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Search Results: 1 - 10 of 277 matches for " Padmini Sekar "
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Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes
Ritesh Kaushal, Daniel Woo, Prodipto Pal, Mary Haverbusch, Huifeng Xi, Charles Moomaw, Padmini Sekar, Brett Kissela, Dawn Kleindorfer, Matthew Flaherty, Laura Sauerbeck, Ranajit Chakraborty, Joseph Broderick, Ranjan Deka
BMC Medical Genetics , 2007, DOI: 10.1186/1471-2350-8-49
Abstract: At the APOE locus, no individual SNP was associated with SAH after correction for multiple comparisons. Haplotype analysis revealed significant association of the major haplotype (Hap1) in APOE with SAH (p = 0.001). The association stemmed from both the 5' promoter and the 3' region of the APOE gene. APOE ε2 and ε 4 were not significantly associated with SAH. No association was observed for ELN at genotype, allele, or haplotype level and our study failed to confirm previous reports of ELN association with aneurysmal SAH.This study suggests a role of the APOE gene in the etiology of aneurysmal SAH.Non-traumatic, spontaneous subarachnoid hemorrhage (SAH) affects 16,000 to 17,000 individuals each year in the United States [1-3]. SAH has a 30-day mortality rate exceeding 40%, and surviving patients often demonstrate significant morbidity [2,4]. Over 80% of SAH can be attributed to intracranial aneurysm (IA) rupture. Familial aggregation studies of SAH have consistently identified an increased risk of a first-degree relative with SAH or family history of SAH independent of smoking and hypertension [5].Variants of the apolipoprotein E (APOE) gene have been associated with Alzheimer's disease, lipid disorders and cardiovascular disease [6-8]. Previous studies have demonstrated that APOE ε4 and/or APOE ε2 are associated with lobar intracerebral hemorrhage (ICH) [9,10]. We recently reported that haplotypes which include polymorphisms in the 5' untranslated region of the APOE gene are risk factors for lobar ICH [11]. Specific to SAH, Kokubo et al. [12] found significant association of APOE ε4 with SAH in a Japanese population. Niskakangas et al. [13] reported association of APOE ε4 with adverse outcome after aneurysmal SAH. No study on other polymorphisms of APOE with regard to risk of SAH has yet been reported.In addition to APOE, the elastin (ELN) gene emerged as a putative gene for IA after linkage was found on 7q11, where ELN is located [14]. However, prior association st
Snapshot of Non-Inclusive Growth: Evidence from Philippine Employment Trends in 2001-2009  [PDF]
Ronald U. Mendoza, Padmini Mahurkar
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.37106
Abstract: This article briefly examines the Philippines’ pattern of job creation during the period 2001-2009 in order to help explain why growth during this period failed to translate into poverty reduction. An analysis of disaggregated employment and sectoral output data provides a much more nuanced picture of the types and sectors of jobs created during the last decade. The empirical evidence suggests that employment creation was inadequate, and skewed in favor of high skilled workers even across industries. Based on these findings, promoting inclusive growth in the Philippines requires a robust job creation strategy in order to meet the growing labor force, along with mechanisms to ensure skill upgrading and better skills matching (notably for the young) as well as efforts to bring even lower skilled workers into the formal sector.
INVESTIGATION OF IN-VITRO ANTHELMINTIC ACTIVITY OF CISSAMPELOS PAREIRA LINN AGAINST PHERETIMA POSTHUMA
Padmini Shukla
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: The world health organization estimates that a staggering 2 billion people harbor parasitic worm infections. Parasitic worms also infect livestock and crops, affecting food production with a resultant economic impact. Development of anthelmintic resistance and high cost of conventional anthelmintic drugs led to the evaluation of medicinal plants has an alternative source of anthelmintics. In view of this, an attempt has been made to study the anthelmintic activity of whole plant of Cissampelos pareira. The activity was checked by in-vitro anthelmintic model by using earthworm. In this current study, alcoholic and aqueous extract at various concentrations (5, 10, 25, 50, 100 mg/ml) were used and studied for paralysis and death of earthworm. All the extract was found not only to paralyze (Vermifuge) but also to kill the earthworm (vermicide). All the extract have significant activity but aqueous extract (100mg/ml) was found to be more effective to execute the earthworm. From this study it is concluded that Cissampelos pareira have potent anthelmintic activity and can be used in the treatment of helminthiasis.
Invasive Alien Plants of Indian Himalayan Region—Diversity and Implication  [PDF]
K. Chandra Sekar
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.32021
Abstract: The present study deals with comprehensive list of Invasive alien plants of Indian Himalayan Region with background information on family, habit and nativity. A total of 190 invasive alien species under 112 genera, belonging to 47 families have been recorded. Among these, the dicotyledons represent by 40 families, 95 genera and 170 species; monocotyledons represent by 7 families, 17 genera and 20 species. The analysis of invasive species reveals that 18 species have been introduced intentionally, while the remaining species established unintentionally through trade. In terms of nativity, amongst 13 geographic regions, the majority of invasive plants reported from American continent (73%). While in life form analysis, the herbs (148 species) are dominant, followed by shrubs (19 species), Grass (11 species), Trees (4 species), sedges and climber (3 species each). Most of the invasive species are annual habit (63%). Apart from these, 90 species (47%) are being used by locals for medicinal purposes. A better planning is needed for early detection to control and reporting of infestations of spread of new and naturalized weeds to be monitored.
Role of Strontium on the Crystallization of Calcium Hydrogen Phosphate Dihydrate (CHPD)  [PDF]
K. Suguna, C. Sekar
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.107048
Abstract: Calcium hydrogen phosphate dihydrate (CHPD, CaHPO4· 2H2O) or brushite is found quite frequently in urinary calculi (stones). Crystallization of brushite has been carried out in sodium metasilicate (SMS) gel with and without adding ‘Sr’ as additive. In pure system, dicalcium phosphate anhydrous (DCPA, CaHPO4) or monetite and hydroxyapatite (HA, Ca5(PO4)3(OH)) grew along with brushite. The presence of Sr suppressed the formation of HA and enhanced the number and size of monetite crystals and changed the morphology of brushite crystals from needle shape to octopus-like shape. The samples were characterized by powder & single crystal X-ray diffraction (XRD), scanning electron microscopy (SEM), Xray fluorescence spectroscopy (XRF), Fourier transform infrared spectroscopy (FTIR) and thermal analyses (TG-DTA).
Effect of Magnesium on the Mechanical and Bioactive Properties of Biphasic Calcium Phosphate  [PDF]
Ponnusamy Kanchana, Chinnathambi Sekar
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2012, DOI: 10.4236/jmmce.2012.1110099
Abstract: Incorporation of trace elements into calcium phosphate structure is of great interest for the development of artificial bone implants. Biphasic calcium phosphate (BCP) composed of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) have been synthesized in the presence of magnesium (5 M% - 20 M%) by gel method under physiological conditions. Crystallization of Mg-BCP in the gel medium mimics the Mg intake in the human body. Powder X-ray dif- fraction and Fourier transform infrared analyses confirmed that the Mg doping leads to the enrichment of β-TCP phase and suppresses the HA content in BCP. Nanoindentation studies indicate a significant decrease in hardness and elastic modulus values of BCP due to Mg doping. In vitro bioactivity study has confirmed the formation of apatite layer on the Mg doped samples making it suitable for bone replacement. The results suggest that the optimum Mg doping promotes the bioactivity which is perquisite for biomedical applications.
Analysis of linear and nonlinear stiff problems using the RK-Butcher algorithm
S. Sekar
Mathematical Problems in Engineering , 2006, DOI: 10.1155/mpe/2006/39246
Abstract: I present a numerical solution of linear and nonlinear stiff problems using the RK-Butcher algorithm. The obtained discrete solutions using the RK-Butcher algorithm are found to be very accurate and are compared with the exact solutions of the linear and nonlinear stiff problems and also with the Runge-Kutta method based on arithmetic mean (RKAM). A topic of stability for the RK-Butcher algorithm is discussed in detail. Error graphs for discrete and exact solutions are presented in a graphical form to show the efficiency of the RK-Butcher algorithm. The results obtained show that RK-Butcher algorithm is more useful for solving linear and nonlinear stiff problems and the solution can be obtained for any length of time.
Analysis of linear and nonlinear stiff problems using the RK-Butcher algorithm
S. Sekar
Mathematical Problems in Engineering , 2006,
Abstract: I present a numerical solution of linear and nonlinear stiff problems using the RK-Butcher algorithm. The obtained discrete solutions using the RK-Butcher algorithm are found to be very accurate and are compared with the exact solutions of the linear and nonlinear stiff problems and also with the Runge-Kutta method based on arithmetic mean (RKAM). A topic of stability for the RK-Butcher algorithm is discussed in detail. Error graphs for discrete and exact solutions are presented in a graphical form to show the efficiency of the RK-Butcher algorithm. The results obtained show that RK-Butcher algorithm is more useful for solving linear and nonlinear stiff problems and the solution can be obtained for any length of time.
Difficulty beyond intubation
Michael Sekar
Indian Journal of Anaesthesia , 2010,
Abstract:
PORTFOLIO OPTIMIZATION USING NEURO FUZZY SYSTEM IN INDIAN STOCK MARKET
Guna Sekar
Journal of Global Research in Computer Science , 2012,
Abstract: This paper describes a portfolio optimization system by using Neuro-Fuzzy framework in order to manage stock portfolio. It is great importance to stock investors and applied researchers. The proposed portfolio optimization approach Neuro-Fuzzy System reasoning in order to make a more yields from the stock portfolio, and hence maximize return and minimize risk of a stock portfolio through diversification and right investment allocation to the particular stock under uncertainty. To evaluate the performance of forecasting and optimization system, BSE Sensex index of India considered as benchmarks in this study to measure efficient forecasting models. The results show that the proposed Neuro Fuzzy system produces much higher accuracy when compared to other portfolio models.
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