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Search Results: 1 - 10 of 798 matches for " Othman Mosleh "
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Neuroblastoma in Saudi Children: A Single Center Experience (2006-2014)  [PDF]
Zaid Al Naqib, Atif A. Ahmed, Musa Al Harbi, Fahad Al Manjomi, Zaheer Ullah Khan, Awatif Alanazi, Othman Mosleh, Walid Ballourah, Mohammed Rayis
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.610098
Abstract: Introduction: Neuroblastoma is the most common extracranial solid tumor in childhood and survival rate has improved during the last few decades. Only a few studies, related to Neuroblastoma in Saudi Arabian children, have been performed. We report epidemiologic data and our clinical experience from the department of Pediatric Hematology Oncology (PHO), King Fahad Medical City (KFMC), Riyadh, Saudi Arabia. Method: A retrospective observational study of all patients, with diagnosis of Neuroblastoma, who attended PHO-KFMC from July 2006 to June 2014 was performed. The survival periods (overall survival and disease-free survival) and the final outcomes for patients treated and followed at KFMC were recorded. The survival data were statistically correlated with the clinical, pathological and biological features of patients and tumors and compared to national and international cohorts. Results: Eight-year data were available for the 42 patients of which 22 (52.4%) were male and 20 (47.6%) were females. Age at diagnosis ranged 0 - 91 months with a mean and median of 26.3 and 18.5 months respectively. 16 (38.1%) patients were under one year and 26 (61.9%) above 1 year of age. The event-free survival (EFS) and overall survival (OS) rates were 66.5% and 71.5% respectively. EFS and OS among those who were <1 year age at presentation was 75% and 82%, whereas ≥1 yr age group had 59% and 62% survival rates respectively. Patients with tumors in the adrenal had considerably lower EFS (59%) and OS (63%); in comparison to patients with tumors sites other than the adrenal who had EFS and OS of 85% and 89% respectively. Both EFS and OS survival rates at the end of follow-up interval were 100.0%, in the low and intermediate risk groups. In contrast, patients in the high risk group had EFS and OS rates of 44% and 48% respectively. This difference was statistically significant (p < 0.05). Conclusion: Our results are very encouraging and comparable with known published international cohorts, and reveal an excellent outcome for stage 1, 2, 3 & 4 s. The prognosis for advanced (stage 4) disease remains rather poor. A collaborative Saudi-wide effort, with an emphasis on research in detecting clinical and biologic characteristics of aggressive disease and tailoring therapy, is needed.
Pediatric Non-Hodgkin Lymphoma: A Retrospective 7-Year Experience in Children & Adolescents with Non-Hodgkin Lymphoma Treated in King Fahad Medical City (KFMC)  [PDF]
Nahla Ali Mobark, Suha A. Tashkandi, Wafa Al Shakweer, Khalid Al Saidi, Suha A. Fataftah, Mohammed M. Al Nemer, Awatif Alanazi, Mohammed Rayis, Walid Ballourah, Othman Mosleh, Zaheer Ullah, Fahad El Manjomi, Musa Al Harbi
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.64033

Background: Non-Hodgkin’s lymphoma is an aggressive malignant disease in children and adolescents. Although it is the fourth most common malignancy in Saudi children as reported in Saudi cancer registry, less information is available about pediatric Non-Hodgkin lymphoma and its outcome in Saudi Arabia. Study Objectives: To provide demographic data, disease characteristics, treatment protocol, toxicity and outcome of treatment in children & adolescents with Non-Hodgkin’s lymphoma treated at KFMC. This study will form base line for future studies about pediatric Non-Hodgkin’s lymphoma in KFMC, which may help to improve outcome for children with cancer in Saudi Arabia. Study Patients and Method: We retrospectively analyzed 28 children and adolescents diagnosed to have Non-Hodgkin’s lymphoma at KFMC between December 2006 and December 2013, followed-up through June 2014. Results: Of the 28 patients, 10 (35.7%) girls and 18 (64.3%) boys, the male-to-female ratio was 1.8; 1. The median age at time of diagnosis was 6.4 years old (range 2.0 to 13.0 years old). The majority of patients (64.3%) were aged between 5 and 12 years old. Burkitt’s lymphoma BL/BLL was the most common pathological subtype (60.7%), and DLBCL was the second most common subtype (21.4%). Abdominal and Retroperitoneal involvement was the most common primary site (78.6%) including the ileocaecal region. Most of the children presented with advanced Stage III and IV (75%), Cytogenetic study which screens specifically for the t (8; 14) (q24; q32) a characteristic genetic feature of Burkitt’s Lymphoma was obtained from 21 patients, variant rearrangement was observed in 3/21 samples and complex chromosomes karyotype in addition to IGH/MYC rearrangement was observed in 2/21 samples. Those patients presented with very aggressive lymphoma and combined BM and CNS involvement. We use the French-American-British Mature B-Cell Lymphoma 96 Protocol (FAB LMB 96) for treatment fornewly diagnosed Mature B-Cell type NHL and high risk ALL CCG 1961 Protocol for lymphoblastic lymphoma and international Anaplastic Large Cell Lymphoma 99 Study Protocol for ALCL. The median follow-up in patients not experiencing an adverse event was 53.1 months. The estimated 3-year EFE and OS rates in the entire cohort of patients with newly diagnosed NHL treated in the KFMC were 85.2% and 89.2% respectively; Overall survival (OS) rate of patients with mature

Drug prescription based on WHO indicators: Tehran university of medical sciences facilities with pharmacy
Mosleh A.
Tehran University Medical Journal , 2007,
Abstract: Background: Rationalize of drug use in societies is one of the main responsibilities of health policy makers. In our country irrational use of dugs has increased in the recent years, for example one study in 1998 has shown that average number of medicines per prescription was 3.6, percentage of prescriptions containing antibiotics was 43% and percentage of prescriptions containing Injections was 39%. One of the best tools for evaluation of drug use is the WHO guideline for calculating prescribing indicators. In this study, we had an assessment about prescribing patterns in South of Tehran, Islamshahr and Rey Health Centers.Methods: In order to evaluating prescribing indicators in Tehran University of Medical Sciences region 35 facilities which had pharmacy were selected according to WHO gridline and 4190 prescription from these facilities were studied. Indicators were calculated according to formulas has explained in article. Results: The average number of drug per prescription was 2.58, percentage of drug prescribed by generic name: 99.8%, percentage of encounters prescribed Antibiotics: 62.39% percentage of encounters prescribed Injection: 28.96% & the percentage of drugs prescribed from PHC formulary 99.46%. These findings were almost similar in the three Health Centers.Conclusions: Health facilities are one of the most important bases to improve rational use of Drugs and general practitioners are the major chain in RUD cycle. Results show that we need to design intervention especially educational interventions to improve two WHO prescribing indicators, percentage of encounters prescribed Antibiotics & Injections in this region. For reaching this goals we need to design educational programs for physicians, pharmacists and people too. These educations can be as workshops, seminars, conferences or printed materials such as books, leaflets and etc.
Development and Evaluation of a Speech Recognition Test for Persian Speaking Adults
Mohammad Mosleh
Audiology , 2001,
Abstract: Method and Materials: This research is carried out for development and evaluation of 25 phonemically balanced word lists for Persian speaking adults in two separate stages: development and evaluation. In the first stage, in order to balance the lists phonemically, frequency -of- occurrences of each 29phonems (6 vowels and 23 Consonants) of the Persian language in adults speech are determined. This section showed some significant differences between some phonemes' frequencies. Then, all Persian monosyllabic words extracted from the Mo ‘in Persian dictionary. The semantically difficult words were refused and the appropriate words choosed according to judgment of 5 adult native speakers of Persian with high school diploma. 12 openset 25 word lists are prepared. The lists were recorded on magnetic tapes in an audio studio by a professional speaker of IRIB. "nIn the second stage, in order to evaluate the test's validity and reliability, 60 normal hearing adults (30 male, 30 female), were randomly selected and evaluated as test and retest. Findings: 1- Normal hearing adults obtained 92-1 0O scores for each list at their MCL through test-retest. 2- No significant difference was observed a/ in test-retest scores in each list (‘P>O.05) b/ between the lists at test or retest scores (P>0.05), c/between sex (P>0.05). Conclusion: This research is reliable and valid, the lists are phonemically balanced and equal in difficulty and valuable for evaluation of Persian speaking adults speech recognition.
Minimal solution of linear formed fuzzy matrix equations
Maryam Mosleh
Journal of Interpolation and Approximation in Scientific Computing , 2012, DOI: 10.5899/2012/jiasc-00014
Abstract: In this paper according to the structured element method, the $m imes n$ inconsistent fuzzy matrix equation $A ilde{X}= ilde{B},$ which are linear formed by fuzzy structured element, is investigated. The necessary and sufficient condition for the existence of a fuzzy solution is also discussed. some examples are presented to illustrate the proposed method.
Solution of Fuzzy Matrix Equation System
Mahmood Otadi,Maryam Mosleh
International Journal of Mathematics and Mathematical Sciences , 2012, DOI: 10.1155/2012/713617
Abstract: The main is to develop a method to solve an arbitrary fuzzy matrix equation system by using the embedding approach. Considering the existing solution to fuzzy matrix equation system is done. To illustrate the proposed model a numerical example is given, and obtained results are discussed. 1. Introduction The concept of fuzzy numbers and fuzzy arithmetic operations was first introduced by Zadeh [1], Dubois, and Prade [2]. We refer the reader to [3] for more information on fuzzy numbers and fuzzy arithmetic. Fuzzy systems are used to study a variety of problems including fuzzy metric spaces [4], fuzzy differential equations [5], fuzzy linear systems [6–8], and particle physics [9, 10]. One of the major applications of fuzzy number arithmetic is treating fuzzy linear systems [11–20], several problems in various areas such as economics, engineering, and physics boil down to the solution of a linear system of equations. Friedman et al. [21] introduced a general model for solving a fuzzy linear system whose coefficient matrix is crisp, and the right-hand side column is an arbitrary fuzzy number vector. They used the parametric form of fuzzy numbers and replaced the original fuzzy linear system by a crisp linear system and studied duality in fuzzy linear systems where and are real matrix, the unknown vector is vector consisting of fuzzy numbers, and the constant is vector consisting of fuzzy numbers, in [22]. In [6–8, 23, 24] the authors presented conjugate gradient, LU decomposition method for solving general fuzzy linear systems, or symmetric fuzzy linear systems. Also, Abbasbandy et al. [25] investigated the existence of a minimal solution of general dual fuzzy linear equation system of the form , where and are real matrices, the unknown vector is vector consisting of fuzzy numbers, and the constants and are vectors consisting of fuzzy numbers. In this paper, we give a new method for solving a fuzzy matrix equation system whose coefficients matrix is crisp, and the right-hand side matrix is an arbitrary fuzzy number matrix by using the embedding method given in Cong-Xin and Min [26] and replace the original fuzzy linear system by two crisp linear systems. It is clear that, in large systems, solving linear system is better than solving linear system. Since perturbation analysis is very important in numerical methods. Recently, Ezzati [27] presented the perturbation analysis for fuzzy linear systems. Now, according to the presented method in this paper, we can investigate perturbation analysis in two crisp matrix equation systems instead of linear system as
A Production-Transportation Problem Casted with Piecewise Linear Concave Costs
Alireza Ghahari,Mohsen Mosleh
Lecture Notes in Engineering and Computer Science , 2011,
Minimal Solution of Non-square Fuzzy Linear Systems
Mahmood Otadi,Maryam Mosleh
Journal of Fuzzy Set Valued Analysis , 2012, DOI: 10.5899/2012/jfsva-00105
Abstract: In this paper, the main is to develop a method to solve an arbitrary inconsistent fuzzy linear system by using the embedding approach. Considering the existing of minimal solution to $mimes n$ linear fuzzy system is done. To illustrate the proposed model numerical examples are given and obtained results are discussed.
Fuzzy Fredholm integro-differential equations with artificial neural networks
Maryam Mosleh,Mahmood Otadi
Communications in Numerical Analysis , 2012, DOI: 10.5899/2012/cna-00128
Abstract: In this paper, we use parametric form of fuzzy number, then feed-forward neural network is presented for obtaining approximate solution for fuzzy Fredholm integro-differential equation of the second kind. This paper presents a method based on neural networks and Newton-Cotes methods with positive coefficient. The ability of neural networks in function approximation is our main objective. The proposed method is illustrated by solving some numerical examples.
Morphometric Analysis of the Brain Ventricles in Normal Subjects Using Computerized Tomography  [PDF]
Moawia Gameraddin, Abdalrahim Alsayed, Amir Ali, Mosleh Al-Raddadi
Open Journal of Radiology (OJRad) , 2015, DOI: 10.4236/ojrad.2015.51003
Abstract: Background and Aim: As ageing advances, the human brain undergoes many gross and histopathological changes with regression of the brain tissue leading to the enlargement of the ventricles. Knowledge of morphometric and size of normal ventricular system of brain is important to understand these changes. Methods: For the present perspective study, computerized tomography (CT) for 152 patients (Male-89 and Females-63) were studied for the measurements of fourth ventricle, third ventricle and lateral ventricle and it was statistically analyzed. Results: The anteroposterior extent of the body of the lateral ventricles on the right side was 74.89 + 9.86 mm and 70.06 + 8.83 mm in the males and females and on the left side was 74.89 + 9.89 mm and 69.56 + 11.42 mm in the males and females; the length of the frontal horns on the right side was 28.53 + 3.88 mm and 26.16 + 4.21 mm in the males and females and on the left side was 28.53 + 3.88mm and 26.17 + 4.237 mm in the males and females respectively. The width and height of the fourth ventricle were 12.54 + 1.90 mm and 9.66 + 2.12 in the males and 11.60 + 2.099 mm and 9.70 + 2.219 in the females respectively. The width of the third ventricle was 5.70 + 1.54 mm and 5.40 + 1.68 mm in the males and females respectively. Conclusion: The present study has defined the morphometric measurements of the lateral ventricles, third ventricle, and fourth ventricle of the brain which has clinical correlations in diagnosis and for further line of treatment.
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