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Search Results: 1 - 10 of 1013 matches for " Osamu Yamato "
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Early Stage of Chronic Kidney Disease with Renal Injury Caused by Hypertension in a Dog
Akira Yabuki,Keijiro Mizukami,Mariko Sawa,Sawane Mitani,Osamu Yamato
Case Reports in Veterinary Medicine , 2011, DOI: 10.1155/2011/149648
Abstract: A 10-year-old spayed female Papillon weighing 4.0 kg presented with a history of persistent hematuria and pollakiuria. Concurrent bladder calculi, a mammary gland tumor, and nonazotemic early stage of chronic kidney disease with contracted kidneys were noted in this dog. The dog underwent cystectomy, unilateral mastectomy, and intraoperative renal biopsy. On the basis of histopathological analysis of renal biopsy results, it was suspected that renal injury of the dog was caused by persistent hypertension, and a follow-up examination revealed severe hypertension. The dog was treated with a combination of an angiotensin-converting enzyme inhibitor and calcium channel blocker. The treatment produced a good outcome in the dog, and there has been no progression of the chronic kidney disease for over 2 years.
Magnetic Resonance Findings of the Corpus Callosum in Canine and Feline Lysosomal Storage Diseases
Daisuke Hasegawa, Shinji Tamura, Yuya Nakamoto, Naoaki Matsuki, Kimimasa Takahashi, Michio Fujita, Kazuyuki Uchida, Osamu Yamato
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083455
Abstract: Several reports have described magnetic resonance (MR) findings in canine and feline lysosomal storage diseases such as gangliosidoses and neuronal ceroid lipofuscinosis. Although most of those studies described the signal intensities of white matter in the cerebrum, findings of the corpus callosum were not described in detail. A retrospective study was conducted on MR findings of the corpus callosum as well as the rostral commissure and the fornix in 18 cases of canine and feline lysosomal storage diseases. This included 6 Shiba Inu dogs and 2 domestic shorthair cats with GM1 gangliosidosis; 2 domestic shorthair cats, 2 familial toy poodles, and a golden retriever with GM2 gangliosidosis; and 2 border collies and 3 chihuahuas with neuronal ceroid lipofuscinoses, to determine whether changes of the corpus callosum is an imaging indicator of those diseases. The corpus callosum and the rostral commissure were difficult to recognize in all cases of juvenile-onset gangliosidoses (GM1 gangliosidosis in Shiba Inu dogs and domestic shorthair cats and GM2 gangliosidosis in domestic shorthair cats) and GM2 gangliosidosis in toy poodles with late juvenile-onset. In contrast, the corpus callosum and the rostral commissure were confirmed in cases of GM2 gangliosidosis in a golden retriever and canine neuronal ceroid lipofuscinoses with late juvenile- to early adult-onset, but were extremely thin. Abnormal findings of the corpus callosum on midline sagittal images may be a useful imaging indicator for suspecting lysosomal storage diseases, especially hypoplasia (underdevelopment) of the corpus callosum in juvenile-onset gangliosidoses.
A New Approach: Chronotherapy in Acute Blood Purification for Septic Shock  [PDF]
Masafumi Yamato, Yusuke Minematsu
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.57004
Abstract: Circadian rhythms are daily oscillations of multiple biological processes. Recently, relationships between circadian rhythms and immune functions have also been described. In a mouse sepsis model, the death rate due to lipopolysaccharide (LPS)-induced endotoxic shock was found to be dependent on LPS administration as determined by circadian time. In humans, a pronounced inflammatory response to endotoxemia differs depending on whether it is daytime or night-time: Levels of tumor necrosis factor-alpha and interleukin-6 were higher during the night. Therefore, it is reasonable to assume that circadian rhythms influence not only organ dysfunction and the prognosis induced by LPS, but also the therapeutic effect of anti-LPS therapy such as Polymyxin-B direct hemoperfusion. We herein postulate the concept that it is important to discuss septic shock treatment in terms of whether or not the treatment is adjusted for the optimal time window as determined by circadian rhythms.
High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1/ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs
Keijiro Mizukami,Akira Yabuki,Hye-Sook Chang,Mohammad Mejbah Uddin,Mohammad Mahbubur Rahman,Kazuya Kushida,Moeko Kohyama,Osamu Yamato
Disease Markers , 2013, DOI: 10.1155/2013/695918
Abstract: A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this mutation, and a genotyping survey was carried out in a population of 472 Border Collies in Japan to determine the current allele frequency. The survey demonstrated the frequencies of the T/T wild type, T/G heterozygote, and G/G mutant homozygote to be 60.0%, 30.3%, and 9.8%, respectively, indicating that the frequency of the mutant G allele is extremely high (24.9%) in Border Collies. The results suggest that this high mutation frequency of the mutation is likely to cause a high prevalence of phenobarbital-resistant epilepsy in Border Collies. 1. Introduction Recently, a single nucleotide substitution associated with phenobarbital-resistant idiopathic epilepsy was found in Border Collies [1], which frequently present with severe epileptic seizures that are poorly controlled with antiepileptic drugs [2]. This polymorphic mutation is a substitution of thymine for guanine at intron 1 near the 5′-end of the canine MDR1/ABCB1 gene (c.-6-180T>G), where the most important promoter elements are located [3]. The mutation is not directly associated with the pathogenesis of idiopathic epilepsy, but it may create resistance to phenobarbital therapy in epileptic Border Collies [1]. However, the c.-6-180T>G mutation has been shown not to be a fully penetrant polymorphic mutation for phenobarbital nonresponsiveness because phenobarbital-resistant, idiopathically epileptic Border Collies in a previous case control study included a homozygous T/T wild-type dog [1]. On the basis of data from a relatively small cohort of Border Collies, it was hypothesized that the mutation might be related to an upregulation of the gene and an overexpression of P-glycoprotein (P-gp) encoded by the MDR1/ABCB1 gene. Therefore, further studies are required to understand the regulatory effect of the mutation and its potential clinical relevance. For these purposes, an accurate method of genotyping for the mutation should be developed, and the frequency of the mutation should be determined in a large, normal population of dogs. In the present study, a PCR-restriction fragment length polymorphism (RFLP) assay was developed in order to discriminate the genotypes of the mutation, and a genotyping survey was conducted in Japan by using samples from clinically healthy Border Collies in order to determine
Calcium Participates in Secretion of Porphyrin from Shell Gland Epithelial Cells of Japanese Quail (Coturnix coturnix japonica)  [PDF]
Osamu Kai
Open Journal of Animal Sciences (OJAS) , 2019, DOI: 10.4236/ojas.2019.91013

To investigate factors involved in the secretion of protoporphyrin IX (PpIX), a superficial eggshell pigment, from shell gland epithelial cells of Japanese quail, we cultured cells in Ham’s F12 medium with calcium chloride and quail plasma. The addition of hormones (prostaglandin F2α, progesterone, estradiol-17β) to the medium did not change the PpIX concentration in the culture supernatant, but changing the calcium chloride (CaCl2) concentration did: a lower concentration of CaCl2 led to a higher PpIX concentration; 0 mM CaCl2 enhanced the secretion of PpIX from epithelial cells prepared at 5 or 7 mM CaCl2. The result suggests that a drop in concentration of CaCl2 mimics the end of shell calcification and stimulates rapid secretion of PpIX in vivo. Bovine serum albumin was almost as effective

CdI2 Extraction with 18-Crown-6 Ether into Various Diluents: Classification of Extracted Cd(II) Complex Ions Based on the HSAB Principle  [PDF]
Yoshihiro Kudo, Yamato Ishikawa, Hikaru Ichikawa
American Journal of Analytical Chemistry (AJAC) , 2018, DOI: 10.4236/ajac.2018.911041
Abstract: CdI2 in water was extracted with 18-crown-6 ether (L) into 10 diluents at 298 K. The following equilibrium constants were determined or evaluated: some extraction constants (Kex/mol-3·dm9 & Kex,ip/mol-2·dm6 for CdLI2, Kex±/mol-2·dm6 for CdLI+ with I-, & Kex2±/mol-1·dm3 for CdL2+ with 2I-), conditional distribution constants (KD,I for I-, KD,CdLI for CdLI+, & KD,CdL for CdL2+) between the two phases, and an ion-pair formation constant (K1,org/mol-1·dm3) for CdLI+ and that (K2,org/mol-1·dm3) for CdLI2 in the organic (org) phases. Using the K1,org and K2,org values, acidities of the complex ions, CdL2+ and CdLA+ (A- = I-, Br-, & Cl-), in the 11 diluents were classified by applying the HSAB rule. Especially, the CdLA+ ions were classified as the soft acids in 9 diluents. Also, molar volumes (Vj/cm3·mol-1) of j = CdLI2 and CdL2+ were determined with the regular-solution-theory plot of logKex,ip vs. logKD,L and its pseudo-plot of logKD,CdL, respectively. Here, KD,L denotes the distribution constant of L between the two phases. So, sizes among CdLA2 and CdL2+ were compared by using the Vj values. Additionally, some distribution equilibrium potentials (dep/V) between the water and org bulk phases were topically calculated from an equation of KD,I with KSD,I, where the symbol KSD,I shows a standard distribution constant of I- at dep = 0 V for a given diluent.
P2P Content Searching Method using Semantic Vector which is Managed on CAN Topoogy
Yoji Yamato,Hiroshi Sunaga
Journal of Multimedia , 2006, DOI: 10.4304/jmm.1.6.1-9
Abstract: With today's advances in Peer-to-Peer (P2P) searching technology, a lot of non-document content has become searchable and usable. In the near future, since a huge amount of content is distributed over the networks, not only index server searching but also P2P searching will become important because of its scalability and robustness. Typical P2P contents sharing services have some problems, such as low search precision ratio, significant increase in traffic and inundations of malicious content such as virus. In this paper, with ideas of the CAN (Content Addressable Network) topology and a vector space method where vectors have a variable length, we propose a new P2P content searching method in which a query is effectively forwarded only to peers that have indices of content semantically similar to the desired one but not forwarded to the same peer repeatedly. The main part of our proposal is to map non-document content to a vector space based on users' evaluation and to manage vector space or to route queries using the CAN topology control. The effectiveness of the proposal is shown both by analytical estimations and simulation experiments. Our simulation experiments clarify that the proposed method is effective in improving the precision and recall ratios while reducing the amount of traffic compared with the Gnutella flooding and the vector space method in which vector lengths are fixed (close to pSearch method). In particular, when there is a lot of malicious content, the proposed method exhibited a higher precision ratio than other methods.
Optimizing the Conditions for Residual Stress Measurement Using a Two-Dimensional XRD Method with Specimen Oscillation  [PDF]
Osamu Takakuwa, Hitoshi Soyama
Advances in Materials Physics and Chemistry (AMPC) , 2013, DOI: 10.4236/ampc.2013.31A002

In order to optimize the conditions for residual stress measurement using a two-dimensional X-ray diffraction (2D-XRD) in terms of both efficiency and accuracy. The measurements have been conducted on three stainless steel specimens in this study. The three specimens were processed by annealing, a cavitating jet in air and a disc grinder, with each method introducing different residual stresses at the surface. The specimens were oscillated in the ω-direction, representing a right-hand rotation of the specimen about the incident X-ray beam. The range of the oscillation, Δω, was varied and optimum Δω was determined. Moreover, combinations of the tilt angle between the specimen surface normal and the diffraction vector, ψ, with the rotation angle about its surface normal, f, have been studied with a view to find the most optimum condition. The results show that the use of ω oscillations is an effective method for improving analysis accuracy, especially for large grain metals. The standard error rapidly decreased with increasing range of the ω oscillation, especially for the annealed specimen which generated strong diffraction spots due to its large grain size.

Role on Moment of Inertia and Vortex Dynamics for a Thin Rotating Plate  [PDF]
Yoshihiro Kubota, Osamu Mochizuki
World Journal of Mechanics (WJM) , 2013, DOI: 10.4236/wjm.2013.36028

In this study, we focused on the lift generation with a thin rotating plate. The objective of this study is to understand the appropriate shape and the role of vortex for rotating thin plate. We determined the shape of the plate through free-flight tests of paper strips and investigated the aerodynamic characteristics of the rotating plate with the selected shape. The rectangular plate with an aspect ratio 7 was relevant from moment of inertia and bending stress. An endplate on a wing tip increased the stability on the lateral vortex structure behind the rotating plate. Velocity field measurement by Particle Image Velocimetry (PIV) showed that the lift force was generated twice in a rotating cycle.

Product Reputation Trend Extraction from Twitter  [PDF]
Aizhan Bizhanova, Osamu Uchida
Social Networking (SN) , 2014, DOI: 10.4236/sn.2014.34024

Micro-blogging today has become a very popular communication tool among the Internet users. Real-time web services such as Twitter allow users to express their opinions and interests, often expressed in the form of short text messages. Many business companies are looking into utilizing these data streams in order to improve their marketing campaigns, refine advertising and better meet their customer needs. In this study, we focus on using Twitter, for the task of extraction product reputation trend. Thus, business could gauge the effectiveness of a recent marketing campaign by aggregating user opinions on Twitter regarding their product. In this paper, we introduce an approach for automatically classifying the sentiment of Twitter messages toward product/brand, using emoticons and by improving pre-processing steps in order to achieve high accuracy.

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