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Search Results: 1 - 10 of 1417 matches for " Pascale Morin "
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Inverse Agonist and Pharmacochaperone Properties of MK-0524 on the Prostanoid DP1 Receptor
Pascale Labrecque, Sébastien J. Roy, Louis Fréchette, Christian Iorio-Morin, Maxime A. Gallant, Jean-Luc Parent
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065767
Abstract: Prostaglandin D2 (PGD2) acts through two G protein-coupled receptors (GPCRs), the prostanoid DP receptor and CRTH2 also known as DP1 and DP2, respectively. Several previously characterized GPCR antagonists are now classified as inverse agonists and a number of GPCR ligands are known to display pharmacochaperone activity towards a given receptor. Here, we demonstrate that a DP1 specific antagonist, MK-0524 (also known as laropiprant), decreased basal levels of intracellular cAMP produced by DP1, a Gαs-coupled receptor, in HEK293 cells. This reduction in cAMP levels was not altered by pertussis toxin treatment, indicating that MK-0524 did not induce coupling of DP1 to Gαi/o proteins and that this ligand is a DP1 inverse agonist. Basal ERK1/2 activation by DP1 was not modulated by MK-0524. Interestingly, treatment of HEK293 cells expressing Flag-tagged DP1 with MK-0524 promoted DP1 cell surface expression time-dependently to reach a maximum increase of 50% compared to control after 24 h. In contrast, PGD2 induced the internalization of 75% of cell surface DP1 after the same time of stimulation. The increase in DP1 cell surface targeting by MK-0524 was inhibited by Brefeldin A, an inhibitor of transport from the endoplasmic reticulum-Golgi to the plasma membrane. Confocal microscopy confirmed that a large population of DP1 remained trapped intracellularly and co-localized with calnexin, an endoplasmic reticulum marker. Redistribution of DP1 from intracellular compartments to the plasma membrane was observed following treatment with MK-0524 for 24 h. Furthermore, MK-0524 promoted the interaction between DP1 and the ANKRD13C protein, which we showed previously to display chaperone-like effects towards the receptor. We thus report that MK-0524 is an inverse agonist and a pharmacochaperone of DP1. Our findings may have important implications during therapeutic treatments with MK-0524 and for the development of new molecules targeting DP1.
Human Face Recognition, Information Processing and Social Behavior in Children with Autism  [PDF]
Pascale Planche
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.511147
Abstract:

The aim of this study was to investigate whether children with high-functioning autism (HFA) and Asperger’s syndrome (AS) can be differentiated from each other and from typically developing children in ability to recognize a human face. The present study included 69 participants: children with autism (high-functioning autism or Asperger’s syndrome, n = 15 per group) and a control group of 39 typically developing children. It involved a face recognition task included in the NEPSY scale. Results showed that the autism groups performed poorer than the typically developing group, but no difference was found between high-functioning and Asperger groups. Both the information processing peculiarities of children with autism and their (interactional and communicative) social impairments could explain their difficulty to recognize human faces.

The dog and rat olfactory receptor repertoires
Pascale Quignon, Mathieu Giraud, Maud Rimbault, Patricia Lavigne, Sandrine Tacher, Emmanuelle Morin, Elodie Retout, Anne-Sophie Valin, Kerstin Lindblad-Toh, Jacques Nicolas, Francis Galibert
Genome Biology , 2005, DOI: 10.1186/gb-2005-6-10-r83
Abstract: We identified five amino acid patterns characteristic of ORs in the recently sequenced boxer dog and brown Norway rat genomes. Using these patterns, we retrieved 1,094 dog genes and 1,493 rat genes from these shotgun sequences. The retrieved sequences constitute the olfactory receptor repertoires of these two animals. Subsets of 20.3% (for the dog) and 19.5% (for the rat) of these genes were annotated as pseudogenes as they had one or several mutations interrupting their open reading frames. We performed phylogenetic studies and organized these two repertoires into classes, families and subfamilies.We have established a complete or almost complete list of OR genes in the dog and the rat and have compared the sequences of these genes within and between the two species. Our results provide insight into the evolutionary development of these genes and the local amplifications that have led to the specific amplification of many subfamilies. We have also compared the human and rat ORs with the human and mouse OR repertoires.Olfaction is one of the senses developed by animals during the course of evolution for communication with the external world, making it possible to identify prey and to avoid danger. The detection of volatile odorant molecules is a complicated process, the first step of which involves specific binding to specialized receptors. Olfactory receptors (ORs) - encoded by the largest known gene superfamily in the mammalian genome, also known as the olfactory subgenome [1] - are expressed on the surface of the cilia of the olfactory sensory neurons lining the neuroepithelium in the nasal cavity. OR proteins belong to the G protein-coupled receptor superfamily, which is characterized by the presence of seven hydrophobic transmembrane domains. G-protein coupling facilitates the transduction of a signal from the activated olfactory sensory neurons to olfactory glomeruli on the anterior surface of the brain. Secondary neurons then convey the signal to the upper pa
Empowerment interventions, knowledge translation and exchange: perspectives of home care professionals, clients and caregivers
Denise Tribble, Frances Gallagher, Linda Bell, Chantal Caron, Pierre Godbout, Jeannette Leblanc, Pascale Morin, Marianne Xhignesse, Louis Voyer, Mélanie Couture
BMC Health Services Research , 2008, DOI: 10.1186/1472-6963-8-177
Abstract: The qualitative design chosen is a fourth generation evaluation combined with case studies. A home care team of a health and social services center situated in the Eastern Townships (Québec, Canada) will be involved at every step in the study. A sample will be formed of 15 health care professionals and 30 of their home care clients and caregiver. Semi-structured interviews, observations of home care interventions and socio-demographic questionnaires will be used to collect the data. Nine instruments used by the team in prior studies will be adapted and reviewed. A personal log will document the observers' perspectives in order to foster objectivity and the focus on the intervention. The in-depth qualitative analysis of the data will illustrate profiles of enabling interventions and individual empowerment.The ongoing process to transform the health care and social services network creates a growing need to examine intervention practices of health care professionals working with clients receiving home care services. This study will provide the opportunity to examine how the intervention process plays out in real-life situations and how health care professionals, clients and caregivers experience it. The intervention process and individual empowerment examined in this study will enhance the growing body of knowledge about empowerment.This study is part of a process to transform health care practices with the aim of strengthening empowerment of clients with chronic health problems. To achieve this objective, an in-depth analysis of home care interventions will be undertaken using an evolving model of empowerment interventions (enabling interventions). The intervention indicators were derived from the findings of previous studies [1-6].This study is concept-oriented and empirical in nature and will help to further refine interventions supporting empowerment. It is in line with the reform of the Québec health care system that calls for a transition of services from health
El campo semántico de la lepra en Siete Partidas de Alfonso el Sabio
Morin,Alejandro;
Temas medievales , 2004,
Abstract: the purpose of this article is to analyse the semasiological field of leprosy in alfonso x′s siete partidas. on the basis of a terminological survey the interaction claw handedness appears in the partidas referred to with three different semasiological terms depending o whether they refer to segregational customs, to the concept of simony or to the generational transmission of punishment.
Crímenes ocultos: La política de develamiento en las lógicas penitencial y jurídica medievales
Morin,Alejandro;
Temas medievales , 2006,
Abstract: alfonso x mentions in the segunda partida the well known symbolic image of the two spades and assigns to each one a different sphere of action. according to the partida the spiritual spade is in charge of hidden sins while the temporal spade does the same with the evident ones.however the partida does not establish any distinction in the character of hidden or evident sins which would explain which sphere each one belongs to. this fact seems to be the outcome of a process of construction which would by itself define the character of the sins to be judged. the author analyzes the antitheses posed to contemporary juridical logic by this division of sins and, consequently, its influence over the construction of the ideas of sin and crime.
A Europa unida entre a associa??o e a barbárie
Morin, Edgar;
Lua Nova: Revista de Cultura e Política , 1999, DOI: 10.1590/S0102-64451999000100009
Abstract: speaking before the definition of the european union the author, deeply involved in the european cause, warns about the alternative: association or barbarism. as the decade comes to its end his words gain a perturbing actuality.
Sin palabras: Notas sobre la inexistencia del término 'suicida' en el latín clásico y medieval
Morin,Alejandro;
Circe de cl??sicos y modernos , 2008,
Abstract: the word 'suicida' is not practically detected until the xviith century, and this fact explains the forced use of periphrasis or related terms that accomplished on the one hand the function of designing suicides but involved on the other senses that exceeded an aseptic notion of autoinflicted death. the objective of this article is to raise the problem of the nonexistence of this term 'suicida' in classical and medieval latin, approaching the interpretations already tried in some works dedicated to the history of suicide in antiquity and middle ages.
Anotaciones para un nuevo emilio: transmisión sistémica del conocimiento
MORIN,EDGAR;
Signo y Pensamiento , 2010,
Abstract: la universidad moderna nace de la reforma de humboldt, quien introdujo las ciencias en plena expansión y contribuyó de manera decisiva a su desarrollo. pero humboldt era también consciente de que la universidad debía proveer una cultura general, antes que una formación profesional especializada, para afrontar los problemas fundamentales y globales que se nos plantean en este siglo de manera cada vez más vital y urgente. este principio cobra aún más vigencia ahora que vivimos una crisis cultural: la cultura de nuestro siglo necesita comunicación e intercambio entre el conocimiento científico y la cultura humanista. sin embargo, en vez de irrigar como se debiera una competencia general, las disciplinas se encierran en sí mismas; la fragmentación del saber desintegra los problemas fundamentales y globales. es entonces a esos problemas que se debería dedicar una nueva reforma de la universidad, que no sería menos histórica que la de humboldt. ciertamente, cada uno de esos problemas requiere una competencia poli o trans-disciplinar (hay ejemplos), pero es justamente al afrontar esos problemas que se desarrolla esa competencia y se forman nuevos formadores.
Complejidad restringida y Complejidad generalizada o las complejidades de la Complejidad
MORIN,Edgar;
Utopìa y Praxis Latinoamericana , 2007,
Abstract: starting from the assertion about the notion of complexity as not being present in philosophy recognized as such, although present in all thinkers that have developed a complex vision of the world, a characterization is put forward about why classical science has rejected complexity from the xviith to the xxth century, when this type of science has reached a crisis because of the developments that have shown the evidence of complexity; not only in quite complicated systems, therefore called as “complex” (which is termed as `restricted complexity′), but in systems of any sort (`generalized complexity′). an understanding of complexity that is loyal toits etimology that dates back to `complexus′ as what `is knitted-in-common′ and onethat goes forward towards a new paradigmatic vision about-conjuntion, that trascends the disjunctive-analytical paradigm of modern science. a new vision in which the notions of `system′, `emergence′ and `chaos′ adquire new meanings and heuristic value; and hat ought to lead us to a new education tha reunites again notions that have been desintegrated and to an ethics or understanding.
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