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Search Results: 1 - 10 of 462311 matches for " Opal A. McInnis "
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The Role of the Val66Met Polymorphism of the Brain Derived Neurotrophic Factor Gene in Coping Strategies Relevant to Depressive Symptoms
Warren Caldwell, Opal A. McInnis, Robyn J. McQuaid, Gele Liu, John D. Stead, Hymie Anisman, Shawn Hayley
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065547
Abstract: Disturbances of brain derived neurotrophic factor (BDNF) signalling have been implicated in the evolution of depression, which likely arises, in part, as a result of diminished synaptic plasticity. Predictably, given stressor involvement in depression, BDNF is affected by recent stressors as well as stressors such as neglect experienced in early life. The effects of early life maltreatment in altering BDNF signalling may be particularly apparent among those individuals with specific BDNF polymorphisms. We examined whether polymorphisms of the Val66Met genotype might be influential in moderating how early-life events play out with respect to later coping styles, cognitive flexibility and depressive features. Among male and female undergraduate students (N = 124), childhood neglect was highly related to subsequent depressive symptoms. This outcome was moderated by the BDNF polymorphism in the sense that depressive symptoms appeared higher in Met carriers who reported low levels of neglect than in those with the Val/Val allele. However, under conditions of high neglect depressive symptoms only increased in the Val/Val individuals. In effect, the Met polymorphism was associated with depressive features, but did not interact with early life neglect in predicting later depressive features. It was further observed that among the Val/Val individuals, the relationship between neglect and depression was mediated by emotion-focused styles and diminished perceived control, whereas this mediation was not apparent in Met carriers. In contrast to the more typical view regarding this polymorphism, the data are consistent with the perspective that in the presence of synaptic plasticity presumably associated with the Val/Val genotype, neglect allows for the emergence of specific appraisal and coping styles, which are tied to depression. In the case of the reduced degree of neuroplasticity expected in the Met carriers, early life adverse experiences are not tied to coping styles, and hence less likely to be translated into depressive states.
Competitive Actions of Open Source Firms
Glen McInnis
Technology Innovation Management Review , 2007,
Abstract: Early in 2006, Microsoft CEO Steve Balmer made a public statement that Microsoft had no trouble competing with open source rivals on features. Balmer was downplaying the fact that Open Source Software (OSS) has changed the nature of competition in the software industry from one of feature-based competition to a much more complex model for competition. Traditional firms like Microsoft are not simply competing against a loose group of programmers who produce OSS; they are competing against other firms who have chosen to use OSS as part of their product or service offering. This article is an examination of competition in this new environment where firm-to-firm competition includes those firms making use of OSS. The evolution of the marketplace becomes evident when competition is viewed as a series of small, but discrete actions that are carried out by a firm. Each of these actions is intended to improve the firm's standing in the marketplace. Such actions can be classified as one of six different types of competitive action: (i) pricing, (ii) marketing, (iii) new products, (iv) capacity, (v) service, and (vi) signaling.
Energy Flows and Jet Production in Tagged e-gamma Events at LEP
A. M. Rooke,for the OPAL collaboration
Physics , 1997,
Abstract: It has already been shown that the energy flow distributions in tagged events disagree with those predicted by QCD models, generating serious systematic errors in the unfolding of the photon structure function $F_{2}^{\gamma}$. This new analysis uses the jet structure in the hadronic final state to identify the class of events which is in worst agreement with the models. A cone jet finder is used to select events with 0,1 or 2 jets whose transverse energy is greater than 3 GeV. Tagged electrons are detected in the OPAL forward detector at angles between 60 and 120 milliradians. As well as the QCD-based Monte Carlo models, HERWIG and PYTHIA, the simple F2GEN program is used to give a comparison sample of events with purely pointlike photon-quark coupling.
Technical Note: Development of an automated lysimeter for the calculation of peat soil actual evapotranspiration
S. Proulx-McInnis,A. St-Hilaire,A. N. Rousseau,S. Jutras
Hydrology and Earth System Sciences Discussions , 2011, DOI: 10.5194/hessd-8-5009-2011
Abstract: A limited number of publications in the literature deal with the measurement of actual evapotranspiration (AET) from a peat soil. AET is an important parameter in the description of water pathways of an ecosystem. In peatlands, where the water table is near the surface and the vegetation is composed of nonvascular plants without stomatal resistance, the AET measurement represents a challenge. This paper discusses the development of an automated lysimeter installed between 12 and 27 July 2010, at a 11-ha bog site, Pont-Rouge (42 km west of Quebec City, Canada). This system was made of an isolated block of peat, maintained at the same water level as the surrounding water table by a system of submersible pressure transmitters and pumps. The change in water level in millimetres in the isolated block of peat was used to calculate the water lost through evapotranspiration (ET) while accounting the precipitation. The rates of AET were calculated for each day of the study period. Temperature fluctuated between 17.2 and 23.3 °C and total rainfall was 43.76 mm. AET rates from 0.6 to 6.9 mm day 1 were recorded, with a ΣAET/ΣP ratio of 1.38. The estimated potential ET (PET) resulting from Thornthwaite's semi-empirical formula suggested values between 2.8 and 3.9 mm day 1. The average AET/PET ratio was 1.13. According to the literature, the results obtained are plausible. This system, relatively inexpensive and simple to install, may eventually be used to calculate AET on peaty soils in the years to come.
Census survival ratio estimates of net migration for Canadian regions
McInnis, R. Marvin
Canadian Studies in Population , 1974,
Body mass index, physical activity, and dietary behaviors among members of an urban community fitness center: a questionnaire survey
Kimberly A Kaphingst, Gary G Bennett, Glorian Sorensen, Karen M Kaphingst, Amy E O'Neil, Kyle McInnis
BMC Public Health , 2007, DOI: 10.1186/1471-2458-7-181
Abstract: We surveyed 135 randomly selected members of an urban YMCA facility in Massachusetts to examine self-reported (1) physical activity, (2) dietary behaviors, (3) body mass index, and (4) correlates of behavior change among short-term (i.e., one year or less) and long-term (i.e., more than one year) members. Chi-square tests were used to assess bivariate associations between variables, and multivariate linear regression models were fit to examine correlates of health behaviors and weight status.Eighty-nine percent of short-term and 94% of long-term members reported meeting current physical activity recommendations. Only 24% of short-term and 19% of long-term members met fruit and vegetable consumption recommendations, however, and more than half were overweight or obese. Length of membership was not significantly related to weight status, dietary behaviors, or physical activity. Most respondents were interested in changing health behaviors, in the preparation stage of change, and had high levels of self-efficacy to change behaviors. Short-term members had less education (p = 0.02), lower household incomes (p = 0.02), and were less likely to identify as white (p = 0.005) than long-term members. In multivariate models, females had lower BMI than males (p = 0.003) and reported less physical activity (p = 0.008). Physical activity was also inversely associated with age (p = 0.0004) and education (p = 0.02).Rates of overweight/obesity and fruit and vegetable consumption suggested that there is a need for a weight control intervention among members of an urban community YMCA. Membership in such a community wellness facility alone might not be sufficient to help members maintain a healthy weight. The data indicate that YMCA members are interested in making changes in their dietary and physical activity behaviors. Targeting newer YMCA members might be an effective way of reaching underserved populations. These data will help inform the development of a weight control intervent
Use of a screening authorization and randomization center for severe sepsis patient qualification and real-time enrollment in a phase 2 trial of eritoran tetrasodium (E5564), a TLR4 antagonist
J Schentag, S Opal, M Lynn, A Wittek, J Wheeler
Critical Care , 2009, DOI: 10.1186/cc8061
Abstract: Advantages of utilizing a screening authorization and randomization center (SAC) method to characterize patients in trials for sepsis modifiers are presented.A central SAC on call 24 hours per day was employed in a phase 2, double-blind, randomized comparison of eritoran 45 and 105 mg versus placebo. SAC activities were conducted (January 2002 to April 2005) by six clinical pharmacists. Severe sepsis was defined with at least three systemic inflammatory response syndrome criteria within 12 hours before onset of ≥1 new organ dysfunction. Patients were randomized and treated within 8 to 12 hours. The 8-hour to 12-hour window for qualification and start of treatment was the primary challenge to the SAC and study sites. Each site used two sequences of drug assignment based on Acute Physiology and Chronic Health Evaluation (APACHE) II predicted mortality to yield a balanced allocation of high and low APACHE II predicted mortality within the three treatment groups: one sequence for subjects with APACHE II predicted mortality 20 to 50%, and another for subjects with predicted mortality 51 to 80% as calculated by the SAC.The SAC screened 1,025 patients from 78 sites; 300 patients from 54 sites were randomized, and 293 were treated. The Independent Clinical Evaluation Committee subsequently qualified 229/293 (78%). Calls to the SAC averaged 24 patients/month; eight patients/month were randomized (33%). Enrollments ranged from 0 to 39 patients/site; 35 sites randomized ≥3 patients; nine sites randomized ≥10 patients. Of 35 sites with ≥3 patients, 6 to 100% led to randomization.Advantages of utilizing the SAC included a high evaluable rate of enrolled patients, correct Predicted Risk of Mortality calculations, timing of qualifying organ failures, drug preparation advice, verification of key clinical data, and eligibility with sponsor prior to enrollment. SAC activities ensured an informative phase 2 trial and will be utilized for the phase 3 trial.
Search for Direc Magnetic Monopoles in e+e- Collisions with the OPAL Detector at LEP2
The OPAL collaboration
Physics , 2007, DOI: 10.1016/j.physletb.2008.03.057
Abstract: This letter describes a direct search for pair produced magnetic monopoles in e+e- collisions. The analysis is based on 62.7 pb^-1 of data collected with the OPAL detector at an average centre-of-mass energy of sqrt(s)= 206.3GeV. The monopole signal was assumed to be characterized by two back-to-back particles with an anomalously high ionization energy loss de/dx in the tracking chambers. No evidence for production of monopoles was observed. Upper limits were obtained on the magnetic monopole pair-production cross-section (sigma) in the mass range 45 GeV/c^2
Search for invisibly decaying Higgs bosons in e+e- -> Zoho production at sqrt(s) = 183 - 209 GeV
The OPAL collaboration
Physics , 2007, DOI: 10.1016/j.physletb.2009.09.010
Abstract: A search is performed for Higgs bosons decaying into invisible final states, produced in association with a Zo boson in e+e- collisions at energies between 183 and 209 GeV. The search is based on data samples collected by the OPAL detector at LEP corresponding to an integrated luminosity of about 660 pb-1. The analysis aims to select events containing the hadronic decay products of the Zo boson and large missing momentum, as expected from Higgs boson decay into a pair of stable weakly interacting neutral particles, such as the lightest neutralino in the Minimal Supersymmetric Standard Model. The same analysis is applied to a search for nearly invisible Higgs boson cascade decays into stable weakly interacting neutral particles. No excess over the expected background from Standard Model processes is observed. Limits on the production of invisibly decaying Higgs bosons produced in association with a Zo boson are derived. Assuming a branching ratio BR(ho->invisible)=1, a lower limit of 108.2 GeV is placed on the Higgs boson mass at the 95% confidence level. Limits on the production of nearly invisibly decaying Higgs bosons are also obtained.
Search for Charged Higgs Bosons in e+e- Collisions at sqrts(s) = 189-209 GeV
The OPAL collaboration
Physics , 2008, DOI: 10.1140/epjc/s10052-012-2076-0
Abstract: A search is made for charged Higgs bosons predicted by Two-Higgs-Doublet extensions of the Standard Model (2HDM) using electron-positron collision data collected by the OPAL experiment at sqrt(s)=189-209 GeV, corresponding to an integrated luminosity of approximately 600 pb-1. Charged Higgs bosons are assumed to be pair-produced and to decay into q qbar, tau nu or A W+-. No signal is observed. Model-independent limits on the charged Higgs-boson production cross section are derived by combining these results with previous searches at lower energies. Under the assumption BR(H+- -> tau nu) + BR(H+- -> qq)=1, motivated by general 2HDM type II models, excluded areas on the [m(H+-), BR(H+- -> tau nu)] plane are presented and charged Higgs bosons are excluded up to a mass of 76.3 GeV at 95% confidence level, independent of the branching ratio BR(H+- -> tau nu). A scan of the 2HDM type I model parameter space is performed and limits on the Higgs-boson masses m(H+-) and m(A) are presented for different choices of tan(beta).
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