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Search Results: 1 - 10 of 22548 matches for " Pan X "
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Exact Solutions for Simply Supported and Multilayered Piezothermoelastic Plates with Imperfect Interfaces
X. Wang and E. Pan
The Open Mechanics Journal , 2007, DOI: 10.2174/1874158400701010001]
Abstract: Exact solutions are derived for three-dimensional, orthotropic, linearly piezothermoelastic, simply-supported, and multilayered rectangular plates with imperfect interfaces under static thermo-electro-mechanical loadings. In this research the imperfect interface is described as thermally weakly (or highly) conducting, mechanically compliant and dielectrically weakly (or highly) conducting. While the homogeneous solutions for one layer are obtained in terms of the socalled pseudo-Stroh formalism, solutions for multilayered plates are expressed in terms of the transfer matrices for both the layer and the imperfect interface. Due to the fact that the thermal effect is incorporated, we adopt a special form of the transfer matrix, resulting in a very concise solution structure for piezothermoelastic multilayered plates. Numerical results are presented to validate the developed formulas and to demonstrate the influence of the interface imperfection on the distributions of the field variables.
Evaluation and Adjustment of Coordinated Development between Land Use and Eco-Environment in Wuxi City  [PDF]
Hua Sun, Hailang Pan, Jing Zhao, Qing-Zeng Qu, F. X. Han
iBusiness (IB) , 2010, DOI: 10.4236/ib.2010.24055
Abstract: The purpose of this paper is to assess the coordinated development degree of land use and eco-environment in Wuxi City and choose the appropriate adjustment mode. Methods employed include documentation analysis, the coordinated development degree model analysis and BP neural network model analysis. The result shows that the coordinated development degree of land use and eco-environment in Wuxi City presents overall ever-increasing trends and that the overall consideration mode can reduce the contradiction between land use and eco-environment, which is a suitable mode for Wuxi City. It is concluded that the coordinated development degree model and BP neural network model have high reliability and practicability in evaluating and adjusting the coordinated development degree of land use and eco-environment in Wuxi City.
Natural History and Clinical Consequences of Hepatitis B Virus Infection
Pan Calvin Q.,Zhang Jin X.
International Journal of Medical Sciences , 2005,
Abstract: Despite the existence of Hepatitis B vaccination, hepatitis B virus (HBV) infection is still prevalent worldwide and accounts for significant morbidity and mortality. It is encouraging that majority of patients do recover from the acute infection, however, those that progress to chronic disease state is at great risk of developing complications such as hepatocellular carcinoma, cirrhosis and liver failure. Hepatitis B virus infection can be influenced by many factors such as host immune status, age at infection, and level of viral replication. The discovery about the existence of various genotypes and its association with different geographic distribution as well as the knowledge regarding mutant species has aid us in better understanding the nature of HBV infection and in delivering better care for patients. It is especially important to recognize those individuals with HBeAg-negative chronic HBV as they have a poorer prognosis compare with their counterparts, HBeAg-positive. Tremendous progress has been made over the years in understanding the behavior and clinical course of the disease; however, the natural history of HBV is complex and we still have much to explore and learn.
Inputs to the Dorsal Striatum of the Mouse Reflect the Parallel Circuit Architecture of the Forebrain
Weixing X. Pan,Joshua T. Dudman
Frontiers in Neuroanatomy , 2010, DOI: 10.3389/fnana.2010.00147
Abstract: The basal ganglia play a critical role in the regulation of voluntary action in vertebrates. Our understanding of the function of the basal ganglia relies heavily upon anatomical information, but continued progress will require an understanding of the specific functional roles played by diverse cell types and their connectivity. An increasing number of mouse lines allow extensive identification, characterization, and manipulation of specified cell types in the basal ganglia. Despite the promise of genetically modified mice for elucidating the functional roles of diverse cell types, there is relatively little anatomical data obtained directly in the mouse. Here we have characterized the retrograde labeling obtained from a series of tracer injections throughout the dorsal striatum of adult mice. We found systematic variations in input along both the medial–lateral and anterior–posterior neuraxes in close agreement with canonical features of basal ganglia anatomy in the rat. In addition to the canonical features we have provided experimental support for the importance of non-canonical inputs to the striatum from the raphe nuclei and the amygdala. To look for organization at a finer scale we have analyzed the correlation structure of labeling intensity across our entire dataset. Using this analysis we found substantial local heterogeneity within the large-scale order. From this analysis we conclude that individual striatal sites receive varied combinations of cortical and thalamic input from multiple functional areas, consistent with some earlier studies in the rat that have suggested the presence of a combinatorial map.
The Tracy-Widom law for the Largest Eigenvalue of F Type Matrix
X. Han,G. M. Pan,B. Zhang
Statistics , 2015,
Abstract: Let $\mathbb{A}_p=\frac{\mathbb{Y}\mathbb{Y}^*}{m}$ and $\mathbb{B}_p=\frac{\mathbb{X}\mathbb{X}^*}{n}$ be two independent random matrices where $\mathbb{X}=(X_{ij})_{p \times n}$ and $\mathbb{Y}=(Y_{ij})_{p \times m}$ respectively consist of real (or complex) independent random variables with $\mathbb{E}X_{ij}=\mathbb{E}Y_{ij}=0$, $\mathbb{E}|X_{ij}|^2=\mathbb{E}|Y_{ij}|^2=1$. Denote by $\lambda_{1}$ the largest root of the determinantal equation $\det(\lambda \mathbb{A}_p-\mathbb{B}_p)=0$. We establish the Tracy-Widom type universality for $\lambda_{1}$ under some moment conditions on $X_{ij}$ and $Y_{ij}$ when $p/m$ and $p/n$ approach positive constants as $p\rightarrow\infty$.
Angiotensin II stimulates MCP-1 production in rat glomerular endothelial cells via NAD(P)H oxidase-dependent nuclear factor-kappa B signaling
Pan, Q.;Yang, X.-H.;Cheng, Y.-X.;
Brazilian Journal of Medical and Biological Research , 2009, DOI: 10.1590/S0100-879X2009000600009
Abstract: angiotensin ii (ang ii) plays a crucial role in the pathogenesis of renal diseases. the objective of the present study was to investigate the possible inflammatory effect of ang ii on glomerular endothelial cells and the underlying mechanism. we isolated and characterized primary cultures of rat glomerular endothelial cells (gecs) and observed that ang ii induced the synthesis of monocyte chemoattractant protein-1 (mcp-1) in gecs as demonstrated by western blot. ang ii stimulation, at concentrations ranging from 0.1 to 10 μm, of rat gecs induced a rapid increase in the generation of reactive oxygen species as indicated by laser fluoroscopy. the level of p47phox protein, an nad(p)h oxidase subunit, was also increased by ang ii treatment. these effects of ang ii on gecs were all reduced by diphenyleneiodonium (1.0 μm), an nad(p)h oxidase inhibitor. ang ii stimulation also promoted the activation of nuclear factor-kappa b (nf-κb). telmisartan (1.0 μm), an at1 receptor blocker, blocked all the effects of ang ii on rat gecs. these data suggest that the inhibition of nad(p)h oxidase-dependent nf-κb signaling reduces the increase in mcp-1 production by gecs induced by ang ii. this may provide a mechanistic basis for the benefits of selective at1 blockade in dealing with chronic renal disease.
Erratum to “Methodology for Anti-Gene Anti-IGF-I Therapy of Malignant Tumours”
Jerzy Trojan,Yuexin X. Pan,Ming X. Wei,Adama Ly
Chemotherapy Research and Practice , 2012, DOI: 10.1155/2012/765703
Abstract:
In vitro and in vivo evaluation of folate receptor-targeting amphiphilic copolymer-modified liposomes loaded with docetaxel
Li X, Tian X, Zhang J, Zhao X, Chen X, Jiang Y, Wang D, Pan W
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S21445
Abstract: vitro and in vivo evaluation of folate receptor-targeting amphiphilic copolymer-modified liposomes loaded with docetaxel Original Research (5478) Total Article Views Authors: Li X, Tian X, Zhang J, Zhao X, Chen X, Jiang Y, Wang D, Pan W Published Date June 2011 Volume 2011:6 Pages 1167 - 1184 DOI: http://dx.doi.org/10.2147/IJN.S21445 Xiang Li1, Xin Tian2, Jing Zhang3, Xu Zhao1, Xiaohui Chen1, Youhong Jiang2, Dongkai Wang1, Weisan Pan1 1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang; 2The Second Laboratory of Cancer Research Institution, The First Hospital of China Medical University, Shenyang; 3Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China Background: The purpose of this study was to develop folate-poly (PEG-cyanoacrylate-co-cholesteryl cyanoacrylate) (FA-PEG-PCHL)-modified freeze-dried liposomes for targeted chemotherapy using docetaxel as a model drug. Methods: FA-PEG-PCHL was synthesized and its cytotoxicity was evaluated by CCK-8 assay in L929. Docetaxel-loaded liposomes modified by FA-PEG-PCHL were prepared by an organic solvent injection method and lyophilized to obtain freeze-dried FA-PEG-PCHL-docetaxel liposomes (FA-PDCT-L). Two carcinoma cell lines (MCF-7 and A-549 cells) were cultured with docetaxel solution, conventional docetaxel-loaded liposomes, or FA-PDCT-L, and the cytotoxicity and apoptosis was evaluated for each preparation. The uptake of the docetaxel preparations into MCF-7 cells was studied by confocal laser scanning microscopy. Liquid chromatography-mass spectrometry was used to study the pharmacokinetics and tissue distribution characteristics of the preparations. Results: The existence of an enlarged fixed aqueous layer on the surface of the liposomes was affirmed by zeta potential analysis. The entrapment efficiency and particle size distribution were almost the same as those of docetaxel-loaded liposomes. The drug release profile showed that the release rate was faster at higher molecular weight of the polymer. Compared with docetaxel solution and docetaxel-loaded liposomes, FA-PDCT-L demonstrated the strongest cytotoxicity against two carcinoma cell lines, the greatest intracellular uptake especially in the nucleus, as well as the most powerful apoptotic efficacy. In pharmacokinetic studies, the area under the plasma concentration-time curve of FA-PDCT-L was increased 3.82 and 6.23 times in comparison with the values for the docetaxel-loaded liposomes and docetaxel solution, respectively. Meanwhile, a lower concentration of docetaxel was observed for FA-PDCT-L in the liver and spleen, and a significantly higher concentration of FA-PDCT-L in tumors suggested that the presence of FA-PEG-PCHL on the liposomes resulted in greater accumulation of the drug in tumor tissue. Conclusion: Liposomes modified by FA-PEG-PCHL could be one of the promising suspensions for the delivery of antitumor dr
Interaction mode between methylene blue-Sm(III) complex and herring sperm DNA
Y Hu, X Wang, H Pan, L Ding
Bulletin of the Chemical Society of Ethiopia , 2012,
Abstract: Spectroscopic and viscosity methods were applied to investigate the interaction between methylene blue (MB)-Sm(III) complex and herring sperm DNA by using acridine orange as a spectral probe in Tris-HCl buffer (pH 7.40). By means of molar ratio method, the binding ratios between MB-Sm(III)and DNA were determined as nSm(III):nMB =1:3, nMB-Sm(III) complex:n DNA = 8:1, and the apparent molar absorption coefficient of εMB-Sm(III)-DNA was found to be 7.01×105 M-1·cm-1. The bonding constants at different temperatures Kθ292K = 7.35×105 M-1, Kθ310K = 1.25×105 M-1 were obtained by double reciprocal method. Thermodynamic function computation demonstrates that ΔrSm is the primary driving power of the interaction between MB-Sm(III)and herring sperm DNA. By combination analysis of the Scatchard method, circular dichroism spectroscopy and viscosity method, it suggests that the interaction mode between MB-Sm(III) complex and herring sperm DNA are a mixed binding, which contains partial intercalation and electrostatic interaction. KEY WORDS: Methylene blue-Sm(III), Complex, Herring sperm DNA, Interaction Bull. Chem. Soc. Ethiop. 2012, 26(3), 395-405. DOI: http://dx.doi.org/10.4314/bcse.v26i3.8
Interactions between environmental quality and economic development in Shanghai, China
X Ni , J Lu, L Lan, FQ Gao, CL Pan
International Journal of Engineering, Science and Technology , 2010,
Abstract: This paper investigates the relationship between environmental quality and economic growth in Shanghai based on the environmental Kuznets curve hypothesis (EKC), using the panel data over 1989-2004. Regarded as the largest city and ecoomic center in China, Shanghai has profoundly changed the local environment with the highest income level in this country. Ambient air quality, surface water quality and near-shore water quality from Shanghai are used as environmental indicators and per capita GDP is used as the economic indicator. We found four types of economy-environment relationships in the studied period in Shanghai. The results also show that surface water indicator supports EKC better than the ambient air and near-shore water indicator. International Journal of Engineering, Science and Technology, Vol. 2, No. 7, 2010, pp. 56-64
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