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Search Results: 1 - 10 of 209199 matches for " Patricia D. Fernandes "
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Synthesis and in vivo evaluation of 5-chloro-5-benzobarbiturates as new central nervous system depressants
Vieira, Andreia A;Gomes, Niele M;Matheus, Maria E;Fernandes, Patricia D;Figueroa-Villar, José D;
Journal of the Brazilian Chemical Society , 2011, DOI: 10.1590/S0103-50532011000200024
Abstract: a new family of barbiturates, 5-chloro-5-benzylbarbituric acids, was prepared using a simple efficient synthetic method from aromatic aldehydes and barbituric acid, followed by reduction and chlorination with trichloro-isocyanuric acid, affording overall yields of 53 to 70%. the in vivo evaluation with mice showed that these compounds present tranquilizing activity.
Understanding RFID Technology within a Business Intelligence Framework  [PDF]
Richard Herschel, Patricia D. Rafferty
Intelligent Information Management (IIM) , 2012, DOI: 10.4236/iim.2012.46046
Abstract: Radio Frequency Identification (RFID) technology provides new and exciting opportunities for increasing organiza- tional, financial, and operational performance. With its focus on organizational efficiency and effectiveness, RFID technology is superior to barcodes in its ability to provide source automation features that increase the speed and volume of data collection for analysis. Today, applications that employ RFID are growing rapidly and this technology is in a continuous state of evolution and growth. As it continues to progress, RFID provides us with new opportunities to use business intelligence (BI) to monitor organizational operations and learn more about markets, as well as consumer attitudes, behaviors, and product preferences. This technology can even be used to prevent potentially faulty or spoiled products from ending up in the hands of consumers. However, RFID offers significant challenges to organizations that attempt to employ this technology. Most significantly, there exists the potential for RFID to overwhelm data collection and BI analytic efforts if organizations fail to effectively address RFID data integration issues. To this end, the purpose of this article is to explicate the dynamic technology of RFID and how it is being used today. Additionally, this article will provide insights into how RFID technology is evolving and how this technology relates to BI and issues related to data integration. This knowledge has never been more essential. While IT academic research into RFID development and issues has declined in recent years, RFID continues to be a vital area of exploration, especially as it relates to BI in the 21st century.
Proteolytic profiling and comparative analyses of active trypsin-like serine peptidases in preimaginal stages of Culex quinquefasciatus
Andre Borges-Veloso, Patricia Cuervo, Leonardo Saboia-Vahia, Renata C Pires, Constan?a Britto, Nilma Fernandes, Claudia M d’Avila-Levy, Jose B De Jesus
Parasites & Vectors , 2012, DOI: 10.1186/1756-3305-5-123
Abstract: The proteolytic profiles of eggs, larvae and pupa of Cx. quinquefasciatus were characterized by SDS-PAGE co-polymerized with 0.1% gelatin, according to the pH, temperature and peptidase inhibitor sensitivity. In addition, the proteolytic activities were characterized in solution using 100 μM of the fluorogenic substrate Z-Phe-Arg-AMC.Comparison of the proteolytic profiles by substrate-SDS-PAGE from all preimaginal stages of the insect revealed qualitative and quantitative differences in the peptidase expression among eggs, larvae and pupae. Use of specific inhibitors revealed that the proteolytic activity from preimaginal stages is mostly due to trypsin-like serine peptidases that display optimal activity at alkaline pH. In-solution, proteolytic assays of the four larval instars using the fluorogenic substrate Z-Phe-Arg-AMC in the presence or absence of a trypsin-like serine peptidase inhibitor confirmed the results obtained by substrate-SDS-PAGE analysis. The trypsin-like serine peptidases of the four larval instars were functional over a wide range of temperatures, showing activities at 25°C and 65°C, with an optimal activity between 37°C and 50°C.The combined use of zymography and in-solution assays, as performed in this study, allowed for a more detailed analysis of the repertoire of proteolytic enzymes in preimaginal stages of the insect. Finally, differences in the trypsin-like serine peptidase profile of preimaginal stages were observed, suggesting that such enzymes exert specific functions during the different stages of the life cycle of the insect.
Atividade antinociceptiva de extratos de a?aí (Euterpe oleraceae Mart.)
Marinho, Bruno G.;Herdy, Simone A.;Sá, Alessandra C.;Santos, Gracilene B.;Matheus, Maria Eline;Menezes, Fábio S.;Fernandes, Patricia D.;
Revista Brasileira de Farmacognosia , 2002, DOI: 10.1590/S0102-695X2002000300025
Abstract: extratos de flores (etfa) e espigas (etea) de a?aí (euterpe oleraceae mart.) foram avaliados quanto a sua atividade antinociceptiva. etfa mostrou significativa atividade periférica, reduzindo em até 50% o número total de contor??es abdominais. já etea mostrou reduzido efeito no modelo de contor??es abdominais, mas seu efeito espinhal pode ser observado com as doses maiores. nenhum dos extratos foi capaz de alterar os índices de analgesia na placa quente.
Novel Potent Imidazo[1,2-a]pyridine-N-Glycinyl-Hydrazone Inhibitors of TNF-α Production: In Vitro and In Vivo Studies
Renata B. Lacerda, Natália M. Sales, Leandro L. da Silva, Roberta Tesch, Ana Luisa P. Miranda, Eliezer J. Barreiro, Patricia D. Fernandes, Carlos A. M. Fraga
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091660
Abstract: In this work, we describe the design, synthesis and pharmacological evaluation of novel imidazo[1,2-a]pyridine-N-glycinyl-hydraz?onederivatives (1a–k) intended for use as inhibitors of tumor necrosis factor alpha (TNF-α) production. The compounds were designed based on the orally active anti-inflammatory prototype LASSBio-1504 (2), which decreases the levels of the pro-inflammatory cytokine TNF-α in vitro and in vivo. The in vitro pharmacological evaluation of the imidazo[1,2-a]pyridine compounds (1) showed that substitution of the N-phenylpyrazole core present in prototype 2 by a bioisosteric imidazo[1,2-a]pyridine scaffold generated anti-TNF-α compounds that were more potent than the previously described N-phenylpyrazole derivative 2 and as potent as SB-203580, a p38 MAPK inhibitor. The most active derivative (E)-2-(2-tert-butylimidazo[1,2-a]pyridin?-3-ylamino)-N’-(4-chlorobenzylidene)acetohydrazide, or LASSBio-1749 (1i) was orally active as an anti-inflammatory agent in a subcutaneous air pouch model, reducing expressively the levels in vivo of TNF-α and other pro-inflammatory cytokines at all of the tested doses.
Divergent Biochemical Fractionation, Not Convergent Temperature, Explains Cellulose Oxygen Isotope Enrichment across Latitudes
Leonel Sternberg, Patricia Fernandes Vendramini Ellsworth
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028040
Abstract: Recent findings based on the oxygen isotope ratios of tree trunk cellulose indicate that the temperature of biomass production in biomes ranging from boreal to subtropical forests converge to an average leaf temperature of 21.4°C. The above conclusion has been drawn under the assumption that biochemically related isotopic fractionations during cellulose synthesis are not affected by temperature. Here we test the above assumption by heterotrophically generating cellulose at different temperatures and measuring the proportion of carbohydrate oxygen that exchange with water during cellulose synthesis and the average biochemical fractionation associated with this exchange. We observed no variation in the proportion of oxygen that exchange with different temperatures, which averaged 0.42 as it has been observed in other studies. On the other hand, the biochemical oxygen isotope fractionation during cellulose synthesis is affected by temperature and can be described by a 2nd order polynomial equation. The biochemical fractionation changes little between temperatures of 20 and 30°C averaging 26‰ but increases at lower temperatures to values of 31‰. This temperature sensitive biochemical fractionation explains the pattern of cellulose oxygen isotope ratios of aquatic plants encompassing several latitudes. The observed temperature sensitive biochemical fractionation also indicates that divergent biochemical fractionation and not convergent leaf temperature explains the increase in oxygen isotope enrichment of cellulose across several biomes.
Prevalence of the TP53 p.R337H Mutation in Breast Cancer Patients in Brazil
Juliana Giacomazzi, Marcia S. Graudenz, Cynthia A. B. T. Osorio, Patricia Koehler-Santos, Edenir I. Palmero, Marcelo Zagonel-Oliveira, Rodrigo A. D. Michelli, Cristovam Scapulatempo Neto, Gabriela C. Fernandes, Maria Isabel W. S. Achatz, Ghyslaine Martel-Planche, Fernando A. Soares, Maira Caleffi, José Roberto Goldim, Pierre Hainaut, Suzi A. Camey, Patricia Ashton-Prolla
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099893
Abstract: Germline TP53 mutations predispose individuals to multiple cancers and are associated with Li-Fraumeni/Li-Fraumeni-Like Syndromes (LFS/LFL). The founder mutation TP53 p.R337H is detected in 0.3% of the general population in southern Brazil. This mutation is associated with an increased risk of childhood adrenal cortical carcinoma (ACC) but is also common in Brazilian LFS/LFL families. Breast Cancer (BC) is one of the most common cancers diagnosed in TP53 mutation carriers. We have assessed the prevalence of p.R337H in two groups: (1) 59 BC affected women with a familial history (FH) suggestive of hereditary cancer syndrome but no LFS/LFL features; (2) 815 BC affected women unselected for cancer FH, diagnosed with BC at or before age 45 or at age 55 or older. Among group 1 and group 2 patients, 2/59 (3.4%, CI95%: 0.4%–11.7%) and 70/815 (8.6%, CI95%: 6.8%–10.7%), respectively, were p.R337H carriers in the germline. The prevalence of p.R337H was higher in women diagnosed with BC at or before age 45 (12.1%, CI95%: 9.1%–15.8%) than at age 55 or older (5.1%, CI95%: 3.2%–7.7%), p<0.001). The Brazilian founder p.R337H haplotype was detected in all carriers analysed. These results suggest that inheritance of p.R337H may significantly contribute to the high incidence of BC in Brazil, in addition to its recently demonstrated impact on the risk of childhood ACC.
Thinking about place: researching and reading the global history of nursing
D'Antonio, Patricia;
Texto & Contexto - Enfermagem , 2009, DOI: 10.1590/S0104-07072009000400019
Abstract: this paper considers place as a category of analysis. as nursing as a practice discipline and the history of nursing as a field of scholarship both enter a more self-consciously global arena and scholars are moving beyond the nation and the nation-state as the primary context for historical inquiry. at the same time, the work of nursing is, has been, and always will be a very private and intimate act. this paper considers two challenges to those interested in exploring how the history of nursing might consider this juxtaposition of the global and the local. the first is conceptual and considers ways to more systematically mine national studies of the history of nursing. the second is structural and explores how we can build a body of scholarship and cadre of scholars that cut across conventional linguistic and cultural boundaries and create a vibrant community of discussion and dialogue.
Consideraciones filogenéticas y biogeográficas preliminares del género Sorghastrum (Poaceae: Andropogoneae).
Patricia Dávila Aranda
Acta botánica mexicana , 1991,
Thinking about place: researching and reading the global history of nursing
Patricia D'Antonio
Texto & Contexto - Enfermagem , 2009,
Abstract: En este estudio se considera el lugar como una categoría de análisis. La enfermería como una disciplina práctica y la historia de la enfermería como un campo de conocimiento. Ambas categorías están situadas en un área mayor de conciencia global, donde los investigadores se desplazan más allá de sus países y estados, estableciendo un contexto primario para la investigación histórica. Al mismo tiempo, el trabajo de la enfermería es, ha sido y siempre será un acto privado e íntimo. Este estudio considera dos retos para los interesados en explorar cómo la historia de la enfermería puede considerar esa yuxtaposición de lo global y lo local. El primer reto es conceptual y considera las maneras de explorar los estudios nacionales de la historia de la enfermería de manera más sistemática. El segundo es estructural y explora cómo podemos construir un corpo de conocimientos y un grupo de investigadores que trasciendan el lenguaje convencional, las barreras culturales y creen una vibrante comunidad de debate y diálogo.
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