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Search Results: 1 - 10 of 122 matches for " Ouaaki Siham "
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Pinealectomy and Exogenous Melatonin Regulate Anxiety-Like and Depressive-Like Behaviors in Male and Female Wistar Rats  [PDF]
El Mrabet Fatima Zahra, Ouaaki Siham, Mesfioui Abdelhalim, El Hessni Aboubakr, Ouichou Ali
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.34049
Abstract: The main objective of this work was to 1) study the influence of endogenous melatonin (Mel) abolishment via pinealectomy and 2) explore exogenous Mel effect on anxiety-like and depressive-like behavior in male and female rats. Rats were shamoperated (Sh) or pinealectomized (Px) and following subgroups were selected 1) Px/NaCl (0.9%) and Sh/NaCl (0.9%) : rats injected subcutaneously, once daily for 8 weeks, with saline solution NaCl (0.9%) as vehicle; 2) Px/Mel (4 mg/Kg) and Sh/Mel (4 mg/Kg): Rats similarly injected with 4 mg/Kg of Mel. All animals were housed under a photoperiod of (LD:16/8). After different treatments animals were tested in the open-field test (OFT), elevated plus maze test (EPM) to determine anxiety-like behavior, and forced swimming test (FST) to evaluate depressive-like level. Our results revealed that level of anxiety-like and depressive-like behavior are significantly higher in Px/NaCl (0.9%) when compared to Sh/NaCl (0.9%) group, suggesting that pinelectomy induced an anxiogenic and depressant effects. The Px effects would be due to the absence of endogenous Mel synthesis and release. Additionally, we clearly demonstrated that the level of anxiety-like and depressive-like behavior are higher in Px/Mel (4 mg/Kg) and Sh/Mel when compared respectively to Px/NaCl (4 mg/Kg) and Sh/NaCl groups suggesting an anxiolytic and antidepressant effects of exogenous Mel. Behavioral responses were sex dependent since the difference between females and males, especially, after melatonin administration, were statistically significant. These experiments provide evidence that pinealectomy and Mel regulated emotionally behavior in male and female rats.
Weakly Nonlinear Quantum Dust Ion-Acoustic Waves  [PDF]
Siham Ghebache, Mouloud Tribeche
Open Journal of Acoustics (OJA) , 2013, DOI: 10.4236/oja.2013.32007
Abstract: The one-dimensional quantum hydrodynamic (QHD) model for a three-specie quantum plasma is used to study the quantum counterpart of the well known dust ion-acoustic wave (DIAW). It is found that owing to the quantum effects, the dynamics of small but finite amplitude quantum dust ion-acoustic waves (QDIA) is governed by a deformed Korteweg-de Vries equation (dK-dV). The latter admits compressive as well as rarefactive stationary QDIA solitary wave solution. In the fully quantum case, the QDIA soliton experiences a spreading which becomes more significant as electron depletion is enhanced.

Minimum degree, independence number and pseudo [2,b]-factors in graphs
Siham Bekkai
Computer Science , 2011,
Abstract: A pseudo [2,b]-factor of a graph G is a spanning subgraph in which each component C on at least three vertices is a [2,b]-graph. The main contibution of this paper, is to give an upper bound to the number of components that are edges or vertices in a pseudo [2,b]-factor of a graph G. This bound is sharp.
La tolerancia inmunológica a 50 a?os del Premio Nobel en Medicina y Fisiología: Una perspectiva como mecanismo de respuesta inmune frente a patógenos
Berrueta,Lisbeth; Salmen,Siham;
Investigación Clínica , 2010,
Abstract: the immune system has the capability of protection against infectious disease which is accomplished by an enormous repertoire of receptors specifically reactive to foreign antigens, but it is tolerant to self-antigens, establishing biological identity. the ability to discriminate between self and non-self is a central property of the immune system, by using complex network of cellular and molecular mechanisms in order to prevent autoimmunity; this function is called immune tolerance. thus, the interaction between immune system and antigens is required for the generation of tolerance and it is critical in different physiological and pathological conditions in order to limit the damage to self tissues. since medawar description, who showed that the tolerance is an acquired property playing a central role in the homeostasis, several mechanism has been proposed to explain it. it is accepted today that an important group of antigen specific cells called regulatory t cell, both natural and induced, are critical as a unifying mechanism to maintain self-tolerance. these suppressor lymphocyte subpopulations had shown to play an important role not only by controlling autoimmune disease but also in the pathogenesis of many chronic infectious diseases, either manipulated by the microorganism to escape from the immune system, or induced by the host to reduce inflammatory damage. this review has the intention of updating about modern concepts in immune tolerance mechanisms, with special emphasis played by treg cell in the tolerance which is unquestionable induced during the course of chronic infections diseases.
La tolerancia inmunológica a 50 a os del Premio Nobel en Medicina y Fisiología: Una perspectiva como mecanismo de respuesta inmune frente a patógenos Immune tolerance at 50 years from the Nobel Prize in Medicine and Physiology: A perspective as a mechanism of immune response against pathogens
Lisbeth Berrueta,Siham Salmen
Investigación Clínica , 2010,
Abstract: El sistema inmune es responsable de proteger al organismo contra agentes extra os mediante el desarrollo de un repertorio de receptores, capaces de reconocer antígenos de toda etiología, diferenciando moléculas propias de extra as, estableciendo además fundamentos para la identidad biológica del individuo. Para ello dispone de una red compleja de mecanismos celulares y moleculares que son los responsables de la llamada tolerancia inmune. La regulación de la interacción entre el sistema inmune y los antígenos que eventualmente puede conducir al desarrollo de tolerancia, es crítica tanto en condiciones fisiológicas como en diferentes estados de patología. Desde las primeras descripciones de Medawar, las cuales mostraron que el fenómeno de tolerancia es adquirido y central para la homeóstasis del sistema inmune, un número importante de mecanismos se han propuesto para explicar la tolerancia inmune. Sin embargo, un mecanismo único de autotolerancia ha surgido: la generación de linfocitos T reguladores antígeno específicos, también conocidos como células T reguladoras (Treg), de origen central o periférico. Esta subpoblación de linfocitos con funciones supresoras ha mostrado un papel muy importante no solo en el control de enfermedades autoinmunes, sino además en la inmunopatogenia de enfermedades infecciosas crónicas, ya sean inducidas por el patógeno como mecanismo de escape o por el hospedador para mitigar el da o tisular consecuencia de la activación de la respuesta inmune. Esta revisión tiene como propósito actualizar los conceptos modernos en tolerancia inmune, con especial énfasis en el papel de las células Treg en la tolerancia inducida durante el curso de infecciones crónicas. The immune system has the capability of protection against infectious disease which is accomplished by an enormous repertoire of receptors specifically reactive to foreign antigens, but it is tolerant to self-antigens, establishing biological identity. The ability to discriminate between self and non-self is a central property of the immune system, by using complex network of cellular and molecular mechanisms in order to prevent autoimmunity; this function is called immune tolerance. Thus, the Interaction between immune system and antigens is required for the generation of tolerance and it is critical in different physiological and pathological conditions in order to limit the damage to self tissues. Since Medawar description, who showed that the tolerance is an acquired property playing a central role in the homeostasis, several mechanism has been proposed to explain it. It i
On Mean Distance and Girth
Siham Bekkai,Mekkia Kouider
Computer Science , 2008,
Abstract: We bound the mean distance in a connected graph which is not a tree in function of its order $n$ and its girth $g$. On one hand, we show that mean distance is at most $\frac{n+1}{3}-\frac{g(g^2-4)}{12n(n-1)}$ if $g$ is even and at most $\frac{n+1}{3}-\frac{g(g^2-1)}{12n(n-1)}$ if $g$ is odd. On the other hand, we prove that mean distance is at least $\frac{ng}{4(n-1)}$ unless $G$ is an odd cycle.
Contribution to Development of Reliability and Optimization Methods Applied to Mechanical Structures  [PDF]
Siham Ouhimmou, Abdelkhalak El Hami, Rachid Ellaia, Mohamed Tkiouat
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.41005
Abstract:

In order to take into account the uncertainties linked to the variables in the evaluation of the statistical properties of structural response, a reliability approach with probabilistic aspect was considered. This is called the Probabilistic Transformation Method (PTM). This method is readily applicable when the function between the input and the output of the system is explicit. However, the situation is much more involved when it is necessary to perform the evaluation of implicit function between the input and the output of the system through numerical models. In this work, we propose a technique that combines Finite Element Analysis (FEA) and Probabilistic Transformation Method (PTM) to evaluate the Probability Density Function (PDF) of response where the function between the input and the output of the system is implicit. This technique is based on the numerical simulations of the Finite Element Analysis (FEA) and the Probabilistic Transformation Method (PTM) using an interface between Finite Element software and Matlab. Some problems of structures are treated in order to prove the applicability of the proposed technique. Moreover, the obtained results are compared to those obtained by the reference method of Monte Carlo. A second aim of this work is to develop an algorithm of global optimization using the local method SQP, because of its effectiveness and its rapidity of convergence. For this reason, we have combined the method SQP with the Multi start method. This developed algorithm is tested on test functions comparing with other methods such as the method of Particle Swarm Optimization (PSO). In order to test the applicability of the proposed approach, a structure is optimized under reliability constraints.

Non Traumatic Myositis Ossificans Mimicking a Malignant Neoplasm: A Case Report  [PDF]
Latifa Tahiri, Laila Chbani, Siham Tizniti, Abdelmajid Elmrini, Taoufik Harzy
Open Journal of Radiology (OJRad) , 2012, DOI: 10.4236/ojrad.2012.24019
Abstract: Myositis ossificans is a benign self limiting condition that usually related to trauma. Despite a clinically and histologically distinct entity, myositis ossificans still causes considerable difficulties in diagnosis. A 33-year-old Moroccan woman presented with a 2-month history of left inguinal inflammatory pain with limping gait, MRI examination suggested a malignant neoplasm such as soft tissue osteosarcoma. A diagnosis of myositis ossificans was made by incisional biopsy. Conservative management with clinical and radiological follow up of 19 months confirm the diagnosis. The symptoms resolved within seven months. Myositis ossificans should be considered by clinicians as a possible diagnosis for a soft tissue lesion.
PUVA versus NB-UVB in Management of Vitiligo, Clinico-Immuno-Pathological Study  [PDF]
Sameh K. Attia, Sherif S. Awad, Siham Yacoub
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2013, DOI: 10.4236/jcdsa.2013.33A2005
Abstract:

Background: Phototherapy is the most commonly used modality in the treatment of vitiligo. Oral PUVA is the classical treatment and the NB-UVB is a recently introduced form excluding the shorter erythemogenic wavelengths. Aims: This study was designed to compare the effects of PUVA and NB-UVB clinically and immuno-pathologically in managing non segmental vitiligo. Patients/Methods: Thirty vitiligo patients were divided randomly into two groups and treated either by oral PUVA or by narrow band UVB for 4 months, and evaluation was done clinically and immuno-pathologically. Results: One patient in PUVA group (3.3%) failed to respond to therapy while 29 patients (93.3%) improved including all NB-UVB cases. Excellent repigmentation was achieved in 6.7% in PUVA group and 66.6% in NB-UVB group; good repigmentation was achieved in 60% in PUVA and 20% in NB-UVB while 26.7% in PUVA and 13.3% in NB-UVB showed mild repigmentation. The color matching was excellent in all NB-UVB patients. Recurrence and activation of vitiligo were demonstrated in some NB-UVB cases and were less in PUVA treated cases. Microscopic examination revealed persistence of dermal lympho-histiocytic infiltrate and the interface changes in biopsies from vitiliginous lesions treated with NB-UVB more than with PUVA. Conclusions: NB-UVB provides significant better results than oral PUVA in managing non-segmental vitiligo. Although NB-UVB therapy gives a rapid effect, yet the observation of

Mild Cognitive Impairment in Parkinson Disease: A Neuropsychological Study of 25 Patients  [PDF]
Siham Sanhaji, Mounia Rahmani, Maria Benabdeljlil, Mustapha El Alaoui Faris
World Journal of Neuroscience (WJNS) , 2018, DOI: 10.4236/wjns.2018.84037
Abstract: Parkinson’s disease (PD) is associated with an increased incidence of cognitive impairment and dementia. Population-based cohort of 25 patients with incident PD underwent a large neuropsychological battery. Executive functions were the most affected cognitive domain including particularly initiation, mental flexibility and inhibition. Episodic memory and visuo-spatial functions were less affected. We found that 92% of patients were classified as having Mild Cognitive Impairment (MCI); most of them experienced PD-MCI Single-Domain (17 patients) with disturbances on executive functions. Less frequently, we identified a group of patients with multiple-domain PD-MCI demonstrating deficits on executive functions as well as on episodic memory and/or visuospatial capacities.
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