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TRAF1/C5 rs3761847 SNP Is Associated with Severe Pattern of Rheumatoid Arthritis in Greek Patients  [PDF]
Alexandros Sarantopoulos, Ioannis Theodorou, Panagiota Boura
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2016, DOI: 10.4236/ojra.2016.61002
Abstract: The era of whole genome study analysis has introduced a profound research in the genetics of autoimmune diseases. Some of the new genetic loci that have been associated with the development or the severity of autoimmune diseases have been thoroughly studied, conferring a more detailed understanding of disease pathophysiology. Furthermore, single nucleotide polymorphisms (SNPs) have been described not only in coding regions of the human genome but also in non-coding areas (introns), the importance of which has not been yet clarified. Over the last years, such an SNP has been associated with the development of rheumatoid arthritis, the most frequent autoimmune disease. This SNP is at the position 122730060 of chromosome 9 in the TRAF1/C5 region and consists of a substitution of the nucleotide base guanine (G)—which is considered the ancestral phenotype— by alanine (A). It has been indicated that G is the aggravating nucleotide, and that G/G is the disease predisposing phenotype, conferring >1.3× risk for RA. On this background, we performed a genome study on a Greek population of northern Greece (Macedonia) in order to identify the association of this SNP with RA in our group.
Chronic Brucellosis Patients Retain Low Frequency of CD4+ T-Lymphocytes Expressing CD25 and CD28 after Escherichia coli LPS Stimulation of PHA-Cultured PBMCs
Panagiotis Skendros,Alexandros Sarantopoulos,Konstantinos Tselios,Panagiota Boura
Clinical and Developmental Immunology , 2008, DOI: 10.1155/2008/327346
Abstract: Chronic brucellosis patients display a defective Th1 response to PHA. We have previously shown that heat-killed B. abortus (HKBA) can downregulate the PHA-induced increase of CD4
Influenza A/H1N1 septic shock in a patient with systemic lupus erythematosus. A case report
Konstantinos Tselios, Ritsa Tsioka, Alexandros Sarantopoulos, Eleni Mouloudi, Panagiota Boura
BMC Infectious Diseases , 2011, DOI: 10.1186/1471-2334-11-358
Abstract: In this case report, an SLE patient with viral-induced septic shock, without overt pulmonary involvement, is discussed. The patient was administered oseltamivir and supportive treatment, including wide-spectrum antibiotics, vasopressors and steroids, according to the guidelines proposed for bacterial sepsis and septic shock. She finally survived and experienced a lupus flare soon after intensive care unit (ICU) discharge.To our knowledge, this is the first case to report severe septic shock from influenza A/H1N1 virus, without overt pulmonary involvement.Infections are among the most important causes of morbidity and mortality in systemic lupus erythematosus (SLE). However, viruses are not considered to cause serious infections in these patients; they, usually, represent reactivation of herpes viruses, such as herpes simplex virus and varicella-zoster virus [1]. Nevertheless, it is reported that immunocompromised patients have an increased risk of mortality, following influenza infection [2].In the recent pandemic, influenza A H1N1 virus has been estimated to cause approximately 18.449 deaths in 214 different countries until August 1st 2010 [3]. Adult respiratory distress syndrome (ARDS), along with bacterial co-infections were the direct causes of death in most cases [4]. However, no cases of viral-induced septic shock without severe pulmonary involvement have been reported. Nevertheless, little is known about this infection in SLE patients [5]. Herein, we report a case of an SLE patient, who developed septic shock due to influenza A H1N1 infection, without acute lung injury.A 46-year old female was admitted to the hospital because of low-grade fever, sore throat and fatigue for four days; she was on clarithromycin 500 mg twice daily, as she was considered to suffer from upper respiratory tract infection by her general practitioner.The patient had a history of SLE for 24 years, antiphospholipid syndrome and autoimmune hypothyroidism. SLE was diagnosed in the backgr
Successful Outcome of Chronic Intrahepatic Cholestasis in an Adult Patient with Sickle Cell/β+ Thalassemia
Efthymia Vlachaki,Panagiotis Andreadis,Nikolaos Neokleous,Aleka Agapidou,Evaggelia Vetsiou,Panagiotis Katsinelos,Panagiota Boura
Case Reports in Hematology , 2014, DOI: 10.1155/2014/213631
Abstract: Sickle cell/ thalassemia (Hb S/ thal) is considered as a variant form of sickle cell disease. Acute episodes of vasoocclusive pain crisis are characteristic for sickle cell disorders and may be complicated by an acute or chronic life-threatening organ dysfunction. Chronic intrahepatic cholestasis is a rare and severe complication in sickle cell disease, characterized by marked hyperbilirubinemia and acute hepatic failure with an often fatal course. Despite the fact that patients with Hb S/ thal usually have a mild type of disease, herein we describe an interesting case of chronic intrahepatic cholestasis with successful outcome in an adult patient with Hb S/ thal. 1. Introduction Sickle cell/β+ thalassemia (Hb S/β+thal) is considered as a variant form of sickle cell disease (SCD). This condition is an inherited hemolytic anemia, associated with multiple acute and chronic complications such as painful vasoocclusive events, cerebral vasculopathy, priapism, liver, spleen, and renal and or lung disease. Chronic intrahepatic cholestasis is a rare and severe complication in sickle cell disease, characterized by marked hyperbilirubinemia and acute hepatic failure with an often fatal course. Despite the fact that patients with Hb S/β+thal usually have a mild type of disease, the low values of Hb A and Hb F might be associated sickle cell disease crises [1, 2]. We report an interesting case of chronic intrahepatic cholestasis with successful outcome in an adult patient with Hb S/β+thal. The patient gave consent to the publication of this report. 2. Case Report A 37 year Caucasian old male patient with known history of sickle cell disease and beta thalassemia (Hb S/β+thal) was attended to our outpatient clinic with a presenting symptom of worsening jaundice. Patient mentioned that he has stopped his regular schedule of exchange transfusions, which for the time being was inevitably his treatment regimen due to his refusal to continue hydroxycarbamide in order to procreate. The general condition of the patient was good. Physical examination was normal except the above-mentioned skin scleral jaundice and a palpable liver (4?cm below the costal margin) with no sign of pain. According to his past medical history, he had splenectomy at the age of 13 due to entrapment, cholecystectomy, right shin metaphysis osteomyelitis, and bilateral aseptic (avascular) hip necrosis. Interestingly, in the last two years the patient also suffered two recurrent episodes of painless cholestasis which resolved with exchange transfusions and hydroxycarbamide at 20?mg/kg per day (maximum
Vorstellungen von "Heimat": Identit t und Repertoire eines griechischen "Gastarbeiters" und Musikers in Deutschland Imagining Homeland: Identity and Repertories of a Greek Labour-immigrant Musician in Germany Imaginando la patria: identidad y repertorios de un músico inmigrante griego en Alemania
Smaragdi Boura
Forum : Qualitative Social Research , 2006,
Abstract: Seit der Staatsbildung Griechenlands und der damit verbundenen Konstituierung einer griechischen Diaspora nimmt die Migration im griechischen Lebenszyklus eine entscheidende Rolle ein. Unabh ngig davon, ob das Migrationsph nomen einen typischen und integralen Bestandteil griechischer Kulturtradition oder Mentalit t darstellt oder ob es als erzwungene Folge spezifischer wirtschaftlicher und politischer Umst nde anzusehen ist – es bedeutet immer einen Faktor des Wandels im Leben von Menschen, die davon betroffen sind. Das Los der "metanastes" (Zuwanderer) und das Leben in "xenitia" (dem Aufnahmeland) konstituiert ein verbreitetes und (wohl) bekanntes Thema lyrischer Texte traditioneller griechischer Lieder ("dimotika tragoudia") und volkstümlicher Weisen ("laika tragoudia"). In diesen Repertoires enthüllt die Musik ihre ganze Kraft der symbolischen Kommunikation und übermittlung; in ihr drücken sich geteilte Vorstellungen, gemeinsame Gefühle und kulturelle Botschaften aus, die für Zuwanderergruppen eine besondere Bedeutung annehmen. Diasporamusik ist – zusammen mit T nzen – ein Grundbestandteil des kulturellen Kapitals von Immigrant(inn)en. Sie dient der Aufrechterhaltung von kultureller Identit t und bildet eine fixe, wenn auch metaphorische Verbindung zwischen dem Herkunfts- und dem Aufnahmeland. Und sie schafft einen Kontext fundamentaler Bedeutungen, durch den sich Zuwanderergruppen als solche identifizieren oder sich in Relation zur Mehrheit bzw. zu anderen Gruppen in ihrer Umgebung rekonstruieren k nnen. Nach dem ersten Jahr meiner Feldforschung unter griechischen Zuwanderergruppen in der Umgebung von Stuttgart m chte ich mit diesem Beitrag auf die Rolle der Musik in der Identit tsbildung eingehen, die von Prozessen des Wandels begleitet ist, wie sie sich durch Ph nomene der Integration, Assimilation oder Transkulturation konstituieren. Hierzu werden die vielf ltigen Identit ten und Repertoires eines griechischen Musikers in Deutschland im Zusammenhang mit einigen Aspekten seines Lebensportraits genauer betrachtet und sowohl emisch als auch etisch interpretiert. URN: urn:nbn:de:0114-fqs0603109 Migration has always played an important and determinative role in the formation of the Greek life-cycle, since the existence of a Greek Diaspora originates back to the institution of the Greek nation. However, whether the migration phenomenon represents a typical and integral part of the Greek cultural tradition or mentality, or appears as a forced consequence of specific economic or political circumstances, it should be pointed out that it has proved to be a
An Assessment of the Market Risk Solvency Capital Requirement Simplifications for Insurance Undertakings  [PDF]
Thomas Poufinas, Panagiota Tsitsika
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.811153
Abstract: The Solvency II regulatory framework has been implemented as of January 1st, 2016 and among other things it introduced economic risk-based capital requirements across all EU Member States for the first time, applicable for insurance and reinsurance undertakings. Similar to Basel II whose scope is banks, the Solvency II directive provides a new regime based on three pillars for insurers and reinsurers: 1) pillar 1: harmonized valuation and risk based capital requirements, 2) pillar 2: harmonized governance and risk management requirements and 3) pillar 3: harmonized supervisory reporting and public disclosure. The Solvency Capital Requirement (SCR) should correspond to the Value-at-Risk of the basic own funds of an insurance or reinsurance undertaking subject to a confidence level of 99.5% over a one-year period. The Solvency II directive provides a range of methods to calculate the SCR. This allows insurance or reinsurance undertakings to choose a method that is proportionate to the nature, scale and complexity of the risk that is measured. In order to calculate the SCR, an insurance undertaking can use a fully internal model, the standard formula and a partial internal model, the standard formula with undertaking-specific parameters, the standard formula as it is or a simplification. When introducing a simplification, the SCR estimate could deviate from the calculation without the simplification. A simplification could lead in important/crucial information missing from the SCR calculation. In some occasions the SCR is overestimated and in some others it is underestimated. It is therefore of interest to find the range of this deviation, potential bounds—if any and the effect it can have on the required capital. In this paper we attempt to measure this deviation for simplifications pertaining to the interest rate risk for insurance companies.
Communication and Powering Scheme for Wireless and Battery-Less Measurement
A. Boura,M. Husak
Radioengineering , 2012,
Abstract: The paper presents solution for wireless and battery-less measurement in the enclosed areas. The principle is based on passive RFID, nevertheless this paper is focused on high power-demanding applications such as MEMS accelerometers, gas sensors, piezoresistive strain gauges, etc. Standard FRID communication scheme (sensing the input current change on the primary side) cannot be used in this case, because the communication channel is overloaded by the high power load. Paper presents possible solution which is based on the dual frequency scheme – one frequency for powering and other for the communication. This is ensuring capability for measurement up to several centimeters on the frequency bands 125 kHz and 375 kHz. It can be suitable for continual measurement in isolated systems such as the rotating objects, concrete walls, enclosed plastic barrels, high temperature chambers etc.
Familias propietarias de empresas informativas en los países nórdicos. Un retrato de la estructura y las características de 25 firmas
Panagiota Koulouvari
Palabra Clave , 2005,
Abstract: éste es el segundo reporte del proyecto de investigación Familias due as de empresas informativas en los países nórdicos . El proyecto ha sido conducido por el Centro de Administración y Trasformación de Medios, Escuela Internacional de Negocios J nk ping, Universidad J nk ping, Suecia. El primer reporte (Koulouvari, 2004) se orientó hacia la relevancia de la disciplina de negocios familiares en la industria de los medios. Este reporte inicia la investigación posterior, presentando los resultados del estudio sobre una encuesta a peque a escala en familias due as de empresas de medios. El estudio deja el fundamento para investigaciones futuras sobre la importancia de los medios familiares para la sociedad, los aspectos y problemas enfrentados por familias que poseen compa ía de medios y las soluciones administrativas y políticas para tales retos.
Teaching English as a Foreign Language to Dyslexic Young Learners: an Intervention Programme
Panagiota Goudi
Research Papers in Language Teaching and Learning , 2010,
Abstract: The scope of this chapter is to study the stimulation of phonological awareness of the English language, in Greek dyslexic young learners, who present a specific reading disability in both their mother tongue as well as in the foreign language. According to scientific research, phonological awareness, i.e. the knowledge of the phonological structure of a language by its user, is intrinsically related to the reading process. At the same time, it has been confirmed that dyslexic learners experience difficulty in segmenting and blending speech sounds, due to insufficiently developed phonological awareness. For this reason, a well-founded intervention programme is designed and put into action, aiming at studying the reading development of dyslexic young learners. The findings have revealed that phonological awareness can be stimulated, resulting in the development of reading accuracy.
The Development of Sport Press in Greece After 1990
Choregia , 2008,
Abstract: In this paper we examine the development of the Press in Greece at the last 25 years and the special case of the Sports Press, using the number of Mass Media publications titles –circulation–readership. The broader aim of this study is to prove that the development of sports newspapers is different than the general course of Press. Sport Press is approved to be a steadfast value in the reading public’s preference, while circulation and readership of the political Press are falling with an equally fast rate.
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