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Search Results: 1 - 10 of 220274 matches for " Paul N Sockett "
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Population distribution and burden of acute gastrointestinal illness in British Columbia, Canada
M Kate Thomas, Shannon E Majowicz, Laura MacDougall, Paul N Sockett, Suzie J Kovacs, Murray Fyfe, Victoria L Edge, Kathryn Doré, James A Flint, Spencer Henson, Andria Q Jones
BMC Public Health , 2006, DOI: 10.1186/1471-2458-6-307
Abstract: The magnitude and distribution of acute GI in British Columbia (BC), Canada was evaluated via a cross-sectional telephone survey of 4,612 randomly selected residents, conducted from June 2002 to June 2003. Respondents were asked if they had experienced vomiting or diarrhoea in the 28 days prior to the interview.A response rate of 44.3% was achieved. A monthly prevalence of 9.2% (95%CI 8.4 – 10.0), an incidence rate of 1.3 (95% CI 1.1–1.4) episodes of acute GI per person-year, and an average probability that an individual developed illness in the year of 71.6% (95% CI 68.0–74.8), weighted by population size were observed. The average duration of illness was 3.7 days, translating into 19.2 million days annually of acute GI in BC.The results corroborate those from previous Canadian and international studies, highlighting the substantial burden of acute GI.Gastrointestinal illness (GI) is a global public health concern. In developed countries, GI is typically mild and self-limiting, but has considerable economic impact due to high morbidity [1-3]. Recent studies on the burden of GI in the general population of a number of countries have been reported [4-12]. To estimate the burden of GI in the Canadian population, the Public Health Agency of Canada (PHAC; formerly Health Canada) developed the National Studies on Acute Gastrointestinal Illness (NSAGI) initiative in 2000. Population-based studies, designed to describe self-reported, acute GI in selected Canadian populations, are part of this initiative. In March 2002, the PHAC completed the first such population study in the City of Hamilton, Ontario, Canada [13]. In order to determine if the burden of GI was the same across the country, a second population study was completed in the province of British Columbia (BC) in June 2003. Additionally, since public health in Canada is primarily a provincial responsibility, this study was conducted to provide information to BC policy makers. The current paper describes the frequen
A GIS-driven integrated real-time surveillance pilot system for national West Nile virus dead bird surveillance in Canada
Jiangping Shuai, Peter Buck, Paul Sockett, Jeff Aramini, Frank Pollari
International Journal of Health Geographics , 2006, DOI: 10.1186/1476-072x-5-17
Abstract: A pilot system was developed to integrate real-time surveillance, real-time GIS, and Open GIS technology in order to enhance West Nile virus dead bird surveillance in Canada.Driven and linked by the newly developed real-time web GIS technology, this integrated real-time surveillance system includes conventional real-time web-based surveillance components, integrated real-time GIS components, and integrated Open GIS components. The pilot system identified the major GIS functions and capacities that may be important to public health surveillance. The six web GIS clients provide a wide range of GIS tools for public health surveillance. The pilot system has been serving Canadian national West Nile virus dead bird surveillance since 2005 and is adaptable to serve other disease surveillance.This pilot system has streamlined, enriched and enhanced national West Nile virus dead bird surveillance in Canada, improved productivity, and reduced operation cost. Its real-time GIS technology, static map technology, WMS integration, and its integration with non-GIS real-time surveillance system made this pilot system unique in surveillance and public health GIS.West Nile virus was first isolated in 1937 in the West Nile district of Uganda. Since then, Egypt, Israel, South Africa, and in parts of Europe, Asia and North America have reported West Nile virus infections. In North America, West Nile virus was first reported in New York City in 1999. During 2002, more than 4,000 people in North America became ill after being infected with West Nile virus. The latter was the largest outbreak of West Nile virus infection recorded. West Nile virus activities were reported in more than 40 states in the United States in 2004 [1].In August 2001, West Nile virus activity was first reported in Canada, when the virus was found in dead birds and mosquito pools in Southern Ontario. In 2002, Canada reported its' first confirmed human cases in parts of Quebec and Ontario. The virus was also found in
Analyse de Virtual Cabinet
Geoffrey Sockett
ALSIC : Apprentissage des Langues et Systèmes d'Information et de Communication , 2007,
Abstract: Cet article analyse un logiciel ou un site Internet. This article reviews a courseware or an Internet site.
Le web social : la complexité au service de l'apprentissage informel de l'anglais The social web: complexity in the service of the informal learning of English
Geoffrey Sockett
ALSIC : Apprentissage des Langues et Systèmes d'Information et de Communication , 2012, DOI: 10.4000/alsic.2505
Abstract: Cet article présente les résultats d'un projet de recherche dans lequel de futurs enseignants de langues sont invités à écrire un blogue au sujet de leurs activités informelles de réseautage social en anglais. Les participants, qui ont suivi une formation dans des domaines tels que les théories de l'acquisition des langues, s'expriment en particulier sur l'impact de ces activités sur leur apprentissage de la langue cible. Le corpus ainsi obtenu est analysé et des résultats sont présentés. Le cadre théorique de cette étude est celui des systèmes complexes et dynamiques. Nous soulignons la pertinence de ce modèle pour décrire l'apprentissage informel de l'anglais en ligne. Les résultats de l'étude font appara tre que le très grand nombre d'interactions entre personnes, médias, langues et interfaces de réseautage social conduit à un développement langagier non linéaire et à des transitions entre différentes phases dans des domaines tels que l'aisance et l'acquisition du vocabulaire. Nous présentons des applications pratiques de cette recherche pour l'enseignement des langues, notamment dans la valorisation des pratiques informelles, et suggérons de futures orientations pour la recherche dans ce domaine. This article presents the results of a research project using blogs written by trainee language teachers to report on their informal online social networking activities in English. The respondents, who are trained in areas such as language acquisition theories, are invited to discuss how they might be learning English through these activities. The resulting corpus of blogs is analysed and the impact of these activities on learning of the target language is discussed. The theoretical framework for this study is dynamic systems theory, and it is argued that this model is particularly pertinent for the description of language learning in an informal online context. The results of the study suggest that the very large number of interactions between people, media, languages and social networking interfaces leads to non-linear language development, and phase transitions are observed in fluency and vocabulary acquisition. Suggested applications include the use of informal learning blogs as a pedagogical tool to allow learners to see their informal activities as valuable for language learning and avenues for further research are suggested.
Analyse de Apprentissages et documents numériques
Geoffrey Sockett,Denyze Toffoli
ALSIC : Apprentissage des Langues et Systèmes d'Information et de Communication , 2011,
Abstract: Cet article analyse un ouvrage ou un document. This article reviews a book or document.
Serotypes of Non-O157 Shigatoxigenic Escherichia coli (STEC)  [PDF]
Karl A. Bettelheim, Paul N. Goldwater
Advances in Microbiology (AiM) , 2014, DOI: 10.4236/aim.2014.47045
Abstract:

Non-O157 STEC has been shown to have a diverse ecological distribution among food-animals. It has been associated with both outbreaks and individual cases of severe illness. This group of the organisms is now considered as a major contributor to human disease. The clinical description of the diseases caused by these organisms is reviewed. The host specificity of these pathogens is described and discussed. These organisms appear widespread among food animals like cattle and sheep, and can therefore affect a range of foods directly from the meat and excretions of these animals being used in farming practices. This article reviews the origins, diversity and pathogenesis of non-O157 STEC.

Mutagenesis of RpoE-like sigma factor genes in Bdellovibrio reveals differential control of groEL and two groES genes
Carey Lambert, Rob Till, Laura Hobley, Renee E. Sockett
BMC Microbiology , 2012, DOI: 10.1186/1471-2180-12-99
Abstract: We find that one sigma factor gene, bd3314, cannot be deleted from Bdellovibrio in either predatory or prey-independent growth states, and is therefore possibly essential, likely being an alternate sigma 70. Deletion of one of two Group IV-like sigma factor genes, bd0881, affects flagellar gene regulation and results in less efficient predation, although not due to motility changes; deletion of the second, bd0743, showed that it normally represses chaperone gene expression and intriguingly we find an alternative groES gene is expressed at timepoints in the predatory cycle where intensive protein synthesis at Bdellovibrio septation, prior to prey lysis, will be occurring.We have taken the first step in understanding how alternate sigma factors regulate different processes in the predatory lifecycle of Bdellovibrio and discovered that alternate chaperones regulated by one of them are expressed at different stages of the lifecycle.
Sequence-Based Typing of Leptospira: Epidemiology in the Genomic Era
Paul N. Levett
PLOS Neglected Tropical Diseases , 2007, DOI: 10.1371/journal.pntd.0000120
Abstract:
A perspective on SIDS pathogenesis. The hypotheses: plausibility and evidence
Paul N Goldwater
BMC Medicine , 2011, DOI: 10.1186/1741-7015-9-64
Abstract: Before committing to this task it is apposite to consider the background and context in which the various hypotheses arose.Beckwith's 1970 definition of SIDS [1] created the presumption that SIDS babies were normal. Questions arose after Kinney et al. [2] developed their hypothesis based on histopathological abnormalities of the brain, a prenatal origin of these and sudden death occurring during a vulnerable period in infancy. Bergman (1970) [3] had argued against a "single characteristic that ordains an infant for death," but for an interaction of risk factors with variable probabilities. This approach was supported by Wedgewood (1972) [4] whose hypothesis consisted of host vulnerability, age-specific risks, and precipitating factors. Others have supported a multifactorial approach (Raring 1975) [5], (Rognum and Saugstag 1993) [6].The triple risk hypothesis of Filiano and Kinney (1994) [7] has been popular with its central focus on brainstem prenatal injury in a subset of SIDS, denoting a not universal finding. The National Institute of Child Health and Development SIDS Strategic Plan 2001 [8], stated unequivocally that 'Knowledge acquired during the past decade supports the general hypothesis that infants who die from SIDS have abnormalities at birth that render them vulnerable to potentially life-threatening challenges during infancy.' In essence, this states that SIDS is a developmental disorder originating during fetal development. Interest in the brainstem began with Naeye's (1976) [9] findings of astrogliosis in 50% of SIDS and controls. Hypoxia was considered to be the underlying cause. Kinney et al. (1983) [10] found gliosis in only about one-fifth of SIDS cases. This shortfall stimulated studies on brainstem neurotransmitters [11,12]. Ambler et al. (1981) [13] could not distinguish SIDS from other deaths on the basis of neuropathological findings and concluded that known causes of sudden death were unsuitable as a control group. Considerable debate over th
Severe congenital protein C deficiency: the use of protein C concentrates (human) as replacement therapy for life-threatening blood-clotting complications
Paul N Knoebl
Biologics: Targets and Therapy , 2008,
Abstract: Paul N KnoeblDepartment of Medicine 1, Division Hematology and Hemostasis, Medical University of Vienna, Vienna, AustriaAbstract: The protein C pathway has an important function in regulating and modulating blood coagulation and ensuring patency of the microcirculation. Protein C deficiency leads to macro- and microvascular thrombosis. Congenital severe protein C deficiency is a life-threatening state with neonatal purpura fulminans and pronounced coagulopathy. Patients with heterozygous protein C deficiency have an increased risk for thromboembolic events or experience coumarin-induced skin necrosis during initiation of coumarin therapy. Replacement with protein C concentrates is an established therapy of congenital protein C deficiency, resulting in rapid resolving of coagulopathy and thrombosis without reasonable side effects. This article summarizes the current knowledge on protein C replacement therapy in congenital protein C deficiency.Keywords: protein C, deficiency, replacement therapy, purpura fulminans, coagulopathy
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