on glycemic control and psychological wellbeing in patients with diabetes mellitus type 2 in daily practice  [PDF]
Thiemo F. Veneman, Fred E. M. G. Storms, Ingo A. Eland, Paul K. P. Bouter
Journal of Diabetes Mellitus (JDM) , 2012, DOI: 10.4236/jdm.2012.21016
Abstract: The success of a specific treatment is traditionally judged according to parameters such as HbA1c. However, other, patient-reported outcomes (PRO) of (insulin) therapy, become increasingly more important. The introduction of (basal) insulin-analogues could possibly improve PRO, particularly “quality of life”. Direct comparative studies between once daily insulin glargine and once to twice or twice daily insulin detemir have previously shown differences in insulin dosage, dosing frequency and weight gain. Whether this leads to a difference in quality of life in patients who are transferred from insulin detemir to insulin glargine remains to be determined. To establish the effect of insulin glargine on quality of life and patient satisfaction in patients with DM2 who are in poor metabolic control with a (human) basal insulin, a large prospective, observational study in Dutch daily practice was performed. The results of the patient population switched from NPH-insulin to insulin glargine have been published previously. In this article the results of the group of patients treated with insulin detemir before the observation period are described. The results of this observational study show that changing basal insulin therapy to insulin glargine in patients with DM2 who are in poor glycemic control with insulin detemir leads to a clinically significant improvement of glycemic control as well as emotional wellbeing, despite a small increase in weight. Whether other factors such as decreased dosing frequency play a role remains to be determined by future studies.
Determination of Lanthanides, Thorium, Uranium and Plutonium in Irradiated (Th, Pu)O2 by Liquid Chromatography Using α-Hydroxyiso Butyric Acid (α-HIBA)  [PDF]
Pranaw Kumar, P. G. Jaison, Vijay M. Telmore, Sumana Paul, Suresh K. Aggarwal
International Journal of Analytical Mass Spectrometry and Chromatography (IJAMSC) , 2013, DOI: 10.4236/ijamsc.2013.11009

An HPLC method is presented for the separation and determination of lanthanides (Lns), thorium (Th), uranium (U) and plutonium (Pu) from irradiated (Th, Pu)O2. Individual separation of Lns, Th, U and Pu is a challenging task becauseof 1) lanthanideshavingsimilar physical and chemical properties, 2) presence of complex matrix like irradiated fuel and 3) the co-existence of multiple oxidation states of Pu. Different procedures were developed for separation of individual lanthanides and actinides.The individual lanthanides were separated on a dynamically modified reversed phase (RP) column using n-octane sulfonic acid as an ion interaction reagentand employingdual gradient(pH and concentration) of α-hydroxyisobutyric acid (HIBA). In order to improve the precision on the determination of Lns, terbium (Tb) was used as an internal standard. The method was validated employing simulated high level liquid waste. Concentrations of lanthanides viz. lanthanum (La) and neodymium (Nd) in the dissolver solution were determined based on their peak areas. Th, U and Pu were separated on a RP column using mobile phase containing HIBA and methanol. Since Pu is prone to exist in multiple oxidation states, all the oxidation states were converted into Pu (IV) using H2O2 in 3M HNO3. Under the optimized conditions, Pu(IV) eluted first followed by Th and U. The concentrations of Th, U and Pu were determined by standard addition method andwere found to be 1.10 ± 0.02 mg/g, 5.3 ± 0.3 μg/g and 27 ± 1 μg/g, respectively, in the dissolver solution of irradiated fuel. These values were in good agreement with the concentration of Th determined by biamperometry and those of U and Puby isotope dilution thermal ionization mass spectrometry.

Surface and Mechanical studies of Bismaleimide coatings
A. S. Bhattacharyya,D. Paul,P. P. Dutta,G. Bhattacharjee
Physics , 2015,
Abstract: Bismaleimide (BMI) resins are a new breed of thermosetting resins used mainly for high temperature applications and have major usage in aerospace. BMI polymer coatings were deposited on aluminum and mild steel substrates. The effect of corrosion on mild steel and aluminum by Ringers Solution and there protection using BMI coatings were observed. X-ray diffraction studies showed crystalline nature of the BMI coatings. Surface contact angle measurements were carried out using goniometer.
Experience of Patients Undergoing Mini-Arthroscopy Compared to MRI in the Earliest Phases of Arthritis  [PDF]
Maria J. H. de Hair, Marleen G. H. van de Sande, Mario Maas, Danielle M. Gerlag, Paul P. Tak
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.412A2001

Objective: To evaluate the expectations and experience of patients undergoing mini-arthroscopy compared to contrast enhanced MRI for research purposes. Methods: Seventeen patients with early, active arthritis (Group A) and 21 autoantibody-positive individuals without any evidence of arthritis upon physical examination (Group B) were included. All subjects underwent both contrast enhanced MRI and synovial biopsy sampling by mini-arthroscopy of the same joint within one week. At inclusion and after both procedures, subjects filled in questionnaires with items about expectations and experience with regard to the procedures. Results: Before procedures, subjects in group B had a higher fear of and reluctance to undergo mini-arthroscopy compared to MRI (p < 0.0001 and p = 0.001, respectively). Before procedures, 42% of the subjects preferred MRI, 11% of the subjects preferred mini-arthroscopy and 47% had no preference for either procedure. After both procedures, subjects preferences changed to 39% for MRI, 32% for mini-arthroscopy and 29% for no preference for one or the other procedure. When comparing Group A with Group B, there were no significant differences in preference before

Direct effects of modest hyperglycaemia on susceptibility to infection in the critically ill patient
Matt P Wise, Anton G Saayman, Paul J Frost
Critical Care , 2008, DOI: 10.1186/cc7089
Abstract: Modest hyperglycaemia has been demonstrated to directly perturbate immune function by more than one mechanism. Macropinocytosis by macrophages involves nonspecific sampling of pathogens in extracellular fluid, which are then directed towards antigen processing with subsequent presentation of microbial peptides to T cells, linking innate and adaptive immunity. Macropinocytosis is reduced in a dose-dependent manner by glucose but not by mannitol. Increasing glucose from 5.5 to 11.1 mmol/l inhibited macropinocytosis by 55% [3]. Surfactant proteins A and D and mannose-binding lectin are important host defence molecules (collectins), which bind pathogens, augment opsonisation, phagocytosis and killing by macrophages and neutrophils, and activate complement. Deficiency in mannose-binding lectin is associated with septic shock and death in critically ill patients [4]. Glucose competitively inhibits pathogen binding by collectins [5] and represents an eloquent mechanism of how modest hyperglycaemia may increase susceptibility to infection.We would suggest that the benefits of strict glycaemic control on immune function in critical care might be explained by the direct effects of glucose rather than by reductions in hyperosmolar stress.The authors declare that they have no competing interests.
On the Evolution of Consanguinities  [PDF]
Paul G. Bamberg
Applied Mathematics (AM) , 2017, DOI: 10.4236/am.2017.84044
Abstract: “Consanguinity” is a gender-neutral term for “fraternity” or “sorority.” Initially a consanguinity includes M male members and F female members. Each week a member, chosen at random, selects a new member, always of the same gender as the member making the selection. This model for evolution is isomorphic to the classic Pólya’s urn. The male and female members play the same roles as the red and black balls in the urn, and the procedure for selecting a new member is equivalent to drawing a ball from the urn, then replacing it and adding a new ball of the same color. It is well known that for Pólya’s urn, the proportion of red balls in the urn is a martingale. It follows that for a consanguinity, the proportion of the membership that is male is a martingale. Furthermore, being bounded, this martingale converges to a limit. For a martingale that is the sum of independent random variables, such as a symmetric random walk, there is also a well-known second-degree martingale from which the variance of the limiting distribution can be deduced. What the author discovered, in the process of solving his own examination problem, is that a similar martingale exists also for Pólya’s urn, even though in this case the number of red balls is the sum of random variables that are not independent. This new martingale can be used to calculate the variance of the limiting distribution. Traditionally, the probability that r red balls will be drawn from Pólya’s urn in n trials is derived by a rather tricky argument involving conditional probability. This article uses an obvious but overlooked simpler approach. Pólya’s formula for the probability that m male members will be chosen in n weeks is derived, without any mention of conditional probability, by an elementary counting argument, and its limit is shown to be a beta distribution.
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