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Search Results: 1 - 10 of 223945 matches for " Pam R Massullo "
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Neutrophil elastase downmodulates native G-CSFR expression and granulocyte-macrophage colony formation
Melissa G Piper, Pam R Massullo, Megan Loveland, Lawrence J Druhan, Tamila L Kindwall-Keller, Jing Ai, Alexander Copelan, Belinda R Avalos
Journal of Inflammation , 2010, DOI: 10.1186/1476-9255-7-5
Abstract: Human peripheral blood PMN isolated from healthy donors were incubated with NE. Expression of the G-CSFR was analyzed by flow cytometry and western blot analyses. Detection of G-CSFR cleavage products from the culture supernatants was also performed. Human bone marrow mononuclear cells were also cultured in the presence or absence of NE to determine its effects on the proliferation of granulocyte-macrophage colony forming units (CFU-GM).Treatment of PMN with NE induced a time-dependent decrease in G-CSFR expression that correlated with its degradation and the appearance of proteolytic cleavage fragments in conditioned media. Immunoblot analysis confirmed the G-CSFR was cleaved at its amino-terminus. Treatment of progenitor cells with NE prior to culture inhibited the growth of granulocyte-macrophage colony forming units.These findings indicate that in addition to transcriptional controls and ligand-induced internalization, direct proteolytic cleavage of the G-CSFR by NE also downregulates G-CSFR expression and inhibits G-CSFR-mediated granulopoiesis in vitro. Our results suggest that NE negatively regulates granulopoiesis through a novel negative feedback loop.Granulocyte colony-stimulating factor (G-CSF) is the major regulator of granulopoiesis and supports the survival, proliferation, and maturation of myeloid progenitor cells along the neutrophil (PMN) lineage [1]. G-CSF also activates certain functions of mature PMN and stimulates hematopoietic stem cell mobilization [2-6]. The growth of neutrophilic granulocytes in vitro from progenitor cells committed to neutrophils and monocytes (CFU-GM) is absolutely dependent upon G-CSF and sigmoidally increases with increasing G-CSF concentrations [2,5,7,8]. A critical role for G-CSF in regulating granulopoiesis in vivo has been demonstrated in G-CSF null mice who have chronic neutropenia and severely impaired granulopoietic responses to infection [6].The biological activities of G-CSF are mediated by the G-CSFR receptor (
Haluk PAMR
Middle East Technical University Journal of the Faculty of Architecture , 2011,
Trigeminal Neuralgia Due To Brainstem Vascular Malformations: Report of Two Cases and Review of The Literature
Selcuk PEKER,?mre USSEL?,Necmettin PAMR
Journal of Neurological Sciences , 2012,
Abstract: Brain stem lesions are known to cause facial pain. Yet, classical trigeminal neuralgia (TN) due to brainstem lesions are very rare. To the best of our knowledge there are 4 cases in the literature with brainstem vascular malformations causing trigeminal neuralgia. We observed two patients with brain stem vascular malformations caused TN. The patient with cavernoma was treated with gamma knife radiosurgery. Second patient with capillary telangiectasia was well responded to medical treatment. We think that the damage to the intra-axial trigeminal nerve pathways resulted with the neuralgia.
Ocular findings in children with severe clinical symptoms of homozygous sickle cell anaemia in Kaduna, Nigeria
U V Eruchalu, V A Pam, R M Akuse
West African Journal of Medicine , 2006,
Synergy Between Moringa oleifera Seed Powder And Alum In The Purification of Domestic Water
MB Dalen, JS Pam, A Izang, R Ekele
Science World Journal , 2009,
Abstract: Moringa oleifera seeds were analyzed for chemical composition. Phytochemical screening indicates the presence of saponnins (+(+)), flavonoids (+(-))and alkaloids(+(-)). Insrumental analysis showed also the presence of sodium(15.21+0.10ppm),aluminum (12.21±0.012) potassium (14.21±0.013ppm) and sulphate (1.72±0.011 ppm). Similarly, commercial alum was also analyzed and the results showed the presence of sodium (10.47±0.1500), aluminum (18.17±0.024ppm), potassium (8.01±0.012ppm) and sulphate (3.73±0.010ppm). Jar test trials on raw water samples displayed favourably characteristics at 60% alum to 40% m.oleifera mg/l blend with total coliform count of 30ml-1 and turbidity of 3.2NTU below the WHO maximum permissible limit of 5NTU. Other parameters determined also showed conformity with WHO standards for drinking water. The results indicate that moringa oleifera has a double advantage compared to commercial alum because of the presence of phytochemicals which have been reported to possess antimicrobial properties with potentials for conjunctive use with alum for water purification in rural communities.
Using the Ages and Stages Questionnaire to teach medical students developmental assessment: a descriptive analysis
Pam Nicol
BMC Medical Education , 2006, DOI: 10.1186/1472-6920-6-29
Abstract: To evaluate the program, an interpretative analysis was completed on the students' reports written during the program and a questionnaire was administered to the parents to gain their perception of the experience. As well, student confidence levels in assessing growth and development were measured at the end of the paediatric term.Although there was an increase in student confidence in developmental assessment at the end of the term, it was not statistically significant. However the findings indicated that students gained increased understanding of the process and enhanced recognition of the parental role, and the study suggested there was increased confidence in some students. Parents indicated that they thought they should be involved in the teaching of students.The ASQ was shown to have been useful in an education program at the level of advanced beginners in developmental assessment.Developmental assessment is a core learning outcome for paediatric and child health students, so when a survey of medical graduates' skills identified a lack of confidence in this area, a program was developed with the aims of increasing both confidence and respect for the parental role. This study evaluates that program.Paediatric and child health practitioners advocate a family-centred care model that requires practitioners to have good interpersonal skills, to have respect for parental judgement and to be flexible in their role [1]. As well, collaborative patient-centred practice is emerging as a framework for interdisciplinary education [2]. For these frameworks to be successful, interpersonal competence, which includes an appreciation of the skill and uniqueness of all individuals involved, is required [3]. The development of these attitudinal and communication attributes in health care practitioners is one of the challenges for health educators interested in family-centred practice.Medical student attitudes are important because they are viewed as a mediating link between clini
Ocular Tumours in Childhood
V. Pam
Nigerian Journal of Surgical Research , 2001,
Abstract: (Nig J Surg Res 2001; 3:1-5)
A Review of 'Women, Science, and Myth: Gender Beliefs from Antiquity to the Present' edited by Sue V. Rosser
Pam Stello
International Journal of Gender, Science and Technology , 2010,
Thinking globally, acting locally: Women activists’ accounts
Alldred Pam
Temida , 2003, DOI: 10.2298/tem0304023a
Abstract: This paper intends to describe the range of forms women’s resistance to globalisation takes, emphasising diverse strategies from everyday acts, the development of practical alternative resources, organising in women’s groups or trades unions, mass demonstrations and symbolic defiance. Recognising that it is the women of the South, in particular, who bear the brunt of the impact of neoliberal ‘free market’ economic policies, it hoped to be sensitive to the struggles for survival that might frame the urgency of resistance amongst women of the South, and make links with some of the strategies of activist women in the more privileged North.
CSCanada PAM
Progress in Applied Mathematics , 2012, DOI: 10.3968/2920
Abstract: The special issue may focus on publishing recent developments of statistical methods for biological, medical and pharmaceutical research. Application of statistical methods has recently been dominated by biostatistical and bioinformatics research including clinical study, survival analysis, genetics and microarray analysis. Advanced statistical methods are being developed for analyzing high-dimensional microarray data as well as various observational data with outliers and measurement errors. The special issue would be a suitable venue for publishing such new developments in statistical research.
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