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Search Results: 1 - 10 of 997 matches for " Pascale Marcorelles "
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Immunohistochemical localization of hepatopancreatic phospholipase in gastropods mollusc, Littorina littorea and Buccinum undatum digestive cells
Zied Zarai, Nicholas Boulais, Pascale Marcorelles, Eric Gobin, Sofiane Bezzine, Hafedh Mejdoub, Youssef Gargouri
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-219
Abstract: We have previously producted an antiserum reacting specifically with mSDPLA2. It labeled zymogen granules of the hepatopancreatic acinar cells and the secretory materials of certain epithelial cells in the depths of epithelial crypts in the hepatopancreas of snail. To confirm this localization a laser capture microdissection was performed targeting stained cells of hepatopancreas tissue sections. A Western blot analysis revealed a strong signal at the expected size (30 kDa), probably corresponding to the PLA2.The present results support the presence of two hepatopancreatic intracellular and extracellular PLA2 in the prosobranchs gastropods molluscs, Littorina littorea and Buccinum undatum and bring insights on their localizations.Snails require lipids for metabolic energy and for maintaining the structure and integrity of cell membranes in common with other animals to tolerate environemental strains [1]. The analyses of lipid composition of digestive gland and pedal muscle of two northern freshwater pulmonate snails Lymnaea stagnalis and Lymnaea ovata and three marine prosobranch gastropods Littorina obtusata, Littorina littorea and Buccinum undatum from the White Sea, shown that the content of triacylglycerides both in digestive gland and pedal was higher in littoral dwellers Littorina, the activity of which depends on the tide level. The presence of massive shell enhances demands in energy needed for supporting movement and activity. Because the intensity of energy metabolism is related to quantity of total phospholipids, mitochondria and activity of their oxidizing ferments, the presence of thick shell in marine snails together with motor activity costs more in terms of energy than in freshwater snails with thin shell [1].In different molluscs, food is processed to varying degrees as it passes through the alimentary tract. It is generally assumed that digestion of ingested material takes place in two phases, an extracellular process and intracellular digestion, w
CD133 Is a Marker of Bioenergetic Stress in Human Glioma
Corinne E. Griguer, Claudia R. Oliva, Eric Gobin, Pascale Marcorelles, Dale J. Benos, Jack R. Lancaster, G. Yancey Gillespie
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003655
Abstract: Mitochondria dysfunction and hypoxic microenvironment are hallmarks of cancer cell biology. Recently, many studies have focused on isolation of brain cancer stem cells using CD133 expression. In this study, we investigated whether CD133 expression is regulated by bioenergetic stresses affecting mitochondrial functions in human glioma cells. First, we determined that hypoxia induced a reversible up-regulation of CD133 expression. Second, mitochondrial dysfunction through pharmacological inhibition of the Electron Transport Chain (ETC) produced an up-regulation of CD133 expression that was inversely correlated with changes in mitochondrial membrane potential. Third, generation of stable glioma cells depleted of mitochondrial DNA showed significant and stable increases in CD133 expression. These glioma cells, termed rho0 or ρ0, are characterized by an exaggerated, uncoupled glycolytic phenotype and by constitutive and stable up-regulation of CD133 through many cell passages. Moreover, these ρ0 cells display the ability to form “tumor spheroids” in serumless medium and are positive for CD133 and the neural progenitor cell marker, nestin. Under differentiating conditions, ρ0 cells expressed multi-lineage properties. Reversibility of CD133 expression was demonstrated by transfering parental mitochondria to ρ0 cells resulting in stable trans-mitochondrial “cybrid” clones. This study provides a novel mechanistic insight about the regulation of CD133 by environmental conditions (hypoxia) and mitochondrial dysfunction (genetic and chemical). Considering these new findings, the concept that CD133 is a marker of brain tumor stem cells may need to be revised.
Human Face Recognition, Information Processing and Social Behavior in Children with Autism  [PDF]
Pascale Planche
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.511147

The aim of this study was to investigate whether children with high-functioning autism (HFA) and Asperger’s syndrome (AS) can be differentiated from each other and from typically developing children in ability to recognize a human face. The present study included 69 participants: children with autism (high-functioning autism or Asperger’s syndrome, n = 15 per group) and a control group of 39 typically developing children. It involved a face recognition task included in the NEPSY scale. Results showed that the autism groups performed poorer than the typically developing group, but no difference was found between high-functioning and Asperger groups. Both the information processing peculiarities of children with autism and their (interactional and communicative) social impairments could explain their difficulty to recognize human faces.

A Missense Mutation in the Alpha-Actinin 1 Gene (ACTN1) Is the Cause of Autosomal Dominant Macrothrombocytopenia in a Large French Family
Paul Guéguen, Karen Rouault, Jian-Min Chen, Odile Raguénès, Yann Fichou, Elisabeth Hardy, Eric Gobin, Brigitte Pan-petesch, Mathieu Kerbiriou, Pascal Trouvé, Pascale Marcorelles, Jean-francois Abgrall, Cédric Le Maréchal, Claude Férec
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074728
Abstract: Inherited thrombocytopenia is a heterogeneous group of disorders characterized by a reduced number of blood platelets. Despite the identification of nearly 20 causative genes in the past decade, approximately half of all subjects with inherited thrombocytopenia still remain unexplained in terms of the underlying pathogenic mechanisms. Here we report a six-generation French pedigree with an autosomal dominant mode of inheritance and the identification of its genetic basis. Of the 55 subjects available for analysis, 26 were diagnosed with isolated macrothrombocytopenia. Genome-wide linkage analysis mapped a 10.9 Mb locus to chromosome 14 (14q22) with a LOD score of 7.6. Candidate gene analysis complemented by targeted next-generation sequencing identified a missense mutation (c.137GA; p.Arg46Gln) in the alpha-actinin 1 gene (ACTN1) that segregated with macrothrombocytopenia in this large pedigree. The missense mutation occurred within actin-binding domain of alpha-actinin 1, a functionally critical domain that crosslinks actin filaments into bundles. The evaluation of cultured mutation-harboring megakaryocytes by electron microscopy and the immunofluorescence examination of transfected COS-7 cells suggested that the mutation causes disorganization of the cellular cytoplasm. Our study concurred with a recently published whole-exome sequence analysis of six small Japanese families with congenital macrothrombocytopenia, adding ACTN1 to the growing list of thrombocytopenia genes.
Patients' perspectives on high-tech home care: a qualitative inquiry into the user-friendliness of four technologies
Pascale Lehoux
BMC Health Services Research , 2004, DOI: 10.1186/1472-6963-4-28
Abstract: Four home care interventions that are frequently used and vary in their technical and clinical features were selected: Antibiotic intravenous therapy, parenteral nutrition, peritoneal dialysis and oxygen therapy. Our qualitative study relied on the triangulation of three sources of data: 1) interviews with patients (n = 16); 2) interviews with carers (n = 6); and 3) direct observation of nursing visits of a different set of patients (n = 16). Participants of varying socioeconomic status were recruited through primary care organizations and hospitals that deliver home care within 100 km of Montreal, the largest urban area in the province of Quebec, Canada.The four interventions have both a negative and positive effect on patients' lives. These technologies were rarely perceived as user-friendly, and user-acceptance was closely linked to user-competence. Compared with acute I.V. patients, who tended to be passive, chronic patients seemed keener to master technical aspects. While some of the technical and human barriers were managed well in the home setting, engaging in the social world was more problematic. Most patients found it difficult to maintain a regular job because of the high frequency of treatment, while some carers found their autonomy and social lives restricted. Patients also tended to withdraw from social activities because of social stigmatization and technical barriers.While technology contributes to improving the patients' health, it also imposes significant constraints on their lives. Policies aimed at developing home care must clearly integrate principles and resources supporting the appropriate use of technology. Close monitoring of patients should be part of all technology-enhanced home care programs.The possibility of managing patients outside of the hospital has rarely been so widely considered. Indeed, home care is often seen as less costly and more patient-friendly [1]. However, the effectiveness and safety of home care have yet to be subjecte
La parte ideal de la crisis: Los mineros cooperativistas de Bolivia frente a la recesión
Cuadernos de antropolog?-a social , 2010,
Abstract: even in the most precarious situations, the responses to the economic recessions are not limited to the practical application of survival resolution. these answers generate imaginaries, moral representations and prior experiences that give sense to the events and organize strategies. taking this fact into account, this paper proposes to analyze the idealistic aspects of the economic global crisis through the experiences of the cooperative workers in the mines of bolivia. their logic of interpretation is far from those proposed by the salary and the welfare state. thus, the crisis appears as an ideal heuristic situation to understand market and labour representations of the social actors. as a matter of fact, we can observe that for the bolivian miners the breakdown of the miner's market was less traumatic that the previously unseen prosperity. this assessment reminds us that the sudden excessive accumulation of wealth can be a crisis equal to that experienced by the economical recession.
Psicodinamica do trabalho e rela??es sociais de sexo: um itinerário interdisciplinar. 1988-2002
Molinier, Pascale;
Produ??o , 2004, DOI: 10.1590/S0103-65132004000300003
Abstract: the psychodynamics of work is defined as the analysis of psychic processes mobilized by the gathering of a subject and the work organization constraints. in the 80s, the researches conducted in male workplace environments allowed to uncover the existence of collective defense strategies against suffering at the work. as from 1988, an important interdisciplinary work with work sociologies was launched. it is concerned with knowing whether the psychodynamics work was heuristic to equally analyze the situations of women at work and to reexamine the preexisting knowledge on men suffering in a sexualized problematic framework. the paper reports the main determinants which led to the establishment of sex social relationships and its challenge, the sexual division of work, a central dimension of the clinic research, the theory and methodology in workplace psychodynamics. an important issue in the paper is the situation of nurses, from which is constituted the main knowledge on the relations between health and work on the women's side.
A dimens?o do cuidar no trabalho hospitalar: abordagem psicodinamica do trabalho de enfermagem e dos servi?os de manuten??o
Molinier, Pascale;
Revista Brasileira de Saúde Ocupacional , 2008, DOI: 10.1590/S0303-76572008000200002
Abstract: starting from both clinic and theory on work psychodynamics, this article shows the importance of the compassion dimension in several activities involving hospital care. the results of investigations held within nursing staff and technical service managers revealed a care dimension included in all kinds of hospital tasks. however, care taking depends not only on good will or greatness of the soul, but it implies concrete organizational conditions.
Landscapes with Figures in Wordsworth’s Prelude (1805) Paysages avec figures dans le Prélude (1805) de William Wordsworth
Pascale Guibert
Revue LISA / LISA e-journal , 2009, DOI: 10.4000/lisa.93
Abstract: Bien que l’iconographie wordsworthienne s’attache à représenter le poète en promeneur solitaire, les paysages qu’il retrace lui-même dans le Prélude de 1805 sont fort peuplés. De multiples personnages — qu’il faudra bien appeler figures — animent ses paysages. Ils les animent au sens propre du terme : c’est-à-dire qu’ils conduisent le mouvement dont les paysages wordsworthiens sont à la fois le produit et la scène. Ces figures, loin de faire de la figuration, donc, configurent, dans un jeu typiquement wordsworthien d’activité passive, la nouvelle vision du monde qui se trame dans ces paysages. Ils effectuent et relayent les principes de la poétique wordsworthienne — combinaison, rayonnement, exaltation — par laquelle “la révolution copernicienne” du romantisme a “lieu”.
Pascale Guibert
Revue LISA / LISA e-journal , 2007, DOI: 10.4000/lisa.1195
Abstract: Ce numéro intitulé En Terre étrangère ? de la Revue LISA/LISA e-journal, se propose de ré-examiner les relations entre poésie et arts graphiques. Composée uniquement de contributions de chercheurs littéraires, elle aura cependant cherché à éviter tout verbocentrisme — de même que son opposé eidolatre . En effet, il se sera agi ici ni de raviver la guerre des signes, ni de l’étouffer, mais d’explorer dans le détail ce qui se passe à la jonction de ces deux formes d’art. Nous ne sati...
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