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Formulation and Dissolution Study of Valsartan Immediate Release Tablets
B. Brahmaiah*, K. Sasikanth, Sreekanth Nama , P.Suresh, Patan Adam Khan
Indian Journal of Pharmaceutical and Biological Research , 2013,
Abstract: In the present study, design of oral immediate release tablets of Valsartan by direct compression techniquewas carried out. The main aim and objective of the work is to formulate immediate release tablets usingdifferent direct compression vehicles (DCV’S) in different ratios. The main motive is to compare thedissolution profile of these formulations and conclude the best formulation which release drug at a fasterrate. To determine the best fit dissolution profile for the dosage forms. Valsartan tablets were formulated byusing microcrystalline cellulose (diluents), potato starch, acacia (binder) and magnesium stearate(lubricant). The granules were compressed into tablets and were subjected to dissolution studies. Thedissolution profile of the formulation F2 was found to have better dissolution rate compared to others. TheIn-vitro dissolution studies of all the formulations were conducted and the results were obtained, it wasconcluded that formulation F2 was the best with fast release of drug compared to others.
An unusual cause of gastric outlet obstruction: A pancreaticoduodenal artery aneurysm
Alhasan Abdulaziz,Khan Patan
Annals of Saudi Medicine , 2009,
Abstract: We present a rare case of gastric outlet obstruction due to compression of the duodenum by a pancreaticoduodenal artery (PDA) aneurysm 2.5 cm in diameter, in a 43-year-old man from Saudi Arabia who presented with persistent vomiting and epigastric pain. The initial investigations and blood works were negative, and esophagogastroduodenoscopy (EGD) was unremarkable. A CT abdomen demonstrated a mass around the duodenum and dilatation of the stomach, and CT angiography showed the PDA aneurysm. The patient was stabilized and then referred to a tertiary center for embolization. Our case demonstrates a diagnostic challenge that physicians may encounter in patients who present with vomiting and epigastric pain.
A Distribution and Ultrastructure of Laticifers in the Phylloclade of Euphorbia caducifolia Haines, a Potential Hydrocarbon Yielding CAM Plant  [PDF]
Bugude Rajeswari, Sake Pradeep Kumar, Allu Prasada Rao, Patan Shaik Sha Valli Khan
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.51011
Abstract:

The present study describes the anatomy, distribution, morphology and ultrastructure of laticifer system in the phylloclades of Euphorbia caducifolia Haines (Family Euphorbiaceae), a potential biofuel yielding, Crassulacean Acid Metabolism (CAM) plant for the first time using light and transmission electron microscopy (TEM). Histochemical tests were performed to identify the principal components of latex using a variety of stains. In cross section, the phylloclade is composed of four distinct regions: the epidermis, cortex, vascular cylinder and pith. The phylloclade anatomy indicated xeromorphic characters and provided an insight about its capacity to grow with very little rainfall and/or inputs on dry or marginal lands. Non-articulated laticifers are present in the cortex, vascular cylinder and pith, but their frequency varies with the tissue type. Highest laticifer frequency was observed in vascular cylinder (9.6%) followed by cortex (3.9%) and pith regions (1.9%). In contrast, laticifer index was found to be higher in the pith (12.7%) followed by cortex (3.8%) and vascular cylinder (2.3%). The discovery of a system of laticifers in E. caducifolia not described earlier could also be of taxonomic value. The histo-chemical tests revealed the presence of lipids, phenols, flavonoids, protein and starch in laticifer. As described by TEM observations laticifers contained distinct cell wall, nucleus and cytoplasm with ribosomes, small and big vacuoles, mitochondria, endoplasmic reticulum, plastids and osmophilic bodies. The lipophilic compounds present in the latex of this species could be used as chemical feedstock for the production of biofuels.

Prostate-specific antigen kallikrein and the heart
Salvatore Patanè
World Journal of Cardiology , 2009,
Abstract: Currently, there is growing interest regarding prostate-specific antigen (PSA) and the cardiovascular system. Increased PSA serum levels have been reported after prolonged cardiopulmonary resuscitation, cardiac surgery, extracorporeal cardiopulmonary bypass, acute myocardial infarction (AMI) and coronary artery stenting. The possible role of PSA in cardiac events has been questioned due to the finding of PSA decrease during AMI and by the correlation of variation in PSA levels with coronary lesions and occurrence of major adverse cardiac events. Complexed PSA forms and uncomplexed PSA forms are observed in the bloodstream but the increasing formation of irreversible bound PSA seems to be a crucial finding during AMI. Large studies need to be carried out to confirm these preliminary results and to elucidate unclear aspects. These findings present many potential directions for future research including the role of uncomplexed forms of PSA, the possible distribution of PSA in the heart, the relative expression levels in heart disease states, the mode of expression regulation and other potential specific substrates. The journey of PSA investigation could be longer than initially expected.
Florogenesis and Female Gametophyte Development in Allium cepa L. cv. Krishnapuram  [PDF]
Gujjula Vijaya Lakshmi, Mondam Muni Raja, Mude Lakshmipathi Naik, Sake Pradeep Kumar, Patan Shaik Sha Valli Khan
American Journal of Plant Sciences (AJPS) , 2017, DOI: 10.4236/ajps.2017.89152
Abstract: Florogenesis is one of the most complicated and interesting processes in the nature. This process involves developmental, physiological and molecular events leading to transformation from vegetative to reproductive phase for optimal seed production and the continuation of species. The basic knowledge about flowering processes, male and female sexual systems support basic and applied research and breeding programs. Most of the onion varieties from India are short day varieties, more diverse than other exotic germplasm and useful as a source of new alleles for supporting breeding programs. The present investigation was focused to study for the first time florogenesis process by scanning electron study for the first time florogenesis process by scanning electron microscopy (SEM) and development of female gametophytes by light microscopy in order to acquire basic knowledge useful for optimizing in vitro process to produce gynogenic haploid to support and speed breeding program in short-day onion Allium cepa L. cv. Krishnapuram (KP) or Bangalore Rose. This study revealed that shoot primordium differentiated into inflorescence meristem in the month of December, while seeds were planted in the field in the September. The individual florets are preceded by a variying number of floral initials. The female gametophyte developed from chalazal side megaspore. The embryo sac development is a bisporic Allium type showing short-lived antipodals. The histological study suggests that the use of big or preanthesis flower buds with embryo sac for production of gynogenic haploids to support breeding program in onion cv. Krishnapuram (KP). However further studies are needed for confirmation of this observation.
The First Paleoindian Fishtail Point Find in Salta Province, Northwestern Argentina  [PDF]
Claudio J. Patané Aráoz, Hugo G. Nami
Archaeological Discovery (AD) , 2014, DOI: 10.4236/ad.2014.22004
Abstract: Fishtail or Fell projectile points represent an excellent marker to know the presence of earliest hunter-gatherers populations living during the end of the Pleistocene and its transition to the Holocene. They are widespread in many places along Central and South America. However, there are certain areas with elusive occurrence. Adding new information on the continental and regional distributions of this paleo South American artefact, this paper reports a detailed morphological and technological study of the first fishtail point found in the Salta province, Northwestern Argentina.
Carbon nanotubeben cuprous oxide composite based pressure sensors

Kh S Karimov,Muhammad Tariq Saeed Chani,Fazal Ahmad Khali,Adam Khan,Rahim Khan,

中国物理 B , 2012,
Abstract:
Complicated sternal dehiscence treated with the strasbourg thoracic osteosyntheses system (STRATOS) and the transposition of greater omentum: a case report
Fabrizio Ceresa, Giuseppe Casablanca, Francesco Patanè
Journal of Cardiothoracic Surgery , 2010, DOI: 10.1186/1749-8090-5-53
Abstract: Middle sternotomy is the most common access to the heart and mediastinum used in the cardiac surgery. The incidence of sternal dehiscence with or without infection range from 0,5 to 5,0% and it is a serious complication after cardiac surgery. Obesity, osteoporosis, chronic obstructive pulmonary disease (COPD), diabetes, intake of corticosteroids and off-midline sternotomy are the main risk factors [1]. Sternal refixation can be performed by simple rewiring or techniqual modification of rewiring as described by Robicsek and colleagues [1]. When the bone quality is poor or there are multiple fractures of the sternum, these classical approaches of rewiring can fail and the rigid fixation systems, recently introduced, can be used for the sternal reconstruction [1,2]. We describe the case of a complicated sternal dehiscence, treated with the implant of the Strasbourg Thoracic Osteosyntheses System (STRATOS) and the transposition of the greater omentum.A 75 years-old man with COPD, diabetes, osteoporosis and recent onset of atrial fibrillation underwent aortic valve replacement for severe aortic valve stenosis, complicated by sternal dehiscence, treated by modified rewiring according to Robicsek's technique. The sternal dehiscence, depending on the fractures of some right ribs, occurred again after a week.After having implanted a polypropylene patch to avoid injuries to the underlying heart, we have initially used the vacuum assisted closure (VAC) device to stabilize the chest wall with the negative pressure produced and to sterilize the wound (Figure 1A).When the wound was germe-free, we performed the sternal reconstruction, utilizing the STATOS.The rib clips were crimped with the rib clip fixation pliers on the second, fourth and sixth ribs of the both sides, after having removed the intercostal muscles and the bundle. (Figure 1B and 1C).The connecting bar was cut to the correct length and secured to the clip by crimping (Figure 2A).The remaining dead space was filled w
Isochronal maps at Mt. Etna volcano (Italy): a simple and reliable tool for investigating large-scale heterogeneities
G. Patanè,C. Centamore,S. La Delfa
Annals of Geophysics , 1997, DOI: 10.4401/ag-3874
Abstract: This paper analyses twelve etnean earthquakes which occurred at various depths and recorded at least by eleven stations. The seismic stations span a wide part of the volcanic edifice; therefore each set of direct P-wave arrival times at these stations can be considered appropriate for tracing isochronal curves. Using this simple methodology and the results obtained by previous studies the authors make a reconstruction of the geometry of the bodies inside the crust beneath Mt. Etna. These bodies are interpreted as a set of cooled magmatic masses, delimited by low-velocity discontinuities which can be considered, at present, the major feeding systems of the volcano.
The geodynamics of Mt. Etna volcano during and after the 1984 eruption
S. La Delfa,G. Patanè,C. Centamore
Annals of Geophysics , 1999, DOI: 10.4401/ag-3739
Abstract: Data concerning M > 2.5 earthquakes that occurred at Mt. Etna volcano (Sicily, Italy) during the period April 15th - October 29th, 1984 are here presented and discussed. Only those events with reliable focal mechanisms (at least eight polarities) have been considered. Instrumental information comes from local seismic networks run by the University of Catania and the CNRS (Grenoble, France). The results obtained support the hypothesis that the seismicity and the volcanic activity at Mt. Etna are related to a complex stress field, due to the combined effects of the tectonics associated with the interaction between the African and Eurasian plates and the movement of magma into the crust. In particular, we hypothesize that the tectonic forces caused the end of the 1984 eruption, by means of a "locking mechanism".
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