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Search Results: 1 - 10 of 4442 matches for " Paola Zavarise "
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A Combination of Tanacetum parthenium, Griffonia simplicifolia and Magnesium (Aurastop) as Symptomatic Acute Treatment for Migraine Aura: A Retrospective Cohort Study  [PDF]
Paola Zavarise, Giorgio Dalla Volta
Open Access Library Journal (OALib Journal) , 2017, DOI: 10.4236/oalib.1103660
Abstract:
Background: effective treatments for migraine aura and related symptoms are not yet well established. In the last years, several herbal and/or nutraceutical preparations have been proposed as potential treatment. We report the results of a retrospective analysis on the synergistic effect of three nutraceutical components (Tanacetum parthenium, Griffonia simpliciofila and Magnesium, Aurastop) as symptomatic treatment of migraine aura and related symptoms. Method: Forty-nine subjects with headache with aura were recruited from the headache Center of the Istituto Clinico Citta’ di Brescia to enter the studied that consist to treat the first 3 aura attacks as usual and the next 3 taking a tablet of Aurastop at the beginning of the aura phenomena. They had to describe aura and headache characteristics of previous three attacks (t1) and the modification of these parameters with the assumption of Aurastop for the following three attacks (t2). Results: A significant reduction (>50%) in aura duration (t1 = 33.6 ± 10.1 minutes vs. t2 = 9.4 ± 6.2 minutes, p < 0.01 FWER corrected) as well as in overall disability (median [interquartile range]) (t1 = 5[4 - 5] vs. t2 = 1[1 - 2], p < 0.01 FWER corrected) was evident. Furthermore, modification of aura type as well as a series of parameters more related to headache (number of headache attacks, duration, intensity, utilization of analgesics and response to symptomatic treatment) was influenced by Aurastop utilization (p < 0.01 FWER corrected). No significant adverse effects were recorded after the assumption of Aurastop. Conclusions: the combined and synergistic effect of Tanacetum parthenium, Griffonia simpliciofila and Magnesium (Aurastop) highlights the idea that symptomatic treatment potentially modulating cortical spreading depression could deserve attention to mitigate aura and related symptoms (migraine as well as long-lasting discomfort). Further blinded, placebo-controlled studies on larger groups are warranted.
Efficacy of a Combination of Tanacetum parthenium, 5-Hydroxy Tryptophan and Magnesium (Aurastop) in the Prevention of High Frequency Migraine with Aura  [PDF]
Giorgio Dalla Volta, Paola Zavarise, Laura Perego, Alessandro Pezzini
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104939
Abstract:
Object: To verify the efficacy and safety of the new combination of Tanacetum parthenium 150 mg, 5-hydrossitriptophan (5-HTTP) 20 mg and magnesium 185 mg (Aurastop) in the prophylactic treatment of high frequency migraine with aura (MWA). According to the international headache classification (IHCD 3 beta version) the aura phenomena have a duration of 5 - 60 minutes for any of the usual disturbances (visual, somatosensory and speech disturbance) but no classification describes the frequency of this phenomena. Patients who experience migraine aura emphasize the emotional impact of such a phenomenon, mostly because of the severe, though transient, disability caused by the aura symptoms (i.e., inability to work or driving a vehicle). Furthermore, a profound asthenia lasts for about 48 hours after the resolution of the painful phase. Materials and Method: 18 patients (F: n = 10, M: n = 8, mean age: 28) presenting with an ICHD-3 beta diagnosis of migraine with aura (MWA) with a frequency of more than 5 attacks of migraine with aura per month since at least 6 months, were enrolled in the survey and treated with Aurastop© twice a day for a period of 3 months. Diary cards were filled in during a 3-month period before the beginning of the survey and during the 3-month duration of the study. The reduction of MWA attacks per month was assessed as the primary end-point; the reduction of the duration and disability of the aura and of the intensity of the headache were considered as secondary end-points. Results: A statistically significant reduction of MWA attacks/month was observed: more than 95% of the patients referred a reduction >50% of the frequency, 66.6% a reduction of more than 70%, and 16.6% a complete disappearance of the attacks after the first week of therapy. Moreover, a sensible reduction of the duration and disability of the aura phenomena was reported by more than 90% of the patients and, in the 55% of the patients also a reduction of the intensity of the headache. No side effects were reported. The efficacy started to appear during the first month of intake and was maintained during the three months of therapy.
New Therapeutic Approach to Primary Stabbing Headache  [PDF]
Gaelle K. Ngonga, Daniela Carli, Paola Zavarise, Stefano Vollaro, Giorgio Dalla Volta
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102529
Abstract: Primary stabbing headache has been known for several decades. However, the pathophysiology of this disease is not still understood. It is clinically characterized by single episodes or short-lasting series of stabbing pain recurring from once to many times per day in an irregular pattern. The diagnosis is clinical and any other possible cause should be excluded. The therapeutic approach indicates Indomethacin as the first choice of treatment, although case reports describe a therapeutic response to Melatonin, Celecoxib, Nidedipine, Paracetamol and Gabapentin. We describe the case of 5 patients with diagnosis of primary stabbing headache without comorbidity of anxiety or depression that shows a partial response to Indomethacin, but do respond to Benzodiazepines. There is little on the use of Benzodiazepines in primary headaches. They are used in patients with chronic migraine when there is a comorbidity of anxiety and depression. The unexpected efficacy of these molecules in our patients is encouraging and represents a hint to think about using these molecules in other types of primary headaches.
Off-line data processing and analysis for the GERDA experiment
M. Agostini,L. Pandola,P. Zavarise
Physics , 2011, DOI: 10.1088/1742-6596/368/1/012047
Abstract: GERDA is an experiment designed to look for the neutrinoless double beta decay of Ge-76. The experiment uses an array of high-purity germanium detectors, enriched in Ge-76, directly immersed in liquid argon. GERDA is presently operating eight enriched coaxial detectors (approximately 15 kg of Ge-76) and about 30 new custom-made enriched BEGe detectors will be deployed in the next phase (additional 20 kg of Ge-76). The paper describes the GERDA off-line analysis of the high-purity germanium detector data. Firstly we present the signal processing flow, focusing on the digital filters and on the algorithms used. Secondly we discuss the rejection of non-physical events and the data quality monitoring. The analysis is performed completely with the GERDA software framework (GELATIO), designed to support a multi-channel processing and to perform a modular analysis of digital signals.
The Employment of Young Graduates in the Period 2000-2010: A Comparison between Six European Countries  [PDF]
Paola Potestio
Modern Economy (ME) , 2011, DOI: 10.4236/me.2011.25099
Abstract: The paper aims to assess the relative importance of participation and unemployment and the interaction between them in affecting the evolution of employment rates of young graduates in selected European countries. The Taylor formula is used to read the behaviour of employment rates in terms of movements in activity and unemployment rates. Using this analytical procedure, the comparison between the selected countries underscores two aspects in particular: the progressive isolation of Italy, due to the poor results of the reform of the higher education system at the end of the 1990s, and the widespread progress within the female segments. On a more general plane, the heterogeneity of European labour markets for young graduates assumes new characteristics in the decade but—it is argued—it remains significant. The relative importance of participation and unemployment, the impact of the reforms of the higher education system, the reaction to the crisis of the late 2000s, and the gender aspects sharply differentiate the evolution of young graduate employment in the individual countries.
GELATIO: a general framework for modular digital analysis of high-purity Ge detector signals
M. Agostini,L. Pandola,P. Zavarise,O. Volynets
Physics , 2011, DOI: 10.1088/1748-0221/6/08/P08013
Abstract: GELATIO is a new software framework for advanced data analysis and digital signal processing developed for the GERDA neutrinoless double beta decay experiment. The framework is tailored to handle the full analysis flow of signals recorded by high purity Ge detectors and photo-multipliers from the veto counters. It is designed to support a multi-channel modular and flexible analysis, widely customizable by the user either via human-readable initialization files or via a graphical interface. The framework organizes the data into a multi-level structure, from the raw data up to the condensed analysis parameters, and includes tools and utilities to handle the data stream between the different levels. GELATIO is implemented in C++. It relies upon ROOT and its extension TAM, which provides compatibility with PROOF, enabling the software to run in parallel on clusters of computers or many-core machines. It was tested on different platforms and benchmarked in several GERDA-related applications. A stable version is presently available for the GERDA Collaboration and it is used to provide the reference analysis of the experiment data.
An Integrated Statistical Model to Measure Academic Teaching Quality  [PDF]
Paola Cerchiello, Paolo Giudici
Open Journal of Statistics (OJS) , 2012, DOI: 10.4236/ojs.2012.25063
Abstract: The aim of this paper is to present a new proposal for the classification of Academic institutions in terms of quality of teaching. Our methodological proposal borrows concepts from operational risk, such as scorecard models, employed to assess University performances, on the basis of both the perceived and the actual quality. We propose to summarize opinion data using new non parametric indexes able to exploit efficiently the ordinal nature of the analysed variables and to integrate different sources of data. In particular we show how web survey methods can improve the quality and robustness of collected data, especially when integrated with students career data. Empirical evidence is given on the basis of real data from the University of Pavia.
Dirichlet Compound Multinomials Statistical Models  [PDF]
Paola Cerchiello, Paolo Giudici
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.312A288
Abstract:

This contribution deals with a generative approach for the analysis of textual data. Instead of creating heuristic rules forthe representation of documents and word counts, we employ a distribution able to model words along texts considering different topics. In this regard, following Minka proposal (2003), we implement a Dirichlet Compound Multinomial (DCM) distribution, then we propose an extension called sbDCM that takes explicitly into account the different latent topics that compound the document. We follow two alternative approaches: on one hand the topics can be unknown, thus to be estimated on the basis of the data, on the other hand topics are determined in advance on the basis of a predefined ontological schema. The two possible approaches are assessed on the basis of real data.

Intraplate Transtensional Tectonics in the East Antarctic Craton: Insight from Buried Subglacial Bedrock in the Lake Vostok—Dome C Region  [PDF]
Paola Cianfarra, Francesco Salvini
International Journal of Geosciences (IJG) , 2013, DOI: 10.4236/ijg.2013.49122
Abstract:

This study presents the results of forward numerical models of a series of sections of the Aurora Trench (East Antarctica) derived from radio echo-sounding data that allowed to reconstruct the 3D shape of the Aurora Fault, a crustal listric normal fault characterized by a length exceeding 100 km. A similar extensional fault setting allows to replicate the asymmetric buried morphology of the magnetic basement at the Lake Vostok depression derived by the available gravity and magnetic profiles. Both the Aurora and Vostok listric fault reach their basal decollment at 34 km depth, possibly the base of the crust in this intracratonic environment. Integration of these results with the existing geologic interpretations of the tectonic origin of the Concordia Trench by normal faulting allowed to frame the Concordia, Aurora and Vostok normal faults within an intraplate transtensional corridor with a left-lateral movement component. The westward projection of the proposed strike-slip deformation belt may develop in correspondence of an older tectonic lineament stretching from the Eastern flanks of the Gamburtsev Subglacial Mts to the Lambert rift and characterized by a poly-phased complex tectonic history. The possible Cenozoic reactivation of these structures is discussed in the paper.

Creativity & Innovation: Four Key Issues from a Literature Review  [PDF]
Francesco Pisanu, Paola Menapace
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.53023
Abstract:

This paper is about creativity and innovation in the educational field. Through a literature review, we describe the results of two decades of research on creativity and innovation in the educational and organizational field, to underline what seemed to work and what did not, to enable these processes functioning effectively. In this literature review, a search of publications dealing with the issues of innovation and creativity and the links between these two issues has been made. We decided to put these studies in four theoretical, ex-post created, dimensions: organizational structures, individual characteristics, training methods and pedagogical practices and training content. The content of this article is based on one of the outputs of the European Commission funded project, named CLEAR (Creativity and innovation: pedagogical framework for the learning chain).

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