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Search Results: 1 - 10 of 1934 matches for " Pamela Corrigan "
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Canonical Wnt Signaling Promotes Early Hematopoietic Progenitor Formation and Erythroid Specification during Embryonic Stem Cell Differentiation
Anuradha Tarafdar, Edwina Dobbin, Pamela Corrigan, Robin Freeburn, Helen Wheadon
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081030
Abstract: The generation of hematopoietic stem cells (HSCs) during development is a complex process linked to morphogenic signals. Understanding this process is important for regenerative medicine applications that require in vitro production of HSC. In this study we investigated the effects of canonical Wnt/β-catenin signaling during early embryonic differentiation and hematopoietic specification using an embryonic stem cell system. Our data clearly demonstrates that following early differentiation induction, canonical Wnt signaling induces a strong mesodermal program whilst maintaining a degree of stemness potential. This involved a complex interplay between β-catenin/TCF/LEF/Brachyury/Nanog. β-catenin mediated up-regulation of TCF/LEF resulted in enhanced brachyury levels, which in-turn lead to Nanog up-regulation. During differentiation, active canonical Wnt signaling also up-regulated key transcription factors and cell specific markers essential for hematopoietic specification, in particular genes involved in establishing primitive erythropoiesis. This led to a significant increase in primitive erythroid colony formation. β-catenin signaling also augmented early hematopoietic and multipotent progenitor (MPP) formation. Following culture in a MPP specific cytokine cocktail, activation of β-catenin suppressed differentiation of the early hematopoietic progenitor population, with cells displaying a higher replating capacity and a propensity to form megakaryocytic erythroid progenitors. This bias towards erythroid lineage commitment was also observed when hematopoietic progenitors were directed to undergo myeloid colony formation. Overall this study underscores the importance of canonical Wnt/β-catenin signaling in mesodermal specification, primitive erythropoiesis and early hematopietic progenitor formation during hematopoietic induction.
Leadership Standards: Marginalizing Diversity
Joe Corrigan
International Journal of Education , 2012, DOI: 10.5296/ije.v4i2.1578
Abstract: This article adopts a macro perspective on the role of leadership standards to comment on the sociological impact of their implementation. Where the growing diversity of learners in Canadian schools has invited a pluralism of ideas, research methods and approaches to learning, leadership standards induce increasingly homogenized responses to complex learning environments. Using a Constructionist theory of knowledge and Foucault’s conceptualization of power, this article asserts leadership standards subordinate the agency of educational leaders. This article will be of interest to educators and educational leaders who must balance administrative priorities with increasingly diverse learner needs.
Leadership for Learning: Tasks of Learning Culture
Joe Corrigan
Higher Education Studies , 2012, DOI: 10.5539/hes.v2n2p155
Abstract: This is a comparative analysis of leadership related to organizational culture and change that occurred at a large Canadian university during a twenty year period 1983 – 2003. From an institutional development perspective, leadership is characterized as a culture creation and development responsibility. By centering on the tasks of learning culture, this case study compared the challenge of leadership in two very different and competing organizational contexts. Using an experiential narrative and Constructionist approach, this research builds upon the work of Schein. This approach offers pragmatic insight into concepts such as trust and psychological safety that are often abstracted and ambiguous within organizational theory.
Evagrius and Gregory: Mind, Soul and Body in the Fourth Century
Kevin Corrigan
Aestimatio : Critical Reviews in the History of Science , 2011,
Abstract:
A frame for the development of preservice science teachers
Deborah CORRIGAN
Asia-Pacific Forum on Science Learning and Teaching , 2007,
Abstract: This paper describes how a frame has been used to articulate the intentions of a preservice chemistry education course to students of that course. The frame, which draws on appropriate knowledge bases for teachers of science, is also used through the teaching of the course as a diagnostic and development tool to assist the learning of these preservice teachers. However, the success of using such a frame also relies on the use of reflective tools to monitor student learning, such as learning logs and portfolios. The paper also presents evaluations from students on the success of using this frame in this preservice chemistry teacher education course.
Reflections
E. Corrigan
Physics , 1996,
Abstract: The purpose of this talk is to address a couple of simple-sounding questions: what boundary conditions are compatible with (a) Classical integrability? (b) Quantum integrability?
Recent developments in affine Toda field theory
E Corrigan
Physics , 1994,
Abstract: Lectures at the CRM-CAP Summer School 'Particles and Fields 94' August 16-24 1994, Banff, Alberta, Canada.
Integrable field theory with boundary conditions
E. Corrigan
Physics , 1996,
Abstract: Talks given at the workshop ``Frontiers in Quantum Field Theory'', held in Urumqi, Xinjiang Uygur Autonomous Region, People's Republic of China, 11-19 August 1996.
Aspects of dual models many years ago
E. Corrigan
Physics , 2008,
Abstract: Invited contribution to the collection of articles: `The Birth of String Theory', edited by Andrea Cappelli, Elena Castellani, Filippo Colomo and Paolo Di Vecchia.
On duality and reflection factors for the sinh-Gordon model
E Corrigan
Physics , 1997, DOI: 10.1142/S0217751X98001372
Abstract: The sinh-Gordon model with integrable boundary conditions is considered in low order perturbation theory. It is pointed out that results obtained by Ghoshal for the sine-Gordon breather reflection factors suggest an interesting dual relationship between models with different boundary conditions. Ghoshal's formula for the lightest breather is checked perturbatively to $O(\beta^2)$ in the special set of cases in which the $\phi\to -\phi$ symmetry is maintained. It is noted that the parametrisation of the boundary potential which is natural for the semi-classical approximation also provides a good parametrisation at the `free-fermion' point.
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