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Search Results: 1 - 10 of 405 matches for " Olive Kearins "
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Male breast carcinoma: increased awareness needed
Jonathan White, Olive Kearins, David Dodwell, Kieran Horgan, Andrew M Hanby, Valerie Speirs
Breast Cancer Research , 2011, DOI: 10.1186/bcr2930
Abstract: Breast cancer is predominantly a female disease with 49,492 cases (invasive and non-invasive) diagnosed in the UK in 2006 [1]. According to data from the International Agency for Research on Cancer, this is broadly in line with figures from other western nations [2]. Tremendous strides in our understanding of breast cancer have been made over the past two decades and, when detected early, breast cancer is one of the most curable and treatable of all cancers. Male breast cancer is much less frequent with 334 cases diagnosed in the UK in 2006 [1], accounting for just under 1% of all breast cancers.Owing to the rarity of male breast cancer, establishing precise risk factors for the disease has proved challenging. Male and female breast cancers share many common risk factors; for example, advancing age and previous family history. In terms of male breast cancer, data from the Breast Cancer Linkage Consortium showed that men harbouring BRCA2 mutations have a relative risk of 80 for developing breast cancer [3] - making BRCA2 the strongest known gene associated with male breast cancer [4,5]. Androgen receptor mutations have also been reported [6]. Some suggested risk factors associated with male breast cancer are summarised in Table 1[4-8].Although still a rare disease, anecdotal evidence from clinical and pathology colleagues coupled with reports from recent literature suggests that male breast cancer is becoming more common [9-12]. As a means of corroborating this, we analysed data from four western nations: England, Scotland, Canada and Australia. Data for England were provided by the West Midlands Cancer Intelligence Unit [13]. Data for Scotland were obtained from the Information Services Division (Scotland) website [14]. Canadian data were obtained from the Public Health Agency of Canada [15], and data for Australia from the Australian Institute of Health and Welfare [16]. As the population of Scotland is considerably smaller than the other three nations, Scottish an
Correction: PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer
Gordon C Wishart, Elizabeth M Azzato, David C Greenberg, Jem Rashbass, Olive Kearins, Gill Lawrence, Carlos Caldas, Paul DP Pharoah
Breast Cancer Research , 2010, DOI: 10.1186/bcr2480
PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer
Gordon C Wishart, Elizabeth M Azzato, David C Greenberg, Jem Rashbass, Olive Kearins, Gill Lawrence, Carlos Caldas, Paul DP Pharoah
Breast Cancer Research , 2010, DOI: 10.1186/bcr2464
Abstract: Using the Eastern Cancer Registration and Information Centre (ECRIC) dataset, information was collated for 5,694 women who had surgery for invasive breast cancer in East Anglia from 1999 to 2003. Breast cancer mortality models for oestrogen receptor (ER) positive and ER negative tumours were derived from these data using Cox proportional hazards, adjusting for prognostic factors and mode of cancer detection (symptomatic versus screen-detected). An external dataset of 5,468 patients from the West Midlands Cancer Intelligence Unit (WMCIU) was used for validation.Differences in overall actual and predicted mortality were <1% at eight years for ECRIC (18.9% vs. 19.0%) and WMCIU (17.5% vs. 18.3%) with area under receiver-operator-characteristic curves (AUC) of 0.81 and 0.79 respectively. Differences in breast cancer specific actual and predicted mortality were <1% at eight years for ECRIC (12.9% vs. 13.5%) and <1.5% at eight years for WMCIU (12.2% vs. 13.6%) with AUC of 0.84 and 0.82 respectively. Model calibration was good for both ER positive and negative models although the ER positive model provided better discrimination (AUC 0.82) than ER negative (AUC 0.75).We have developed a prognostication model for early breast cancer based on UK cancer registry data that predicts breast cancer survival following surgery for invasive breast cancer and includes mode of detection for the first time. The model is well calibrated, provides a high degree of discrimination and has been validated in a second UK patient cohort.Accurate prediction of survival is an essential part of the decision making process following surgery for early breast cancer and allows clinicians to determine which patients will benefit from adjuvant therapy. At present these decisions are largely based on known pathological prognostic factors that retain independent significance on multivariate analysis including tumour size, tumour grade and lymph node status in addition to the efficacy of any adjuvant thera
Optimal Adiposity Measurement and Risk Stratification in Established Ischaemic Stroke  [PDF]
Olive Lennon, Catherine Blake
World Journal of Cardiovascular Diseases (WJCD) , 2014, DOI: 10.4236/wjcd.2014.413077
Abstract: Background: Prevention strategies post-stroke should target risk factor reduction which includes consideration of weight, diet and lipoprotein profiles. Limited data informs the optimal adiposity measurement post-stroke to target those at highest recurrent risk. This study aims to identify adiposity measurement/s post-stroke that best predict cardiovascular and co-morbid risk. Subjects and Methods: 142 stroke patients (100 males, 42 females; mean age 63 years) participated. Adiposity and metabolic profiles included BMI, waist circumference, waist to height ratio (WHR), triglyceride levels and hypertriglyceridemic waist. The predictive ability of these measures with indices of cardiovascular risk (Cardiovascular Risk Score) and co-morbidity (Charlson’s co-morbidity index) were examined. Results: In hierarchical multiple regression models, age and gender controlled, waist (p = 0.002), triglyceride levels (p = 0.006), BMI and WHR (p = 0.014), uniquely and significantly contributed to the variance in cardiovascular risk, in their models. Only one combination of measures (waist and triglyceride levels) improved the predictive ability of waist in cardiovascular risk stratification (p = 0.001). In men, waist (p = 0.013) and in women triglyceride levels (p = 0.012) performed as the best predictors of cardiovascular risk respectively. No combination of measures was superior to triglyceride levels in women or waist circumference measures in men in predicting cardiovascular risk. With Charlson’s co-morbidity index as the dependent variable, triglyceride levels significantly contributed to variance of the model with age and gender influences controlled (p = 0.047). No combination of measures improved the predictive ability of triglyceride levels for co-morbidity. Conclusion: Waist circumference and triglyceride levels should form a minimum dataset for adiposity when considering cardiovascular and comorbid risk post-stroke.
Competition and Dispute Settlement for Fishery Resources: A case study of Property Regimes in Sarangani Bay
Steve Olive
Kasarinlan : Philippine Journal of Third World Studies , 1993,
Abstract: The study examines the depletion of fishery resources in Sarangani Bay by describing the property regimes in the area and how these regimes manipulate dispute settlement processes in order to control fishery resources. The four property regimes of Sarangani Bay are the open access property regime wherein the resources are open to anyone; the state property regime; the private property regime that comprises local fishers and the fishing industries; and the common property regime, which consists of fishing communities. All these regimes participate in managing and controlling fishery resources and allocating fishing rights. A major cause of depletion is the level of uncertainty on how disputes are settled. Two major legal traditions are followed in dispute settlements: the state legal code and local codes based on culture, ethnicity, and religion. Stakeholders use both competitive and cooperative strategies in dispute resolution. The state property regime is weak and inefficient in managing fishery resources, settling disputes, and enforcing laws. The study argues that the stakeholders can exploit the state’s weakness by manipulating state processes in order to protect their interests. For instance, some of them pressure the state or cooperate with NGOs in order to gain access to fishery resources. They are likely to select dispute settlement processes that will ensure the greatest degree of advantage to them. Private property and common property regimes are more successful in controlling fishery resources for their own interest. Meanwhile, fishers (producers) are frequently victimized by classifiers and financiers and hindered by the state from asserting their rights. This makes the dispute settlement outcome more competitive and uncertain, and consequently reduces the supply of fishery resources. Aside from understanding the power dynamics of Sarangani Bay, the stakeholders should make use of dispute settlement processes that increase participation and debate and promote cooperative strategies.
Prospective elementary school teachers’ ways of making sense of mathematical problem posing (Modos en que futuros profesores de primaria dan sentido a la invención de problemas matemáticos)
Olive Chapman
PNA , 2012,
Abstract: The study tackled prospective teachers’ sense-making of mathematical problem posing and the impact of posing different contextual problems on their learning. Focus was on the generation of new problems and reformulation of given problems. Participants were 40 prospective elementary teachers. The findings provide insights into possible ways these teachers could make sense of problem posing of contextual mathematical problems and the learning afforded by posing diverse problems. Highlighted are five perspectives and nine categories of problem posing tasks to support development of proficiency in problem-posing knowledge for teaching. El estudio indagó sobre los modos en que futuros profesores de primaria dan sentido a la invención de problemas matemáticos y el impacto de plantear diferentes problemas contextualizados en su aprendizaje. El foco fue la invención de nuevos problemas y la reformulación de otros dados. Los participantes fueron 40 futuros maestros de primaria. Los resultados proporcionan elementos sobre posibles modos en que estos maestros dan sentido a la invención de problemas matemáticos y el aprendizaje que ofrece plantear diversos problemas. Se destacan cinco perspectivas y nueve categorías de tareas en la invención de problemas para apoyar el desarrollo de la competencia de plantear problemas en la ense anza.
Children's Number Sequences: An Explanation of Steffe's Constructs and an Extrapolation to Rational Numbers of Arithmetic
John Olive
Mathematics Educator , 2001,
La Soudière des Trois Lucs (Marseille) - Etudes historiques et fouilles préliminaires
Gilles Olive
Atelier du Centre de Recherches Historiques , 2012, DOI: 10.4000/acrh.4189
Abstract: L’approvisionnement en soude végétale est interrompu en 1808 suite à l’entrée de l’Armée de Napoléon Ier en Espagne. Pour cette raison des fabriques de soude (factice) exploitant le brevet déposé en 1791 par Nicolas Leblanc virent le jour entre juin 1808 et fin 1810 à Paris, Rouen et Marseille principalement. à Marseille une de ces soudière s’installa en 1810 dans le quartier des Trois Lucs. Grace à tout ce qui a pu être trouvé, elle a été localisée avec précision permettant ainsi des fouilles préliminaires. The soda factory of the Trois Lucs at Marseilles (France) - Historical studies and preliminaries excavationsThe supplying of vegetable soda was interrupted in 1808 after Napoleon’s army had entered Spain. Therefore, (artificial) soda factories using Nicolas Leblanc’s patent from 1791 opened mainly in Paris, Rouen and Marseille between June 1808 and the end of 1810. In Marseille, one of these factories was set up in 1810 in the district called Les Trois Lucs. Thanks to everything that could have been discovered, it was perfectly located, thus allowing the preliminary excavations.
Asymptotically Optimal Regression Prediction Intervals and Prediction Regions for Multivariate Data
David Olive
International Journal of Statistics and Probability , 2013, DOI: 10.5539/ijsp.v2n1p90
Abstract: This paper presents asymptotically optimal prediction intervals and prediction regions. The prediction intervals are for a future response $Y_f$ given a $p imes 1$ vector $x_f$ of predictors when the regression model has the form $Y_i = m(x_i) + e_i$ where $m$ is a function of $x_i$ and the errors $e_i$ are iid from a continuous unimodal distribution. The prediction intervals have coverage near or higher than the nominal coverage for many techniques even for moderate sample size $n$, say $n >$ 10(model degrees of freedom). The prediction regions are for a future vector of measurements $x_f$ from a multivariate distribution. The nonparametric prediction region developed in this paper has correct asymptotic coverage if the data $x_1, ..., x_n$ are iid from a distribution with a nonsingular covariance matrix. For many distributions, this prediction region appears to have good coverage for $n > 20 p$, and this region is asymptotically optimal on a large class of elliptically contoured distributions. Hence the prediction intervals and regions perform well for moderate sample sizes as well as asymptotically.
L’art pensable.
Laure Olive
EspacesTemps.net , 2002,
Abstract: La réflexion sur l’art estaujourd’hui florissante, affirme le numéro de juin-juilllet 2001 de la revue Critique . Et il le démontre, à travers onze articles qui commentent et discutent seize ouvrages récents. Son titre, Rouvrir l’art , est significatif. Rouvrir l’art, c’est remettre dans le champ des questions à poser le statut et l’essence de l’art, c’est déverrouiller (p. 472) la question des rapports entre l’art et la nature. C’est repenser des notions ...
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