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Search Results: 1 - 10 of 138875 matches for " Olukemi K Amodu "
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Early home treatment of childhood fevers with ineffective antimalarials is deleterious in the outcome of severe malaria
Adebola E Orimadegun, Olukemi K Amodu, Peter E Olumese, Olayemi O Omotade
Malaria Journal , 2008, DOI: 10.1186/1475-2875-7-143
Abstract: Two hundred and sixty-eight children with a median age of 30 months comprising 114 children with cerebral malaria and 154 with severe malarial anaemia (as defined by WHO) were prospectively enrolled. Data on socio-demographic data, treatments given at home, clinical course and outcome of admission were collected and analysed.A total of 168 children had treatment with an antimalarial treatment at home before presenting at the hospital when there was no improvement. There were no significant differences in the haematocrit levels, parasite counts and nutritional status of the pre-hospital treated and untreated groups. The most commonly used antimalarial medicine was chloroquine. Treatment policy was revised to Artemesinin-based Combination Therapy (ACT) in 2005 as a response to unacceptable levels of therapeutic failures with chloroquine, however chloroquine use remains high. The risk of presenting as cerebral malaria was 1.63 times higher with pre-hospital use of chloroquine for treatment of malaria, with a four-fold increase in the risk of mortality. Controlling for other confounding factors including age and clinical severity, pre-hospital treatment with chloroquine was an independent predictor of mortality.This study showed that, home treatment with chloroquine significantly impacts on the outcome of severe malaria. This finding underscores the need for wide-scale monitoring to withdraw chloroquine from circulation in Nigeria and efforts intensified at promoting prompt treatment with effective medicines in the community.Malaria remains a significant cause of morbidity and mortality among children and creates enormous social, economic and disease burdens in endemic regions[1,2]. Current control efforts focus on reducing malaria-attributable morbidity and mortality. Prompt evaluation of all febrile illness, case-recognition and use of appropriate antimalarial therapy are essential to malarial control in order to optimize clinical outcomes of malaria-infected patients
Rapid Adsorption of Crystal Violet onto Magnetic Zeolite Synthesized from Fly Ash and Magnetite Nanoparticles  [PDF]
Olusola S. Amodu, Tunde V. Ojumu, Seteno K. Ntwampe, Olushola S. Ayanda
Journal of Encapsulation and Adsorption Sciences (JEAS) , 2015, DOI: 10.4236/jeas.2015.54016
Abstract: This work reports the adsorption of crystal violet (CV) dye onto magnetic zeolite (MZ) nanoparticles, synthesized by direct fusion of fly ash (FA) and magnetite particles. The synthesised MZ showed high capacity for CV dye adsorption, removing 95% of the dye at an equilibrium adsorption time of 10 min and 25℃. The effects of adsorbent dosage, dye concentration, and pH, on adsorption were evaluated. Adsorption data were best described by the Langmuir adsorption isotherm (R2 = 0.9986), while the adsorption kinetics was best fitted by the pseudo-second-order kinetic model (R2 = 0.9999). Application of the MZs synthesised from inexpensive resources such as FA could ensure the sustainability and cost effectiveness of treating industrial effluent containing basic dyes, especially effluent from the textile industries.
Quality of Antenatal Care: Comparison between Secondary and Tertiary Health Facilities in Ibadan, Nigeria  [PDF]
Oluwasomidoyin Olukemi Bello
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.86063
Abstract: Background: Patient satisfaction is related to the quality of services received and the extent to which specific needs are met. Satisfied patients are likely to come back for the health services and recommend it to others. Objective: To assess and compare patients’ satisfaction with the quality of prenatal/antenatal care (QPC) services received at a tertiary and secondary health facility in Ibadan, Nigeria. Methods: A comparative cross sectional study used an interviewer administered questionnaire to assess and compare the quality of antenatal care among women who had antenatal care and delivered live baby in two government health facilities—Adeoyo Maternity Hospital (secondary health facility) and University College Hospital (tertiary health facility). A total of 500 women were interviewed within 48 hours post delivery and data obtained was analyzed with SPSS version 20. Results: The mean age was 29.7 (SD = 4.95) years. About half of the respondents had more than four antenatal visits, almost two-thirds (61.4%) were primipara, and 55.6% delivered per vagina. Almost all (98.4%) the women were very satisfied with the QPC received while a little above half (54.0%) received high QPC. Health facility and mode of delivery were found to be significantly associated with the satisfaction of the QPC. Factors predicting high QPC comparing the tertiary and secondary health facility are “availability” (OR = 0.341, 95%CI = 0.173 - 0.672) and “support and respect” (OR = 5.599, 95%CI = 3.621 - 8.659) of health care
Utilizing Short Tandem Repeats (STRs) as a Resolving Matrix in Parental Dispute DNA Analysis  [PDF]
George Gborienemi Simeon, Alade Tolulope Olukemi
American Journal of Molecular Biology (AJMB) , 2018, DOI: 10.4236/ajmb.2018.83013
Abstract: Interest in DNA analysis using short tandem repeats (STR) as finger printing tools in forensic medicine has gained tremendous application, as expression of these nuclear factors have enhanced forensic examination. Here we used this Biochemical characterization after conventional extraction process, polymerase chain reaction (PCR), gel electrophoresiss and a sequencer to distinguish and resolve parental dispute. The differential migration of labeled DNA fragments which attains excitation energy with a laser elicits fluorescent light of different wavelength depending on the dye used. A data collection software (Genemapper) collects raw data (spectrograph) and converts it to an electropherogram that is interpreted. By comparing the DNA profiles, inclusion and exclusion criteria were elucidated to resolve disputes. The inherent discriminating power of STRs used in analysis enhances resolution of cell mixtures, genetic aberration, substantiation of tissue origin and provides genetic distinction which is a robust and reliable approach in resolving parental disputes.
Aeromonas- related diarrhoea in Nasarawa, Nigeria
Kandakai-Olukemi Y,Mawak J,Olukemi M,Ojumah S
Annals of African Medicine , 2007,
Abstract: Background : Two hundred and fifty volunteer patients attending 5 major hospitals in Nasarawa town, Nasarawa State, Nigeria were involved in this study to determine the prevalence of Aeromonas spp in persons with diarrhoea. The study population consisted of 133 males and 117 females between the ages of 0-70 years. Methods : Stool samples (148 diarrhoeal and 102 non-diarrhoeal) were analysed for the presence of Aeromonas spp. using standard bacteriological methods. The isolates were also subjected to antimicrobial susceptibility testing using the disc diffusion method. Results : Four (1.60%) of the 250 stool samples were positive for Aeromonas spp. Three (2.03%) of the isolates were recovered from diarrhoeal specimens and 1 (0.98%) from non-diarrhoeal (control) samples. The difference was statistically significant (P< 0.05). The highest numbers of isolates 3 (3.66%) were recovered from age group 0-10 years while age group 61-70 years yielded 1 (14.29%). All isolates were found to be Aeromonas hydrophilia. The isolates were all sensitive to tetracycline, gentamicin, chloramphenicol, cotrimoxazole and streptomycin but resistant to penicillin and ampicillin. Other enteropathogens isolated were Shigella spp 5 (2.0%) and Salmonella spp 2(0.8%). Conclusion : This study has shown that a small percentage of gastroenteritis can be attributed to Aeromonas hydrophilia.
Modelling the Long Run Determinants of Domestic Private Investment in Nigeria
Kazeem Bello Ajide,Olukemi Lawanson
Asian Social Science , 2012, DOI: 10.5539/ass.v8n13p139
Abstract: The paper seeks to model the long run determinants of domestic private investment in Nigeria over the period 1970 to 2010, employing advanced econometric technique of Auto-Regressive Distributed Lag (ARDL) bounds testing approach. Emanated from the estimated models are intriguing findings which showed clearly that difference exist between long and short run determinants. Public investment, real GDP, real interest rate, exchange rate, credit to the private sector, terms of trade, external debts and reforms dummy are the key long run determinants of domestic private investment while public investment, real GDP and terms of trade are statistically significant in the short run. The policy prescriptions are that necessary infrastructures to complement domestic private investment should be put in place; that external debts be reduced to the barest minimum and negative effects of external shocks engendered by foreign direct investment uncertainty and deficit terms of trade should be prevented altogether.
Inflation Thresholds and Economic Growth: Evidence from Nigeria
Kazeem Bello Ajide,Olukemi Lawanson
Asian Economic and Financial Review , 2012,
Abstract: Inflation is one of the most challenging macroeconomic objectives capable of frustrating every pragmatic effort at achieving other macroeconomics goals if not curtailed. To this end, the paper empirically examines the threshold inflation rate that is considered optimally reasonable for maintaining a sustainable economic growth. The study in specific terms employs a least square multivariate approach to estimate a threshold level of inflation. Further, error correction modeling (ECM) approach was explored to identify the long run relationship among other major determinants of real GDP growth using a simple augmented production function. In addition, a pairwise granger causality test was conducted to explore the causal link between the inflation and growth of real GDP. Interestingly, it was observed from the causality test that there was neither bidirectional nor unidirectional causality between the two but rather an independent relationship. The findings from least square estimation also established 9% threshold inflation level. The results from ECM confirmed the values of lagged of real GDP growth rates, investment, current inflation, population growth and terms of trade as important factors affecting growth rates of real GDP in Nigeria. Based on the outcome of the results it was therefore suggested that an identification of country-specific inflation thresholds in the inflation-growth relationship might provide useful information about the appropriate location and width of an inflation targeting band.
Heme Mediated STAT3 Activation in Severe Malaria
Mingli Liu, Audu S. Amodu, Sidney Pitts, John Patrickson, Jacqueline M. Hibbert, Monica Battle, Solomon F. Ofori-Acquah, Jonathan K. Stiles
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034280
Abstract: Background The mortality of severe malaria [cerebral malaria (CM), severe malaria anemia (SMA), acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)] remains high despite the availability associated with adequate treatments. Recent studies in our laboratory and others have revealed a hitherto unknown correlation between chemokine CXCL10/CXCR3, Heme/HO-1 and STAT3 and cerebral malaria severity and mortality. Although Heme/HO-1 and CXCL10/CXCR3 interactions are directly involved in the pathogenesis of CM and fatal disease, the mechanism dictating how Heme/HO-1 and CXCL10/CXCR3 are expressed and regulated under these conditions is still unknown. We therefore tested the hypothesis that these factors share common signaling pathways and may be mutually regulated. Methods We first clarified the roles of Heme/HO-1, CXCL10/CXCR3 and STAT3 in CM pathogenesis utilizing a well established experimental cerebral malaria mouse (ECM, P. berghei ANKA) model. Then, we further determined the mechanisms how STAT3 regulates HO-1 and CXCL10 as well as mutual regulation among them in CRL-2581, a murine endothelial cell line. Results The results demonstrate that (1) STAT3 is activated by P. berghei ANKA (PBA) infection in vivo and Heme in vitro. (2) Heme up-regulates HO-1 and CXCL10 production through STAT3 pathway, and regulates CXCL10 at the transcriptional level in vitro. (3) HO-1 transcription is positively regulated by CXCL10. (4) HO-1 regulates STAT3 signaling. Conclusion Our data indicate that Heme/HO-1, CXCL10/CXCR3 and STAT3 molecules as well as related signaling pathways play very important roles in the pathogenesis of severe malaria. We conclude that these factors are mutually regulated and provide new opportunities to develop potential novel therapeutic targets that could be used to supplement traditional prophylactics and treatments for malaria and improve clinical outcomes while reducing malaria mortality. Our ultimate goal is to develop novel therapies targeting Heme or CXCL10-related biological signaling molecules associated with development of fatal malaria.
Total serum vitamin C concentration in pregnant women: implications for a healthy pregnancy
Hassan, Garba Ibrahim;Onu, Amodu Bala;
Revista Brasileira de Saúde Materno Infantil , 2006, DOI: 10.1590/S1519-38292006000300005
Abstract: objectives: total serum vitamin c (l-ascorbic acid) concentration was measured in 90 pregnant women, 30 in each trimester (age range 18-35 years) and a control group of age-matched non-pregnant women. methods: total serum vitamin c concentration was measured using the 2.4-dinitrophenylhydrazine method which involves the conversion of vitamin c to dehydroascorbic acid in the presence of copper (ii) ions and subsequent measurement of the resulting bis-hydrazone at 540nm. results: the total vitamin c concentration in the first trimester was 2.55 ± 0.82 mg/dl and 2.32 ± 0.40 mg/dl and 0.77 ± 0.10 mg/dl in the second and third trimesters respectively. relative to serum total vitamin c concentration in the controls (3.15 ± 0.13 mg/dl) these values are significantly lower (p < 0.05). conclusions: low serum vitamin c in pregnancy may indicate utilization of this vitamin to mop up the excess reactive oxygen species and maintain its normal homeostasis. therefore, vitamin c supplementation during pregnancy is recommended in order to boost the body's low vitamin c level and prevent the predisposition to low birth weight babies, premature delivery and pre-eclamsia all of which are known to be associated with sub-optimal vitamin c levels during pregnancy.
Assessment of Farmers (Women)’ Access to Agricultural Extension, Inputs and Credit Facility in Sabon-Gari Local Government Area of Kaduna State
JO Owolabi, BZ Abubakar, MY Amodu
Nigerian Journal of Basic and Applied Sciences , 2011,
Abstract: This study examines the accessibility of women to three main production inputs namely: Farm inputs (fertilizers, modern technology, improved seed etc), Credit facility and Contact with extension agents. Structured interview schedule, personal observation and analysis of records were used to collect information for the study. The findings revealed that women in the study area were engaged in farming activities such as crop production and rearing of livestock. Traditional technology is still the practice among women farmers. Majority of the women sampled were small-scale farmers with low level of income and education. Women interviewed complained of lack of access to farm inputs, credit facilities and contact with extension workers, the situation which has constrained them from investing in agricultural production. The study recommended that women farmers should be given incentives, particularly in the area of production inputs (credit facilities, fertilizer, and improved seeds among others) and educational opportunities.
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