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Search Results: 1 - 10 of 4896 matches for " Pain "
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Sex affects the feeling of pain in the mice, possible involvement of nitric oxide
"Zahra Fatehi-Hassanabad,Mostafa Jafarzadeh,Mohammad Fatehi,Mohammad Taghi Razavi-Tossi"
DARU : Journal of Pharmaceutical Sciences , 2005,
Abstract: It has been shown that nitric oxide is a mediator with a major role in pain signaling at the level of dorsal root ganglion neurons of the spinal cord. The main objective of the present study was to elucidate the influence of sex on the effects of nitric oxide on pain mediation in mice. Painful stimuli such as heat induced by light beam focused on tail and hot plate chamber were applied. Animals were injected with either morphine (0.5, 5 and 50 mg/100g body weight) or L-NAME (0.1, 0.5 and 1 mg/100g body weight) intraperitonealy. Changes in tail flick latency and responses to the hot plate chamber were measured in different groups of mice. The tail flick latency was increased significantly in both male and female animals treated with morphine (control male (sec): 2.45 ± 0.16, male which received morphine 50 mg/100g body weight: 13.5 ± 0.6, control female: 3.4 ± 0.3, female which received morphine 50 mg/100g body weight: 13.8 ± 0.6; P<0.001 vs control in both cases). The response time to the hot plate chamber was also increased significantly by morphine pretreatment in both male and female mice. The tail flick latency and the response time to the hot plate chamber were significantly higher in the female mice (eg,the response time to the hot plate chamber (sec) in male: 7.3 ± 0.8, in female: 13.7 ± 1.6, P<0.01 vs female mice). Pretreatment with L-NAME at all concentrations caused a significant non-dose dependent increase in the response time to the hot plate chamber only in the male mice. These results may suggest that pain is mediated through different mediators in male and female mice and probable involves sex hormones. Furthermore, from the effect of L-NAME on pain sensation, it maybe suggested that Larginine-nitric oxide pathway is more important in male in comparison with female in pain signaling.
Laparoscopic diagnosis of endometriosis—Clinical study  [PDF]
Henri Lahdemaki, Markku Santala, Markku Ryynanen
Open Journal of Obstetrics and Gynecology (OJOG) , 2013, DOI: 10.4236/ojog.2013.39122

Objective: To examine the laparoscopic findings in patients with suspicion of endometriosis. Study Design: Retrospective study. Setting: Department of Obstetrics and Gynecology, University of Oulu, Finland. Sample: First-time laparoscopy, without any known surgical diagnosis, was made in 53 consecutive patients between January 2006 and November 2011. Main Outcome Measures: The laparoscopic findings, staging of endometriosis, the percentages of different symptoms linked with endometriosis. Results: Laparoscopy revealed endometriosis in 40% of cases. Most frequent symptoms were dysmenorrhea (86%) and dyspareunia (81%) followed with vibration pain (71%), urinary symptoms (29%) and lowered fertility (24%). Only 5% of patients with endometriosis complained of bowel symptoms, which were significantly more common in patients without endometriosis (28%) (p = 0.034). The median interval between the onset of symptoms and laparoscopic diagnosis was 1.9 years (SD 3.2, range 0.6 - 11). Conclusions: The interval between the onset of symptoms and laparoscopic diagnosis is short reflecting the prompt availability of the necessary facilities in specialist health care. Finally laparoscopy seems to be safe in cases of endometriosis suspicion.

Discogenic pain: Who cares?  [PDF]
José Pedro Lavrador, Nuno Simas, Edson Oliveira, Joaquim Cruz Teixeira, Diogo Sim?o, Sérgio Livraghi
Health (Health) , 2013, DOI: 10.4236/health.2013.511261

Chronic low back pain has a huge impact on daily living and a negative economic and professional effect. It is a matter of debate and concern for all health professionals involved, particularly spine surgeons. Recent discoveries on the innervation and biochemical properties of the intervertebral disc clarify the role of this structure as a possible cause of chronic low back pain. However, multiple causes may be present in the same patient making the diagnosis a challenging process. Discogenic pain is defined as a chronic low back pain induced by a degenerative disc disease. There are no specific characteristics of discogenic pain, although it has a higher incidence in younger age, it is usually localized medially in the back, worsens with axial loading and improves with recumbence. In the last decades we have assisted the emergence of multiple treatment techniques. However, neither the conservative treatment nor the interventional management has strong evidence in treating discogenic pain. Randomized control clinical trials are sought to improve patient outcome. Meanwhile, we believe each patient should be approached on an individual base. Discogenic pain: we care.


Analysis of the Efficacy of the Lidocaine Patch 5% in the Treatment of Neuropathic Pain: Our Feedback  [PDF]
P. Hernández-Puiggròs, R. Pélaez, A. Morell, A. Ya?ez, J. L. Aguilar
Pain Studies and Treatment (PST) , 2014, DOI: 10.4236/pst.2014.22015

Objective: the objective of this study was to evaluate the efficacy of the lidocaine patch 5% in different types of neuropathic pain. Methods: a prospective, longitudinal, observational study on a sample of 16 patients who consulted for neuropathic pain. A lidocaine patch 5% was applied to the painful area and as primary endpoint, the severity of the pain was studied using the Verbal Numeric Rating Scale (VNRS). Secondary quality of life-related endpoints were sleep during the night, mood and patient global impression of the treatment. Results: demographic data: 62.5% female and 37.5% male; mean age 55.31 ± 13.9 years; time since onset of the pain 8.4 months; and classified into 4 diagnosis groups: post-herpetic neuralgia 18.8%; complex regional pain syndrome 25%; surgical wound 50%; and others 6.3%. There was a reduction of more than 2 points in pain on the VNRS (median 6.5 to 3.5; p = 0.001), an improvement in sleep during the night, mood and relief (p < 0.05), less use of analgesics, no complications and over 30% of subjects reported improvement of over 50%. Conclusions: The lidocaine patch 5% could be a useful tool for the control of neuropathic pain, not only for post-herpetic neuralgia, and it has a good safety and tolerability profile.

Avalia??o psicofísica da percep??o de dor
Silva, José Aparecido da;Ribeiro-Filho, Nilton Pinto;
Psicologia USP , 2011, DOI: 10.1590/S0103-65642011005000009
Abstract: pain is a personal, subjective experience influenced by cultural, situational, attentive factors, and other psychological variables. approaches to the measurement of pain include verbal and numeric self-rating scales, behavioral observational scales, and physiological indicators. in this review, we described and analyzed as sophisticated psychophysical techniques can be designed to measure separately the sensory and cognitive dimensions of pain. these procedures have been shown to be valid and reliable measurements of pain with ratio-scaling properties and have recently been used in clinical settings.
Liga de Dor: uma experiência de ensino extracurricular
Pimenta, Cibele Andrucioli de Mattos;Teixeira, Manoel Jacobsen;Sim?es, Patrícia;Sim?es, César;Cruz, Diná de A Lopes Monteiro da;Okada, Massako;
Revista da Escola de Enfermagem da USP , 1998, DOI: 10.1590/S0080-62341998000300011
Abstract: although anatomical and physiological base of pain are subject of the basic sciences in health undergraduate curriculum, it is not usually to have pain, concepts and therapy into undergraduate programs. describing the league against pain objectives and organization and the students' opinions about their participation in this league were the aim of this stduy. the league against pain statute was consulted to describe its objectives and organization, the opinions of all of the students that attended the league against pain program in 1995 and 1996 were investigated. the league against pain was organized at an university hospital in 1995, it is composed by nurses and medical students and professionals (physicians in varied specialties and nurses). all the activities are voluntary and the students are the managers of the league. the objectives of the league are: improving the quality of teaching of pain subjects in nursing and medical schools; developing research in epidemyological, clinical and therapeuthics aspects of pain and to promote a model of multidisciplinary and multiprofessional assistance. the most frequent students' opinions about their participation in the league were: their habilities in pain control and in professional and client relationship were improved; they achievied their objectives; that pain should be included into undergraduate courses; and they would recommend the league for other students. the results are promising. the students' opinions about their experience in. the league against pain have showed that the league against pain could be an usefull model to introduce pain, subjects to undergraduate nursing and medical students.
Effect of 0.3-Millisecond Multi-Pulsed 1064-nm Nd:YAG Laser in Patients with Postherpetic Neuralgia  [PDF]
Koji Itai, Ayumi Korekawa, Kayo Jin, Takayuki Aizu, Akiko Rokunohe, Chihiro Hagiwara, Katsumi Hanada, Daisuke Sawamura
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2012, DOI: 10.4236/jcdsa.2012.21003
Abstract: Postherpetic neuralgia (PHN) is the most common complication following acute varicella zoster virus infection. PHN is associated with chronic severe pain and is resistant to conservative management treatments. The purpose of this study was to evaluate the effect of 0.3-millisecond multi-pulsed 1064-nm Nd:YAG laser treatment on PHN. Five subjects were treated with 2 - 3 sessions at 2-week interval. After the treatments, reduced visual analog scale (VAS) scores were noted in all patients. Treatments showed no adverse or intolerant effects and all patients felt warmth and comfort during the therapy. We first reported treating PHN patients using 0.3-millisecond multi-pulsed 1064-nm laser Nd:YAG. The results showed remarkable improvements in pain. This laser treatment could be an alternative choice for PHN patients with intractable neuralgia.
Pain Management in Prostate Cancer  [PDF]
Ali Eman, Serbülent G?khan Beyaz, Hasan Sa?lam, Mustafa Emre Gürcü
Open Journal of Urology (OJU) , 2012, DOI: 10.4236/oju.2012.223031
Abstract: Prostate cancer is the most common urogenital malignity of western communities and is the second leading cause of cancer-related deaths in this population. Pain is often due to bone metastasis in prostate cancer. For the patient diagnosed with cancer and for his family, pain is the most feared aspect of cancer following the likelihood of failure to treat and death. Quality of life is severely impaired together with complaint of pain which arises high rates as 80% in advanced stage cancers.
Successful Peripartum Use of an Intrathecal Morphine Pump  [PDF]
Julie T. Vuong, Jill M. Eckert
Open Journal of Anesthesiology (OJAnes) , 2012, DOI: 10.4236/ojanes.2012.25051
Abstract: As intrathecal pumps are now widely used for management of pain and spasticity, there are more women of child-bearing age who have intrathecal pumps already implanted at time of conception of their children. There is little in the way of guidelines for how to manage these women, especially those with intrathecal pumps infusing analgesics, throughout pregnancy and after birth. We present a woman who presented at 19 weeks of gestation for consultation of long term pain management, with 3 years of postpartum follow up.
Pharyngeal gonorrhea presenting with isolated neck pain  [PDF]
Lourdes DelRosso, Jennifer Smith, Michael Harper, Romy Hoque
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.21012

We present a case of a 22-year-old man with isolated neck pain due to pharyngeal gonorrhea.

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