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Search Results: 1 - 10 of 18378 matches for " Paola Di Pietro "
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Infrared evidence of a Slater metal-insulator transition in NaOsO3
Irene Lo Vecchio,Andrea Perucchi,Paola Di Pietro,Odeta Limaj,Ulrich Schade,Ying Sun,Masao Arai,Kazunari Yamaura,Stefano Lupi
Physics , 2013, DOI: 10.1038/srep02990
Abstract: The magnetically driven metal-insulator transition (MIT) was predicted by Slater in the fifties. Here a long-range antiferromagnetic (AF) order can open up a gap at the Brillouin electronic band boundary regardless of the Coulomb repulsion magnitude. However, while many low-dimensional organic conductors display evidence for an AF driven MIT, in three-dimensional (3D) systems the Slater MIT still remains elusive. We employ terahertz and infrared spectroscopy to investigate the MIT in the NaOsO3 3D antiferromagnet. From the optical conductivity analysis we find evidence for a continuous opening of the energy gap, whose temperature dependence can be well described in terms of a second order phase transition. The comparison between the experimental Drude spectral weight and the one calculated through Local Density Approximation (LDA) shows that electronic correlations play a limited role in the MIT. All the experimental evidence demonstrates that NaOsO3 is the first known 3D Slater insulator.
"Mi voglio bene": a pediatrician-based randomized controlled trial for the prevention of obesity in Italian preschool children
Paolo Brambilla, Giorgio Bedogni, Carmen Buongiovanni, Guido Brusoni, Giuseppe Di Mauro, Mario Di Pietro, Marco Giussani, Manuel Gnecchi, Lorenzo Iughetti, Paola Manzoni, Maura Sticco, Sergio Bernasconi
Italian Journal of Pediatrics , 2010, DOI: 10.1186/1824-7288-36-55
Abstract: "Mi voglio bene" is a parallel-arm RCT. Family pediatricians willing to participate to the trial will be randomly assigned to a control group and to an experimental group. The control group will provide the usual standard of care while the experimental group will implement 10 preventive actions (promotion of breastfeeding, avoidance of solid foods, control of protein intake, avoidance of sugar-sweetened beverages, avoidance of bottle, active means of transportation, identification of early adiposity rebound, limitation of television viewing, promotion of movement, and teaching portion size) at 10 time points during a 6-yr follow-up. The main outcome measures is the prevalence of overweight and obesity at 6 years of age. The experimental intervention is expected to reduce the prevalence of overweight and obesity from 25% to 20% and the study requires a total of 3610 children. Each pediatrician will enroll 30 consecutive newborns into the study so that a total of 120 pediatricians will participate to the study."Mi voglio bene" is expected to provide important information for the INHS and possibly other institutional child care settings about the effectiveness of a pediatrician-based approach to the prevention of childhood obesity. We published this study protocol with the aim of opening a discussion with all people interested in fighting childhood obesity and to receive useful criticisms.The first years of life are crucial to start preventive interventions that can have an impact on lifestyle and later overweight and obesity [1]. Accordingly, preventive interventions focusing on children between the ages of birth and 5 years are gaining increasing attention from researchers [1,2].A recent systematic review identified 7 randomized controlled trials (RCT) aimed at preventing obesity in preschool children [1]. Four trials were carried out in preschool setting, 2 were family-based and 1 was carried out in maternity hospitals by promoting breastfeeding. None of these trial
Single Amino Acid Substitutions in the Chemotactic Sequence of Urokinase Receptor Modulate Cell Migration and Invasion
Katia Bifulco, Immacolata Longanesi-Cattani, Paola Franco, Vincenzo Pavone, Pietro Mugione, Gioconda Di Carluccio, Maria Teresa Masucci, Claudio Arra, Giuseppe Pirozzi, Maria Patrizia Stoppelli, Maria Vincenza Carriero
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044806
Abstract: The receptor for urokinase-type plasminogen activator (uPAR) plays an important role in controlling cell migration. uPAR binds urokinase and vitronectin extracellular ligands, and signals in complex with transmembrane receptors such as Formyl-peptide Receptors (FPR)s and integrins. Previous work from this laboratory has shown that synthetic peptides, corresponding to the uPAR88–92 chemotactic sequence, when carrying the S90P or S90E substitutions, up- or down-regulate cell migration, respectively. To gain mechanistic insights into these opposite cell responses, the functional consequences of S90P and S90E mutations in full-length uPAR were evaluated. First, (HEK)-293 embryonic kidney cells expressing uPARS90P exhibit enhanced FPR activation, increased random and directional cell migration, long-lasting Akt phosphorylation, and increased adhesion to vitronectin, as well as uPAR/vitronectin receptor association. In contrast, the S90E substitution prevents agonist-triggered FPR activation and internalization, decreases binding and adhesion to vitronectin, and inhibits uPAR/vitronectin receptor association. Also, 293/uPARS90P cells appear quite elongated and their cytoskeleton well organized, whereas 293/uPARS90E cells assume a large flattened morphology, with random orientation of actin filaments. Interestingly, when HT1080 cells co-express wild type uPAR with uPAR S90E, the latter behaves as a dominant-negative, impairing uPAR-mediated signaling and reducing cell wound repair as well as lung metastasis in nude mice. In contrast, signaling, wound repair and in vivo lung metastasis of HT1080 cells bearing wild type uPAR are enhanced when they co-express uPARS90P. In conclusion, our findings indicate that Ser90 is a critical residue for uPAR signaling and that the S90P and S90E exert opposite effects on uPAR activities. These findings may be accommodated in a molecular model, in which uPARS90E and uPARS90P are forced into inactive and active forms, respectively, suggesting important implications for the development of novel drugs targeting uPAR function.
Lack or Inhibition of Dopaminergic Stimulation Induces a Development Increase of Striatal Tyrosine Hydroxylase-Positive Interneurons
Carla Letizia Busceti, Domenico Bucci, Gemma Molinaro, Paola Di Pietro, Luca Zangrandi, Roberto Gradini, Rosario Moratalla, Giuseppe Battaglia, Valeria Bruno, Ferdinando Nicoletti, Francesco Fornai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044025
Abstract: We examined the role of endogenous dopamine (DA) in regulating the number of intrinsic tyrosine hydroxylase-positive (TH+) striatal neurons using mice at postnatal day (PND) 4 to 8, a period that corresponds to the developmental peak in the number of these neurons. We adopted the strategy of depleting endogenous DA by a 2-day treatment with α-methyl-p-tyrosine (αMpT, 150 mg/kg, i.p.). This treatment markedly increased the number of striatal TH+ neurons, assessed by stereological counting, and the increase was highly correlated to the extent of DA loss. Interestingly, TH+ neurons were found closer to the clusters of DA fibers after DA depletion, indicating that the concentration gradient of extracellular DA critically regulates the distribution of striatal TH+ neurons. A single i.p. injection of the D1 receptor antagonist, SCH23390 (0.1 mg/kg), the D2/D3 receptor antagonist, raclopride (0.1 mg/kg), or the D4 receptor antagonist, L-745,870 (5 mg/kg) in mice at PND4 also increased the number of TH+ neurons after 4 days. Treatment with the D1-like receptor agonist SKF38393 (10 mg/kg) or with the D2-like receptor agonist, quinpirole (1 mg/kg) did not change the number of TH+ neurons. At least the effects of SCH23390 were prevented by a combined treatment with SKF38393. Immunohistochemical analysis indicated that striatal TH+ neurons expressed D2 and D4 receptors, but not D1 receptors. Moreover, treatment with the α4β2 receptor antagonist dihydro-β-erythroidine (DHβE) (3.2 mg/kg) also increased the number of TH+ neurons. The evidence that DHβE mimicked the action of SCH23390 in increasing the number of TH+ neurons supports the hypothesis that activation of D1 receptors controls the number of striatal TH+ neurons by enhancing the release of acetylcholine. These data demonstrate for the first time that endogenous DA negatively regulates the number of striatal TH+ neurons by direct and indirect mechanisms mediated by multiple DA receptor subtypes.
Transient elastography: A non-invasive tool for assessing liver fibrosis in HIV/HCV patients
Valentina Li Vecchi, Maurizio Soresi, Claudia Colomba, Giovanni Mazzola, Pietro Colletti, Maurizio Mineo, Paola Di Carlo, Emanuele La Spada, Giovanni Vizzini, Giuseppe Montalto
World Journal of Gastroenterology , 2010,
Abstract: AIM: To assess the prevalence of advanced liver fibrosis (ALF) in human immunodeficiency virus (HIV), hepatitis C virus (HCV) and HIV/HCV patients using transient elastography, and to identify factors associated with ALF.METHODS: Between September 2008 and October 2009, 71 HIV mono-infected, 57 HIV/HCV co-infected and 53 HCV mono-infected patients on regular follow-up at our Center were enrolled in this study. Alcohol intake, the main parameters of liver function, presence of HCV-RNA, HIV-RNA, duration of highly active anti-retroviral therapy (HAART) and CD4 cell count were recorded. ALF was defined as liver stiffness (LS) ≥ 9.5 kPa. To estimate liver fibrosis (LF) a further 2 reliable biochemical scores, aspartate aminotransferase platelet ratio index (APRI) and FIB-4, were also used.RESULTS: LS values of co-infected patients were higher than in either HIV or HCV mono-infected patients (χ2MH = 4, P < 0.04). In fact, LS ≥ 9.5 was significantly higher in co-infected than in HIV and HCV mono-infected patients (χ2 = 5, P < 0.03). Also APRI and the FIB-4 index showed more LF in co-infected than in HIV mono-infected patients (P < 0.0001), but not in HCV mono-infected patients. In HIV HCV co-infected patients, the extent of LS was significantly associated with alcohol intake (P < 0.04) and lower CD4+ cell count (P < 0.02). In HCV patients, LS was correlated with alcohol intake (P < 0.001) and cholesterol levels (P < 0.03). Body mass index, diabetes, HCV- and HIV-viremia were not significantly correlated with LS. In addition, 20% of co-infected patients had virologically unsuccessful HAART; in 50% compliance was low, CD4+ levels were < 400 cells/mm3 and LS was > 9.5 kPa. There was no significant correlation between extent of LF and HAART exposure or duration of HAART exposure, in particular with specific dideoxynucleoside analogues.CONCLUSION: ALF was more frequent in co-infected than mono-infected patients. This result correlated with lower CD4 levels. Protective immunological effects of HAART on LF progression outweigh its hepatotoxic effects.
Virological effectiveness and CD4+ T-cell increase over early and late courses in HIV infected patients on antiretroviral therapy: focus on HCV and anchor class received
Davide Motta, Nigritella Brianese, Emanuele Focà, Paola Nasta, Franco Maggiolo, Massimiliano Fabbiani, Giuliana Cologni, Simona Di Giambenedetto, Massimo Di Pietro, Nicoletta Ladisa, Laura Sighinolfi, Silvia Costarelli, Filippo Castelnuovo, Carlo Torti
AIDS Research and Therapy , 2012, DOI: 10.1186/1742-6405-9-18
Abstract: We performed a longitudinal analysis of 3,262 patients from the MASTER cohort, who started HAART from 2000 to 2008. Patients were stratified into 6 groups by HCV status and type of anchor class. The early virological outcome was the achievement of HIV RNA <500 copies/ml 4–8?months after HAART initiation. Time to virological response was also evaluated by Kaplan-Meier analysis. The main outcome measure of early immunological response was the achievement of CD4+ T-cell increase by ≥100/mm3 from baseline to month 4–8 in virological responder patients. Late immunological outcome was absolute variation of CD4+ T-cell count with respect to baseline up to month 24. Multivariable analysis (ANCOVA) investigated predictors for this outcome.The early virological response was higher in HCV Ab-negative than HCV Ab-positive patients prescribed PI/r (92.2% versus 88%; p?=?0.01) or NNRTI (88.5% versus 84.7%; p?=?0.06). HCV Ab-positive serostatus was a significant predictor of a delayed virological suppression independently from other variables, including types of anchor class. Reactivity for HCV antibodies was associated with a lower probability of obtaining ≥100/mm3 CD4+ increase within 8?months from HAART initiation in patients treated with PI/r (62.2% among HCV Ab-positive patients versus 70.9% among HCV Ab-negative patients; p?=?0.003) and NNRTI (63.7% versus 74.7%; p?<?0.001). Regarding late CD4+ increase, positive HCV Ab appeared to impair immune reconstitution in terms of absolute CD4+ T-cell count increase both in patients treated with PI/r (p?=?0.013) and in those treated with NNRTI (p?=?0.002). This was confirmed at a multivariable analysis up to 12?months of follow-up.In this large cohort, HCV Ab reactivity was associated with an inferior virological outcome and an independent association between HCV Ab-positivity and smaller CD4+ increase was evident up to 12?months of follow-up. Although the difference in CD4+ T-cell count was modest, a stricter follow-up and optimizat
José Ingenieros: "Algunas aproximaciones sobre las fuerzas morales"
Di Pietro,Alejandro;
Cuadernos de la Facultad de Humanidades y Ciencias Sociales. Universidad Nacional de Jujuy , 2008,
Abstract: jose ingenieros warns in the prologue of his texts 'moral strengths', that his book completes the panoramic vision of a functional ethics. 'mediocre man' is a critique to morality; 'to wards a moral without dogmas' a morality theory, 'moral strengths', a deontology of morality. it prevails in cell these works of his the concept of ethical idealism in the function of social experience, unmistakable with captions idealism of ancient metaphysics. ingenieros affirms that a man who treasures these forces acquires moral values, honorable duty feeling that conditions his dignity. a man that thinks as he must, says what he feels and acts as he wants. a man that does not pursues rewards nor he fears misfortunes. a man who receives contrast with serenity and victory with prudence. a man who accepts the responsibilities of his own errors and who refuses any complicity with other people's errors. moral values are the only ones that support the ones who expend their lives for their country or their own doctrines trying to achieve heroism. nothing is less similar to the occasional temerity of that of the bully or that of the praetorian, who face futile risks due to vanity of stipend. an hour of episodic bravery does not equate socrates' valour, that of christ's, nor spinoza's, which is a constant convergence of thought and action, pulchritude of sentence in opposition to insane of past superstitions. pointing out some comparisons with our nation's present time is trying to demonstrate that time has thought ingenieros is right or he is not and this is partly the purpose of this contribution about an argentinian thinker of substance put away and forgotten in every library of this country.
New Dry Grassland Associations from the Ausoni-Aurunci Mountains (Central Italy) - Syntaxonomical Updating and Discussion on the Higher Rank Syntaxa
Romeo Di Pietro
Hacquetia , 2011, DOI: 10.2478/v10028-011-0011-9
Abstract: A phytosociological study on the most extensive dry grassland communities of the coastal limestone massif of the Ausoni-Aurunci mountains (southern Latium, central Italy) is here presented. Violo pseudogracilis-Koelerietum splendentis ass. nova is restricted to the montane belt of the Aurunci mountains where it is dynamically related to the mesophilous Ostrya carpinifolia or Fagus sylvatica woodlands. Helichryso italici-Brometum erecti ass. nova is found within the upper hilly and submontane belt of both the Ausoni mountains (typical aspect) and the Aurunci mountains (subassociation saturejetosum montanae), where it is dynamically related with termophilous Ostrya carpinifolia woods and mesophilous Quercus ilex woods. Helichryso-Brometum is differentiated from Violo-Koelerietum in that it has a higher incidence of the steno-Mediterranean therophytic component. As far as the higher rank syntaxa are concerned, in this study the following changes were made in accordance with the rules of ICPN: the name Phleo ambigui-Bromion erecti Biondi et al. 1995 was considered invalid due to the invalidity of its nomenclatural type Asperulo purpureae-Brometum erecti. In contrast, the validity of the old name Cytiso spinescentis-Bromion erecti Bonin 1978 was demonstrated and its nomenclatural type, Lavandulo-Asphodelinetum luteae Bonin 1978, was lectotypified. Thus Cytiso spinescenti-Bromion erecti Bonin 1978 henceforth substitutes Phleo ambigui-Bromion erecti (nom. inval.) as the syntaxonomical reference for the endemic alliance of the hilly and montane limestone dry grasslands of the central and southern Apennines. Cytiso-Bromion is here divided into two suballiances: Sideritidenion italicae Biondi et al. 1995, Phleo ambigui-Bromenion erecti Biondi et al. ex Di Pietro suball. nov. Cytiso-Bromion belong to the new suborder Festuco circummediterraneae-Seslerienalia nitidae (Ubaldi 2003) stat. nov. and to the order Artemisio albae-Brometalia erecti Ubaldi ex Mucina & Dengler 2009. New and updated packages of characteristic and differential species for both Cytiso spinescenti-Bromion erecti and its related suballiances are proposed. Furthermore the validity of the name Astragaletum calabrici Giacomini & Gentile ex Bonin 1978, was proved and the association lectotypified. This association, which was previously included in Cytiso-Bromion erecti, is moved into Koelerio brutiae-Astragalion calabrici. Finally some interesting coenological and syndynamical similarities with Scorzonero-Chrysopogonetalia western Dalmatia submediterranean dry pastures are discussed.
Habitus, política y educación
Susana Beatriz di Pietro
Política y cultura , 2002,
Abstract: For Bourdieu, the concept of habitus is essential in the consideration about central issues of political and educational theory. Topics as those of power, domination, legitimacy, State, social reproduction and the contribution in it of the scholar system, would request the use of that notion, able to surmount, in addition, the dichotomy between objectivism and subjectivism that characterizes social science. The present article displays the notion of habitus in the frame of the broader thinking of its author, attempting to formulate some critical considerations on the described theory, its limits and explanatory possibilities. In order to do so, it s focused specially in the subjects of order, politics and body, closely bounded with it.
Scale factor duality in quintessence models ?
Elisa Di Pietro
Physics , 2001,
Abstract: We consider several kinds of quintessence models in the framework of scale factor duality. We show that this symmetry exists only for a very small number of quintessence potentials. We then apply the duality transformations found to several analytical solutions. It turns out that, in some cases, the presence of the potential allows a smooth connection between the pre- and the post-Big Bang phases. This may be a first step toward the resolution of the singularity problem.
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