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Search Results: 1 - 10 of 8051 matches for " Park JH "
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Heat content asymptotics for operators of Laplace type with spectral boundary conditions
P. Gilkey,K. Kirsten,JH. Park
Physics , 2003, DOI: 10.1023/B:MATH.0000043236.80871.34
Abstract: Let $P$ be an operator of Dirac type and let $D=P^2$ be the associated operator of Laplace type. We impose spectral boundary conditions and study the leading heat content coefficients for $D$.
Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect
Kim D, Park JH, Kweon DJ, Han GD
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S38430
Abstract: ioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect Original Research (748) Total Article Views Authors: Kim D, Park JH, Kweon DJ, Han GD Published Date February 2013 Volume 2013:8 Pages 451 - 459 DOI: http://dx.doi.org/10.2147/IJN.S38430 Received: 23 September 2012 Accepted: 24 November 2012 Published: 05 February 2013 Dongyeop Kim,1,3* Jin-Hong Park,2* Dae-Jun Kweon,2 Gi Dong Han1 1Department of Food Science and Technology, College of Natural Resources, Yeungnam University, Gyeongsan, Republic of Korea; 2BioHealth Convergence Center, Daegu Technopark, Daegu, Republic of Korea; 3Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan *These authors contributed equally to this work Background: The aim of this study was to enhance the bioavailability of conjugated linoleic acid (CLA), which has low water solubility, using nanoemulsion technology and to evaluate the effects of its improved bioavailability as an antiobesity agent. Methods: The antiobesity effect of nanoemulsified water-soluble conjugated linoleic acid (N-CLA) was evaluated using in vitro and in vivo studies. Differentiated 3T3-L1 adipocytes were treated with CLA and N-CLA to assess their lipolytic effect. Further, to confirm the antiobesity effect of N-CLA, male Sprague-Dawley rats were randomly separated into four groups, ie, a group fed a normal diet, a group fed a high-fat diet (obesity rat model), a CLA-treated group, and an N-CLA-treated group. Results: N-CLA showed a greater lipolytic effect on differentiated 3T3-L1 adipocytes compared with normal CLA. N-CLA enhanced the release of glycerol from triglycerides, which accumulated in differentiated 3T3-L1 adipocytes. Further, N-CLA enhanced leptin secretion to an extent similar to that of orlistat, an antiobesity agent. In an animal obesity model fed a high-fat diet, N-CLA attenuated accumulation of triglycerides, total cholesterol, and low-density lipoprotein cholesterol in serum, and also significantly decreased the volume of triglycerides and cholesterol in liver tissue. Conclusion: These results indicate that N-CLA has a greater antiobesity effect than CLA as a result of its improved bioavailability.
Bioavailability of nanoemulsified conjugated linoleic acid for an antiobesity effect
Kim D,Park JH,Kweon DJ,Han GD
International Journal of Nanomedicine , 2013,
Abstract: Dongyeop Kim,1,3* Jin-Hong Park,2* Dae-Jun Kweon,2 Gi Dong Han11Department of Food Science and Technology, College of Natural Resources, Yeungnam University, Gyeongsan, Republic of Korea; 2BioHealth Convergence Center, Daegu Technopark, Daegu, Republic of Korea; 3Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan *These authors contributed equally to this workBackground: The aim of this study was to enhance the bioavailability of conjugated linoleic acid (CLA), which has low water solubility, using nanoemulsion technology and to evaluate the effects of its improved bioavailability as an antiobesity agent.Methods: The antiobesity effect of nanoemulsified water-soluble conjugated linoleic acid (N-CLA) was evaluated using in vitro and in vivo studies. Differentiated 3T3-L1 adipocytes were treated with CLA and N-CLA to assess their lipolytic effect. Further, to confirm the antiobesity effect of N-CLA, male Sprague-Dawley rats were randomly separated into four groups, ie, a group fed a normal diet, a group fed a high-fat diet (obesity rat model), a CLA-treated group, and an N-CLA-treated group.Results: N-CLA showed a greater lipolytic effect on differentiated 3T3-L1 adipocytes compared with normal CLA. N-CLA enhanced the release of glycerol from triglycerides, which accumulated in differentiated 3T3-L1 adipocytes. Further, N-CLA enhanced leptin secretion to an extent similar to that of orlistat, an antiobesity agent. In an animal obesity model fed a high-fat diet, N-CLA attenuated accumulation of triglycerides, total cholesterol, and low-density lipoprotein cholesterol in serum, and also significantly decreased the volume of triglycerides and cholesterol in liver tissue.Conclusion: These results indicate that N-CLA has a greater antiobesity effect than CLA as a result of its improved bioavailability.Keywords: conjugated linoleic acid, nanoemulsion, water-soluble, improved bioavailability, antiobesity
Recent trends in the characteristics and prognosis of patients hospitalized with acute heart failure
Park D,McManus D,Darling C,Goldberg JH
Clinical Epidemiology , 2011,
Abstract: David Park1, David McManus1, Chad Darling3, Jordan H Goldberg2, Joel M Gore1,2, Darleen Lessard2, Robert J Goldberg21Department of Medicine, University of Massachusetts Medical School, 2Division of Epidemiology of Chronic Diseases, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 3Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USABackground: Despite the magnitude and impact of heart failure (HF) in the United States, relatively little data are available that describe the prognosis associated with acute HF, especially from the perspective of a population-based investigation. The purpose of this nonconcurrent prospective study was to describe the overall, and changing trends therein, prognosis of 4228 patients discharged from all eleven greater Worcester (MA) medical centers after a documented episode of acute HF and factors associated with an increased risk of dying after hospital discharge.Methods: The study population consisted of residents of the Worcester metropolitan area discharged after being hospitalized for acute HF at all greater Worcester medical centers during 1995 (n = 1783) and 2000 (n = 2445).Results: The 3-month (20% versus 18%), 1-year (41% versus 38%), and 5-year (84% versus 82%) death rates were lower in patients discharged from all metropolitan Worcester hospitals in 2000 versus 1995, respectively. Improving long-term survival rates for patients discharged in 2000 as compared with 1995 were magnified after controlling for several confounding demographic and clinical factors of prognostic importance. A number of potentially modifiable demographic, medical history, and clinical factors were associated with an increased risk of dying during the first year after hospital discharge for acute HF.Conclusion: The results of this community-wide observational study suggest improving trends in the long-term prognosis after acute HF. Despite these encouraging trends, the long-term prognosis for patients with acute HF remains poor, and several at-risk groups can be identified for early intervention and increased monitoring efforts.Keywords: population-based study, long-term prognosis, post-discharge survivors
A nanohybrid system for taste masking of sildenafil
Lee JH, Choi G, Oh YJ, Park JW, Choy YB, Park MC, Yoon YJ, Lee HJ, Chang HC, Choy JH
International Journal of Nanomedicine , 2012, DOI: http://dx.doi.org/10.2147/IJN.S28264
Abstract: nanohybrid system for taste masking of sildenafil Original Research (3259) Total Article Views Authors: Lee JH, Choi G, Oh YJ, Park JW, Choy YB, Park MC, Yoon YJ, Lee HJ, Chang HC, Choy JH Published Date March 2012 Volume 2012:7 Pages 1635 - 1649 DOI: http://dx.doi.org/10.2147/IJN.S28264 Received: 15 November 2011 Accepted: 02 February 2012 Published: 26 March 2012 Ji-Hee Lee1,*, Goeun Choi1,*, Yeon-Ji Oh1, Je Won Park1, Young Bin Choy3, Mung Chul Park1, Yeo Joon Yoon1, Hwa Jeong Lee2, Hee Chul Chang4, Jin-Ho Choy1 1Center for Intelligent Nano-Bio Materials (CINBM), Department of Bioinspired Science and Department of Chemistry and Nano Science, 2Division of Life and Pharmaceutical Sciences and College of Pharmacy, Ewha Womans University, Seoul, Korea; 3Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea; 4Global Strategy Center and Pharmaceutical Research Institute, Daewoong Pharmaceutical Co., Ltd., Seoul, Korea *These authors contributed equally to this work Abstract: A nanohybrid was prepared with an inorganic clay material, montmorillonite (MMT), for taste masking of sildenafil (SDN). To further improve the taste-masking efficiency and enhance the drug-release rate, we coated the nanohybrid of SDN–MMT with a basic polymer, polyvinylacetal diethylaminoacetate (AEA). Powder X-ray diffraction and Fourier transform infrared experiments showed that SDN was successfully intercalated into the interlayer space of MMT. The AEA-coated SDN–MMT nanohybrid showed drug release was much suppressed at neutral pH (release rate, 4.70 ± 0.53%), suggesting a potential for drug taste masking at the buccal cavity. We also performed in vitro drug release experiments in a simulated gastric fluid (pH = 1.2) and compared the drug-release profiles of AEA-coated SDN–MMT and Viagra , an approved dosage form of SDN. As a result, about 90% of SDN was released from the AEA-coated SDN–MMT during the first 2 hours while almost 100% of drug was released from Viagra . However, an in vivo experiment showed that the AEA-coated SDN–MMT exhibited higher drug exposure than Viagra . For the AEA-coated SDN–MMT, the area under the plasma concentration–time curve from 0 hours to infinity (AUC0-∞) and maximum concentration (Cmax) were 78.8 ± 2.32 μg hour/mL and 12.4 ± 0.673 μg/mL, respectively, both of which were larger than those obtained with Viagra (AUC0-∞ = 69.2 ± 3.19 μg hour/mL; Cmax = 10.5 ± 0.641 μg/mL). Therefore, we concluded that the MMT-based nanohybrid is a promising delivery system for taste masking of SDN with possibly improved drug exposure.
Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups
Hong SC, Lee JH, Lee J, Kim HY, Park JY, Cho J, Lee J, Han DW
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S26355
Abstract: btle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups Original Research (4218) Total Article Views Authors: Hong SC, Lee JH, Lee J, Kim HY, Park JY, Cho J, Lee J, Han DW Published Date December 2011 Volume 2011:6 Pages 3219 - 3231 DOI: http://dx.doi.org/10.2147/IJN.S26355 Seong Cheol Hong1,*, Jong Ho Lee1,*, Jaewook Lee1, Hyeon Yong Kim1, Jung Youn Park2, Johann Cho3, Jaebeom Lee1, Dong-Wook Han1 1Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience and Nanotechnology, Pusan National University, 2Department of Biotechnology Research, National Fisheries Research and Development Institute, Busan, 3Electronic Materials Lab, Samsung Corning Precision Materials Co, Ltd, Gumi City, Gyeongsangbukdo, Korea *These authors contributed equally to this work Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely utilized for the diagnosis and therapy of specific diseases, as magnetic resonance imaging (MRI) contrast agents and drug-delivery carriers, due to their easy transportation to targeted areas by an external magnetic field. For such biomedical applications, SPIONs must have multifunctional characteristics, including optimized size and modified surface. However, the biofunctionality and biocompatibility of SPIONs with various surface functional groups of different sizes have yet to be elucidated clearly. Therefore, it is important to carefully monitor the cytotoxicity and genotoxicity of SPIONs that are surfaced-modified with various functional groups of different sizes. In this study, we evaluated SPIONs with diameters of approximately 10 nm and 100~150 nm, containing different surface functional groups. SPIONs were covered with –O-groups, so-called bare SPIONs. Following this, they were modified with three different functional groups – hydroxyl (–OH), carboxylic (–COOH), and amine (–NH2) groups – by coating their surfaces with tetraethyl orthosilicate (TEOS), (3-aminopropyl)trimethoxysilane (APTMS), TEOS-APTMS, or citrate, which imparted different surface charges and sizes to the particles. The effects of SPIONs coated with these functional groups on mitochondrial activity, intracellular accumulation of reactive oxygen species, membrane integrity, and DNA stability in L-929 fibroblasts were determined by water-soluble tetrazolium, 2',7'-dichlorodihydrofluorescein, lactate dehydrogenase, and comet assays, respectively. Our toxicological observations suggest that the functional groups and sizes of SPIONs are critical determinants of cellular responses, degrees of cytotoxicity and genotoxicity, and potential mechanisms of toxicity. Nanoparticles with various surface modifications and of different sizes induced slight, but possibly meaningful, changes in cell cytotoxicity and genotoxicity, which would be significantly valuable in further studies of bioconjugation and cell interaction for drug delivery, cell cu
Review on Pharmacologically Active Metabolites from Yarsagumba (Ophiocordyceps sinensis), an Epitome of Himalayan Elixir
S Shrestha,AK Shrestha,JH Park,DY Lee,JG Cho,B Shrestha,NI Baek
Nepal Journal of Science and Technology , 2013, DOI: 10.3126/njst.v14i2.10415
Abstract: Yarsagumba ( Ophiocordyceps sinensis (Berk.) Sung et al .) is a well-known entomogenous fungus native to alpine nival terrain of trans-Himalaya and Tibetan Plateau. The traditional use of O. sinensis in Ayurvedic medicine as well as in traditional Chinese medicine for range of human health requirements with well documented evidences are themselves testimony of its value. It is regarded as winter worm, summer grass due to its association with Thitarodes ( Hepialus ) larvae. The extremities of habitat condition and endurance of fungus to sustain adversaries by production of metabolites has led to unique profile of metabolites including nucleosides, proteins and nitrogenous compounds, polysaccharides, sterols, fatty acids and their derivatives, as well as some vitamins and inorganics. There are wide ranges of biological activities that have been reported from O. sinensis including anti-inflammatory, antioxidant, anti-tumor, anti-metastatic, immunomodulatory, antimicrobial, insecticidal, hypolipidaemic, hypoglycemic, antiageing, lipolytic, neuroprotective, renoprotective effects, etc. Although several components can be responsible for activity of compounds, understanding ultimate compounds which fit with biomolecular target is crucial to combat diseases and development of new class of effective drugs. In this review a concise evaluation of pharmacological activities of metabolites reported for O. sinensis are done to provide insight into its biologically active components. DOI: http://dx.doi.org/10.3126/njst.v14i2.10415 ? Nepal Journal of Science and Technology Vol. 14, No. 2 (2013) 49-58
High density diets for dwarf layers
JH Quisenberry
Genetics Selection Evolution , 1972, DOI: 10.1186/1297-9686-4-2-271
Abstract:
Rations concentrées pour les pondeuses naines
JH Quisenberry
Genetics Selection Evolution , 1971, DOI: 10.1186/1297-9686-3-3-389
Abstract:
Breeding for beef production and dairy cattle ranching in Latin America
JH Weniger
Genetics Selection Evolution , 1982, DOI: 10.1186/1297-9686-14-1-102a
Abstract:
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